| 1 | Mon Nov 7 | vs UT Arlington | W77-66 | 1-0 | 1.000 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 2 | Thu Nov 10 | vs S Illinois | L60-61 | 1-1 | .500 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 3 | Sun Nov 13 | at Oakland | W91-62 | 2-1 | .667 | - | | Athletics Center O'rena · Rochester, MI |
| 4 | Fri Nov 18 | vs UCF | L56-60 (OT) | 2-2 | .500 | - | CBS | Gallagher-Iba Arena · Stillwater, OK |
| 5 | Sun Nov 20 | vs DePaul | W82-78 | 3-2 | .600 | - | CBS | Gallagher-Iba Arena · Stillwater, OK |
| 6 | Fri Nov 25 | vs Tulsa | W82-56 | 4-2 | .667 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 7 | Sun Nov 27 | vs Prairie View | W78-53 | 5-2 | .714 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 8 | Thu Dec 1 | at UConn | L64-74 | 5-3 | .625 | - | FS1 | Gampel Pavilion · Storrs, CT |
| 9 | Tue Dec 6 | vs Sam Houston | W65-51 | 6-3 | .667 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
| 10 | Sun Dec 11 | at Virginia Tech | L65-70 | 6-4 | .600 | - | ESPN2 | Cassell Coliseum · Blacksburg, VA |
| 11 | Sat Dec 17 | at Wichita St | W59-49 | 7-4 | .636 | - | ESPNU | Charles Koch Arena · Wichita, KS |
| 12 | Tue Dec 20 | vs Texas A&M-CC | W81-58 | 8-4 | .667 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 13 | Sat Dec 31 | at #4Kansas | L67-69 | 8-5 | .615 | - | CBS | Allen Fieldhouse · Lawrence, KS |
| 14 | Mon Jan 2 | vs West Virginia | W67-60 | 9-5 | .643 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
| 15 | Sat Jan 7 | vs #6Texas | L46-56 | 9-6 | .600 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
| 16 | Tue Jan 10 | at #11Kansas St | L57-65 | 9-7 | .563 | - | ESPNU | Bramlage Coliseum · Manhattan, KS |
| 17 | Sat Jan 14 | at Baylor | L58-74 | 9-8 | .529 | - | ESPNEWS | Ferrell Center · Waco, TX |
| 18 | Wed Jan 18 | vs Oklahoma | W72-56 | 10-8 | .556 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
| 19 | Sat Jan 21 | vs #12Iowa State | W61-59 | 11-8 | .579 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 20 | Tue Jan 24 | at#10Texas | L75-89 | 11-9 | .550 | - | LHN | Moody Center · Austin, TX |
| 21 | Sat Jan 28 | vs Ole Miss | W82-60 | 12-9 | .571 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 22 | Wed Feb 1 | atOklahoma | W71-61 | 13-9 | .591 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 23 | Sat Feb 4 | vs #15TCU | W79-73 | 14-9 | .609 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 24 | Wed Feb 8 | vs Texas Tech | W71-68 | 15-9 | .625 | - | | Gallagher-Iba Arena · Stillwater, OK |
| 25 | Sat Feb 11 | at#11Iowa State | W64-56 | 16-9 | .640 | - | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 26 | Tue Feb 14 | vs#5Kansas | L76-87 | 16-10 | .615 | - | ESPN | Gallagher-Iba Arena · Stillwater, OK |
| 27 | Sat Feb 18 | at#22TCU | L75-100 | 16-11 | .593 | - | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 28 | Mon Feb 20 | atWest Virginia | L67-85 | 16-12 | .571 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 29 | Sat Feb 25 | vs#14Kansas St | L68-73 | 16-13 | .552 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
| 30 | Mon Feb 27 | vs#7Baylor | L68-74 | 16-14 | .533 | - | ESPN | Gallagher-Iba Arena · Stillwater, OK |
| 31 | Sat Mar 4 | atTexas Tech | W71-68 | 17-14 | .548 | - | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 32 | Wed Mar 8 | vsOklahoma | W57-49 | 18-14 | .563 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
| 33 | Thu Mar 9 | atTexas | L47-61 | 18-15 | .545 | - | ESPN2 | Moody Center · Austin, TX |
| 34 | Wed Mar 15 | at Youngstown St | W69-64 | 19-15 | .559 | - | | Beeghly Center · Youngstown, OH |
| 35 | Sun Mar 19 | vs E Washington | W71-60 | 20-15 | .571 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 36 | Tue Mar 21 | vs North Texas | L59-65 (OT) | 20-16 | .556 | - | ESPN | Gallagher-Iba Arena · Stillwater, OK |
