| 1 | Wed Nov 25 | vs Tennessee Tech | W89-59 | 1-0 | 1.000 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 2 | Mon Nov 30 | atProvidence | W79-58 | 2-0 | 1.000 | - | ESPN2 | Amica Mutual Pavilion · Providence, RI |
| 3 | Tue Dec 1 | vsTexas | L44-66 | 2-1 | .667 | - | ESPN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 4 | Wed Dec 2 | atStanford | W79-63 | 3-1 | .750 | - | ESPN | Maples Pavilion · Stanford, CA |
| 5 | Wed Dec 9 | atFlorida St | L67-69 (OT) | 3-2 | .600 | - | ESPN | Donald L. Tucker Center · Tallahassee, FL |
| 6 | Sun Dec 13 | vsNorth Alabama | W87-52 | 4-2 | .667 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 7 | Sat Dec 19 | vsButler | W68-60 | 5-2 | .714 | - | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 8 | Wed Dec 23 | vsNorthwestern | L67-74 | 5-3 | .625 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 9 | Sat Dec 26 | at18Illinois | L60-69 | 5-4 | .556 | - | FS1 | State Farm Center · Champaign, IL |
| 10 | Wed Dec 30 | vsPenn State | W87-85 (OT) | 6-4 | .600 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 11 | Mon Jan 4 | vsMaryland | W63-55 | 7-4 | .636 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 12 | Thu Jan 7 | at8Wisconsin | L73-80 (2OT) | 7-5 | .583 | - | FS1 | Kohl Center · Madison, WI |
| 13 | Sun Jan 10 | atNebraska | W84-76 | 8-5 | .615 | - | | Pinnacle Bank Arena · Lincoln, NE |
| 14 | Thu Jan 14 | vsPurdue | L69-81 | 8-6 | .571 | - | | Simon Skjodt Assembly Hall · Bloomington, IN |
| 15 | Sun Jan 17 | atMichigan St | PPD | 12-15 | .444 | - | | Breslin Center · East Lansing, MI |
| 16 | Thu Jan 21 | at4Iowa | W81-69 | 9-6 | .600 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 17 | Sun Jan 24 | vsRutgers | L70-74 | 9-7 | .563 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 19 | Tue Feb 2 | vs12Illinois | L71-75 (OT) | 9-8 | .529 | - | ESPN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 20 | Sun Feb 7 | vs8Iowa | W67-65 | 10-8 | .556 | - | FOX | Simon Skjodt Assembly Hall · Bloomington, IN |
| 21 | Wed Feb 10 | atNorthwestern | W79-76 (2OT) | 11-8 | .579 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 22 | Sat Feb 13 | at4Ohio State | L59-78 | 11-9 | .550 | - | ESPN | Value City Arena · Columbus, OH |
| 23 | Wed Feb 17 | vsMinnesota | W82-72 | 12-9 | .571 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 24 | Sat Feb 20 | vsMichigan St | L71-78 | 12-10 | .545 | - | ESPN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 25 | Wed Feb 24 | atRutgers | L63-74 | 12-11 | .522 | - | | Jersey Mike’s Arena · Piscataway, NJ |
| 26 | Sat Feb 27 | vs3Michigan | L57-73 | 12-12 | .500 | - | | Simon Skjodt Assembly Hall · Bloomington, IN |
| 27 | Tue Mar 2 | atMichigan St | L58-64 | 12-13 | .480 | - | BTN | Breslin Center · East Lansing, MI |
| 28 | Sat Mar 6 | at23Purdue | L58-67 | 12-14 | .462 | - | ESPN | Mackey Arena · West Lafayette, IN |
| 29 | Thu Mar 11 | atRutgers | L50-61 | 12-15 | .444 | - | BTN | Lucas Oil Stadium · Indianapolis, IN |
