| 1 | Fri Apr 2 | at Red Sox | W3-0 | 1-0 | 1.000 | Fenway Park · Boston, MA |
| 2 | Sat Apr 3 | at Red Sox | W4-2 | 2-0 | 1.000 | Fenway Park · Boston, MA |
| 3 | Sun Apr 4 | at Red Sox | W11-3 | 3-0 | 1.000 | Fenway Park · Boston, MA |
| 4 | Mon Apr 5 | at Yankees | L0-7 | 3-1 | .750 | Yankee Stadium · The Bronx, NY |
| 5 | Tue Apr 6 | at Yankees | L2-7 | 3-2 | .600 | Yankee Stadium · The Bronx, NY |
| 6 | Wed Apr 7 | at Yankees | W4-3 (11) | 4-2 | .667 | Yankee Stadium · The Bronx, NY |
| 7 | Thu Apr 8 | vs Red Sox | L3-7 | 4-3 | .571 | Camden Yards · Baltimore, MD |
| 8 | Sat Apr 10 | vs Red Sox | L4-6 (10) | 4-4 | .500 | Camden Yards · Baltimore, MD |
| 9 | Sun Apr 11 | vs Red Sox | L9-14 | 4-5 | .444 | Camden Yards · Baltimore, MD |
| 10 | Tue Apr 13 | vs Mariners | L3-4 (8) | 4-6 | .400 | Camden Yards · Baltimore, MD |
| 11 | Tue Apr 13 | vs Mariners | W7-6 | 5-6 | .455 | Camden Yards · Baltimore, MD |
| 12 | Thu Apr 15 | vs Mariners | L2-4 | 5-7 | .417 | Camden Yards · Baltimore, MD |
| 13 | Thu Apr 15 | vs Mariners | L1-2 | 5-8 | .385 | Camden Yards · Baltimore, MD |
| 14 | Fri Apr 16 | at Rangers | W5-2 | 6-8 | .429 | Globe Life Field · Arlington, TX |
| 15 | Sat Apr 17 | at Rangers | W6-1 | 7-8 | .467 | Globe Life Field · Arlington, TX |
| 16 | Sun Apr 18 | at Rangers | L0-1 (10) | 7-9 | .438 | Globe Life Field · Arlington, TX |
| 17 | Tue Apr 20 | at Marlins | W7-5 | 8-9 | .471 | LoanDepot Park · Miami, FL |
| 18 | Wed Apr 21 | at Marlins | L0-3 | 8-10 | .444 | LoanDepot Park · Miami, FL |
| 19 | Fri Apr 23 | vs Athletics | L1-3 | 8-11 | .421 | Camden Yards · Baltimore, MD |
| 20 | Sat Apr 24 | vs Athletics | L2-7 | 8-12 | .400 | Camden Yards · Baltimore, MD |
| 21 | Sun Apr 25 | vs Athletics | W8-1 | 9-12 | .429 | Camden Yards · Baltimore, MD |
| 22 | Mon Apr 26 | vs Yankees | W4-2 | 10-12 | .455 | Camden Yards · Baltimore, MD |
| 23 | Tue Apr 27 | vs Yankees | L1-5 | 10-13 | .435 | Camden Yards · Baltimore, MD |
| 24 | Wed Apr 28 | vs Yankees | L0-7 | 10-14 | .417 | Camden Yards · Baltimore, MD |
| 25 | Thu Apr 29 | vs Yankees | W4-3 (10) | 11-14 | .440 | Camden Yards · Baltimore, MD |
| 26 | Fri Apr 30 | at Athletics | W3-2 | 12-14 | .462 | RingCentral Coliseum · Oakland, CA |
| 27 | Sat May 1 | at Athletics | W8-4 | 13-14 | .481 | RingCentral Coliseum · Oakland, CA |
| 28 | Sun May 2 | at Athletics | L5-7 | 13-15 | .464 | RingCentral Coliseum · Oakland, CA |
| 29 | Mon May 3 | at Mariners | W5-3 | 14-15 | .483 | T-Mobile Park · Seattle, WA |
| 30 | Tue May 4 | at Mariners | L2-5 | 14-16 | .467 | T-Mobile Park · Seattle, WA |
| 31 | Wed May 5 | at Mariners | W6-0 | 15-16 | .484 | T-Mobile Park · Seattle, WA |
| 32 | Fri May 7 | vs Red Sox | L2-6 | 15-17 | .469 | Camden Yards · Baltimore, MD |
| 33 | Sat May 8 | vs Red Sox | L6-11 | 15-18 | .455 | Camden Yards · Baltimore, MD |
