| 1 | Thu Mar 28 | vs Red Sox | L4-6 | 0-1 | .000 | T-Mobile Park · Seattle, WA |
| 2 | Fri Mar 29 | vs Red Sox | W1-0 | 1-1 | .500 | T-Mobile Park · Seattle, WA |
| 3 | Sat Mar 30 | vs Red Sox | W4-3 (10) | 2-1 | .667 | T-Mobile Park · Seattle, WA |
| 4 | Sun Mar 31 | vs Red Sox | L1-5 | 2-2 | .500 | T-Mobile Park · Seattle, WA |
| 5 | Mon Apr 1 | vs Guardians | W5-4 | 3-2 | .600 | T-Mobile Park · Seattle, WA |
| 6 | Tue Apr 2 | vs Guardians | L2-5 | 3-3 | .500 | T-Mobile Park · Seattle, WA |
| 7 | Wed Apr 3 | vs Guardians | L0-8 | 3-4 | .429 | T-Mobile Park · Seattle, WA |
| 8 | Fri Apr 5 | at Brewers | L5-6 | 3-5 | .375 | American Family Field · Milwaukee, WI |
| 9 | Sat Apr 6 | at Brewers | W5-3 | 4-5 | .444 | American Family Field · Milwaukee, WI |
| 10 | Sun Apr 7 | at Brewers | L4-12 | 4-6 | .400 | American Family Field · Milwaukee, WI |
| 11 | Mon Apr 8 | at Blue Jays | L2-5 | 4-7 | .364 | Rogers Centre · Toronto, ON |
| 12 | Tue Apr 9 | at Blue Jays | L3-5 | 4-8 | .333 | Rogers Centre · Toronto, ON |
| 13 | Wed Apr 10 | at Blue Jays | W6-1 (10) | 5-8 | .385 | Rogers Centre · Toronto, ON |
| 14 | Fri Apr 12 | vs Cubs | W4-2 | 6-8 | .429 | T-Mobile Park · Seattle, WA |
| 15 | Sat Apr 13 | vs Cubs | L1-4 | 6-9 | .400 | T-Mobile Park · Seattle, WA |
| 16 | Sun Apr 14 | vs Cubs | L2-3 | 6-10 | .375 | T-Mobile Park · Seattle, WA |
| 17 | Mon Apr 15 | vs Reds | W9-3 | 7-10 | .412 | T-Mobile Park · Seattle, WA |
| 18 | Tue Apr 16 | vs Reds | W3-1 | 8-10 | .444 | T-Mobile Park · Seattle, WA |
| 19 | Wed Apr 17 | vs Reds | W5-1 | 9-10 | .474 | T-Mobile Park · Seattle, WA |
| 20 | Sat Apr 20 | at Rockies | W7-0 | 10-10 | .500 | Coors Field · Denver, CO |
| 21 | Sun Apr 21 | at Rockies | L1-2 (10) | 10-11 | .476 | Coors Field · Denver, CO |
| 22 | Sun Apr 21 | at Rockies | W10-2 | 11-11 | .500 | Coors Field · Denver, CO |
| 23 | Tue Apr 23 | at Rangers | W4-0 | 12-11 | .522 | Globe Life Field · Arlington, TX |
| 24 | Wed Apr 24 | at Rangers | L1-5 | 12-12 | .500 | Globe Life Field · Arlington, TX |
| 25 | Thu Apr 25 | at Rangers | W4-3 | 13-12 | .520 | Globe Life Field · Arlington, TX |
| 26 | Fri Apr 26 | vs D-backs | W6-1 | 14-12 | .538 | T-Mobile Park · Seattle, WA |
| 27 | Sat Apr 27 | vs D-backs | W3-1 | 15-12 | .556 | T-Mobile Park · Seattle, WA |
| 28 | Sun Apr 28 | vs D-backs | L2-3 | 15-13 | .536 | T-Mobile Park · Seattle, WA |
| 29 | Mon Apr 29 | vs Braves | W2-1 | 16-13 | .552 | T-Mobile Park · Seattle, WA |
| 30 | Tue Apr 30 | vs Braves | W3-2 | 17-13 | .567 | T-Mobile Park · Seattle, WA |
| 31 | Wed May 1 | vs Braves | L2-5 | 17-14 | .548 | T-Mobile Park · Seattle, WA |
| 32 | Fri May 3 | at Astros | L3-5 | 17-15 | .531 | Minute Maid Park · Houston, TX |
| 33 | Sat May 4 | at Astros | W5-0 | 18-15 | .545 | Minute Maid Park · Houston, TX |
| 34 | Sun May 5 | at Astros | W5-4 | 19-15 | .559 | Minute Maid Park · Houston, TX |
| 35 | Mon May 6 | at Twins | L1-3 | 19-16 | .543 | Target Field · Minneapolis, MN |
| 36 | Tue May 7 | at Twins | W10-6 | 20-16 | .556 | Target Field · Minneapolis, MN |
| 37 | Wed May 8 | at Twins | L3-6 | 20-17 | .541 | Target Field · Minneapolis, MN |
| 38 | Thu May 9 | at Twins | L1-11 | 20-18 | .526 | Target Field · Minneapolis, MN |
