| 1 | Mon Nov 7 | vs TBD | W85-57 | 1-0 | 1.000 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 2 | Sat Nov 12 | at Purdue FW | L76-81 | 1-1 | .500 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 3 | Tue Nov 15 | at Missouri | L80-105 | 1-2 | .333 | - | | Mizzou Arena · Columbia, MO |
| 4 | Fri Nov 18 | vs Fairleigh | W79-78 | 2-2 | .500 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 5 | Sat Nov 19 | at VMI | W93-67 | 3-2 | .600 | - | | Cameron Hall · Lexington, VA |
| 6 | Sun Nov 20 | at Longwood | W61-56 | 4-2 | .667 | - | | Willett Hall · Farmville, VA |
| 7 | Sat Nov 26 | at Kansas City | W64-54 | 5-2 | .714 | - | | Swinney Recreation Center · Kansas City, MO |
| 8 | Tue Nov 29 | vsTBD | W89-54 | 6-2 | .750 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 9 | Sat Dec 3 | vs Troy | W78-72 | 7-2 | .778 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 10 | Tue Dec 6 | vs Bradley | L54-56 | 7-3 | .700 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 11 | Sat Dec 10 | at Illinois St | L71-77 | 7-4 | .636 | - | | Redbird Arena · Normal, IL |
| 12 | Sun Dec 18 | vsTBD | W93-78 | 8-4 | .667 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 13 | Wed Dec 21 | at Saint Louis | W69-67 | 9-4 | .692 | - | | Chaifetz Arena · St. Louis, MO |
| 14 | Thu Dec 29 | vs Tennessee Tech | W64-51 | 10-4 | .714 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 15 | Sat Dec 31 | at SE Missouri St | L73-82 | 10-5 | .667 | - | | Show Me Center · Cape Girardeau, MO |
| 16 | Thu Jan 5 | vs Tennessee St | W81-72 | 11-5 | .688 | - | ESPNEWS | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 17 | Sat Jan 7 | at So Indiana | W69-62 | 12-5 | .706 | - | | Screaming Eagles Arena · Evansville, IN |
| 18 | Thu Jan 12 | at E Illinois | W80-62 | 13-5 | .722 | - | | Lantz Arena · Charleston, IL |
| 19 | Sat Jan 14 | vs Lindenwood | W68-58 | 14-5 | .737 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 20 | Thu Jan 19 | vs Morehead St | L58-67 | 14-6 | .700 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 21 | Sat Jan 21 | vsSo Indiana | L72-82 | 14-7 | .667 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 22 | Thu Jan 26 | atTennessee Tech | L68-80 | 14-8 | .636 | - | ESPNEWS | Hooper Eblen Center · Cookeville, TN |
| 23 | Sat Jan 28 | atMorehead St | L50-55 | 14-9 | .609 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 24 | Thu Feb 2 | vs UT Martin | W89-75 | 15-9 | .625 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 25 | Sat Feb 4 | at Little Rock | W84-81 | 16-9 | .640 | - | | Jack Stephens Center · Little Rock, AR |
| 26 | Thu Feb 9 | atLindenwood | W63-58 | 17-9 | .654 | - | | placeholder · sf, ca |
| 27 | Sat Feb 11 | vsE Illinois | L73-84 | 17-10 | .630 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 28 | Thu Feb 16 | atUT Martin | L84-90 | 17-11 | .607 | - | | Kathleen and Tom Elam Center · Martin, TN |
| 29 | Sat Feb 18 | atTennessee St | L85-100 | 17-12 | .586 | - | | Gentry Center · Nashville, TN |
| 30 | Thu Feb 23 | vsLittle Rock | L74-79 | 17-13 | .567 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 31 | Sat Feb 25 | vsSE Missouri St | W93-78 | 18-13 | .581 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 32 | Wed Mar 1 | vsSo Indiana | W68-54 | 19-13 | .594 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 33 | Thu Mar 2 | atUT Martin | L75-81 | 19-14 | .576 | - | | Kathleen and Tom Elam Center · Martin, TN |