| 34 | Sun May 9 | vs Red Sox | L3-4 | 15-19 | .441 | Camden Yards · Baltimore, MD |
| 35 | Mon May 10 | vs Red Sox | W4-1 | 16-19 | .457 | Camden Yards · Baltimore, MD |
| 36 | Tue May 11 | at Mets | L2-3 | 16-20 | .444 | Citi Field · Queens, NY |
| 37 | Wed May 12 | at Mets | L1-7 | 16-21 | .432 | Citi Field · Queens, NY |
| 38 | Fri May 14 | vs Yankees | L4-5 | 16-22 | .421 | Camden Yards · Baltimore, MD |
| 39 | Sat May 15 | vs Yankees | L2-8 | 16-23 | .410 | Camden Yards · Baltimore, MD |
| 40 | Sun May 16 | vs Yankees | W10-6 | 17-23 | .425 | Camden Yards · Baltimore, MD |
| 41 | Tue May 18 | vs Rays | L6-13 | 17-24 | .415 | Camden Yards · Baltimore, MD |
| 42 | Wed May 19 | vs Rays | L7-9 | 17-25 | .405 | Camden Yards · Baltimore, MD |
| 43 | Thu May 20 | vs Rays | L1-10 | 17-26 | .395 | Camden Yards · Baltimore, MD |
| 44 | Fri May 21 | at Nationals | L2-4 | 17-27 | .386 | Nationals Park · Washington, D.C. |
| 45 | Sat May 22 | at Nationals | L9-12 | 17-28 | .378 | Nationals Park · Washington, D.C. |
| 46 | Sun May 23 | at Nationals | L5-6 | 17-29 | .370 | Nationals Park · Washington, D.C. |
| 47 | Mon May 24 | at Twins | L3-8 | 17-30 | .362 | Target Field · Minneapolis, MN |
| 48 | Tue May 25 | at Twins | L4-7 | 17-31 | .354 | Target Field · Minneapolis, MN |
| 49 | Wed May 26 | at Twins | L2-3 | 17-32 | .347 | Target Field · Minneapolis, MN |
| 50 | Thu May 27 | at White Sox | L1-5 | 17-33 | .340 | Guaranteed Rate Field · Chicago, IL |
| 51 | Sat May 29 | at White Sox | L4-7 | 17-34 | .333 | Guaranteed Rate Field · Chicago, IL |
| 52 | Sat May 29 | at White Sox | L1-3 | 17-35 | .327 | Guaranteed Rate Field · Chicago, IL |
| 53 | Sun May 30 | at White Sox | L1-3 | 17-36 | .321 | Guaranteed Rate Field · Chicago, IL |
| 54 | Mon May 31 | vs Twins | L2-3 (10) | 17-37 | .315 | Camden Yards · Baltimore, MD |
| 55 | Tue Jun 1 | vs Twins | W7-4 | 18-37 | .327 | Camden Yards · Baltimore, MD |
| 56 | Wed Jun 2 | vs Twins | W6-3 | 19-37 | .339 | Camden Yards · Baltimore, MD |
| 57 | Fri Jun 4 | vs Guardians | W3-1 | 20-37 | .351 | Camden Yards · Baltimore, MD |
| 58 | Sat Jun 5 | vs Guardians | L4-10 | 20-38 | .345 | Camden Yards · Baltimore, MD |
| 59 | Sun Jun 6 | vs Guardians | W18-5 | 21-38 | .356 | Camden Yards · Baltimore, MD |
| 60 | Tue Jun 8 | vs Mets | W10-3 | 22-38 | .367 | Camden Yards · Baltimore, MD |
| 61 | Wed Jun 9 | vs Mets | L1-14 | 22-39 | .361 | Camden Yards · Baltimore, MD |
| 62 | Fri Jun 11 | at Rays | L2-4 | 22-40 | .355 | Tropicana Field · St. Petersburg, FL |
| 63 | Sat Jun 12 | at Rays | L4-5 | 22-41 | .349 | Tropicana Field · St. Petersburg, FL |
| 64 | Sun Jun 13 | at Rays | L1-7 | 22-42 | .344 | Tropicana Field · St. Petersburg, FL |
| 65 | Mon Jun 14 | at Guardians | L3-4 | 22-43 | .338 | Progressive Field · Cleveland, OH |
