| 1 | Tue Nov 7 | vs FGCU | W69-63 | 1-0 | 1.000 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 2 | Sun Nov 12 | vsArmy | W72-64 | 2-0 | 1.000 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 3 | Thu Nov 16 | vsWright St | W89-80 | 3-0 | 1.000 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 4 | Sun Nov 19 | vs5UConn | L57-77 | 3-1 | .750 | - | ESPN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 5 | Mon Nov 20 | atLouisville | W74-66 | 4-1 | .800 | - | ESPNU | KFC Yum! Center · Louisville, KY |
| 6 | Sun Nov 26 | vsHarvard | W89-76 | 5-1 | .833 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 7 | Fri Dec 1 | vsMaryland | W65-53 | 6-1 | .857 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 8 | Tue Dec 5 | atMichigan | W78-75 | 7-1 | .875 | - | | Crisler Center · Ann Arbor, MI |
| 9 | Sat Dec 9 | vsAuburn | L76-104 | 7-2 | .778 | - | ESPN2 | State Farm Arena · Atlanta, GA |
| 10 | Sat Dec 16 | vs2Kansas | L71-75 | 7-3 | .700 | - | CBS | Simon Skjodt Assembly Hall · Bloomington, IN |
| 11 | Tue Dec 19 | vsMorehead St | W69-68 | 8-3 | .727 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 12 | Thu Dec 21 | vsNorth Alabama | W83-66 | 9-3 | .750 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 13 | Fri Dec 29 | vsKennesaw St | W100-87 | 10-3 | .769 | - | | Simon Skjodt Assembly Hall · Bloomington, IN |
| 14 | Wed Jan 3 | atNebraska | L70-86 | 10-4 | .714 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 15 | Sat Jan 6 | vsOhio State | W71-65 | 11-4 | .733 | - | FOX | Simon Skjodt Assembly Hall · Bloomington, IN |
| 16 | Tue Jan 9 | atRutgers | L57-66 | 11-5 | .688 | - | | Jersey Mike’s Arena · Piscataway, NJ |
| 17 | Fri Jan 12 | vsMinnesota | W74-62 | 12-5 | .706 | - | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 18 | Tue Jan 16 | vs2Purdue | L66-87 | 12-6 | .667 | - | | Simon Skjodt Assembly Hall · Bloomington, IN |
| 19 | Fri Jan 19 | at11Wisconsin | L79-91 | 12-7 | .632 | - | FS1 | Kohl Center · Madison, WI |
| 20 | Sat Jan 27 | at10Illinois | L62-70 | 12-8 | .600 | - | FOX | State Farm Center · Champaign, IL |
| 21 | Tue Jan 30 | vsIowa | W74-68 | 13-8 | .619 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 22 | Sat Feb 3 | vsPenn State | L71-85 | 13-9 | .591 | - | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 23 | Tue Feb 6 | atOhio State | W76-73 | 14-9 | .609 | - | | Value City Arena · Columbus, OH |
| 24 | Sat Feb 10 | at2Purdue | L59-79 | 14-10 | .583 | - | FOX | Mackey Arena · West Lafayette, IN |
| 25 | Sun Feb 18 | vsNorthwestern | L72-76 | 14-11 | .560 | - | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 26 | Wed Feb 21 | vsNebraska | L70-85 | 14-12 | .538 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 27 | Sat Feb 24 | atPenn State | L74-83 | 14-13 | .519 | - | BTN | Bryce Jordan Center · University Park, PA |
| 28 | Tue Feb 27 | vsWisconsin | W74-70 | 15-13 | .536 | - | | Simon Skjodt Assembly Hall · Bloomington, IN |
| 29 | Sun Mar 3 | atMaryland | W83-78 | 16-13 | .552 | - | CBS | XFINITY Center · College Park, MD |
| 30 | Wed Mar 6 | atMinnesota | W70-58 | 17-13 | .567 | - | BTN | Williams Arena · Minneapolis, MN |
| 31 | Sun Mar 10 | vsMichigan St | W65-64 | 18-13 | .581 | - | CBS | Simon Skjodt Assembly Hall · Bloomington, IN |
| 32 | Thu Mar 14 | vsPenn State | W61-59 | 19-13 | .594 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 33 | Fri Mar 15 | atNebraska | L66-93 | 19-14 | .576 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
