| 1 | Thu Oct 9 | vs Wild | 8:00 PM | 45-30-7 | 97 PTS | Enterprise Center · St. Louis, MO |
| 2 | Sat Oct 11 | atFlames | 4:00 PM | 41-27-14 | 96 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 3 | Mon Oct 13 | atCanucks | 7:30 PM | 38-30-14 | 90 PTS | Rogers Arena · Vancouver, British Columbia |
| 4 | Wed Oct 15 | vsBlackhawks | 9:30 PM | 25-46-11 | 61 PTS | Enterprise Center · St. Louis, MO |
| 5 | Sat Oct 18 | vsStars | 7:00 PM | 50-26-6 | 106 PTS | Enterprise Center · St. Louis, MO |
| 6 | Tue Oct 21 | vsKings | 8:00 PM | 48-25-9 | 105 PTS | Enterprise Center · St. Louis, MO |
| 7 | Thu Oct 23 | vsMammoth | 8:00 PM | 0-0-0 | 0 PTS | Enterprise Center · St. Louis, MO |
| 8 | Sat Oct 25 | atRed Wings | 7:00 PM | 39-35-8 | 86 PTS | Little Caesars Arena · Detroit, MI |
| 9 | Mon Oct 27 | atPenguins | 7:00 PM | 34-36-12 | 80 PTS | PPG Paints Arena · Pittsburgh, PA |
| 10 | Tue Oct 28 | vsRed Wings | 8:15 PM | 39-35-8 | 86 PTS | Enterprise Center · St. Louis, MO |
| 11 | Thu Oct 30 | vsCanucks | 8:00 PM | 38-30-14 | 90 PTS | Enterprise Center · St. Louis, MO |
| 12 | Sat Nov 1 | atJackets | 7:00 PM | 40-33-9 | 89 PTS | Nationwide Arena · Columbus, OH |
| 13 | Mon Nov 3 | vsOilers | 8:30 PM | 48-29-5 | 101 PTS | Enterprise Center · St. Louis, MO |
| 14 | Wed Nov 5 | atCapitals | 7:30 PM | 51-22-9 | 111 PTS | Capital One Arena · Washington, D.C. |
| 15 | Thu Nov 6 | atSabres | 7:00 PM | 36-39-7 | 79 PTS | KeyBank Center · Buffalo, NY |
| 16 | Sat Nov 8 | vsKraken | 7:00 PM | 35-41-6 | 76 PTS | Enterprise Center · St. Louis, MO |
| 17 | Tue Nov 11 | vsFlames | 8:00 PM | 41-27-14 | 96 PTS | Enterprise Center · St. Louis, MO |
| 18 | Fri Nov 14 | vsFlyers | 8:00 PM | 33-39-10 | 76 PTS | Enterprise Center · St. Louis, MO |
| 19 | Sat Nov 15 | vsKnights | 8:00 PM | 50-22-10 | 110 PTS | Enterprise Center · St. Louis, MO |
| 20 | Tue Nov 18 | atMaple Leafs | 7:00 PM | 52-26-4 | 108 PTS | Scotiabank Arena · Toronto, ON |
| 21 | Thu Nov 20 | atFlyers | 7:00 PM | 33-39-10 | 76 PTS | Wells Fargo Center · Philadelphia, PA |
| 22 | Sat Nov 22 | atIslanders | 3:30 PM | 35-35-12 | 82 PTS | UBS Arena · Elmont, NY |
| 23 | Mon Nov 24 | atRangers | 7:00 PM | 39-36-7 | 85 PTS | Madison Square Garden · Manhattan, NY |
| 24 | Wed Nov 26 | atDevils | 7:00 PM | 42-33-7 | 91 PTS | Prudential Center · Newark, NJ |
| 25 | Fri Nov 28 | vsSenators | 4:00 PM | 45-30-7 | 97 PTS | Enterprise Center · St. Louis, MO |
| 26 | Sat Nov 29 | vsMammoth | 8:00 PM | 0-0-0 | 0 PTS | Enterprise Center · St. Louis, MO |
| 27 | Mon Dec 1 | vsDucks | 8:00 PM | 35-37-10 | 80 PTS | Enterprise Center · St. Louis, MO |
