| 1 | Mon Nov 7 | vs Howard | W95-63 | 1-0 | 1.000 | #4 | SEC Network | Rupp Arena · Lexington, KY |
| 2 | Fri Nov 11 | vsDuquesne | W77-52 | 2-0 | 1.000 | #4 | SEC Network | Rupp Arena · Lexington, KY |
| 3 | Tue Nov 15 | atMichigan St | L77-86 (2OT) | 2-1 | .667 | - | ESPN | Breslin Center · East Lansing, MI |
| 4 | Thu Nov 17 | vsSC State | W106-63 | 3-1 | .750 | #4 | SEC Network | Rupp Arena · Lexington, KY |
| 5 | Sun Nov 20 | at2Gonzaga | L72-88 | 3-2 | .600 | #4 | ESPN | McCarthey Athletic Center · Spokane, WA |
| 6 | Wed Nov 23 | vsNorth Florida | W96-56 | 4-2 | .667 | #15 | | Rupp Arena · Lexington, KY |
| 7 | Tue Nov 29 | vsBellarmine | W60-41 | 5-2 | .714 | #19 | | Rupp Arena · Lexington, KY |
| 8 | Sun Dec 4 | vsMichigan | W73-69 | 6-2 | .750 | - | ABC | Rupp Arena · Lexington, KY |
| 9 | Sat Dec 10 | vsYale | W69-59 | 7-2 | .778 | #16 | SEC Network | Rupp Arena · Lexington, KY |
| 10 | Sat Dec 17 | vsUCLA | L53-63 | 7-3 | .700 | - | CBS | Rupp Arena · Lexington, KY |
| 11 | Wed Dec 21 | vsFAMU | W88-68 | 8-3 | .727 | #19 | SEC Network | Rupp Arena · Lexington, KY |
| 12 | Wed Dec 28 | atMissouri | L75-89 | 8-4 | .667 | #19 | SEC Network | Mizzou Arena · Columbia, MO |
| 13 | Sat Dec 31 | vsLouisville | W86-63 | 9-4 | .692 | #19 | CBS | Rupp Arena · Lexington, KY |
| 14 | Tue Jan 3 | vsLSU | W74-71 | 10-4 | .714 | - | ESPN | Rupp Arena · Lexington, KY |
| 15 | Sat Jan 7 | at7Alabama | L52-78 | 10-5 | .667 | - | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 16 | Tue Jan 10 | vsSouth Carolina | L68-71 | 10-6 | .625 | - | ESPN2 | Rupp Arena · Lexington, KY |
| 17 | Sat Jan 14 | at5Tennessee | W63-56 | 11-6 | .647 | - | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 18 | Tue Jan 17 | vsGeorgia | W85-71 | 12-6 | .667 | - | ESPN | Rupp Arena · Lexington, KY |
| 19 | Sat Jan 21 | vsTexas A&M | W76-67 | 13-6 | .684 | - | ESPN | Rupp Arena · Lexington, KY |
| 20 | Tue Jan 24 | atVanderbilt | W69-53 | 14-6 | .700 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 21 | Sat Jan 28 | vsKansas | L68-77 | 14-7 | .667 | - | ESPN | Rupp Arena · Lexington, KY |
| 22 | Tue Jan 31 | atOle Miss | W75-66 | 15-7 | .682 | - | ESPN | SJB Pavilion · Oxford, MS |
| 23 | Sat Feb 4 | vsFlorida | W72-67 | 16-7 | .696 | - | ESPN | Rupp Arena · Lexington, KY |
| 24 | Tue Feb 7 | vsArkansas | L73-88 | 16-8 | .667 | - | ESPN | Rupp Arena · Lexington, KY |
| 25 | Sat Feb 11 | atGeorgia | L68-75 | 16-9 | .640 | - | ESPN | Stegeman Coliseum · Athens, GA |
| 26 | Wed Feb 15 | atMississippi St | W71-68 | 17-9 | .654 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 27 | Sat Feb 18 | vs10Tennessee | W66-54 | 18-9 | .667 | - | CBS | Rupp Arena · Lexington, KY |
| 28 | Wed Feb 22 | atFlorida | W82-74 | 19-9 | .679 | - | ESPN | O'Connell Center · Gainesville, FL |
| 29 | Sat Feb 25 | vsAuburn | W86-54 | 20-9 | .690 | - | CBS | Rupp Arena · Lexington, KY |
| 30 | Wed Mar 1 | vsVanderbilt | L66-68 | 20-10 | .667 | #23 | SEC Network | Rupp Arena · Lexington, KY |
| 31 | Sat Mar 4 | atArkansas | W88-79 | 21-10 | .677 | #23 | CBS | Bud Walton Arena · Fayetteville, AR |
| 32 | Fri Mar 10 | vsVanderbilt | L73-80 | 21-11 | .656 | - | SEC Network | Rupp Arena · Lexington, KY |
| 33 | Fri Mar 17 | vs11Providence | W61-53 | 22-11 | .667 | #6 | CBS | Greensboro Coliseum · Greensboro, NC |
| 34 | Sun Mar 19 | at3Kansas St | L69-75 | 22-12 | .647 | #6 | CBS | Greensboro Coliseum · Greensboro, NC |
