| 1 | Mon Nov 6 | at Dayton | L47-63 | 0-1 | .000 | - | | UD Arena · Dayton, OH |
| 2 | Thu Nov 9 | vs TBD | W92-67 | 1-1 | .500 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 3 | Mon Nov 13 | at Missouri | L50-68 | 1-2 | .333 | - | | Mizzou Arena · Columbia, MO |
| 4 | Thu Nov 16 | vs Denver | W77-74 | 2-2 | .500 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 5 | Fri Nov 17 | at Nicholls | W60-51 | 3-2 | .600 | - | | David R. Stopher Gymnasium · Thibodaux, LA |
| 6 | Sun Nov 19 | at South Alabama | L74-86 | 3-3 | .500 | - | | Mitchell Center · Mobile, AL |
| 7 | Sat Nov 25 | vs Detroit Mercy | W81-67 | 4-3 | .571 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 8 | Tue Nov 28 | vsTBD | W86-62 | 5-3 | .625 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 9 | Fri Dec 1 | at Troy | L60-83 | 5-4 | .556 | - | | Trojan Arena · Troy, AL |
| 10 | Wed Dec 6 | vs Green Bay | W78-69 | 6-4 | .600 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 11 | Sun Dec 10 | at Ball State | L71-83 | 6-5 | .545 | - | | Worthen Arena · Muncie, IN |
| 12 | Mon Dec 18 | vsTBD | W99-56 | 7-5 | .583 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 13 | Thu Dec 21 | at Bradley | L64-75 | 7-6 | .538 | - | | Carver Arena · Peoria, IL |
| 14 | Fri Dec 29 | vs E Illinois | W67-58 | 8-6 | .571 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 15 | Sun Dec 31 | vs W Illinois | L70-78 | 8-7 | .533 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 16 | Thu Jan 4 | at Little Rock | L80-88 | 8-8 | .500 | - | | Jack Stephens Center · Little Rock, AR |
| 17 | Thu Jan 11 | vs So Indiana | W67-64 | 9-8 | .529 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 18 | Sat Jan 13 | vs Morehead St | W61-48 | 10-8 | .556 | - | ESPNU | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 19 | Thu Jan 18 | at Lindenwood | W78-59 | 11-8 | .579 | - | | placeholder · sf, ca |
| 20 | Sat Jan 20 | at SE Missouri St | L47-52 | 11-9 | .550 | - | | Show Me Center · Cape Girardeau, MO |
| 21 | Sat Jan 27 | vs Tennessee Tech | W74-57 | 12-9 | .571 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 22 | Thu Feb 1 | vsLittle Rock | W68-66 | 13-9 | .591 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 23 | Sat Feb 3 | vs UT Martin | L79-90 | 13-10 | .565 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 24 | Thu Feb 8 | atMorehead St | L68-79 | 13-11 | .542 | - | ESPNU | Ellis T. Johnson Arena · Morehead, KY |
| 25 | Sat Feb 10 | atSo Indiana | L67-84 | 13-12 | .520 | - | | Screaming Eagles Arena · Evansville, IN |
| 26 | Thu Feb 15 | vsLindenwood | W91-63 | 14-12 | .538 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 27 | Sat Feb 17 | vsSE Missouri St | W80-76 | 15-12 | .556 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 28 | Thu Feb 22 | atTennessee Tech | W78-77 | 16-12 | .571 | - | | Hooper Eblen Center · Cookeville, TN |
| 29 | Sat Feb 24 | at Tennessee St | L71-76 | 16-13 | .552 | - | | Gentry Center · Nashville, TN |
| 30 | Tue Feb 27 | atE Illinois | L79-84 | 16-14 | .533 | - | | Lantz Arena · Charleston, IL |
| 31 | Sat Mar 2 | atW Illinois | L65-76 | 16-15 | .516 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 32 | Wed Mar 6 | vsE Illinois | W68-57 | 17-15 | .531 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 33 | Thu Mar 7 | atMorehead St | L63-78 | 17-16 | .515 | - | | Ellis T. Johnson Arena · Morehead, KY |
