| 1 | Wed Nov 25 | vs Morehead St | W81-45 | 1-0 | 1.000 | - | SEC Network | Rupp Arena · Lexington, KY |
| 3 | Sun Nov 29 | vsRichmond | L64-76 | 1-1 | .500 | - | ESPN | Rupp Arena · Lexington, KY |
| 4 | Tue Dec 1 | vsKansas | L62-65 | 1-2 | .333 | - | ESPN | Rupp Arena · Lexington, KY |
| 5 | Sun Dec 6 | atGeorgia Tech | L62-79 | 1-3 | .250 | - | ESPN | State Farm Arena · Atlanta, GA |
| 6 | Sat Dec 12 | vsNotre Dame | L63-64 | 1-4 | .200 | - | CBS | Rupp Arena · Lexington, KY |
| 8 | Sat Dec 19 | vsUNC | L63-75 | 1-5 | .167 | - | CBS | Rupp Arena · Lexington, KY |
| 9 | Sat Dec 26 | atLouisville | L59-62 | 1-6 | .143 | - | ESPN | KFC Yum! Center · Louisville, KY |
| 10 | Tue Dec 29 | vsSouth Carolina | PPD | 9-16 | .360 | - | ESPN2 | Rupp Arena · Lexington, KY |
| 11 | Sat Jan 2 | atMississippi St | W78-73 (2OT) | 2-6 | .250 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 12 | Tue Jan 5 | vsVanderbilt | W77-74 | 3-6 | .333 | - | SEC Network | Rupp Arena · Lexington, KY |
| 13 | Sat Jan 9 | atFlorida | W76-58 | 4-6 | .400 | - | ESPN | O'Connell Center · Gainesville, FL |
| 14 | Tue Jan 12 | vsAlabama | L65-85 | 4-7 | .364 | - | ESPN | Rupp Arena · Lexington, KY |
| 15 | Sat Jan 16 | atAuburn | L59-66 | 4-8 | .333 | - | ESPN | Neville Arena · Auburn, AL |
| 16 | Wed Jan 20 | atGeorgia | L62-63 | 4-9 | .308 | - | SEC Network | Stegeman Coliseum · Athens, GA |
| 17 | Sat Jan 23 | vsLSU | W82-69 | 5-9 | .357 | - | ESPN | Rupp Arena · Lexington, KY |
| 18 | Tue Jan 26 | at9Alabama | L59-70 | 5-10 | .333 | - | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 20 | Wed Feb 3 | at18Missouri | L70-75 | 5-11 | .313 | - | ESPN2 | Mizzou Arena · Columbia, MO |
| 21 | Sat Feb 6 | vs11Tennessee | L71-82 | 5-12 | .294 | - | ESPN | Rupp Arena · Lexington, KY |
| 22 | Tue Feb 9 | vsArkansas | L80-81 | 5-13 | .278 | - | ESPN | Rupp Arena · Lexington, KY |
| 23 | Sat Feb 13 | vsAuburn | W82-80 | 6-13 | .316 | - | CBS | Rupp Arena · Lexington, KY |
| 24 | Wed Feb 17 | atVanderbilt | W82-78 | 7-13 | .350 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 25 | Sat Feb 20 | at19Tennessee | W70-55 | 8-13 | .381 | - | CBS | Thompson-Boling Arena · Knoxville, TN |
| 27 | Sat Feb 27 | vsFlorida | L67-71 | 8-14 | .364 | - | CBS | Rupp Arena · Lexington, KY |
| 28 | Tue Mar 2 | atOle Miss | L62-70 | 8-15 | .348 | - | ESPN | SJB Pavilion · Oxford, MS |
| 29 | Sat Mar 6 | vsSouth Carolina | W92-64 | 9-15 | .375 | - | ESPN | Rupp Arena · Lexington, KY |
| 30 | Thu Mar 11 | vsMississippi St | L73-74 | 9-16 | .360 | - | SEC Network | Rupp Arena · Lexington, KY |