| 28 | Thu Dec 4 | atBruins | 7:00 PM | 33-39-10 | 76 PTS | TD Garden · Boston, MA |
| 29 | Sat Dec 6 | atSenators | 7:00 PM | 45-30-7 | 97 PTS | Canadian Tire Centre · Ottawa, ON |
| 30 | Sun Dec 7 | atCanadiens | 7:00 PM | 40-31-11 | 91 PTS | Bell Centre · Montreal, QC |
| 31 | Tue Dec 9 | vsBruins | 8:00 PM | 33-39-10 | 76 PTS | Enterprise Center · St. Louis, MO |
| 32 | Thu Dec 11 | atPredators | 8:00 PM | 30-44-8 | 68 PTS | Bridgestone Arena · Nashville, TN |
| 33 | Fri Dec 12 | vsBlackhawks | 8:00 PM | 25-46-11 | 61 PTS | Enterprise Center · St. Louis, MO |
| 34 | Mon Dec 15 | vsPredators | 8:00 PM | 30-44-8 | 68 PTS | Enterprise Center · St. Louis, MO |
| 35 | Wed Dec 17 | vsJets | 8:00 PM | 56-22-4 | 116 PTS | Enterprise Center · St. Louis, MO |
| 36 | Thu Dec 18 | vsRangers | 8:00 PM | 39-36-7 | 85 PTS | Enterprise Center · St. Louis, MO |
| 37 | Sat Dec 20 | atPanthers | 6:00 PM | 47-31-4 | 98 PTS | Amerant Bank Arena · Sunrise, FL |
| 38 | Mon Dec 22 | atLightning | 7:00 PM | 47-27-8 | 102 PTS | AMALIE Arena · Tampa, FL |
| 39 | Sat Dec 27 | vsPredators | 8:00 PM | 30-44-8 | 68 PTS | Enterprise Center · St. Louis, MO |
| 40 | Mon Dec 29 | vsSabres | 8:00 PM | 36-39-7 | 79 PTS | Enterprise Center · St. Louis, MO |
| 41 | Wed Dec 31 | atAvalanche | 9:00 PM | 49-29-4 | 102 PTS | Ball Arena · Denver, CO |
| 42 | Fri Jan 2 | vsKnights | 3:00 PM | 50-22-10 | 110 PTS | Enterprise Center · St. Louis, MO |
| 43 | Sat Jan 3 | vsCanadiens | 4:00 PM | 40-31-11 | 91 PTS | Enterprise Center · St. Louis, MO |
| 44 | Wed Jan 7 | atBlackhawks | 9:30 PM | 25-46-11 | 61 PTS | United Center · Chicago, IL |
| 45 | Fri Jan 9 | atMammoth | 9:00 PM | 0-0-0 | 0 PTS | Delta Center · Salt Lake City, UT |
| 46 | Sat Jan 10 | atKnights | 10:00 PM | 50-22-10 | 110 PTS | T-Mobile Arena · Las Vegas, NV |
| 47 | Tue Jan 13 | vsHurricanes | 7:30 PM | 47-30-5 | 99 PTS | Enterprise Center · St. Louis, MO |
| 48 | Fri Jan 16 | vsLightning | 8:00 PM | 47-27-8 | 102 PTS | Enterprise Center · St. Louis, MO |
| 49 | Sun Jan 18 | atOilers | 8:00 PM | 48-29-5 | 101 PTS | Rogers Place · Edmonton, AB |
| 50 | Tue Jan 20 | atJets | 8:00 PM | 56-22-4 | 116 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 51 | Fri Jan 23 | atStars | 8:00 PM | 50-26-6 | 106 PTS | American Airlines Center · Dallas, TX |
| 52 | Sat Jan 24 | vsKings | 8:00 PM | 48-25-9 | 105 PTS | Enterprise Center · St. Louis, MO |
| 53 | Tue Jan 27 | vsStars | 8:00 PM | 50-26-6 | 106 PTS | Enterprise Center · St. Louis, MO |
| 54 | Thu Jan 29 | vsPanthers | 8:00 PM | 47-31-4 | 98 PTS | Enterprise Center · St. Louis, MO |
| 55 | Sat Jan 31 | vsJackets | 7:00 PM | 40-33-9 | 89 PTS | Enterprise Center · St. Louis, MO |
