| 1 | Mon Nov 4 | vs Green Bay | W89-76 | 1-0 | 1.000 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 2 | Sun Nov 10 | vsSt Thomas (MN) | W80-71 | 2-0 | 1.000 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 3 | Thu Nov 14 | vsS Illinois | W85-78 | 3-0 | 1.000 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 4 | Thu Nov 21 | atFAU | L78-86 | 3-1 | .750 | - | ESPNU | TD Arena · Charleston, SC |
| 5 | Fri Nov 22 | vsMiami | W80-74 | 4-1 | .800 | - | ESPNU | TD Arena · Charleston, SC |
| 6 | Sun Nov 24 | atNevada | L78-90 | 4-2 | .667 | - | ESPN | TD Arena · Charleston, SC |
| 7 | Wed Dec 4 | atTulsa | W76-55 | 5-2 | .714 | - | ESPN+ | Donald W. Reynolds Center · Tulsa, OK |
| 8 | Sun Dec 8 | atSeton Hall | W85-76 | 6-2 | .750 | - | FS1 | Prudential Center · Newark, NJ |
| 9 | Sat Dec 14 | at13Oklahoma | L65-80 | 6-3 | .667 | - | ESPNU | Paycom Center · Oklahoma City, OK |
| 10 | Wed Dec 18 | vsTarleton | W66-61 | 7-3 | .700 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 11 | Sun Dec 22 | vsOral Roberts | W86-74 | 8-3 | .727 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 12 | Mon Dec 30 | vs14Houston | L47-60 | 8-4 | .667 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 13 | Sat Jan 4 | atWest Virginia | L50-69 | 8-5 | .615 | - | CBSSN | WVU Coliseum · Morgantown, WV |
| 14 | Tue Jan 7 | vsKansas St | W79-66 | 9-5 | .643 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 15 | Sat Jan 11 | atUtah | L62-83 | 9-6 | .600 | - | ESPN+ | Jon M. Huntsman Center · Salt Lake City, UT |
| 16 | Tue Jan 14 | atBYU | L69-85 | 9-7 | .563 | - | ESPN+ | Marriott Center · Provo, UT |
| 17 | Sat Jan 18 | vsColorado | W83-73 | 10-7 | .588 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 18 | Tue Jan 21 | vsArizona | L78-92 | 10-8 | .556 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
| 19 | Sun Jan 26 | atTexas Tech | L54-64 | 10-9 | .526 | - | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 20 | Wed Jan 29 | atKansas St | L57-85 | 10-10 | .500 | - | CBSSN | Bramlage Coliseum · Manhattan, KS |
| 21 | Sat Feb 1 | vsUtah | W81-72 | 11-10 | .524 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 22 | Tue Feb 4 | at5Houston | L63-72 | 11-11 | .500 | - | ESPN+ | Fertitta Center · Houston, TX |
| 23 | Sun Feb 9 | vsArizona St | W86-73 | 12-11 | .522 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 24 | Wed Feb 12 | atTCU | L72-73 | 12-12 | .500 | - | CBSSN | Schollmaier Arena · Fort Worth, TX |
| 25 | Sat Feb 15 | vs12Texas Tech | L55-93 | 12-13 | .480 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 26 | Wed Feb 19 | vsUCF | W104-95 | 13-13 | .500 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
| 27 | Sat Feb 22 | at23Kansas | L64-96 | 13-14 | .481 | - | CBS | Allen Fieldhouse · Lawrence, KS |
| 28 | Tue Feb 25 | vs9Iowa State | W74-68 | 14-14 | .500 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 29 | Sat Mar 1 | atBaylor | L61-71 | 14-15 | .483 | - | ESPN+ | Ferrell Center · Waco, TX |
| 30 | Wed Mar 5 | atUCF | L70-83 | 14-16 | .467 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 31 | Sat Mar 8 | vsCincinnati | W78-67 | 15-16 | .484 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 32 | Tue Mar 11 | vsCincinnati | L68-87 | 15-17 | .469 | - | ESPN+ | T-Mobile Center · Kansas City, MOS |
| 33 | Tue Mar 18 | vsWichita St | W89-79 | 16-17 | .485 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 34 | Sun Mar 23 | atSMU | W85-83 | 17-17 | .500 | - | ESPN2 | Moody Coliseum · Dallas, TX |
| 35 | Tue Mar 25 | vsNorth Texas | L59-61 | 17-18 | .486 | - | ESPN | Gallagher-Iba Arena · Stillwater, OK |
