| 1 | Mon Mar 31 | at Angels | W10-3 | 1-0 | 1.000 | Angel Stadium · Anaheim, CA |
| 2 | Tue Apr 1 | at Angels | W8-3 | 2-0 | 1.000 | Angel Stadium · Anaheim, CA |
| 3 | Wed Apr 2 | at Angels | W8-2 | 3-0 | 1.000 | Angel Stadium · Anaheim, CA |
| 4 | Thu Apr 3 | at Athletics | L2-3 (12) | 3-1 | .750 | RingCentral Coliseum · Oakland, CA |
| 5 | Sat Apr 5 | at Athletics | W3-1 | 4-1 | .800 | RingCentral Coliseum · Oakland, CA |
| 6 | Sun Apr 6 | at Athletics | L3-6 | 4-2 | .667 | RingCentral Coliseum · Oakland, CA |
| 7 | Tue Apr 8 | vs Angels | W5-3 | 5-2 | .714 | T-Mobile Park · Seattle, WA |
| 8 | Wed Apr 9 | vs Angels | L0-2 | 5-3 | .625 | T-Mobile Park · Seattle, WA |
| 9 | Fri Apr 11 | vs Athletics | W6-4 | 6-3 | .667 | T-Mobile Park · Seattle, WA |
| 10 | Sat Apr 12 | vs Athletics | L1-3 | 6-4 | .600 | T-Mobile Park · Seattle, WA |
| 11 | Sun Apr 13 | vs Athletics | L0-3 | 6-5 | .545 | T-Mobile Park · Seattle, WA |
| 12 | Mon Apr 14 | at Rangers | W7-1 | 7-5 | .583 | Globe Life Field · Arlington, TX |
| 13 | Tue Apr 15 | at Rangers | L0-5 | 7-6 | .538 | Globe Life Field · Arlington, TX |
| 14 | Wed Apr 16 | at Rangers | L2-3 | 7-7 | .500 | Globe Life Field · Arlington, TX |
| 15 | Thu Apr 17 | at Rangers | L6-8 | 7-8 | .467 | Globe Life Field · Arlington, TX |
| 16 | Fri Apr 18 | at Marlins | L4-8 | 7-9 | .438 | LoanDepot Park · Miami, FL |
| 17 | Sat Apr 19 | at Marlins | L0-7 | 7-10 | .412 | LoanDepot Park · Miami, FL |
| 18 | Sun Apr 20 | at Marlins | L2-3 | 7-11 | .389 | LoanDepot Park · Miami, FL |
| 19 | Mon Apr 21 | vs Astros | L2-7 | 7-12 | .368 | T-Mobile Park · Seattle, WA |
| 20 | Tue Apr 22 | vs Astros | L2-5 | 7-13 | .350 | T-Mobile Park · Seattle, WA |
| 21 | Wed Apr 23 | vs Astros | W5-3 | 8-13 | .381 | T-Mobile Park · Seattle, WA |
| 22 | Fri Apr 25 | vs Rangers | W6-5 | 9-13 | .409 | T-Mobile Park · Seattle, WA |
| 23 | Sat Apr 26 | vs Rangers | L3-6 | 9-14 | .391 | T-Mobile Park · Seattle, WA |
| 24 | Sun Apr 27 | vs Rangers | W6-5 | 10-14 | .417 | T-Mobile Park · Seattle, WA |
| 25 | Tue Apr 29 | at Yankees | W6-3 | 11-14 | .440 | Yankee Stadium · The Bronx, NY |
| 26 | Thu May 1 | at Yankees | W4-2 | 12-14 | .462 | Yankee Stadium · The Bronx, NY |
| 27 | Fri May 2 | at Astros | L4-5 (11) | 12-15 | .444 | Minute Maid Park · Houston, TX |
| 28 | Sat May 3 | at Astros | W9-8 | 13-15 | .464 | Minute Maid Park · Houston, TX |
| 29 | Sun May 4 | at Astros | W8-7 | 14-15 | .483 | Minute Maid Park · Houston, TX |
| 30 | Mon May 5 | at Athletics | W4-2 | 15-15 | .500 | RingCentral Coliseum · Oakland, CA |
| 31 | Tue May 6 | at Athletics | W8-3 | 16-15 | .516 | RingCentral Coliseum · Oakland, CA |
| 32 | Wed May 7 | at Athletics | W6-4 (10) | 17-15 | .531 | RingCentral Coliseum · Oakland, CA |
| 33 | Wed May 7 | at Athletics | L0-2 | 17-16 | .515 | RingCentral Coliseum · Oakland, CA |
