| 1 | Wed Nov 25 | at Saint Louis | L52-89 | 0-1 | .000 | - | | Chaifetz Arena · St. Louis, MO |
| 2 | Thu Nov 26 | atLSU | L81-94 | 0-2 | .000 | - | | Pete Maravich Assembly Center · Baton Rouge, LA |
| 3 | Sat Nov 28 | vsTBD | W80-45 | 1-2 | .333 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 4 | Wed Dec 2 | atN Illinois | W73-53 | 2-2 | .500 | - | | NIU Convocation Center · Dekalb, IL |
| 5 | Sat Dec 5 | vsOmaha | L63-65 | 2-3 | .400 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 6 | Wed Dec 9 | atValparaiso | L58-80 | 2-4 | .333 | - | | Athletics-Recreation Center · Valparaiso, IN |
| 9 | Fri Dec 18 | atMorehead St | W69-65 | 3-4 | .429 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 10 | Mon Dec 21 | vsE Illinois | PPD | 9-17 | .346 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 12 | Tue Jan 5 | atE Illinois | PPD | 9-17 | .346 | - | | Lantz Arena · Charleston, IL |
| 13 | Thu Jan 7 | vsAustin Peay | PPD | 9-17 | .346 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 14 | Sat Jan 9 | vsMurray St | PPD | 9-17 | .346 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 15 | Tue Jan 12 | vsE Illinois | PPD | 9-17 | .346 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 16 | Thu Jan 14 | vsE Kentucky | PPD | 9-17 | .346 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 18 | Thu Jan 21 | atTennessee St | W67-65 | 4-4 | .500 | - | | Gentry Center · Nashville, TN |
| 19 | Sat Jan 23 | atBelmont | L62-114 | 4-5 | .444 | - | | Curb Event Center Arena · Nashville, TN |
| 20 | Tue Jan 26 | atE Illinois | W87-74 | 5-5 | .500 | - | | Lantz Arena · Charleston, IL |
| 21 | Thu Jan 28 | atSE Missouri St | L62-64 | 5-6 | .455 | - | | Show Me Center · Cape Girardeau, MO |
| 22 | Sat Jan 30 | atUT Martin | W76-60 | 6-6 | .500 | - | | Kathleen and Tom Elam Center · Martin, TN |
| 23 | Mon Feb 1 | vsAustin Peay | L59-74 | 6-7 | .462 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 24 | Tue Feb 2 | vsE Illinois | L61-70 | 6-8 | .429 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 25 | Thu Feb 4 | vsTennessee St | W68-60 | 7-8 | .467 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 26 | Sat Feb 6 | vsBelmont | L62-94 | 7-9 | .438 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 27 | Mon Feb 8 | vsE Kentucky | L74-78 | 7-10 | .412 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 28 | Tue Feb 9 | vsMurray St | PPD | 9-17 | .346 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 29 | Thu Feb 11 | atTennessee Tech | W81-63 | 8-10 | .444 | - | | Hooper Eblen Center · Cookeville, TN |
| 30 | Sat Feb 13 | atJ'Ville St | L60-80 | 8-11 | .421 | - | | Pete Mathews Coliseum · Jacksonville, AL |
| 31 | Mon Feb 15 | vsMurray St | L57-86 | 8-12 | .400 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 32 | Thu Feb 18 | atAustin Peay | L57-79 | 8-13 | .381 | - | | Winfield Dunn Center · Clarksville, TN |
| 33 | Sat Feb 20 | atMurray St | L62-89 | 8-14 | .364 | - | | CFSB Center · Murray, KY |
| 34 | Mon Feb 22 | vsMorehead St | L48-56 | 8-15 | .348 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 35 | Thu Feb 25 | vsUT Martin | W66-53 | 9-15 | .375 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 36 | Sat Feb 27 | vsSE Missouri St | L63-69 | 9-16 | .360 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 37 | Wed Mar 3 | atBelmont | L61-78 | 9-17 | .346 | - | | Curb Event Center Arena · Nashville, TN |
