| 1 | Wed Jan 13 | at Avalanche | W4-1 | 1-0-0 | 2 PTS | Ball Arena · Denver, CO |
| 2 | Fri Jan 15 | at Avalanche | L0-8 | 1-1-0 | 2 PTS | Ball Arena · Denver, CO |
| 3 | Mon Jan 18 | vs Sharks | W5-4 | 2-1-0 | 4 PTS | Enterprise Center · St. Louis, MO |
| 4 | Wed Jan 20 | vs Sharks | L1-2 (SO) | 2-1-1 | 5 PTS | Enterprise Center · St. Louis, MO |
| 5 | Sat Jan 23 | vs Kings | W4-2 | 3-1-1 | 7 PTS | Enterprise Center · St. Louis, MO |
| 6 | Sun Jan 24 | vs Kings | L3-6 | 3-2-1 | 7 PTS | Enterprise Center · St. Louis, MO |
| 7 | Tue Jan 26 | at Knights | W5-4 (SO) | 4-2-1 | 9 PTS | T-Mobile Arena · Las Vegas, NV |
| 8 | Sat Jan 30 | at Ducks | W6-1 | 5-2-1 | 11 PTS | Honda Center · Anaheim, CA |
| 9 | Sun Jan 31 | at Ducks | W4-1 | 6-2-1 | 13 PTS | Honda Center · Anaheim, CA |
| 10 | Tue Feb 2 | vs Coyotes | W4-3 | 7-2-1 | 15 PTS | Enterprise Center · St. Louis, MO |
| 11 | Thu Feb 4 | vs Coyotes | L3-4 | 7-3-1 | 15 PTS | Enterprise Center · St. Louis, MO |
| 12 | Sat Feb 6 | vs Coyotes | L1-3 | 7-4-1 | 15 PTS | Enterprise Center · St. Louis, MO |
| 13 | Mon Feb 8 | vs Coyotes | L3-4 (SO) | 7-4-2 | 16 PTS | Enterprise Center · St. Louis, MO |
| 14 | Fri Feb 12 | at Coyotes | W4-1 | 8-4-2 | 18 PTS | Mullett Arena · Tempe, AZ |
| 15 | Sat Feb 13 | at Coyotes | W5-4 (OT) | 9-4-2 | 20 PTS | Mullett Arena · Tempe, AZ |
| 16 | Mon Feb 15 | at Coyotes | L0-1 | 9-5-2 | 20 PTS | Mullett Arena · Tempe, AZ |
| 17 | Thu Feb 18 | vs Sharks | W3-2 (OT) | 10-5-2 | 22 PTS | Enterprise Center · St. Louis, MO |
| 18 | Sat Feb 20 | vs Sharks | L4-5 | 10-6-2 | 22 PTS | Enterprise Center · St. Louis, MO |
| 19 | Mon Feb 22 | vs Kings | L0-3 | 10-7-2 | 22 PTS | Enterprise Center · St. Louis, MO |
| 20 | Wed Feb 24 | vs Kings | L1-2 | 10-8-2 | 22 PTS | Enterprise Center · St. Louis, MO |
| 21 | Sat Feb 27 | at Sharks | W7-6 | 11-8-2 | 24 PTS | SAP Center · San Jose, CA |
| 22 | Mon Mar 1 | at Ducks | W5-4 | 12-8-2 | 26 PTS | Honda Center · Anaheim, CA |
| 23 | Wed Mar 3 | at Ducks | W3-2 | 13-8-2 | 28 PTS | Honda Center · Anaheim, CA |
| 24 | Fri Mar 5 | at Kings | W3-2 (OT) | 14-8-2 | 30 PTS | Crypto.com Arena · Los Angeles, CA |
| 25 | Sat Mar 6 | at Kings | L3-4 (OT) | 14-8-3 | 31 PTS | Crypto.com Arena · Los Angeles, CA |
| 26 | Mon Mar 8 | at Sharks | L2-3 (OT) | 14-8-4 | 32 PTS | SAP Center · San Jose, CA |
| 27 | Fri Mar 12 | vs Knights | L4-5 (OT) | 14-8-5 | 33 PTS | Enterprise Center · St. Louis, MO |
| 28 | Sat Mar 13 | vs Knights | L1-5 | 14-9-5 | 33 PTS | Enterprise Center · St. Louis, MO |
| 29 | Wed Mar 17 | at Kings | L1-4 | 14-10-5 | 33 PTS | Crypto.com Arena · Los Angeles, CA |
| 30 | Fri Mar 19 | at Sharks | W2-1 (SO) | 15-10-5 | 35 PTS | SAP Center · San Jose, CA |
