| 1 | Mon Nov 6 | vs New Mexico St | W86-46 | 1-0 | 1.000 | #16 | SEC Network | Rupp Arena · Lexington, KY |
| 2 | Fri Nov 10 | vs E Texas A&M | W81-61 | 2-0 | 1.000 | #16 | | Rupp Arena · Lexington, KY |
| 3 | Tue Nov 14 | at #1Kansas | L84-89 | 2-1 | .667 | #17 | ESPN | Allen Fieldhouse · Lawrence, KS |
| 4 | Fri Nov 17 | vs Stonehill | W101-67 | 3-1 | .750 | #17 | | Rupp Arena · Lexington, KY |
| 5 | Mon Nov 20 | vs Saint Joseph's | W96-88 (OT) | 4-1 | .800 | #16 | SEC Network | Rupp Arena · Lexington, KY |
| 6 | Fri Nov 24 | vs Marshall | W118-82 | 5-1 | .833 | #16 | SEC Network | Rupp Arena · Lexington, KY |
| 7 | Tue Nov 28 | vs #8Miami | W95-73 | 6-1 | .857 | #12 | ESPN | Rupp Arena · Lexington, KY |
| 8 | Sat Dec 2 | vs UNC Wilmington | L73-80 | 6-2 | .750 | #12 | SEC Network | Rupp Arena · Lexington, KY |
| 9 | Sat Dec 9 | vs Penn | W81-66 | 7-2 | .778 | #16 | ESPN2 | Rupp Arena · Lexington, KY |
| 10 | Sat Dec 16 | vs #9UNC | W87-83 | 8-2 | .800 | #14 | CBS | Rupp Arena · Lexington, KY |
| 11 | Thu Dec 21 | at Louisville | W95-76 | 9-2 | .818 | #9 | ESPN | KFC Yum! Center · Louisville, KY |
| 12 | Fri Dec 29 | vs Illinois St | W96-70 | 10-2 | .833 | #8 | SEC Network | Rupp Arena · Lexington, KY |
| 13 | Sat Jan 6 | at Florida | W87-85 | 11-2 | .846 | #6 | ESPN | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
| 14 | Tue Jan 9 | vs Missouri | W90-77 | 12-2 | .857 | #6 | ESPN | Rupp Arena · Lexington, KY |
| 15 | Sat Jan 13 | at Texas A&M | L92-97 (OT) | 12-3 | .800 | #6 | ESPN | Reed Arena · College Station, TX |
| 16 | Wed Jan 17 | vs Mississippi St | W90-77 | 13-3 | .813 | #8 | ESPN2 | Rupp Arena · Lexington, KY |
| 17 | Sat Jan 20 | vs Georgia | W105-96 | 14-3 | .824 | #8 | SEC Network | Rupp Arena · Lexington, KY |
| 18 | Tue Jan 23 | at South Carolina | L62-79 | 14-4 | .778 | #6 | SEC Network | Colonial Life Arena · Columbia, SC |
| 19 | Sat Jan 27 | at Arkansas | W63-57 | 15-4 | .789 | #6 | ESPN | Bud Walton Arena · Fayetteville, AR |
| 20 | Wed Jan 31 | vsFlorida | L91-94 (OT) | 15-5 | .750 | #10 | ESPN | Rupp Arena · Lexington, KY |
| 21 | Sat Feb 3 | vs #5Tennessee | L92-103 | 15-6 | .714 | #10 | ESPN | Rupp Arena · Lexington, KY |
| 22 | Tue Feb 6 | at Vanderbilt | W109-77 | 16-6 | .727 | #17 | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 23 | Sat Feb 10 | vs Gonzaga | L85-89 | 16-7 | .696 | #17 | CBS | Rupp Arena · Lexington, KY |
| 24 | Tue Feb 13 | vs Ole Miss | W75-63 | 17-7 | .708 | #22 | ESPN | Rupp Arena · Lexington, KY |
| 25 | Sat Feb 17 | at #13Auburn | W70-59 | 18-7 | .720 | #22 | ESPN | Neville Arena · Auburn, AL |
| 26 | Wed Feb 21 | at LSU | L74-75 | 18-8 | .692 | #17 | ESPN | Pete Maravich Assembly Center · Baton Rouge, LA |
| 27 | Sat Feb 24 | vs #13Alabama | W117-95 | 19-8 | .704 | #17 | CBS | Rupp Arena · Lexington, KY |
| 28 | Tue Feb 27 | atMississippi St | W91-89 | 20-8 | .714 | #16 | ESPN | Humphrey Coliseum · Starkville, MS |
| 29 | Sat Mar 2 | vsArkansas | W111-102 | 21-8 | .724 | #16 | CBS | Rupp Arena · Lexington, KY |
| 30 | Wed Mar 6 | vsVanderbilt | W93-77 | 22-8 | .733 | #15 | SEC Network | Rupp Arena · Lexington, KY |
| 31 | Sat Mar 9 | at#4Tennessee | W85-81 | 23-8 | .742 | #15 | CBS | Thompson-Boling Arena · Knoxville, TN |
| 32 | Fri Mar 15 | vsTexas A&M | L87-97 | 23-9 | .719 | #9 | SEC Network | Rupp Arena · Lexington, KY |
| 33 | Thu Mar 21 | vs #14Oakland | L76-80 | 23-10 | .697 | #3 | CBS | Rupp Arena · Lexington, KY |