| 34 | Thu May 8 | vs Royals | W1-0 | 18-16 | .529 | T-Mobile Park · Seattle, WA |
| 35 | Fri May 9 | vs Royals | L1-6 | 18-17 | .514 | T-Mobile Park · Seattle, WA |
| 36 | Sat May 10 | vs Royals | W3-1 | 19-17 | .528 | T-Mobile Park · Seattle, WA |
| 37 | Sun May 11 | vs Royals | L7-9 | 19-18 | .514 | T-Mobile Park · Seattle, WA |
| 38 | Mon May 12 | vs Rays | W12-5 | 20-18 | .526 | T-Mobile Park · Seattle, WA |
| 39 | Tue May 13 | vs Rays | L1-2 | 20-19 | .513 | T-Mobile Park · Seattle, WA |
| 40 | Wed May 14 | vs Rays | L0-2 | 20-20 | .500 | T-Mobile Park · Seattle, WA |
| 41 | Fri May 16 | at Twins | L4-5 | 20-21 | .488 | Target Field · Minneapolis, MN |
| 42 | Sat May 17 | at Twins | L3-4 | 20-22 | .476 | Target Field · Minneapolis, MN |
| 43 | Sun May 18 | at Twins | W6-2 | 21-22 | .488 | Target Field · Minneapolis, MN |
| 44 | Tue May 20 | at Rangers | W6-2 | 22-22 | .500 | Globe Life Field · Arlington, TX |
| 45 | Wed May 21 | at Rangers | L3-4 | 22-23 | .489 | Globe Life Field · Arlington, TX |
| 46 | Thu May 22 | vs Astros | W3-1 | 23-23 | .500 | T-Mobile Park · Seattle, WA |
| 47 | Fri May 23 | vs Astros | W6-1 | 24-23 | .511 | T-Mobile Park · Seattle, WA |
| 48 | Sat May 24 | vs Astros | L4-9 | 24-24 | .500 | T-Mobile Park · Seattle, WA |
| 49 | Sun May 25 | vs Astros | L1-4 | 24-25 | .490 | T-Mobile Park · Seattle, WA |
| 50 | Mon May 26 | vs Angels | W5-1 | 25-25 | .500 | T-Mobile Park · Seattle, WA |
| 51 | Tue May 27 | vs Angels | L4-6 | 25-26 | .490 | T-Mobile Park · Seattle, WA |
| 52 | Wed May 28 | vs Angels | W3-1 | 26-26 | .500 | T-Mobile Park · Seattle, WA |
| 53 | Thu May 29 | vs Angels | L5-7 | 26-27 | .491 | T-Mobile Park · Seattle, WA |
| 54 | Fri May 30 | vs Tigers | L3-6 | 26-28 | .481 | T-Mobile Park · Seattle, WA |
| 55 | Sat May 31 | vs Tigers | W3-2 | 27-28 | .491 | T-Mobile Park · Seattle, WA |
| 56 | Sun Jun 1 | vs Tigers | W4-0 | 28-28 | .500 | T-Mobile Park · Seattle, WA |
| 57 | Mon Jun 2 | at Yankees | W10-2 | 29-28 | .509 | Yankee Stadium · The Bronx, NY |
| 58 | Tue Jun 3 | at Braves | W7-5 | 30-28 | .517 | Truist Park · Cumberland, GA |
| 59 | Wed Jun 4 | at Braves | W2-0 | 31-28 | .525 | Truist Park · Cumberland, GA |
| 60 | Fri Jun 6 | at Rays | L0-4 | 31-29 | .517 | Tropicana Field · St. Petersburg, FL |
| 61 | Sat Jun 7 | at Rays | W7-4 | 32-29 | .525 | Tropicana Field · St. Petersburg, FL |
| 62 | Sun Jun 8 | at Rays | W5-0 | 33-29 | .532 | Tropicana Field · St. Petersburg, FL |
| 63 | Mon Jun 9 | at Rays | W3-0 | 34-29 | .540 | Tropicana Field · St. Petersburg, FL |
| 64 | Tue Jun 10 | vs Yankees | L2-3 | 34-30 | .531 | T-Mobile Park · Seattle, WA |
| 65 | Wed Jun 11 | vs Yankees | L2-4 | 34-31 | .523 | T-Mobile Park · Seattle, WA |
| 66 | Thu Jun 12 | vs Yankees | L3-6 | 34-32 | .515 | T-Mobile Park · Seattle, WA |
