| 1 | Mon Nov 4 | at Western KY | W91-84 | 1-0 | 1.000 | - | CBSSN | E. A. Diddle Arena · Bowling Green, KY |
| 2 | Sat Nov 9 | vsMontana St | W89-69 | 2-0 | 1.000 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 3 | Thu Nov 14 | vsNorthern Iowa | W79-73 | 3-0 | 1.000 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 4 | Mon Nov 18 | vsMonmouth | W70-66 | 4-0 | 1.000 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 5 | Fri Nov 22 | atSaint Louis | W88-63 | 5-0 | 1.000 | - | Peacock | T-Mobile Center · Kansas City, MOS |
| 6 | Thu Nov 28 | vsMinnesota | W68-66 (OT) | 6-0 | 1.000 | - | ESPN2 | Charles Koch Arena · Wichita, KS |
| 7 | Fri Nov 29 | at18Florida | L51-88 | 6-1 | .857 | - | ESPN | O'Connell Center · Gainesville, FL |
| 8 | Wed Dec 4 | vsAlcorn St | W78-54 | 7-1 | .875 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 9 | Sat Dec 7 | vsETSU | W96-87 | 8-1 | .889 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 10 | Sat Dec 14 | atDePaul | L72-91 | 8-2 | .800 | - | FS1 | Wintrust Arena · Chicago, IL |
| 11 | Tue Dec 17 | vsKansas City | L64-74 | 8-3 | .727 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 12 | Sat Dec 21 | vsKansas St | W84-65 | 9-3 | .750 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 13 | Sun Dec 29 | vsTBD | W87-72 | 10-3 | .769 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 14 | Fri Jan 3 | atTemple | L85-91 | 10-4 | .714 | - | ESPN2 | Liacouras Center · Philadelphia, PA |
| 15 | Mon Jan 6 | vsSouth Florida | L72-91 | 10-5 | .667 | - | ESPN2 | Charles Koch Arena · Wichita, KS |
| 16 | Sat Jan 11 | atUTSA | L75-88 | 10-6 | .625 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 17 | Tue Jan 14 | vsCharlotte | W68-59 | 11-6 | .647 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 18 | Sat Jan 18 | vsE Carolina | L72-75 | 11-7 | .611 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 19 | Thu Jan 23 | at24Memphis | L53-61 | 11-8 | .579 | - | ESPN2 | FedExForum · Memphis, TN |
| 20 | Sun Jan 26 | atTulsa | L77-84 | 11-9 | .550 | - | ESPN+ | Donald W. Reynolds Center · Tulsa, OK |
| 21 | Wed Jan 29 | vsNorth Texas | L54-58 | 11-10 | .524 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 22 | Tue Feb 4 | atCharlotte | W66-58 | 12-10 | .545 | - | ESPNU | Dale F. Halton Arena · Charlotte, NC |
| 23 | Sun Feb 9 | atSouth Florida | W75-70 | 13-10 | .565 | - | ESPN+ | Yuengling Center · Tampa, FL |
| 24 | Wed Feb 12 | vsUTSA | W69-64 | 14-10 | .583 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 25 | Sun Feb 16 | vs14Memphis | W84-79 (OT) | 15-10 | .600 | - | ESPN | Charles Koch Arena · Wichita, KS |
| 26 | Thu Feb 20 | atFAU | W75-68 | 16-10 | .615 | - | ESPN2 | FAU Arena · Boca Raton, FL |
| 27 | Sun Feb 23 | vsTulane | W78-67 | 17-10 | .630 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 28 | Thu Feb 27 | vsUAB | L72-80 | 17-11 | .607 | - | ESPNU | Charles Koch Arena · Wichita, KS |
| 29 | Mon Mar 3 | atNorth Texas | L66-68 | 17-12 | .586 | - | ESPN2 | The Super Pit · Denton, TX |
| 30 | Thu Mar 6 | atRice | W63-59 | 18-12 | .600 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 31 | Sun Mar 9 | vsTulsa | L63-73 | 18-13 | .581 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 32 | Thu Mar 13 | vsSouth Florida | W73-68 | 19-13 | .594 | - | ESPNU | Charles Koch Arena · Wichita, KS |
| 33 | Fri Mar 14 | at16Memphis | L80-83 | 19-14 | .576 | - | ESPN2 | FedExForum · Memphis, TN |
| 34 | Tue Mar 18 | atOklahoma St | L79-89 | 19-15 | .559 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
