| 1 | Wed Nov 6 | vs SIUE | W80-61 | 1-0 | 1.000 | #17 | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 2 | Sun Nov 10 | vsE Illinois | W90-55 | 2-0 | 1.000 | #17 | B1G+ | Simon Skjodt Assembly Hall · Bloomington, IN |
| 3 | Sat Nov 16 | vsSouth Carolina | W87-71 | 3-0 | 1.000 | #16 | Peacock | Simon Skjodt Assembly Hall · Bloomington, IN |
| 4 | Thu Nov 21 | vsUNC Greensboro | W69-58 | 4-0 | 1.000 | #16 | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 5 | Wed Nov 27 | vsLouisville | L61-89 | 4-1 | .800 | #14 | ESPN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 6 | Thu Nov 28 | vs3Gonzaga | L73-89 | 4-2 | .667 | #14 | ESPN2 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 7 | Fri Nov 29 | vsProvidence | W89-73 | 5-2 | .714 | #14 | ESPN2 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 8 | Tue Dec 3 | vsSam Houston | W97-71 | 6-2 | .750 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 9 | Fri Dec 6 | vsMiami OH | W76-57 | 7-2 | .778 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 10 | Mon Dec 9 | vsMinnesota | W82-67 | 8-2 | .800 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 11 | Fri Dec 13 | atNebraska | L68-85 | 8-3 | .727 | - | FOX | Pinnacle Bank Arena · Lincoln, NE |
| 12 | Sat Dec 21 | vsChattanooga | W74-65 | 9-3 | .750 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 13 | Sun Dec 29 | vsWinthrop | W77-68 | 10-3 | .769 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 14 | Thu Jan 2 | vsRutgers | W84-74 | 11-3 | .786 | - | Peacock | Simon Skjodt Assembly Hall · Bloomington, IN |
| 15 | Sun Jan 5 | atPenn State | W77-71 | 12-3 | .800 | - | BTN | The Palestra · Philadelphia, PA |
| 16 | Wed Jan 8 | vsUSC | W82-69 | 13-3 | .813 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 17 | Sat Jan 11 | atIowa | L60-85 | 13-4 | .765 | - | FOX | Carver-Hawkeye Arena · Iowa City, IA |
| 18 | Tue Jan 14 | vs19Illinois | L69-94 | 13-5 | .722 | - | Peacock | Simon Skjodt Assembly Hall · Bloomington, IN |
| 19 | Fri Jan 17 | atOhio State | W77-76 (OT) | 14-5 | .737 | - | FOX | Value City Arena · Columbus, OH |
| 20 | Wed Jan 22 | atNorthwestern | L70-79 | 14-6 | .700 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 21 | Sun Jan 26 | vsMaryland | L78-79 | 14-7 | .667 | - | CBS | Simon Skjodt Assembly Hall · Bloomington, IN |
| 22 | Fri Jan 31 | at10Purdue | L76-81 | 14-8 | .636 | - | FOX | Mackey Arena · West Lafayette, IN |
| 23 | Tue Feb 4 | at21Wisconsin | L64-76 | 14-9 | .609 | - | Peacock | Kohl Center · Madison, WI |
| 24 | Sat Feb 8 | vs24Michigan | L67-70 | 14-10 | .583 | - | CBS | Simon Skjodt Assembly Hall · Bloomington, IN |
| 25 | Tue Feb 11 | at11Michigan St | W71-67 | 15-10 | .600 | - | Peacock | Breslin Center · East Lansing, MI |
| 26 | Fri Feb 14 | vsUCLA | L68-72 | 15-11 | .577 | - | FOX | Simon Skjodt Assembly Hall · Bloomington, IN |
| 27 | Sun Feb 23 | vs13Purdue | W73-58 | 16-11 | .593 | - | CBS | Simon Skjodt Assembly Hall · Bloomington, IN |
| 28 | Wed Feb 26 | vsPenn State | W83-78 | 17-11 | .607 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 29 | Sat Mar 1 | atWashington | W78-62 | 18-11 | .621 | - | Peacock | Alaska Airlines Arena · Seattle, WA |
| 30 | Tue Mar 4 | atOregon | L64-73 | 18-12 | .600 | - | FS1 | Matthew Knight Arena · Eugene, OR |
| 31 | Sat Mar 8 | vsOhio State | W66-60 | 19-12 | .613 | - | CBS | Simon Skjodt Assembly Hall · Bloomington, IN |
| 32 | Thu Mar 13 | at23Oregon | L59-72 | 19-13 | .594 | - | BTN | Matthew Knight Arena · Eugene, OR |
