| 76 | Thu Jun 18 | vs Orioles | 4:10 PM | 35-40 | .467 | T-Mobile Park · Seattle, WA |
| 77 | Fri Jun 19 | vs Red Sox | 10:10 PM | 29-42 | .408 | T-Mobile Park · Seattle, WA |
| 78 | Sat Jun 20 | vs Red Sox | 10:10 PM | 29-42 | .408 | T-Mobile Park · Seattle, WA |
| 79 | Sun Jun 21 | vs Red Sox | 4:10 PM | 29-42 | .408 | T-Mobile Park · Seattle, WA |
| 80 | Tue Jun 23 | at Pirates | 6:40 PM | 38-37 | .507 | PNC Park · Pittsburgh, PA |
| 81 | Wed Jun 24 | at Pirates | 6:40 PM | 38-37 | .507 | PNC Park · Pittsburgh, PA |
| 82 | Thu Jun 25 | at Pirates | 12:35 PM | 38-37 | .507 | PNC Park · Pittsburgh, PA |
| 83 | Fri Jun 26 | at Guardians | 7:10 PM | 39-35 | .527 | Progressive Field · Cleveland, OH |
| 84 | Sat Jun 27 | at Guardians | 7:10 PM | 39-35 | .527 | Progressive Field · Cleveland, OH |
| 85 | Sun Jun 28 | at Guardians | 1:40 PM | 39-35 | .527 | Progressive Field · Cleveland, OH |
| 86 | Mon Jun 29 | vs Angels | 9:40 PM | 30-45 | .400 | T-Mobile Park · Seattle, WA |
| 87 | Tue Jun 30 | vs Angels | 9:40 PM | 30-45 | .400 | T-Mobile Park · Seattle, WA |
| 88 | Thu Jul 2 | vs Angels | 9:40 PM | 30-45 | .400 | T-Mobile Park · Seattle, WA |
| 89 | Fri Jul 3 | vs Blue Jays | 10:10 PM | 36-38 | .486 | T-Mobile Park · Seattle, WA |
| 90 | Sat Jul 4 | vs Blue Jays | 4:10 PM | 36-38 | .486 | T-Mobile Park · Seattle, WA |
| 91 | Sun Jul 5 | vs Blue Jays | 5:00 PM | 36-38 | .486 | T-Mobile Park · Seattle, WA |
| 92 | Tue Jul 7 | at Marlins | 6:40 PM | 37-38 | .493 | LoanDepot Park · Miami, FL |
| 93 | Wed Jul 8 | at Marlins | 6:40 PM | 37-38 | .493 | LoanDepot Park · Miami, FL |
| 94 | Thu Jul 9 | at Marlins | 6:40 PM | 37-38 | .493 | LoanDepot Park · Miami, FL |
| 95 | Fri Jul 10 | at Rays | 7:10 PM | 41-30 | .577 | Tropicana Field · St. Petersburg, FL |
| 96 | Sat Jul 11 | at Rays | 4:10 PM | 41-30 | .577 | Tropicana Field · St. Petersburg, FL |
| 97 | Sun Jul 12 | at Rays | 1:40 PM | 41-30 | .577 | Tropicana Field · St. Petersburg, FL |
| 98 | Fri Jul 17 | vs Giants | 10:10 PM | 31-43 | .419 | T-Mobile Park · Seattle, WA |
| 99 | Sat Jul 18 | vs Giants | 8:08 PM | 31-43 | .419 | T-Mobile Park · Seattle, WA |
| 100 | Sun Jul 19 | vs Giants | 4:10 PM | 31-43 | .419 | T-Mobile Park · Seattle, WA |
| 101 | Mon Jul 20 | vs Reds | 9:40 PM | 35-38 | .479 | T-Mobile Park · Seattle, WA |
| 102 | Tue Jul 21 | vs Reds | 9:40 PM | 35-38 | .479 | T-Mobile Park · Seattle, WA |
| 103 | Wed Jul 22 | vs Reds | 3:40 PM | 35-38 | .479 | T-Mobile Park · Seattle, WA |
| 104 | Fri Jul 24 | at Rangers | 8:05 PM | 35-38 | .479 | Globe Life Field · Arlington, TX |