| 66 | Tue Jun 15 | at Guardians | L2-7 | 22-44 | .333 | Progressive Field · Cleveland, OH |
| 67 | Wed Jun 16 | at Guardians | L7-8 | 22-45 | .328 | Progressive Field · Cleveland, OH |
| 68 | Thu Jun 17 | at Guardians | L3-10 | 22-46 | .324 | Progressive Field · Cleveland, OH |
| 69 | Fri Jun 18 | vs Blue Jays | W7-1 | 23-46 | .333 | Camden Yards · Baltimore, MD |
| 70 | Sat Jun 19 | vs Blue Jays | L7-10 | 23-47 | .329 | Camden Yards · Baltimore, MD |
| 71 | Sun Jun 20 | vs Blue Jays | L4-7 | 23-48 | .324 | Camden Yards · Baltimore, MD |
| 72 | Mon Jun 21 | vs Astros | L2-10 | 23-49 | .319 | Camden Yards · Baltimore, MD |
| 73 | Tue Jun 22 | vs Astros | L1-3 | 23-50 | .315 | Camden Yards · Baltimore, MD |
| 74 | Wed Jun 23 | vs Astros | L0-13 | 23-51 | .311 | Camden Yards · Baltimore, MD |
| 75 | Thu Jun 24 | at Blue Jays | L0-9 | 23-52 | .307 | Rogers Centre · Toronto, ON |
| 76 | Fri Jun 25 | at Blue Jays | W6-5 (10) | 24-52 | .316 | Rogers Centre · Toronto, ON |
| 77 | Sat Jun 26 | at Blue Jays | L4-12 | 24-53 | .312 | Rogers Centre · Toronto, ON |
| 78 | Sun Jun 27 | at Blue Jays | L2-5 | 24-54 | .308 | Rogers Centre · Toronto, ON |
| 79 | Mon Jun 28 | at Astros | W9-7 | 25-54 | .316 | Minute Maid Park · Houston, TX |
| 80 | Tue Jun 29 | at Astros | W13-3 | 26-54 | .325 | Minute Maid Park · Houston, TX |
| 81 | Wed Jun 30 | at Astros | W5-2 | 27-54 | .333 | Minute Maid Park · Houston, TX |
| 82 | Fri Jul 2 | at Angels | L7-8 | 27-55 | .329 | Angel Stadium · Anaheim, CA |
| 83 | Sat Jul 3 | at Angels | L1-4 | 27-56 | .325 | Angel Stadium · Anaheim, CA |
| 84 | Sun Jul 4 | at Angels | L5-6 | 27-57 | .321 | Angel Stadium · Anaheim, CA |
| 85 | Tue Jul 6 | vs Blue Jays | W7-5 | 28-57 | .329 | Camden Yards · Baltimore, MD |
| 86 | Wed Jul 7 | vs Blue Jays | L2-10 | 28-58 | .326 | Camden Yards · Baltimore, MD |
| 87 | Fri Jul 9 | vs White Sox | L1-12 | 28-59 | .322 | Camden Yards · Baltimore, MD |
| 88 | Sat Jul 10 | vs White Sox | L3-8 | 28-60 | .318 | Camden Yards · Baltimore, MD |
| 89 | Sun Jul 11 | vs White Sox | L5-7 (10) | 28-61 | .315 | Camden Yards · Baltimore, MD |
| 90 | Fri Jul 16 | at Royals | L2-9 | 28-62 | .311 | Kauffman Stadium · Kansas City, MO |
| 91 | Sat Jul 17 | at Royals | W8-4 | 29-62 | .319 | Kauffman Stadium · Kansas City, MO |
| 92 | Sun Jul 18 | at Royals | W5-0 | 30-62 | .326 | Kauffman Stadium · Kansas City, MO |
| 93 | Mon Jul 19 | at Rays | W6-1 | 31-62 | .333 | Tropicana Field · St. Petersburg, FL |
| 94 | Tue Jul 20 | at Rays | L3-9 | 31-63 | .330 | Tropicana Field · St. Petersburg, FL |
| 95 | Wed Jul 21 | at Rays | L4-5 | 31-64 | .326 | Tropicana Field · St. Petersburg, FL |
| 96 | Fri Jul 23 | vs Nationals | W6-1 | 32-64 | .333 | Camden Yards · Baltimore, MD |
| 97 | Sat Jul 24 | vs Nationals | W5-3 | 33-64 | .340 | Camden Yards · Baltimore, MD |
