| 1 | Tue Nov 9 | vs E Michigan | W68-62 | 1-0 | 1.000 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 2 | Fri Nov 12 | vsN Illinois | W85-49 | 2-0 | 1.000 | - | | Simon Skjodt Assembly Hall · Bloomington, IN |
| 3 | Wed Nov 17 | vsSt John's | W76-74 | 3-0 | 1.000 | - | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 4 | Sun Nov 21 | vsLouisiana | W76-44 | 4-0 | 1.000 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 5 | Tue Nov 23 | vsJackson St | W70-35 | 5-0 | 1.000 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 6 | Sat Nov 27 | vsMarshall | W90-79 | 6-0 | 1.000 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 7 | Tue Nov 30 | atSyracuse | L110-112 (2OT) | 6-1 | .857 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 8 | Sat Dec 4 | vsNebraska | W68-55 | 7-1 | .875 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 9 | Wed Dec 8 | at22Wisconsin | L59-64 | 7-2 | .778 | - | BTN | Kohl Center · Madison, WI |
| 10 | Sun Dec 12 | vsMerrimack | W81-49 | 8-2 | .800 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 11 | Sat Dec 18 | atNotre Dame | W64-56 | 9-2 | .818 | - | FOX | Purcell Pavilion · South Bend, IN |
| 12 | Wed Dec 22 | vsN Kentucky | W79-61 | 10-2 | .833 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 14 | Sun Jan 2 | atPenn State | L58-61 | 10-3 | .769 | - | BTN | Bryce Jordan Center · University Park, PA |
| 15 | Thu Jan 6 | vs13Ohio State | W67-51 | 11-3 | .786 | - | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 16 | Sun Jan 9 | vsMinnesota | W73-60 | 12-3 | .800 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 17 | Thu Jan 13 | atIowa | L74-83 | 12-4 | .750 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 18 | Mon Jan 17 | atNebraska | W78-71 | 13-4 | .765 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 19 | Thu Jan 20 | vs4Purdue | W68-65 | 14-4 | .778 | - | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 20 | Sun Jan 23 | vsMichigan | L62-80 | 14-5 | .737 | - | CBS | Simon Skjodt Assembly Hall · Bloomington, IN |
| 21 | Wed Jan 26 | vsPenn State | W74-57 | 15-5 | .750 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 22 | Sat Jan 29 | atMaryland | W68-55 | 16-5 | .762 | - | FOX | XFINITY Center · College Park, MD |
| 23 | Sat Feb 5 | vs18Illinois | L57-74 | 16-6 | .727 | - | ESPN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 24 | Tue Feb 8 | atNorthwestern | L51-59 | 16-7 | .696 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 25 | Sat Feb 12 | at17Michigan St | L61-76 | 16-8 | .667 | - | FOX | Breslin Center · East Lansing, MI |
| 26 | Tue Feb 15 | vs15Wisconsin | L69-74 | 16-9 | .640 | - | ESPN2 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 27 | Mon Feb 21 | at22Ohio State | L69-80 (OT) | 16-10 | .615 | - | FS1 | Value City Arena · Columbus, OH |
| 28 | Thu Feb 24 | vsMaryland | W74-64 | 17-10 | .630 | - | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 29 | Sun Feb 27 | atMinnesota | W84-79 | 18-10 | .643 | - | ESPN2 | Williams Arena · Minneapolis, MN |
| 30 | Wed Mar 2 | vsRutgers | L63-66 | 18-11 | .621 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 31 | Sat Mar 5 | at8Purdue | L67-69 | 18-12 | .600 | - | ESPN | Mackey Arena · West Lafayette, IN |
| 32 | Thu Mar 10 | atMichigan | W74-69 | 19-12 | .613 | - | BTN | Crisler Center · Ann Arbor, MI |
| 33 | Fri Mar 11 | atIllinois | W65-63 | 20-12 | .625 | - | BTN | State Farm Center · Champaign, IL |
| 34 | Sat Mar 12 | atIowa | L77-80 | 20-13 | .606 | - | CBS | Carver-Hawkeye Arena · Iowa City, IA |
| 34 | Tue Mar 15 | at12Wyoming | W66-58 | 21-13 | .618 | #12 | truTV | UD Arena · Dayton, OH |
| 35 | Thu Mar 17 | at5Saint Mary's | L53-82 | 21-14 | .600 | #12 | TBS | Moda Center · Portland, OR |