| 67 | Fri Jun 13 | vs Rangers | L0-1 | 34-33 | .507 | T-Mobile Park · Seattle, WA |
| 68 | Sat Jun 14 | vs Rangers | L3-4 | 34-34 | .500 | T-Mobile Park · Seattle, WA |
| 69 | Sun Jun 15 | vs Rangers | W5-1 | 35-34 | .507 | T-Mobile Park · Seattle, WA |
| 70 | Mon Jun 16 | vs Padres | W5-1 | 36-34 | .514 | T-Mobile Park · Seattle, WA |
| 71 | Tue Jun 17 | vs Padres | W6-1 | 37-34 | .521 | T-Mobile Park · Seattle, WA |
| 72 | Wed Jun 18 | at Padres | L1-2 | 37-35 | .514 | Petco Park · San Diego, CA |
| 73 | Thu Jun 19 | at Padres | L1-4 | 37-36 | .507 | Petco Park · San Diego, CA |
| 74 | Fri Jun 20 | at Royals | W7-5 | 38-36 | .514 | Kauffman Stadium · Kansas City, MO |
| 75 | Sat Jun 21 | at Royals | W2-1 | 39-36 | .520 | Kauffman Stadium · Kansas City, MO |
| 76 | Sun Jun 22 | at Royals | W2-1 | 40-36 | .526 | Kauffman Stadium · Kansas City, MO |
| 77 | Mon Jun 23 | vs Red Sox | W12-3 | 41-36 | .532 | T-Mobile Park · Seattle, WA |
| 78 | Tue Jun 24 | vs Red Sox | W8-2 | 42-36 | .538 | T-Mobile Park · Seattle, WA |
| 79 | Wed Jun 25 | vs Red Sox | L4-5 | 42-37 | .532 | T-Mobile Park · Seattle, WA |
| 80 | Fri Jun 27 | vs Guardians | W3-2 | 43-37 | .537 | T-Mobile Park · Seattle, WA |
| 81 | Sat Jun 28 | vs Guardians | L0-5 | 43-38 | .531 | T-Mobile Park · Seattle, WA |
| 82 | Sun Jun 29 | vs Guardians | W3-0 | 44-38 | .537 | T-Mobile Park · Seattle, WA |
| 83 | Mon Jun 30 | at Astros | W10-4 | 45-38 | .542 | Minute Maid Park · Houston, TX |
| 84 | Tue Jul 1 | at Astros | W13-2 | 46-38 | .548 | Minute Maid Park · Houston, TX |
| 85 | Wed Jul 2 | at Astros | W5-2 | 47-38 | .553 | Minute Maid Park · Houston, TX |
| 86 | Fri Jul 4 | at White Sox | L1-7 | 47-39 | .547 | Guaranteed Rate Field · Chicago, IL |
| 87 | Sat Jul 5 | at White Sox | W3-2 (14) | 48-39 | .552 | Guaranteed Rate Field · Chicago, IL |
| 88 | Sun Jul 6 | at White Sox | L0-1 | 48-40 | .545 | Guaranteed Rate Field · Chicago, IL |
| 89 | Mon Jul 7 | vs Twins | W2-0 | 49-40 | .551 | T-Mobile Park · Seattle, WA |
| 90 | Tue Jul 8 | vs Twins | L0-2 | 49-41 | .544 | T-Mobile Park · Seattle, WA |
| 91 | Wed Jul 9 | vs Twins | L1-8 | 49-42 | .538 | T-Mobile Park · Seattle, WA |
| 92 | Thu Jul 10 | vs Twins | L2-4 | 49-43 | .533 | T-Mobile Park · Seattle, WA |
| 93 | Fri Jul 11 | vs Athletics | W3-2 | 50-43 | .538 | T-Mobile Park · Seattle, WA |
| 94 | Sat Jul 12 | vs Athletics | W6-2 | 51-43 | .543 | T-Mobile Park · Seattle, WA |
| 95 | Sun Jul 13 | vs Athletics | L1-4 | 51-44 | .537 | T-Mobile Park · Seattle, WA |
| 96 | Fri Jul 18 | at Angels | L2-3 (16) | 51-45 | .531 | Angel Stadium · Anaheim, CA |
| 97 | Sat Jul 19 | at Angels | W3-2 (12) | 52-45 | .536 | Angel Stadium · Anaheim, CA |
| 98 | Sun Jul 20 | at Angels | L5-6 | 52-46 | .531 | Angel Stadium · Anaheim, CA |
