| 1 | Thu Oct 12 | at Stars | L1-2 (SO) | 0-0-1 | 1 PTS | American Airlines Center · Dallas, TX |
| 2 | Sat Oct 14 | vsKraken | W2-1 (SO) | 1-0-1 | 3 PTS | Enterprise Center · St. Louis, MO |
| 3 | Thu Oct 19 | vsCoyotes | L2-6 | 1-1-1 | 3 PTS | Enterprise Center · St. Louis, MO |
| 4 | Sat Oct 21 | vsPenguins | W4-2 | 2-1-1 | 5 PTS | Enterprise Center · St. Louis, MO |
| 5 | Tue Oct 24 | atJets | L2-4 | 2-2-1 | 5 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 6 | Thu Oct 26 | atFlames | W3-0 | 3-2-1 | 7 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 7 | Fri Oct 27 | atCanucks | L0-5 | 3-3-1 | 7 PTS | Rogers Arena · Vancouver, British Columbia |
| 8 | Wed Nov 1 | atAvalanche | L1-4 | 3-4-1 | 7 PTS | Ball Arena · Denver, CO |
| 9 | Fri Nov 3 | vsDevils | W4-1 | 4-4-1 | 9 PTS | Enterprise Center · St. Louis, MO |
| 10 | Sat Nov 4 | vsCanadiens | W6-3 | 5-4-1 | 11 PTS | Enterprise Center · St. Louis, MO |
| 11 | Tue Nov 7 | vsJets | L2-5 | 5-5-1 | 11 PTS | Enterprise Center · St. Louis, MO |
| 12 | Thu Nov 9 | vsCoyotes | W2-1 | 6-5-1 | 13 PTS | Enterprise Center · St. Louis, MO |
| 13 | Sat Nov 11 | atAvalanche | W8-2 | 7-5-1 | 15 PTS | Ball Arena · Denver, CO |
| 14 | Tue Nov 14 | vsLightning | W5-0 | 8-5-1 | 17 PTS | Enterprise Center · St. Louis, MO |
| 15 | Thu Nov 16 | atSharks | L1-5 | 8-6-1 | 17 PTS | SAP Center · San Jose, CA |
| 16 | Sat Nov 18 | atKings | L1-5 | 8-7-1 | 17 PTS | Crypto.com Arena · Los Angeles, CA |
| 17 | Sun Nov 19 | atDucks | W3-1 | 9-7-1 | 19 PTS | Honda Center · Anaheim, CA |
| 18 | Wed Nov 22 | atCoyotes | W6-5 | 10-7-1 | 21 PTS | Mullett Arena · Tempe, AZ |
| 19 | Fri Nov 24 | vsPredators | L3-8 | 10-8-1 | 21 PTS | Enterprise Center · St. Louis, MO |
| 20 | Sun Nov 26 | atBlackhawks | W4-2 | 11-8-1 | 23 PTS | United Center · Chicago, IL |
| 21 | Tue Nov 28 | atWild | L1-3 | 11-9-1 | 23 PTS | Xcel Energy Center · St. Paul, MN |
| 22 | Thu Nov 30 | vsSabres | W6-4 | 12-9-1 | 25 PTS | Enterprise Center · St. Louis, MO |
| 23 | Sat Dec 2 | atCoyotes | L1-4 | 12-10-1 | 25 PTS | Mullett Arena · Tempe, AZ |
| 24 | Mon Dec 4 | atKnights | W2-1 (OT) | 13-10-1 | 27 PTS | T-Mobile Arena · Las Vegas, NV |
| 25 | Wed Dec 6 | vsKnights | L3-6 | 13-11-1 | 27 PTS | Enterprise Center · St. Louis, MO |
| 26 | Fri Dec 8 | atJackets | L2-5 | 13-12-1 | 27 PTS | Nationwide Arena · Columbus, OH |
| 27 | Sat Dec 9 | atBlackhawks | L1-3 | 13-13-1 | 27 PTS | United Center · Chicago, IL |
| 28 | Tue Dec 12 | vsRed Wings | L4-6 | 13-14-1 | 27 PTS | Enterprise Center · St. Louis, MO |