| 98 | Sun Jul 25 | vs Nationals | W5-4 | 34-64 | .347 | Camden Yards · Baltimore, MD |
| 99 | Tue Jul 27 | vs Marlins | L3-7 | 34-65 | .343 | Camden Yards · Baltimore, MD |
| 100 | Wed Jul 28 | vs Marlins | W8-7 | 35-65 | .350 | Camden Yards · Baltimore, MD |
| 101 | Thu Jul 29 | at Tigers | L2-6 | 35-66 | .347 | Comerica Park · Detroit, MI |
| 102 | Fri Jul 30 | at Tigers | W4-3 | 36-66 | .353 | Comerica Park · Detroit, MI |
| 103 | Sat Jul 31 | at Tigers | W5-2 | 37-66 | .359 | Comerica Park · Detroit, MI |
| 104 | Sun Aug 1 | at Tigers | L2-6 | 37-67 | .356 | Comerica Park · Detroit, MI |
| 105 | Mon Aug 2 | at Yankees | W7-1 | 38-67 | .362 | Yankee Stadium · The Bronx, NY |
| 106 | Tue Aug 3 | at Yankees | L1-13 | 38-68 | .358 | Yankee Stadium · The Bronx, NY |
| 107 | Wed Aug 4 | at Yankees | L3-10 | 38-69 | .355 | Yankee Stadium · The Bronx, NY |
| 108 | Fri Aug 6 | vs Rays | L6-10 | 38-70 | .352 | Camden Yards · Baltimore, MD |
| 109 | Sat Aug 7 | vs Rays | L3-12 | 38-71 | .349 | Camden Yards · Baltimore, MD |
| 110 | Sun Aug 8 | vs Rays | L6-9 | 38-72 | .345 | Camden Yards · Baltimore, MD |
| 111 | Tue Aug 10 | vs Tigers | L4-9 | 38-73 | .342 | Camden Yards · Baltimore, MD |
| 112 | Wed Aug 11 | vs Tigers | L2-5 | 38-74 | .339 | Camden Yards · Baltimore, MD |
| 113 | Thu Aug 12 | vs Tigers | L4-6 | 38-75 | .336 | Camden Yards · Baltimore, MD |
| 114 | Fri Aug 13 | at Red Sox | L1-8 | 38-76 | .333 | Fenway Park · Boston, MA |
| 115 | Sat Aug 14 | at Red Sox | L2-16 | 38-77 | .330 | Fenway Park · Boston, MA |
| 116 | Sun Aug 15 | at Red Sox | L2-6 | 38-78 | .328 | Fenway Park · Boston, MA |
| 117 | Mon Aug 16 | at Rays | L2-9 | 38-79 | .325 | Tropicana Field · St. Petersburg, FL |
| 118 | Tue Aug 17 | at Rays | L0-10 | 38-80 | .322 | Tropicana Field · St. Petersburg, FL |
| 119 | Wed Aug 18 | at Rays | L4-8 | 38-81 | .319 | Tropicana Field · St. Petersburg, FL |
| 120 | Thu Aug 19 | at Rays | L2-7 | 38-82 | .317 | Tropicana Field · St. Petersburg, FL |
| 121 | Fri Aug 20 | vs Braves | L0-3 | 38-83 | .314 | Camden Yards · Baltimore, MD |
| 122 | Sat Aug 21 | vs Braves | L4-5 | 38-84 | .311 | Camden Yards · Baltimore, MD |
| 123 | Sun Aug 22 | vs Braves | L1-3 | 38-85 | .309 | Camden Yards · Baltimore, MD |
| 124 | Tue Aug 24 | vs Angels | L8-14 | 38-86 | .306 | Camden Yards · Baltimore, MD |
| 125 | Wed Aug 25 | vs Angels | W10-6 | 39-86 | .312 | Camden Yards · Baltimore, MD |
| 126 | Thu Aug 26 | vs Angels | W13-1 | 40-86 | .317 | Camden Yards · Baltimore, MD |
| 127 | Fri Aug 27 | vs Rays | L3-6 | 40-87 | .315 | Camden Yards · Baltimore, MD |
| 128 | Sat Aug 28 | vs Rays | L3-4 | 40-88 | .313 | Camden Yards · Baltimore, MD |
| 129 | Sun Aug 29 | vs Rays | L8-12 | 40-89 | .310 | Camden Yards · Baltimore, MD |
| 130 | Mon Aug 30 | at Blue Jays | L3-7 | 40-90 | .308 | Rogers Centre · Toronto, ON |
