| 1 | Tue Nov 5 | vs TBD | W61-52 | 1-0 | 1.000 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 2 | Fri Nov 8 | at Iowa | L60-87 | 1-1 | .500 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 3 | Tue Nov 12 | vs Valparaiso | L76-89 | 1-2 | .333 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 4 | Sat Nov 16 | at Incarnate Word | W57-55 | 2-2 | .500 | - | | Alice P. McDermott Convocation Center · San Antonio, TX |
| 5 | Mon Nov 18 | at South Dakota | L56-71 | 2-3 | .400 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 6 | Sat Nov 23 | vs N Illinois | L64-68 | 2-4 | .333 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 7 | Tue Nov 26 | at Pacific | L50-78 | 2-5 | .286 | - | | Alex G. Spanos Center · Stockton, CA |
| 8 | Fri Nov 29 | at UC Riverside | L51-69 | 2-6 | .250 | - | | SRC Arena · Riverside, CA |
| 9 | Wed Dec 4 | vs Chicago St | L81-89 | 2-7 | .222 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 10 | Sun Dec 15 | at Northwestern | L54-72 | 2-8 | .200 | - | ESPNU | Welsh-Ryan Arena · Evanston, IL |
| 11 | Tue Dec 17 | at Winthrop | L73-93 | 2-9 | .182 | - | | Winthrop Coliseum · Rock Hill, SC |
| 12 | Sat Dec 21 | at Detroit Mercy | L55-81 | 2-10 | .167 | - | | Calihan Hall · Detroit, MI |
| 13 | Sun Dec 29 | vs Lindenwood | W96-48 | 3-10 | .231 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 14 | Thu Jan 2 | at Belmont | W79-69 | 4-10 | .286 | - | | Curb Event Center Arena · Nashville, TN |
| 15 | Sat Jan 4 | at Tennessee St | L74-79 | 4-11 | .267 | - | | Gentry Center · Nashville, TN |
| 16 | Thu Jan 9 | at Morehead St | L77-83 | 4-12 | .250 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 17 | Sat Jan 11 | at E Kentucky | L72-78 | 4-13 | .235 | - | | McBrayer Arena · Richmond, KY |
| 18 | Thu Jan 16 | vs Tennessee Tech | L69-72 | 4-14 | .222 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 19 | Sat Jan 18 | vs J'Ville St | L56-64 | 4-15 | .211 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 20 | Thu Jan 23 | vs SE Missouri St | W84-65 | 5-15 | .250 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 21 | Sat Jan 25 | vs UT Martin | L76-79 | 5-16 | .238 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 22 | Thu Jan 30 | at Austin Peay | L58-82 | 5-17 | .227 | - | | Winfield Dunn Center · Clarksville, TN |
| 23 | Sat Feb 1 | at Murray St | L55-74 | 5-18 | .217 | - | | CFSB Center · Murray, KY |
| 24 | Thu Feb 6 | vsMorehead St | L49-58 | 5-19 | .208 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 25 | Sat Feb 8 | vsE Kentucky | W83-75 | 6-19 | .240 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 26 | Thu Feb 13 | at E Illinois | W76-74 | 7-19 | .269 | - | | Lantz Arena · Charleston, IL |
| 27 | Sat Feb 15 | atSE Missouri St | L71-75 | 7-20 | .259 | - | | Show Me Center · Cape Girardeau, MO |
| 28 | Thu Feb 20 | vsAustin Peay | L60-78 | 7-21 | .250 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 29 | Sat Feb 22 | vsMurray St | L58-59 | 7-22 | .241 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 30 | Thu Feb 27 | atUT Martin | W90-75 | 8-22 | .267 | - | | Kathleen and Tom Elam Center · Martin, TN |
| 31 | Sat Feb 29 | vsE Illinois | L52-70 | 8-23 | .258 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