| 29 | Thu Dec 14 | vsSenators | W4-2 | 14-14-1 | 29 PTS | Enterprise Center · St. Louis, MO |
| 30 | Sat Dec 16 | vsStars | W4-3 (OT) | 15-14-1 | 31 PTS | Enterprise Center · St. Louis, MO |
| 31 | Tue Dec 19 | atLightning | L1-6 | 15-15-1 | 31 PTS | AMALIE Arena · Tampa, FL |
| 32 | Thu Dec 21 | atPanthers | W4-1 | 16-15-1 | 33 PTS | Amerant Bank Arena · Sunrise, FL |
| 33 | Sat Dec 23 | vsBlackhawks | W7-5 | 17-15-1 | 35 PTS | Enterprise Center · St. Louis, MO |
| 34 | Wed Dec 27 | vsStars | W2-1 | 18-15-1 | 37 PTS | Enterprise Center · St. Louis, MO |
| 35 | Fri Dec 29 | vsAvalanche | L1-2 | 18-16-1 | 37 PTS | Enterprise Center · St. Louis, MO |
| 36 | Sat Dec 30 | atPenguins | L2-4 | 18-17-1 | 37 PTS | PPG Paints Arena · Pittsburgh, PA |
| 37 | Thu Jan 4 | vsCanucks | W2-1 | 19-17-1 | 39 PTS | Enterprise Center · St. Louis, MO |
| 38 | Sat Jan 6 | atHurricanes | W2-1 (SO) | 20-17-1 | 41 PTS | PNC Arena · Raleigh, NC |
| 39 | Tue Jan 9 | vsPanthers | L1-5 | 20-18-1 | 41 PTS | Enterprise Center · St. Louis, MO |
| 40 | Thu Jan 11 | vsRangers | W5-2 | 21-18-1 | 43 PTS | Enterprise Center · St. Louis, MO |
| 41 | Sat Jan 13 | vsBruins | L3-4 (OT) | 21-18-2 | 44 PTS | Enterprise Center · St. Louis, MO |
| 42 | Mon Jan 15 | vsFlyers | L2-4 | 21-19-2 | 44 PTS | Enterprise Center · St. Louis, MO |
| 43 | Thu Jan 18 | atCapitals | L2-5 | 21-20-2 | 44 PTS | Capital One Arena · Washington, D.C. |
| 44 | Sat Jan 20 | vsCapitals | W3-0 | 22-20-2 | 46 PTS | Enterprise Center · St. Louis, MO |
| 45 | Tue Jan 23 | atFlames | W4-3 | 23-20-2 | 48 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 46 | Wed Jan 24 | atCanucks | W4-3 (OT) | 24-20-2 | 50 PTS | Rogers Arena · Vancouver, British Columbia |
| 47 | Fri Jan 26 | atKraken | W4-3 (OT) | 25-20-2 | 52 PTS | Climate Pledge Arena · Seattle, WA |
| 48 | Sun Jan 28 | vsKings | W4-3 (OT) | 26-20-2 | 54 PTS | Enterprise Center · St. Louis, MO |
| 49 | Tue Jan 30 | vsJackets | L0-1 | 26-21-2 | 54 PTS | Enterprise Center · St. Louis, MO |
| 50 | Sat Feb 10 | atSabres | W3-1 | 27-21-2 | 56 PTS | KeyBank Center · Buffalo, NY |
| 51 | Sun Feb 11 | atCanadiens | W7-2 | 28-21-2 | 58 PTS | Bell Centre · Montreal, QC |
| 52 | Tue Feb 13 | atMaple Leafs | L1-4 | 28-22-2 | 58 PTS | Scotiabank Arena · Toronto, ON |
| 53 | Thu Feb 15 | vsOilers | W6-3 | 29-22-2 | 60 PTS | Enterprise Center · St. Louis, MO |
| 54 | Sat Feb 17 | vsPredators | L2-5 | 29-23-2 | 60 PTS | Enterprise Center · St. Louis, MO |
| 55 | Mon Feb 19 | vsMaple Leafs | L2-4 | 29-24-2 | 60 PTS | Enterprise Center · St. Louis, MO |
