| 1 | Tue Nov 4 | vs Nicholls | 7:00 PM | 20-13 | .606 | #9 | SECN+ | Rupp Arena · Lexington, KY |
| 2 | Fri Nov 7 | vsValparaiso | 7:00 PM | 15-19 | .441 | #9 | SECN+ | Rupp Arena · Lexington, KY |
| 3 | Tue Nov 11 | at#11Louisville | 8:00 PM | 27-8 | .771 | #9 | ESPN | KFC Yum! Center · Louisville, KY |
| 4 | Fri Nov 14 | vsE Illinois | 7:00 PM | 12-19 | .387 | #9 | SECN+ | Rupp Arena · Lexington, KY |
| 5 | Tue Nov 18 | vs#22Michigan St | 6:30 PM | 30-7 | .811 | #9 | ESPN | Rupp Arena · Lexington, KY |
| 6 | Fri Nov 21 | vsLoyola MD | 7:00 PM | 12-19 | .387 | #9 | SECN+ | Rupp Arena · Lexington, KY |
| 7 | Wed Nov 26 | vsTennessee Tech | 7:00 PM | 15-17 | .469 | #9 | SEC Network | Rupp Arena · Lexington, KY |
| 8 | Tue Dec 2 | vs#25UNC | 9:30 PM | 23-14 | .622 | #9 | ESPN | Rupp Arena · Lexington, KY |
| 9 | Fri Dec 5 | vs#21Gonzaga | 7:00 PM | 26-9 | .743 | #9 | ESPN2 | Rupp Arena · Lexington, KY |
| 10 | Tue Dec 9 | vsNC Central | 7:00 PM | 14-19 | .424 | #9 | SEC Network | Rupp Arena · Lexington, KY |
| 11 | Sat Dec 13 | vsIndiana | 7:30 PM | 19-13 | .594 | #9 | ESPN | Rupp Arena · Lexington, KY |
| 12 | Sat Dec 20 | vs#5St John's | 12:30 PM | 31-5 | .861 | #9 | CBS | Rupp Arena · Lexington, KY |
| 13 | Tue Dec 23 | vsBellarmine | 1:00 PM | 5-26 | .161 | #9 | SECN+ | Rupp Arena · Lexington, KY |
| 14 | Sat Jan 3 | at#15Alabama | 1:00 PM | 28-9 | .757 | #9 | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 15 | Wed Jan 7 | vsMissouri | 7:00 PM | 22-12 | .647 | #9 | ESPN2 | Rupp Arena · Lexington, KY |
| 16 | Sat Jan 10 | vsMississippi St | 8:30 PM | 21-13 | .618 | #9 | SEC Network | Rupp Arena · Lexington, KY |
| 17 | Wed Jan 14 | atLSU | 7:00 PM | 14-18 | .438 | #9 | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 18 | Sat Jan 17 | at#18Tennessee | 12:00 PM | 30-8 | .789 | #9 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 19 | Wed Jan 21 | vsTexas | 7:00 PM | 19-16 | .543 | #9 | SEC Network | Rupp Arena · Lexington, KY |
| 20 | Sat Jan 24 | vsOle Miss | 12:00 PM | 24-12 | .667 | #9 | ESPN | Rupp Arena · Lexington, KY |
| 21 | Tue Jan 27 | atVanderbilt | 9:00 PM | 20-13 | .606 | #9 | ESPN | Memorial Gymnasium (TN) · Nashville, TN |
| 22 | Sat Jan 31 | at#14Arkansas | 6:30 PM | 22-14 | .611 | #9 | ESPN | Bud Walton Arena · Fayetteville, AR |
| 23 | Wed Feb 4 | vsOklahoma | 7:00 PM | 20-14 | .588 | #9 | ESPN2 | Rupp Arena · Lexington, KY |
| 24 | Sat Feb 7 | vs#18Tennessee | 8:30 PM | 30-8 | .789 | #9 | ESPN | Rupp Arena · Lexington, KY |
| 25 | Sat Feb 14 | at#3Florida | 3:00 PM | 36-4 | .900 | #9 | ABC | O'Connell Center · Gainesville, FL |
| 26 | Tue Feb 17 | vsGeorgia | 9:00 PM | 20-13 | .606 | #9 | | Rupp Arena · Lexington, KY |
| 27 | Sat Feb 21 | at#20Auburn | 8:30 PM | 32-6 | .842 | #9 | ESPN | Neville Arena · Auburn, AL |
| 28 | Tue Feb 24 | atSouth Carolina | 7:00 PM | 12-20 | .375 | #9 | SEC Network | Colonial Life Arena · Columbia, SC |
| 29 | Sat Feb 28 | vsVanderbilt | 2:00 PM | 20-13 | .606 | #9 | | Rupp Arena · Lexington, KY |
| 30 | Tue Mar 3 | atTexas A&M | 7:00 PM | 23-11 | .676 | #9 | | Reed Arena · College Station, TX |
| 31 | Sat Mar 7 | vs#3Florida | 4:00 PM | 36-4 | .900 | #9 | ESPN | Rupp Arena · Lexington, KY |