| 31 | Sat Mar 20 | at Sharks | W5-2 | 16-10-5 | 37 PTS | SAP Center · San Jose, CA |
| 32 | Mon Mar 22 | at Knights | L1-5 | 16-11-5 | 37 PTS | T-Mobile Arena · Las Vegas, NV |
| 33 | Thu Mar 25 | at Wild | L0-2 | 16-12-5 | 37 PTS | Xcel Energy Center · St. Paul, MN |
| 34 | Fri Mar 26 | vs Ducks | L1-4 | 16-13-5 | 37 PTS | Enterprise Center · St. Louis, MO |
| 35 | Sun Mar 28 | vs Ducks | L2-3 (OT) | 16-13-6 | 38 PTS | Enterprise Center · St. Louis, MO |
| 36 | Fri Apr 2 | at Avalanche | L2-3 | 16-14-6 | 38 PTS | Ball Arena · Denver, CO |
| 37 | Sat Apr 3 | at Avalanche | L1-2 | 16-15-6 | 38 PTS | Ball Arena · Denver, CO |
| 38 | Mon Apr 5 | vs Knights | L1-6 | 16-16-6 | 38 PTS | Enterprise Center · St. Louis, MO |
| 39 | Wed Apr 7 | vs Knights | W3-1 | 17-16-6 | 40 PTS | Enterprise Center · St. Louis, MO |
| 40 | Fri Apr 9 | vs Wild | W9-1 | 18-16-6 | 42 PTS | Enterprise Center · St. Louis, MO |
| 41 | Sat Apr 10 | vs Wild | W3-2 (OT) | 19-16-6 | 44 PTS | Enterprise Center · St. Louis, MO |
| 42 | Wed Apr 14 | vs Avalanche | L3-4 | 19-17-6 | 44 PTS | Enterprise Center · St. Louis, MO |
| 43 | Sat Apr 17 | at Coyotes | L2-3 | 19-18-6 | 44 PTS | Mullett Arena · Tempe, AZ |
| 44 | Thu Apr 22 | vs Avalanche | L2-4 | 19-19-6 | 44 PTS | Enterprise Center · St. Louis, MO |
| 45 | Sat Apr 24 | vs Avalanche | W5-3 | 20-19-6 | 46 PTS | Enterprise Center · St. Louis, MO |
| 46 | Mon Apr 26 | vs Avalanche | W4-1 | 21-19-6 | 48 PTS | Enterprise Center · St. Louis, MO |
| 47 | Wed Apr 28 | at Wild | W4-3 | 22-19-6 | 50 PTS | Xcel Energy Center · St. Paul, MN |
| 48 | Thu Apr 29 | at Wild | W5-4 (OT) | 23-19-6 | 52 PTS | Xcel Energy Center · St. Paul, MN |
| 49 | Sat May 1 | at Wild | L3-4 (OT) | 23-19-7 | 53 PTS | Xcel Energy Center · St. Paul, MN |
| 50 | Mon May 3 | vs Ducks | W3-1 | 24-19-7 | 55 PTS | Enterprise Center · St. Louis, MO |
| 51 | Wed May 5 | vs Ducks | L2-3 (SO) | 24-19-8 | 56 PTS | Enterprise Center · St. Louis, MO |
| 52 | Fri May 7 | at Knights | L3-4 (OT) | 24-19-9 | 57 PTS | T-Mobile Arena · Las Vegas, NV |
| 53 | Sat May 8 | at Knights | L1-4 | 24-20-9 | 57 PTS | T-Mobile Arena · Las Vegas, NV |
| 54 | Mon May 10 | at Kings | W2-1 (OT) | 25-20-9 | 59 PTS | Crypto.com Arena · Los Angeles, CA |
| 55 | Wed May 12 | vs Wild | W4-0 | 26-20-9 | 61 PTS | Enterprise Center · St. Louis, MO |
| 56 | Thu May 13 | vs Wild | W7-3 | 27-20-9 | 63 PTS | Enterprise Center · St. Louis, MO |
| 1 | Mon May 17 | at Avalanche | L1-4 | 0-1 | .000 | Ball Arena · Denver, CO |
| 2 | Wed May 19 | at Avalanche | L3-6 | 0-2 | .000 | Ball Arena · Denver, CO |
| 3 | Fri May 21 | vs Avalanche | L1-5 | 0-3 | .000 | Enterprise Center · St. Louis, MO |
| 4 | Sun May 23 | vs Avalanche | L2-5 | 0-4 | .000 | Enterprise Center · St. Louis, MO |