| 1 | Tue Nov 9 | at Duke | L71-79 | 0-1 | .000 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 2 | Fri Nov 12 | vs Robert Morris | W100-60 | 1-1 | .500 | - | SEC Network | Rupp Arena · Lexington, KY |
| 3 | Tue Nov 16 | vs Mount St Mary | W80-55 | 2-1 | .667 | - | SEC Network | Rupp Arena · Lexington, KY |
| 4 | Fri Nov 19 | vs Ohio | W77-59 | 3-1 | .750 | - | SEC Network | Rupp Arena · Lexington, KY |
| 5 | Mon Nov 22 | vs Albany | W86-61 | 4-1 | .800 | #10 | | Rupp Arena · Lexington, KY |
| 6 | Fri Nov 26 | vs North Florida | W86-52 | 5-1 | .833 | #10 | SEC Network | Rupp Arena · Lexington, KY |
| 7 | Mon Nov 29 | vs C Michigan | W85-57 | 6-1 | .857 | #9 | | Rupp Arena · Lexington, KY |
| 8 | Tue Dec 7 | vs Southern | W76-64 | 7-1 | .875 | #10 | SEC Network | Rupp Arena · Lexington, KY |
| 9 | Sat Dec 11 | at Notre Dame | L62-66 | 7-2 | .778 | #10 | ESPN | Purcell Pavilion · South Bend, IN |
| 10 | Sat Dec 18 | vs UNC | W98-69 | 8-2 | .800 | - | CBS | Rupp Arena · Lexington, KY |
| 11 | Wed Dec 22 | vs Western KY | W95-60 | 9-2 | .818 | #20 | ESPN | Rupp Arena · Lexington, KY |
| 12 | Wed Dec 29 | vs Missouri | W83-56 | 10-2 | .833 | #18 | SEC Network | Rupp Arena · Lexington, KY |
| 13 | Fri Dec 31 | vs High Point | W92-48 | 11-2 | .846 | #18 | SEC Network | Rupp Arena · Lexington, KY |
| 14 | Tue Jan 4 | at #21LSU | L60-65 | 11-3 | .786 | #16 | ESPN | Pete Maravich Assembly Center · Baton Rouge, LA |
| 15 | Sat Jan 8 | vs Georgia | W92-77 | 12-3 | .800 | #16 | SEC Network | Rupp Arena · Lexington, KY |
| 16 | Tue Jan 11 | at Vanderbilt | W78-66 | 13-3 | .813 | #18 | ESPN | Memorial Gymnasium (TN) · Nashville, TN |
| 17 | Sat Jan 15 | vs #22Tennessee | W107-79 | 14-3 | .824 | #18 | ESPN | Rupp Arena · Lexington, KY |
| 18 | Wed Jan 19 | at Texas A&M | W64-58 | 15-3 | .833 | #12 | SEC Network | Reed Arena · College Station, TX |
| 19 | Sat Jan 22 | at #2Auburn | L71-80 | 15-4 | .789 | #12 | CBS | Neville Arena · Auburn, AL |
| 20 | Tue Jan 25 | vs Mississippi St | W82-74 (OT) | 16-4 | .800 | #12 | ESPN | Rupp Arena · Lexington, KY |
| 21 | Sat Jan 29 | at Kansas | W80-62 | 17-4 | .810 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 22 | Wed Feb 2 | vsVanderbilt | W77-70 | 18-4 | .818 | #5 | SEC Network | Rupp Arena · Lexington, KY |
| 23 | Sat Feb 5 | at Alabama | W66-55 | 19-4 | .826 | #5 | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 24 | Tue Feb 8 | at South Carolina | W86-76 | 20-4 | .833 | #5 | ESPN | Colonial Life Arena · Columbia, SC |
| 25 | Sat Feb 12 | vs Florida | W78-57 | 21-4 | .840 | #5 | ESPN | Rupp Arena · Lexington, KY |
| 26 | Tue Feb 15 | at#16Tennessee | L63-76 | 21-5 | .808 | #4 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 27 | Sat Feb 19 | vs#25Alabama | W90-81 | 22-5 | .815 | #4 | CBS | Rupp Arena · Lexington, KY |
| 28 | Wed Feb 23 | vsLSU | W71-66 | 23-5 | .821 | #6 | ESPN | Rupp Arena · Lexington, KY |
| 29 | Sat Feb 26 | at #18Arkansas | L73-75 | 23-6 | .793 | #6 | CBS | Bud Walton Arena · Fayetteville, AR |
| 30 | Tue Mar 1 | vs Ole Miss | W83-72 | 24-6 | .800 | #7 | ESPN | Rupp Arena · Lexington, KY |
| 31 | Sat Mar 5 | atFlorida | W71-63 | 25-6 | .806 | #7 | CBS | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
| 32 | Fri Mar 11 | vsVanderbilt | W77-71 | 26-6 | .813 | - | SEC Network | Rupp Arena · Lexington, KY |
| 33 | Sat Mar 12 | atTennessee | L62-69 | 26-7 | .788 | - | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 34 | Thu Mar 17 | vs #15Saint Peter's | L79-85 (OT) | 26-8 | .765 | #2 | CBS | Rupp Arena · Lexington, KY |
