| 1 | Sat Oct 15 | vs Jackets | W5-2 | 1-0-0 | 2 PTS | Enterprise Center · St. Louis, MO |
| 2 | Wed Oct 19 | atKraken | W4-3 (OT) | 2-0-0 | 4 PTS | Climate Pledge Arena · Seattle, WA |
| 3 | Sat Oct 22 | atOilers | W2-0 | 3-0-0 | 6 PTS | Rogers Place · Edmonton, AB |
| 4 | Mon Oct 24 | atJets | L0-4 | 3-1-0 | 6 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 5 | Wed Oct 26 | vsOilers | L1-3 | 3-2-0 | 6 PTS | Enterprise Center · St. Louis, MO |
| 6 | Thu Oct 27 | atPredators | L2-6 | 3-3-0 | 6 PTS | Bridgestone Arena · Nashville, TN |
| 7 | Sat Oct 29 | vsCanadiens | L4-7 | 3-4-0 | 6 PTS | Enterprise Center · St. Louis, MO |
| 8 | Mon Oct 31 | vsKings | L1-5 | 3-5-0 | 6 PTS | Enterprise Center · St. Louis, MO |
| 9 | Thu Nov 3 | vsIslanders | L2-5 | 3-6-0 | 6 PTS | Enterprise Center · St. Louis, MO |
| 10 | Mon Nov 7 | atBruins | L1-3 | 3-7-0 | 6 PTS | TD Garden · Boston, MA |
| 11 | Tue Nov 8 | atFlyers | L1-5 | 3-8-0 | 6 PTS | Wells Fargo Center · Philadelphia, PA |
| 12 | Thu Nov 10 | vsSharks | W5-3 | 4-8-0 | 8 PTS | Enterprise Center · St. Louis, MO |
| 13 | Sat Nov 12 | atKnights | W3-2 | 5-8-0 | 10 PTS | T-Mobile Arena · Las Vegas, NV |
| 14 | Mon Nov 14 | atAvalanche | W3-2 | 6-8-0 | 12 PTS | Ball Arena · Denver, CO |
| 15 | Wed Nov 16 | atBlackhawks | W5-2 | 7-8-0 | 14 PTS | United Center · Chicago, IL |
| 16 | Thu Nov 17 | vsCapitals | W5-4 (SO) | 8-8-0 | 16 PTS | Enterprise Center · St. Louis, MO |
| 17 | Sat Nov 19 | vsDucks | W6-2 | 9-8-0 | 18 PTS | Enterprise Center · St. Louis, MO |
| 18 | Mon Nov 21 | vsDucks | W3-1 | 10-8-0 | 20 PTS | Enterprise Center · St. Louis, MO |
| 19 | Wed Nov 23 | atSabres | L2-6 | 10-9-0 | 20 PTS | KeyBank Center · Buffalo, NY |
| 20 | Fri Nov 25 | atLightning | L2-5 | 10-10-0 | 20 PTS | AMALIE Arena · Tampa, FL |
| 21 | Sat Nov 26 | atPanthers | W5-4 (OT) | 11-10-0 | 22 PTS | Amerant Bank Arena · Sunrise, FL |
| 22 | Mon Nov 28 | vsStars | L1-4 | 11-11-0 | 22 PTS | Enterprise Center · St. Louis, MO |
| 23 | Thu Dec 1 | vsHurricanes | L4-6 | 11-12-0 | 22 PTS | Enterprise Center · St. Louis, MO |
| 24 | Sat Dec 3 | atPenguins | L2-6 | 11-13-0 | 22 PTS | PPG Paints Arena · Pittsburgh, PA |
| 25 | Mon Dec 5 | atRangers | L4-6 | 11-14-0 | 22 PTS | Madison Square Garden · Manhattan, NY |
| 26 | Tue Dec 6 | atIslanders | W7-4 | 12-14-0 | 24 PTS | UBS Arena · Elmont, NY |
| 27 | Thu Dec 8 | vsJets | L2-5 | 12-15-0 | 24 PTS | Enterprise Center · St. Louis, MO |
| 28 | Sun Dec 11 | vsAvalanche | L2-3 (OT) | 12-15-1 | 25 PTS | Enterprise Center · St. Louis, MO |
