| 1 | Tue Nov 5 | vs Omaha | W68-54 | 1-0 | 1.000 | - | | Charles Koch Arena · Wichita, KS |
| 2 | Sat Nov 9 | vsTexas So | W69-63 | 2-0 | 1.000 | - | | Charles Koch Arena · Wichita, KS |
| 3 | Sat Nov 16 | vsUT Martin | W103-62 | 3-0 | 1.000 | - | | Charles Koch Arena · Wichita, KS |
| 4 | Tue Nov 19 | vsGardner-Webb | W74-52 | 4-0 | 1.000 | - | | Charles Koch Arena · Wichita, KS |
| 5 | Sat Nov 23 | vsOral Roberts | W68-59 | 5-0 | 1.000 | - | | Charles Koch Arena · Wichita, KS |
| 6 | Tue Nov 26 | atSouth Carolina | W70-47 | 6-0 | 1.000 | - | CBSSN | Colonial Life Arena · Columbia, SC |
| 7 | Wed Nov 27 | atWest Virginia | L63-75 | 6-1 | .857 | - | CBSSN | WVU Coliseum · Morgantown, WV |
| 8 | Thu Dec 5 | vsC Arkansas | W95-69 | 7-1 | .875 | - | | Charles Koch Arena · Wichita, KS |
| 9 | Sun Dec 8 | atOklahoma St | W80-61 | 8-1 | .889 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
| 10 | Sat Dec 14 | vsOklahoma | W80-75 | 9-1 | .900 | - | ESPN2 | Charles Koch Arena · Wichita, KS |
| 11 | Sat Dec 21 | vsVCU | W73-63 | 10-1 | .909 | - | ESPN2 | Charles Koch Arena · Wichita, KS |
| 12 | Sun Dec 29 | vsAbilene Chrstn | W84-66 | 11-1 | .917 | - | | Charles Koch Arena · Wichita, KS |
| 13 | Wed Jan 1 | vsE Carolina | W75-69 | 12-1 | .923 | #24 | ESPNU | Charles Koch Arena · Wichita, KS |
| 14 | Sat Jan 4 | vsOle Miss | W74-54 | 13-1 | .929 | #24 | ESPNU | Charles Koch Arena · Wichita, KS |
| 15 | Thu Jan 9 | vs#21Memphis | W76-67 | 14-1 | .933 | #23 | ESPN2 | Charles Koch Arena · Wichita, KS |
| 16 | Sun Jan 12 | atUConn | W89-86 (2OT) | 15-1 | .938 | #23 | CBSSN | Gampel Pavilion · Storrs, CT |
| 17 | Wed Jan 15 | atTemple | L53-65 | 15-2 | .882 | #16 | ESPNU | Liacouras Center · Philadelphia, PA |
| 18 | Sat Jan 18 | vsHouston | L54-65 | 15-3 | .833 | #16 | ESPN2 | Charles Koch Arena · Wichita, KS |
| 19 | Tue Jan 21 | atSouth Florida | W56-43 | 16-3 | .842 | - | ESPNEWS | Yuengling Center · Tampa, FL |
| 20 | Sat Jan 25 | vsUCF | W87-79 | 17-3 | .850 | - | ESPNU | Charles Koch Arena · Wichita, KS |
| 21 | Sat Feb 1 | atTulsa | L51-54 | 17-4 | .810 | #23 | ESPNU | Donald W. Reynolds Center · Tulsa, OK |
| 22 | Thu Feb 6 | vsCincinnati | L79-80 | 17-5 | .773 | - | ESPN | Charles Koch Arena · Wichita, KS |
| 23 | Sun Feb 9 | at#25Houston | L43-76 | 17-6 | .739 | - | ESPN | Fertitta Center · Houston, TX |
| 24 | Thu Feb 13 | atUCF | W75-58 | 18-6 | .750 | - | ESPN2 | Addition Financial Arena · Orlando, FL |
| 25 | Sun Feb 16 | vsTulane | W82-57 | 19-6 | .760 | - | CBSSN | Charles Koch Arena · Wichita, KS |
| 26 | Thu Feb 20 | vsSouth Florida | W65-55 | 20-6 | .769 | - | CBSSN | Charles Koch Arena · Wichita, KS |
| 27 | Sun Feb 23 | atCincinnati | L64-67 | 20-7 | .741 | - | ESPN | Fifth Third Arena · Cincinnati, OH |
| 28 | Thu Feb 27 | vsTemple | W72-69 | 21-7 | .750 | - | ESPN | Charles Koch Arena · Wichita, KS |
| 29 | Sun Mar 1 | atSMU | W66-62 | 22-7 | .759 | - | ESPNU | Moody Coliseum · Dallas, TX |
| 30 | Thu Mar 5 | atMemphis | L60-68 | 22-8 | .733 | - | ESPN | FedExForum · Memphis, TN |
| 31 | Sun Mar 8 | vsTulsa | W79-57 | 23-8 | .742 | - | CBSSN | Charles Koch Arena · Wichita, KS |