| 105 | Sat Jul 25 | at Rangers | 7:15 PM | 35-38 | .479 | Globe Life Field · Arlington, TX |
| 106 | Sun Jul 26 | at Rangers | 2:35 PM | 35-38 | .479 | Globe Life Field · Arlington, TX |
| 107 | Mon Jul 27 | at Rangers | 2:35 PM | 35-38 | .479 | Globe Life Field · Arlington, TX |
| 108 | Tue Jul 28 | at Dodgers | 10:10 PM | 48-27 | .640 | Dodger Stadium · Los Angeles, CA |
| 109 | Wed Jul 29 | at Dodgers | 10:10 PM | 48-27 | .640 | Dodger Stadium · Los Angeles, CA |
| 110 | Thu Jul 30 | at Dodgers | 10:10 PM | 48-27 | .640 | Dodger Stadium · Los Angeles, CA |
| 111 | Fri Jul 31 | vs Twins | 10:10 PM | 35-40 | .467 | T-Mobile Park · Seattle, WA |
| 112 | Sat Aug 1 | vs Twins | 4:10 PM | 35-40 | .467 | T-Mobile Park · Seattle, WA |
| 113 | Sun Aug 2 | vs Twins | 4:10 PM | 35-40 | .467 | T-Mobile Park · Seattle, WA |
| 114 | Tue Aug 4 | vs Tigers | 9:40 PM | 30-44 | .405 | T-Mobile Park · Seattle, WA |
| 115 | Wed Aug 5 | vs Tigers | 9:40 PM | 30-44 | .405 | T-Mobile Park · Seattle, WA |
| 116 | Thu Aug 6 | vs Tigers | 4:10 PM | 30-44 | .405 | T-Mobile Park · Seattle, WA |
| 117 | Fri Aug 7 | vs Rays | 9:40 PM | 41-30 | .577 | T-Mobile Park · Seattle, WA |
| 118 | Sat Aug 8 | vs Rays | 9:50 PM | 41-30 | .577 | T-Mobile Park · Seattle, WA |
| 119 | Sun Aug 9 | vs Rays | 4:10 PM | 41-30 | .577 | T-Mobile Park · Seattle, WA |
| 120 | Tue Aug 11 | at Yankees | 7:05 PM | 45-27 | .625 | Yankee Stadium · The Bronx, NY |
| 121 | Wed Aug 12 | at Yankees | 7:05 PM | 45-27 | .625 | Yankee Stadium · The Bronx, NY |
| 122 | Thu Aug 13 | at Yankees | 1:35 PM | 45-27 | .625 | Yankee Stadium · The Bronx, NY |
| 123 | Fri Aug 14 | at Astros | 8:10 PM | 35-41 | .461 | Minute Maid Park · Houston, TX |
| 124 | Sat Aug 15 | at Astros | 7:10 PM | 35-41 | .461 | Minute Maid Park · Houston, TX |
| 125 | Sun Aug 16 | at Astros | 7:20 PM | 35-41 | .461 | Minute Maid Park · Houston, TX |
| 126 | Tue Aug 18 | at Brewers | 7:40 PM | 45-26 | .634 | American Family Field · Milwaukee, WI |
| 127 | Wed Aug 19 | at Brewers | 7:40 PM | 45-26 | .634 | American Family Field · Milwaukee, WI |
| 128 | Thu Aug 20 | at Brewers | 2:10 PM | 45-26 | .634 | American Family Field · Milwaukee, WI |
| 129 | Fri Aug 21 | vs Cubs | 10:10 PM | 39-36 | .520 | T-Mobile Park · Seattle, WA |
| 130 | Sat Aug 22 | vs Cubs | 7:15 PM | 39-36 | .520 | T-Mobile Park · Seattle, WA |
| 131 | Sun Aug 23 | vs Cubs | 4:10 PM | 39-36 | .520 | T-Mobile Park · Seattle, WA |
| 132 | Mon Aug 24 | vs Phillies | 9:40 PM | 40-34 | .541 | T-Mobile Park · Seattle, WA |
| 133 | Tue Aug 25 | vs Phillies | 9:40 PM | 40-34 | .541 | T-Mobile Park · Seattle, WA |