| 56 | Mon Feb 2 | atPredators | 8:00 PM | 30-44-8 | 68 PTS | Bridgestone Arena · Nashville, TN |
| 57 | Wed Feb 4 | atStars | 9:30 PM | 50-26-6 | 106 PTS | American Airlines Center · Dallas, TX |
| 58 | Thu Feb 26 | vsKraken | 8:00 PM | 35-41-6 | 76 PTS | Enterprise Center · St. Louis, MO |
| 59 | Sat Feb 28 | vsDevils | 5:00 PM | 42-33-7 | 91 PTS | Enterprise Center · St. Louis, MO |
| 60 | Sun Mar 1 | atWild | 5:00 PM | 45-30-7 | 97 PTS | Xcel Energy Center · St. Paul, MN |
| 61 | Wed Mar 4 | atKraken | 10:00 PM | 35-41-6 | 76 PTS | Climate Pledge Arena · Seattle, WA |
| 62 | Fri Mar 6 | atSharks | 10:00 PM | 20-50-12 | 52 PTS | SAP Center · San Jose, CA |
| 63 | Sun Mar 8 | atDucks | 9:00 PM | 35-37-10 | 80 PTS | Honda Center · Anaheim, CA |
| 64 | Tue Mar 10 | vsIslanders | 7:30 PM | 35-35-12 | 82 PTS | Enterprise Center · St. Louis, MO |
| 65 | Thu Mar 12 | atHurricanes | 7:00 PM | 47-30-5 | 99 PTS | PNC Arena · Raleigh, NC |
| 66 | Fri Mar 13 | vsOilers | 8:00 PM | 48-29-5 | 101 PTS | Enterprise Center · St. Louis, MO |
| 67 | Sun Mar 15 | atJets | 3:00 PM | 56-22-4 | 116 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 68 | Wed Mar 18 | atFlames | 9:30 PM | 41-27-14 | 96 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 69 | Sat Mar 21 | atCanucks | 7:00 PM | 38-30-14 | 90 PTS | Rogers Arena · Vancouver, British Columbia |
| 70 | Tue Mar 24 | vsCapitals | 8:00 PM | 51-22-9 | 111 PTS | Enterprise Center · St. Louis, MO |
| 71 | Thu Mar 26 | vsSharks | 8:00 PM | 20-50-12 | 52 PTS | Enterprise Center · St. Louis, MO |
| 72 | Sat Mar 28 | vsMaple Leafs | 7:00 PM | 52-26-4 | 108 PTS | Enterprise Center · St. Louis, MO |
| 73 | Mon Mar 30 | atSharks | 10:00 PM | 20-50-12 | 52 PTS | SAP Center · San Jose, CA |
| 74 | Wed Apr 1 | atKings | 9:00 PM | 48-25-9 | 105 PTS | Crypto.com Arena · Los Angeles, CA |
| 75 | Fri Apr 3 | atDucks | 10:00 PM | 35-37-10 | 80 PTS | Honda Center · Anaheim, CA |
| 76 | Sun Apr 5 | atAvalanche | 9:30 PM | 49-29-4 | 102 PTS | Ball Arena · Denver, CO |
| 77 | Tue Apr 7 | vsAvalanche | 8:00 PM | 49-29-4 | 102 PTS | Enterprise Center · St. Louis, MO |
| 78 | Thu Apr 9 | vsJets | 8:00 PM | 56-22-4 | 116 PTS | Enterprise Center · St. Louis, MO |
| 79 | Sat Apr 11 | atBlackhawks | 5:00 PM | 25-46-11 | 61 PTS | United Center · Chicago, IL |
| 80 | Mon Apr 13 | vsWild | 8:00 PM | 45-30-7 | 97 PTS | Enterprise Center · St. Louis, MO |
| 81 | Tue Apr 14 | vsPenguins | 9:30 PM | 34-36-12 | 80 PTS | Enterprise Center · St. Louis, MO |
| 82 | Thu Apr 16 | atMammoth | 8:00 PM | 0-0-0 | 0 PTS | Delta Center · Salt Lake City, UT |
