| 1 | Wed Nov 6 | vs Oral Roberts | W80-75 | 1-0 | 1.000 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 2 | Sat Nov 9 | vsKansas City | W69-51 | 2-0 | 1.000 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 3 | Wed Nov 13 | atCharleston | W73-54 | 3-0 | 1.000 | - | CBS | TD Arena · Charleston, SC |
| 4 | Sun Nov 17 | vsYale | W64-57 | 4-0 | 1.000 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 5 | Fri Nov 22 | vsW Michigan | W70-63 | 5-0 | 1.000 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 6 | Wed Nov 27 | atSyracuse | W86-72 | 6-0 | 1.000 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 7 | Fri Nov 29 | vsOle Miss | W78-37 | 7-0 | 1.000 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 8 | Wed Dec 4 | vsGeorgetown | L74-81 | 7-1 | .875 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 9 | Sun Dec 8 | vsWichita St | L61-80 | 7-2 | .778 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
| 10 | Sun Dec 15 | atHouston | W61-55 | 8-2 | .800 | - | ESPN | Fertitta Center · Houston, TX |
| 11 | Sat Dec 21 | vsMinnesota | L66-86 | 8-3 | .727 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 12 | Sun Dec 29 | vsSE Louisiana | W82-31 | 9-3 | .750 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 13 | Sat Jan 4 | at#22Texas Tech | L50-85 | 9-4 | .692 | - | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 14 | Mon Jan 6 | vs#17West Virginia | L41-55 | 9-5 | .643 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 15 | Sat Jan 11 | atTCU | L40-52 | 9-6 | .600 | - | ESPN2 | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 16 | Wed Jan 15 | vsTexas | L64-76 | 9-7 | .563 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 17 | Sat Jan 18 | vs#2Baylor | L68-75 | 9-8 | .529 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 18 | Tue Jan 21 | atIowa State | L82-89 | 9-9 | .500 | - | | James H. Hilton Coliseum · Ames, IA |
| 19 | Sat Jan 25 | atTexas A&M | W73-62 | 10-9 | .526 | - | ESPNU | Reed Arena · College Station, TX |
| 20 | Mon Jan 27 | vs#3Kansas | L50-65 | 10-10 | .500 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 21 | Sat Feb 1 | atOklahoma | L69-82 | 10-11 | .476 | - | ABC | Lloyd Noble Center · Norman, OK |
| 22 | Wed Feb 5 | vsTCU | W72-57 | 11-11 | .500 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 23 | Sat Feb 8 | at#1Baylor | L70-78 | 11-12 | .478 | - | ESPN2 | Ferrell Center · Waco, TX |
| 24 | Tue Feb 11 | atKansas St | W64-59 | 12-12 | .500 | - | ESPNU | Bramlage Coliseum · Manhattan, KS |
| 25 | Sat Feb 15 | vs#24Texas Tech | W73-70 | 13-12 | .520 | - | CBS | Gallagher-Iba Arena · Stillwater, OK |
| 26 | Tue Feb 18 | at#17West Virginia | L47-65 | 13-13 | .500 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 27 | Sat Feb 22 | vsOklahoma | W83-66 | 14-13 | .519 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 28 | Mon Feb 24 | at#1Kansas | L58-83 | 14-14 | .500 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 29 | Sat Feb 29 | vsIowa State | W73-61 | 15-14 | .517 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
| 30 | Wed Mar 4 | vsKansas St | W69-63 | 16-14 | .533 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
| 31 | Sat Mar 7 | atTexas | W81-59 | 17-14 | .548 | - | ESPN2 | Moody Center · Austin, TX |
| 32 | Wed Mar 11 | vsIowa State | W72-71 | 18-14 | .563 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