| 134 | Wed Aug 26 | vs Phillies | 4:10 PM | 40-34 | .541 | T-Mobile Park · Seattle, WA |
| 135 | Fri Aug 28 | at Blue Jays | 7:07 PM | 36-38 | .486 | Rogers Centre · Toronto, ON |
| 136 | Sat Aug 29 | at Blue Jays | 3:07 PM | 36-38 | .486 | Rogers Centre · Toronto, ON |
| 137 | Sun Aug 30 | at Blue Jays | 1:37 PM | 36-38 | .486 | Rogers Centre · Toronto, ON |
| 138 | Mon Aug 31 | at Red Sox | 6:45 PM | 29-42 | .408 | Fenway Park · Boston, MA |
| 139 | Tue Sep 1 | at Red Sox | 6:45 PM | 29-42 | .408 | Fenway Park · Boston, MA |
| 140 | Wed Sep 2 | at Red Sox | 4:10 PM | 29-42 | .408 | Fenway Park · Boston, MA |
| 141 | Thu Sep 3 | vs Athletics | 9:40 PM | 36-38 | .486 | T-Mobile Park · Seattle, WA |
| 142 | Fri Sep 4 | vs Athletics | 10:10 PM | 36-38 | .486 | T-Mobile Park · Seattle, WA |
| 143 | Sat Sep 5 | vs Athletics | 9:40 PM | 36-38 | .486 | T-Mobile Park · Seattle, WA |
| 144 | Sun Sep 6 | vs Athletics | 4:10 PM | 36-38 | .486 | T-Mobile Park · Seattle, WA |
| 145 | Tue Sep 8 | vs Rangers | 9:40 PM | 35-38 | .479 | T-Mobile Park · Seattle, WA |
| 146 | Wed Sep 9 | vs Rangers | 4:10 PM | 35-38 | .479 | T-Mobile Park · Seattle, WA |
| 147 | Thu Sep 10 | vs Rangers | 4:10 PM | 35-38 | .479 | T-Mobile Park · Seattle, WA |
| 148 | Fri Sep 11 | at Athletics | 9:40 PM | 36-38 | .486 | Sutter Health Park · West Sacramento, CA |
| 149 | Sat Sep 12 | at Athletics | 9:40 PM | 36-38 | .486 | Sutter Health Park · West Sacramento, CA |
| 150 | Sun Sep 13 | at Athletics | 4:05 PM | 36-38 | .486 | Sutter Health Park · West Sacramento, CA |
| 151 | Mon Sep 14 | at Angels | 9:38 PM | 30-45 | .400 | Angel Stadium · Anaheim, CA |
| 152 | Tue Sep 15 | at Angels | 9:38 PM | 30-45 | .400 | Angel Stadium · Anaheim, CA |
| 153 | Wed Sep 16 | at Angels | 9:38 PM | 30-45 | .400 | Angel Stadium · Anaheim, CA |
| 154 | Fri Sep 18 | at Rockies | 8:10 PM | 28-47 | .373 | Coors Field · Denver, CO |
| 155 | Sat Sep 19 | at Rockies | 8:10 PM | 28-47 | .373 | Coors Field · Denver, CO |
| 156 | Sun Sep 20 | at Rockies | 3:10 PM | 28-47 | .373 | Coors Field · Denver, CO |
| 157 | Tue Sep 22 | vs Astros | 9:40 PM | 35-41 | .461 | T-Mobile Park · Seattle, WA |
| 158 | Wed Sep 23 | vs Astros | 10:10 PM | 35-41 | .461 | T-Mobile Park · Seattle, WA |
| 159 | Thu Sep 24 | vs Angels | 9:40 PM | 30-45 | .400 | T-Mobile Park · Seattle, WA |
| 160 | Fri Sep 25 | vs Angels | 10:10 PM | 30-45 | .400 | T-Mobile Park · Seattle, WA |
| 161 | Sat Sep 26 | vs Angels | 9:40 PM | 30-45 | .400 | T-Mobile Park · Seattle, WA |
| 162 | Sun Sep 27 | vs Angels | 3:10 PM | 30-45 | .400 | T-Mobile Park · Seattle, WA |