| 56 | Thu Feb 22 | vsIslanders | W4-0 | 30-24-2 | 62 PTS | Enterprise Center · St. Louis, MO |
| 57 | Sat Feb 24 | atRed Wings | L1-6 | 30-25-2 | 62 PTS | Little Caesars Arena · Detroit, MI |
| 58 | Tue Feb 27 | atJets | L2-4 | 30-26-2 | 62 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 59 | Wed Feb 28 | atOilers | L2-3 (OT) | 30-26-3 | 63 PTS | Rogers Place · Edmonton, AB |
| 60 | Sat Mar 2 | vsWild | W3-1 | 31-26-3 | 65 PTS | Enterprise Center · St. Louis, MO |
| 61 | Mon Mar 4 | atFlyers | W2-1 (SO) | 32-26-3 | 67 PTS | Wells Fargo Center · Philadelphia, PA |
| 62 | Tue Mar 5 | atIslanders | L2-4 | 32-27-3 | 67 PTS | UBS Arena · Elmont, NY |
| 63 | Thu Mar 7 | atDevils | L1-4 | 32-28-3 | 67 PTS | Prudential Center · Newark, NJ |
| 64 | Sat Mar 9 | atRangers | L0-4 | 32-29-3 | 67 PTS | Madison Square Garden · Manhattan, NY |
| 65 | Mon Mar 11 | atBruins | W5-1 | 33-29-3 | 69 PTS | TD Garden · Boston, MA |
| 66 | Wed Mar 13 | vsKings | W3-1 | 34-29-3 | 71 PTS | Enterprise Center · St. Louis, MO |
| 67 | Sat Mar 16 | vsWild | W3-2 (SO) | 35-29-3 | 73 PTS | Enterprise Center · St. Louis, MO |
| 68 | Sun Mar 17 | vsDucks | W4-2 | 36-29-3 | 75 PTS | Enterprise Center · St. Louis, MO |
| 69 | Tue Mar 19 | vsAvalanche | L3-4 | 36-30-3 | 75 PTS | Enterprise Center · St. Louis, MO |
| 70 | Thu Mar 21 | atSenators | W5-2 | 37-30-3 | 77 PTS | Canadian Tire Centre · Ottawa, ON |
| 71 | Sat Mar 23 | atWild | W5-4 (OT) | 38-30-3 | 79 PTS | Xcel Energy Center · St. Paul, MN |
| 72 | Mon Mar 25 | vsKnights | L1-2 (OT) | 38-30-4 | 80 PTS | Enterprise Center · St. Louis, MO |
| 73 | Thu Mar 28 | vsFlames | W5-3 | 39-30-4 | 82 PTS | Enterprise Center · St. Louis, MO |
| 74 | Sat Mar 30 | vsSharks | L0-4 | 39-31-4 | 82 PTS | Enterprise Center · St. Louis, MO |
| 75 | Mon Apr 1 | vsOilers | W3-2 (OT) | 40-31-4 | 84 PTS | Enterprise Center · St. Louis, MO |
| 76 | Thu Apr 4 | atPredators | L3-6 | 40-32-4 | 84 PTS | Bridgestone Arena · Nashville, TN |
| 77 | Sat Apr 6 | atSharks | L2-3 (OT) | 40-32-5 | 85 PTS | SAP Center · San Jose, CA |
| 78 | Sun Apr 7 | atDucks | W6-5 (SO) | 41-32-5 | 87 PTS | Honda Center · Anaheim, CA |
| 79 | Wed Apr 10 | vsBlackhawks | W5-2 | 42-32-5 | 89 PTS | Enterprise Center · St. Louis, MO |
| 80 | Fri Apr 12 | vsHurricanes | L2-5 | 42-33-5 | 89 PTS | Enterprise Center · St. Louis, MO |
| 81 | Sun Apr 14 | vsKraken | W4-1 | 43-33-5 | 91 PTS | Enterprise Center · St. Louis, MO |
| 82 | Wed Apr 17 | atStars | L1-2 (SO) | 43-33-6 | 92 PTS | American Airlines Center · Dallas, TX |