| 29 | Mon Dec 12 | vsPredators | W1-0 (OT) | 13-15-1 | 27 PTS | Enterprise Center · St. Louis, MO |
| 30 | Thu Dec 15 | atOilers | W4-3 (SO) | 14-15-1 | 29 PTS | Rogers Place · Edmonton, AB |
| 31 | Fri Dec 16 | atFlames | W5-2 | 15-15-1 | 31 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 32 | Mon Dec 19 | atCanucks | W5-1 | 16-15-1 | 33 PTS | Rogers Arena · Vancouver, British Columbia |
| 33 | Tue Dec 20 | atKraken | L2-5 | 16-16-1 | 33 PTS | Climate Pledge Arena · Seattle, WA |
| 34 | Fri Dec 23 | atKnights | L4-5 (SO) | 16-16-2 | 34 PTS | T-Mobile Arena · Las Vegas, NV |
| 35 | Tue Dec 27 | vsMaple Leafs | L4-5 (OT) | 16-16-3 | 35 PTS | Enterprise Center · St. Louis, MO |
| 36 | Thu Dec 29 | vsBlackhawks | W3-1 | 17-16-3 | 37 PTS | Enterprise Center · St. Louis, MO |
| 37 | Sat Dec 31 | vsWild | L2-5 | 17-17-3 | 37 PTS | Enterprise Center · St. Louis, MO |
| 38 | Tue Jan 3 | atMaple Leafs | W6-5 (SO) | 18-17-3 | 39 PTS | Scotiabank Arena · Toronto, ON |
| 39 | Thu Jan 5 | atDevils | W5-3 | 19-17-3 | 41 PTS | Prudential Center · Newark, NJ |
| 40 | Sat Jan 7 | atCanadiens | L4-5 | 19-18-3 | 41 PTS | Bell Centre · Montreal, QC |
| 41 | Sun Jan 8 | atWild | W3-0 | 20-18-3 | 43 PTS | Xcel Energy Center · St. Paul, MN |
| 42 | Tue Jan 10 | vsFlames | W4-3 (OT) | 21-18-3 | 45 PTS | Enterprise Center · St. Louis, MO |
| 43 | Thu Jan 12 | vsFlames | L1-4 | 21-19-3 | 45 PTS | Enterprise Center · St. Louis, MO |
| 44 | Sat Jan 14 | vsLightning | L2-4 | 21-20-3 | 45 PTS | Enterprise Center · St. Louis, MO |
| 45 | Mon Jan 16 | vsSenators | W2-1 | 22-20-3 | 47 PTS | Enterprise Center · St. Louis, MO |
| 46 | Thu Jan 19 | vsPredators | W5-2 | 23-20-3 | 49 PTS | Enterprise Center · St. Louis, MO |
| 47 | Sat Jan 21 | vsBlackhawks | L3-5 | 23-21-3 | 49 PTS | Enterprise Center · St. Louis, MO |
| 48 | Tue Jan 24 | vsSabres | L3-5 | 23-22-3 | 49 PTS | Enterprise Center · St. Louis, MO |
| 49 | Thu Jan 26 | atCoyotes | L0-5 | 23-23-3 | 49 PTS | Mullett Arena · Tempe, AZ |
| 50 | Sat Jan 28 | atAvalanche | L2-4 | 23-24-3 | 49 PTS | Ball Arena · Denver, CO |
| 51 | Mon Jan 30 | atJets | L2-4 | 23-25-3 | 49 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 52 | Sat Feb 11 | vsCoyotes | W6-5 (OT) | 24-25-3 | 51 PTS | Enterprise Center · St. Louis, MO |
| 53 | Tue Feb 14 | vsPanthers | W6-2 | 25-25-3 | 53 PTS | Enterprise Center · St. Louis, MO |
| 54 | Thu Feb 16 | vsDevils | W4-2 | 26-25-3 | 55 PTS | Enterprise Center · St. Louis, MO |
| 55 | Sat Feb 18 | vsAvalanche | L1-4 | 26-26-3 | 55 PTS | Enterprise Center · St. Louis, MO |
