| 1 | Tue Nov 5 | vs Michigan St | W69-62 | 1-0 | 1.000 | - | ESPN | Rupp Arena · Lexington, KY |
| 2 | Fri Nov 8 | vs E Kentucky | W91-49 | 2-0 | 1.000 | #2 | SEC Network | Rupp Arena · Lexington, KY |
| 3 | Tue Nov 12 | vs Evansville | L64-67 | 2-1 | .667 | #1 | SEC Network | Rupp Arena · Lexington, KY |
| 4 | Mon Nov 18 | vs Utah Valley | W82-74 | 3-1 | .750 | - | ESPN2 | Rupp Arena · Lexington, KY |
| 5 | Fri Nov 22 | vs Mount St Mary | W82-62 | 4-1 | .800 | - | SEC Network | Rupp Arena · Lexington, KY |
| 6 | Sun Nov 24 | vs Lamar | W81-56 | 5-1 | .833 | - | SEC Network | Rupp Arena · Lexington, KY |
| 7 | Fri Nov 29 | vs UAB | W69-58 | 6-1 | .857 | - | SEC Network | Rupp Arena · Lexington, KY |
| 8 | Sat Dec 7 | vs Fairleigh | W83-52 | 7-1 | .875 | #8 | SEC Network | Rupp Arena · Lexington, KY |
| 9 | Sat Dec 14 | vs Georgia Tech | W67-53 | 8-1 | .889 | #8 | ESPN | Rupp Arena · Lexington, KY |
| 10 | Wed Dec 18 | vs Utah | L66-69 | 8-2 | .800 | #6 | ESPN2 | Rupp Arena · Lexington, KY |
| 11 | Sat Dec 21 | vs Ohio State | L65-71 | 8-3 | .727 | - | CBS | Rupp Arena · Lexington, KY |
| 12 | Sat Dec 28 | vs #3Louisville | W78-70 (OT) | 9-3 | .750 | #19 | CBS | Rupp Arena · Lexington, KY |
| 13 | Sat Jan 4 | vs Missouri | W71-59 | 10-3 | .769 | #17 | SEC Network | Rupp Arena · Lexington, KY |
| 14 | Tue Jan 7 | at Georgia | W78-69 | 11-3 | .786 | #14 | ESPN | Stegeman Coliseum · Athens, GA |
| 15 | Sat Jan 11 | vs Alabama | W76-67 | 12-3 | .800 | #14 | ESPN | Rupp Arena · Lexington, KY |
| 16 | Wed Jan 15 | at South Carolina | L78-81 | 12-4 | .750 | #10 | SEC Network | Colonial Life Arena · Columbia, SC |
| 17 | Sat Jan 18 | at Arkansas | W73-66 | 13-4 | .765 | #10 | ESPN | Bud Walton Arena · Fayetteville, AR |
| 18 | Tue Jan 21 | vsGeorgia | W89-79 | 14-4 | .778 | #15 | ESPN | Rupp Arena · Lexington, KY |
| 19 | Sat Jan 25 | at Texas Tech | W76-74 (OT) | 15-4 | .789 | - | ESPN | United Supermarkets Arena · Lubbock, TX |
| 20 | Wed Jan 29 | vs Vanderbilt | W71-62 | 16-4 | .800 | #13 | SEC Network | Rupp Arena · Lexington, KY |
| 21 | Sat Feb 1 | at #17Auburn | L66-75 | 16-5 | .762 | #13 | ESPN | Neville Arena · Auburn, AL |
| 22 | Tue Feb 4 | vs Mississippi St | W80-72 | 17-5 | .773 | #15 | ESPN | Rupp Arena · Lexington, KY |
| 23 | Sat Feb 8 | at Tennessee | W77-64 | 18-5 | .783 | #15 | CBS | Thompson-Boling Arena · Knoxville, TN |
| 24 | Tue Feb 11 | atVanderbilt | W78-64 | 19-5 | .792 | #12 | ESPN | Memorial Gymnasium (TN) · Nashville, TN |
| 25 | Sat Feb 15 | vs Ole Miss | W67-62 | 20-5 | .800 | #12 | ESPN | Rupp Arena · Lexington, KY |
| 26 | Tue Feb 18 | at LSU | W79-76 | 21-5 | .808 | #10 | ESPN | Pete Maravich Assembly Center · Baton Rouge, LA |
| 27 | Sat Feb 22 | vs Florida | W65-59 | 22-5 | .815 | #10 | ESPN | Rupp Arena · Lexington, KY |
| 28 | Tue Feb 25 | at Texas A&M | W69-60 | 23-5 | .821 | #8 | ESPN | Reed Arena · College Station, TX |
| 29 | Sat Feb 29 | vs#15Auburn | W73-66 | 24-5 | .828 | #8 | CBS | Rupp Arena · Lexington, KY |
| 30 | Tue Mar 3 | vsTennessee | L73-81 | 24-6 | .800 | #6 | ESPN | Rupp Arena · Lexington, KY |
| 31 | Sat Mar 7 | atFlorida | W71-70 | 25-6 | .806 | #6 | CBS | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