| 99 | Mon Jul 21 | vs Mets | W5-2 | 53-46 | .535 | T-Mobile Park · Seattle, WA |
| 100 | Tue Jul 22 | vs Mets | L1-3 | 53-47 | .530 | T-Mobile Park · Seattle, WA |
| 101 | Wed Jul 23 | vs Mets | L2-3 | 53-48 | .525 | T-Mobile Park · Seattle, WA |
| 102 | Thu Jul 24 | vs Orioles | L0-4 | 53-49 | .520 | T-Mobile Park · Seattle, WA |
| 103 | Fri Jul 25 | vs Orioles | L1-2 (10) | 53-50 | .515 | T-Mobile Park · Seattle, WA |
| 104 | Sat Jul 26 | vs Orioles | W4-3 | 54-50 | .519 | T-Mobile Park · Seattle, WA |
| 105 | Sun Jul 27 | vs Orioles | L2-3 (10) | 54-51 | .514 | T-Mobile Park · Seattle, WA |
| 106 | Tue Jul 29 | at Guardians | W5-2 | 55-51 | .519 | Progressive Field · Cleveland, OH |
| 107 | Wed Jul 30 | at Guardians | L0-2 | 55-52 | .514 | Progressive Field · Cleveland, OH |
| 108 | Thu Jul 31 | at Guardians | W6-5 | 56-52 | .519 | Progressive Field · Cleveland, OH |
| 109 | Fri Aug 1 | at Orioles | L1-2 | 56-53 | .514 | Camden Yards · Baltimore, MD |
| 110 | Sat Aug 2 | at Orioles | W6-3 | 57-53 | .518 | Camden Yards · Baltimore, MD |
| 111 | Sun Aug 3 | at Orioles | L0-1 | 57-54 | .514 | Camden Yards · Baltimore, MD |
| 112 | Tue Aug 5 | vs Braves | W4-2 | 58-54 | .518 | T-Mobile Park · Seattle, WA |
| 113 | Wed Aug 6 | vs Braves | W7-3 | 59-54 | .522 | T-Mobile Park · Seattle, WA |
| 114 | Thu Aug 7 | vs White Sox | W13-3 | 60-54 | .526 | T-Mobile Park · Seattle, WA |
| 115 | Fri Aug 8 | vs White Sox | W4-1 | 61-54 | .530 | T-Mobile Park · Seattle, WA |
| 116 | Sat Aug 9 | vs White Sox | L1-2 (10) | 61-55 | .526 | T-Mobile Park · Seattle, WA |
| 117 | Sun Aug 10 | vs White Sox | W4-2 | 62-55 | .530 | T-Mobile Park · Seattle, WA |
| 118 | Mon Aug 11 | vs Blue Jays | W11-1 | 63-55 | .534 | T-Mobile Park · Seattle, WA |
| 119 | Tue Aug 12 | vs Blue Jays | W6-3 | 64-55 | .538 | T-Mobile Park · Seattle, WA |
| 120 | Wed Aug 13 | vs Blue Jays | W2-0 | 65-55 | .542 | T-Mobile Park · Seattle, WA |
| 121 | Fri Aug 15 | at Tigers | W7-2 | 66-55 | .545 | Comerica Park · Detroit, MI |
| 122 | Sat Aug 16 | at Tigers | L2-4 | 66-56 | .541 | Comerica Park · Detroit, MI |
| 123 | Sun Aug 17 | at Tigers | W8-1 | 67-56 | .545 | Comerica Park · Detroit, MI |
| 124 | Mon Aug 18 | at Phillies | L1-4 | 67-57 | .540 | Citizens Bank Park · Philadelphi, PA |
| 125 | Tue Aug 19 | at Phillies | W5-2 | 68-57 | .544 | Citizens Bank Park · Philadelphi, PA |
| 126 | Wed Aug 20 | at Phillies | L3-4 | 68-58 | .540 | Citizens Bank Park · Philadelphi, PA |
| 127 | Fri Aug 22 | at Red Sox | W5-3 | 69-58 | .543 | Fenway Park · Boston, MA |
| 128 | Sat Aug 23 | at Red Sox | W7-3 | 70-58 | .547 | Fenway Park · Boston, MA |
| 129 | Sun Aug 24 | at Red Sox | W8-6 | 71-58 | .550 | Fenway Park · Boston, MA |
| 130 | Mon Aug 25 | vs Rangers | L0-2 | 71-59 | .546 | T-Mobile Park · Seattle, WA |