| 56 | Sun Feb 19 | atSenators | L2-7 | 26-27-3 | 55 PTS | Canadian Tire Centre · Ottawa, ON |
| 57 | Tue Feb 21 | atHurricanes | L1-4 | 26-28-3 | 55 PTS | PNC Arena · Raleigh, NC |
| 58 | Thu Feb 23 | vsCanucks | L2-3 (OT) | 26-28-4 | 56 PTS | Enterprise Center · St. Louis, MO |
| 59 | Sat Feb 25 | vsPenguins | L2-3 (OT) | 26-28-5 | 57 PTS | Enterprise Center · St. Louis, MO |
| 60 | Tue Feb 28 | vsKraken | L3-5 | 26-29-5 | 57 PTS | Enterprise Center · St. Louis, MO |
| 61 | Thu Mar 2 | atSharks | W6-3 | 27-29-5 | 59 PTS | SAP Center · San Jose, CA |
| 62 | Sat Mar 4 | atKings | L2-4 | 27-30-5 | 59 PTS | Crypto.com Arena · Los Angeles, CA |
| 63 | Tue Mar 7 | atCoyotes | L2-6 | 27-31-5 | 59 PTS | Mullett Arena · Tempe, AZ |
| 64 | Thu Mar 9 | vsSharks | W4-2 | 28-31-5 | 61 PTS | Enterprise Center · St. Louis, MO |
| 65 | Sat Mar 11 | atJackets | W5-2 | 29-31-5 | 63 PTS | Nationwide Arena · Columbus, OH |
| 66 | Sun Mar 12 | vsKnights | L3-5 | 29-32-5 | 63 PTS | Enterprise Center · St. Louis, MO |
| 67 | Wed Mar 15 | vsWild | L5-8 | 29-33-5 | 63 PTS | Enterprise Center · St. Louis, MO |
| 68 | Fri Mar 17 | atCapitals | W5-2 | 30-33-5 | 65 PTS | Capital One Arena · Washington, D.C. |
| 69 | Sun Mar 19 | vsJets | W3-0 | 31-33-5 | 67 PTS | Enterprise Center · St. Louis, MO |
| 70 | Tue Mar 21 | vsRed Wings | L2-3 (SO) | 31-33-6 | 68 PTS | Enterprise Center · St. Louis, MO |
| 71 | Thu Mar 23 | atRed Wings | W4-3 | 32-33-6 | 70 PTS | Little Caesars Arena · Detroit, MI |
| 72 | Sat Mar 25 | atDucks | W6-3 | 33-33-6 | 72 PTS | Honda Center · Anaheim, CA |
| 73 | Sun Mar 26 | atKings | L6-7 | 33-34-6 | 72 PTS | Crypto.com Arena · Los Angeles, CA |
| 74 | Tue Mar 28 | vsCanucks | W6-5 (OT) | 34-34-6 | 74 PTS | Enterprise Center · St. Louis, MO |
| 75 | Thu Mar 30 | atBlackhawks | W5-3 | 35-34-6 | 76 PTS | United Center · Chicago, IL |
| 76 | Sat Apr 1 | atPredators | L1-6 | 35-35-6 | 76 PTS | Bridgestone Arena · Nashville, TN |
| 77 | Sun Apr 2 | vsBruins | L3-4 (SO) | 35-35-7 | 77 PTS | Enterprise Center · St. Louis, MO |
| 78 | Tue Apr 4 | vsFlyers | W4-2 | 36-35-7 | 79 PTS | Enterprise Center · St. Louis, MO |
| 79 | Thu Apr 6 | vsRangers | W3-2 (OT) | 37-35-7 | 81 PTS | Enterprise Center · St. Louis, MO |
| 80 | Sat Apr 8 | atWild | L3-5 | 37-36-7 | 81 PTS | Xcel Energy Center · St. Paul, MN |
| 81 | Wed Apr 12 | vsStars | L2-5 | 37-37-7 | 81 PTS | Enterprise Center · St. Louis, MO |
| 82 | Thu Apr 13 | atStars | L0-1 | 37-38-7 | 81 PTS | American Airlines Center · Dallas, TX |