| 131 | Tue Aug 31 | at Blue Jays | W4-2 | 41-90 | .313 | Rogers Centre · Toronto, ON |
| 132 | Wed Sep 1 | at Blue Jays | L4-5 | 41-91 | .311 | Rogers Centre · Toronto, ON |
| 133 | Fri Sep 3 | at Yankees | L3-4 (11) | 41-92 | .308 | Yankee Stadium · The Bronx, NY |
| 134 | Sat Sep 4 | at Yankees | W4-3 | 42-92 | .313 | Yankee Stadium · The Bronx, NY |
| 135 | Sun Sep 5 | at Yankees | W8-7 | 43-92 | .319 | Yankee Stadium · The Bronx, NY |
| 136 | Mon Sep 6 | vs Royals | L2-3 | 43-93 | .316 | Camden Yards · Baltimore, MD |
| 137 | Tue Sep 7 | vs Royals | W7-3 | 44-93 | .321 | Camden Yards · Baltimore, MD |
| 138 | Wed Sep 8 | vs Royals | W9-8 | 45-93 | .326 | Camden Yards · Baltimore, MD |
| 139 | Thu Sep 9 | vs Royals | L0-6 | 45-94 | .324 | Camden Yards · Baltimore, MD |
| 140 | Fri Sep 10 | vs Blue Jays | W6-3 | 46-94 | .329 | Camden Yards · Baltimore, MD |
| 141 | Sat Sep 11 | vs Blue Jays | L10-11 | 46-95 | .326 | Camden Yards · Baltimore, MD |
| 142 | Sat Sep 11 | vs Blue Jays | L2-11 | 46-96 | .324 | Camden Yards · Baltimore, MD |
| 143 | Sun Sep 12 | vs Blue Jays | L7-22 | 46-97 | .322 | Camden Yards · Baltimore, MD |
| 144 | Tue Sep 14 | vs Yankees | L2-7 | 46-98 | .319 | Camden Yards · Baltimore, MD |
| 145 | Wed Sep 15 | vs Yankees | L3-4 | 46-99 | .317 | Camden Yards · Baltimore, MD |
| 146 | Thu Sep 16 | vs Yankees | W3-2 (10) | 47-99 | .322 | Camden Yards · Baltimore, MD |
| 147 | Fri Sep 17 | at Red Sox | L1-7 | 47-100 | .320 | Fenway Park · Boston, MA |
| 148 | Sat Sep 18 | at Red Sox | L3-9 | 47-101 | .318 | Fenway Park · Boston, MA |
| 149 | Sun Sep 19 | at Red Sox | L6-8 | 47-102 | .315 | Fenway Park · Boston, MA |
| 150 | Mon Sep 20 | at Phillies | W2-0 | 48-102 | .320 | Citizens Bank Park · Philadelphi, PA |
| 151 | Tue Sep 21 | at Phillies | L2-3 (10) | 48-103 | .318 | Citizens Bank Park · Philadelphi, PA |
| 152 | Wed Sep 22 | at Phillies | L3-4 | 48-104 | .316 | Citizens Bank Park · Philadelphi, PA |
| 153 | Thu Sep 23 | vs Rangers | W3-0 | 49-104 | .320 | Camden Yards · Baltimore, MD |
| 154 | Fri Sep 24 | vs Rangers | L5-8 | 49-105 | .318 | Camden Yards · Baltimore, MD |
| 155 | Sat Sep 25 | vs Rangers | W3-2 | 50-105 | .323 | Camden Yards · Baltimore, MD |
| 156 | Sun Sep 26 | vs Rangers | L4-7 | 50-106 | .321 | Camden Yards · Baltimore, MD |
| 157 | Tue Sep 28 | vs Red Sox | W4-2 | 51-106 | .325 | Camden Yards · Baltimore, MD |
| 158 | Wed Sep 29 | vs Red Sox | L0-6 | 51-107 | .323 | Camden Yards · Baltimore, MD |
| 159 | Thu Sep 30 | vs Red Sox | W6-2 | 52-107 | .327 | Camden Yards · Baltimore, MD |
| 160 | Fri Oct 1 | at Blue Jays | L4-6 | 52-108 | .325 | Rogers Centre · Toronto, ON |
| 161 | Sat Oct 2 | at Blue Jays | L1-10 | 52-109 | .323 | Rogers Centre · Toronto, ON |
| 162 | Sun Oct 3 | at Blue Jays | L4-12 | 52-110 | .321 | Rogers Centre · Toronto, ON |