| 131 | Tue Aug 26 | vs Rangers | W5-0 | 72-59 | .550 | T-Mobile Park · Seattle, WA |
| 132 | Wed Aug 27 | vs Rangers | L4-12 | 72-60 | .545 | T-Mobile Park · Seattle, WA |
| 133 | Fri Aug 29 | vs Nationals | L3-8 | 72-61 | .541 | T-Mobile Park · Seattle, WA |
| 134 | Sat Aug 30 | vs Nationals | L1-3 | 72-62 | .537 | T-Mobile Park · Seattle, WA |
| 135 | Sun Aug 31 | vs Nationals | W5-3 | 73-62 | .541 | T-Mobile Park · Seattle, WA |
| 136 | Mon Sep 1 | at Athletics | L1-6 | 73-63 | .537 | RingCentral Coliseum · Oakland, CA |
| 137 | Tue Sep 2 | at Athletics | W6-5 | 74-63 | .540 | RingCentral Coliseum · Oakland, CA |
| 138 | Wed Sep 3 | at Athletics | W2-1 | 75-63 | .543 | RingCentral Coliseum · Oakland, CA |
| 139 | Thu Sep 4 | at Rangers | W10-2 | 76-63 | .547 | Globe Life Field · Arlington, TX |
| 140 | Fri Sep 5 | at Rangers | W7-5 | 77-63 | .550 | Globe Life Field · Arlington, TX |
| 141 | Sat Sep 6 | at Rangers | W4-2 | 78-63 | .553 | Globe Life Field · Arlington, TX |
| 142 | Sun Sep 7 | at Rangers | L0-1 | 78-64 | .549 | Globe Life Field · Arlington, TX |
| 143 | Mon Sep 8 | vs Astros | W4-1 | 79-64 | .552 | T-Mobile Park · Seattle, WA |
| 144 | Tue Sep 9 | vs Astros | L1-2 | 79-65 | .549 | T-Mobile Park · Seattle, WA |
| 145 | Wed Sep 10 | vs Astros | L2-5 | 79-66 | .545 | T-Mobile Park · Seattle, WA |
| 146 | Fri Sep 12 | vs Athletics | W4-2 | 80-66 | .548 | T-Mobile Park · Seattle, WA |
| 147 | Sat Sep 13 | vs Athletics | L2-3 (10) | 80-67 | .544 | T-Mobile Park · Seattle, WA |
| 148 | Sun Sep 14 | vs Athletics | L0-4 | 80-68 | .541 | T-Mobile Park · Seattle, WA |
| 149 | Mon Sep 15 | at Angels | L1-8 | 80-69 | .537 | Angel Stadium · Anaheim, CA |
| 150 | Tue Sep 16 | at Angels | W13-2 | 81-69 | .540 | Angel Stadium · Anaheim, CA |
| 151 | Wed Sep 17 | at Angels | L0-5 | 81-70 | .536 | Angel Stadium · Anaheim, CA |
| 152 | Thu Sep 18 | at Angels | W3-1 | 82-70 | .539 | Angel Stadium · Anaheim, CA |
| 153 | Fri Sep 19 | at Astros | W10-5 | 83-70 | .542 | Minute Maid Park · Houston, TX |
| 154 | Sat Sep 20 | at Astros | L1-10 | 83-71 | .539 | Minute Maid Park · Houston, TX |
| 155 | Sun Sep 21 | at Astros | L3-8 | 83-72 | .535 | Minute Maid Park · Houston, TX |
| 156 | Mon Sep 22 | at Blue Jays | L4-14 | 83-73 | .532 | Rogers Centre · Toronto, ON |
| 157 | Tue Sep 23 | at Blue Jays | L2-10 | 83-74 | .529 | Rogers Centre · Toronto, ON |
| 158 | Wed Sep 24 | at Blue Jays | L0-1 | 83-75 | .525 | Rogers Centre · Toronto, ON |
| 159 | Thu Sep 25 | at Blue Jays | W7-5 | 84-75 | .528 | Rogers Centre · Toronto, ON |
| 160 | Fri Sep 26 | vs Angels | W4-3 | 85-75 | .531 | T-Mobile Park · Seattle, WA |
| 161 | Sat Sep 27 | vs Angels | W2-1 (11) | 86-75 | .534 | T-Mobile Park · Seattle, WA |
| 162 | Sun Sep 28 | vs Angels | W4-1 | 87-75 | .537 | T-Mobile Park · Seattle, WA |