| 39 | Fri May 10 | vs Athletics | W8-1 | 21-18 | .538 | T-Mobile Park · Seattle, WA |
| 40 | Sat May 11 | vs Athletics | L1-8 | 21-19 | .525 | T-Mobile Park · Seattle, WA |
| 41 | Sun May 12 | vs Athletics | W8-4 | 22-19 | .537 | T-Mobile Park · Seattle, WA |
| 42 | Mon May 13 | vs Royals | W6-2 | 23-19 | .548 | T-Mobile Park · Seattle, WA |
| 43 | Tue May 14 | vs Royals | L2-4 | 23-20 | .535 | T-Mobile Park · Seattle, WA |
| 44 | Wed May 15 | vs Royals | W4-2 | 24-20 | .545 | T-Mobile Park · Seattle, WA |
| 45 | Fri May 17 | at Orioles | L2-9 | 24-21 | .533 | Camden Yards · Baltimore, MD |
| 46 | Sat May 18 | at Orioles | W4-3 | 25-21 | .543 | Camden Yards · Baltimore, MD |
| 47 | Sun May 19 | at Orioles | L3-6 | 25-22 | .532 | Camden Yards · Baltimore, MD |
| 48 | Mon May 20 | at Yankees | W5-4 | 26-22 | .542 | Yankee Stadium · The Bronx, NY |
| 49 | Tue May 21 | at Yankees | W6-3 | 27-22 | .551 | Yankee Stadium · The Bronx, NY |
| 50 | Wed May 22 | at Yankees | L3-7 | 27-23 | .540 | Yankee Stadium · The Bronx, NY |
| 51 | Thu May 23 | at Yankees | L0-5 | 27-24 | .529 | Yankee Stadium · The Bronx, NY |
| 52 | Fri May 24 | at Nationals | L1-6 | 27-25 | .519 | Nationals Park · Washington, D.C. |
| 53 | Sat May 25 | at Nationals | L1-3 | 27-26 | .509 | Nationals Park · Washington, D.C. |
| 54 | Sun May 26 | at Nationals | W9-5 | 28-26 | .519 | Nationals Park · Washington, D.C. |
| 55 | Mon May 27 | vs Astros | W3-2 | 29-26 | .527 | T-Mobile Park · Seattle, WA |
| 56 | Tue May 28 | vs Astros | W4-2 | 30-26 | .536 | T-Mobile Park · Seattle, WA |
| 57 | Wed May 29 | vs Astros | W2-1 (10) | 31-26 | .544 | T-Mobile Park · Seattle, WA |
| 58 | Thu May 30 | vs Astros | L0-4 | 31-27 | .534 | T-Mobile Park · Seattle, WA |
| 59 | Fri May 31 | vs Angels | W5-4 | 32-27 | .542 | T-Mobile Park · Seattle, WA |
| 60 | Sat Jun 1 | vs Angels | W9-0 | 33-27 | .550 | T-Mobile Park · Seattle, WA |
| 61 | Sun Jun 2 | vs Angels | W5-1 | 34-27 | .557 | T-Mobile Park · Seattle, WA |
| 62 | Tue Jun 4 | at Athletics | W4-3 | 35-27 | .565 | RingCentral Coliseum · Oakland, CA |
| 63 | Wed Jun 5 | at Athletics | L1-2 | 35-28 | .556 | RingCentral Coliseum · Oakland, CA |
| 64 | Thu Jun 6 | at Athletics | W3-0 | 36-28 | .563 | RingCentral Coliseum · Oakland, CA |
| 65 | Fri Jun 7 | at Royals | L9-10 | 36-29 | .554 | Kauffman Stadium · Kansas City, MO |
| 66 | Sat Jun 8 | at Royals | L4-8 | 36-30 | .545 | Kauffman Stadium · Kansas City, MO |
| 67 | Sun Jun 9 | at Royals | W6-5 (10) | 37-30 | .552 | Kauffman Stadium · Kansas City, MO |
| 68 | Mon Jun 10 | vs White Sox | W8-4 | 38-30 | .559 | T-Mobile Park · Seattle, WA |
| 69 | Tue Jun 11 | vs White Sox | W4-3 | 39-30 | .565 | T-Mobile Park · Seattle, WA |
| 70 | Wed Jun 12 | vs White Sox | W2-1 (10) | 40-30 | .571 | T-Mobile Park · Seattle, WA |
| 71 | Thu Jun 13 | vs White Sox | L2-3 (10) | 40-31 | .563 | T-Mobile Park · Seattle, WA |
| 72 | Fri Jun 14 | vs Rangers | W3-2 | 41-31 | .569 | T-Mobile Park · Seattle, WA |
| 73 | Sat Jun 15 | vs Rangers | W7-5 | 42-31 | .575 | T-Mobile Park · Seattle, WA |
| 74 | Sun Jun 16 | vs Rangers | W5-0 | 43-31 | .581 | T-Mobile Park · Seattle, WA |
| 75 | Tue Jun 18 | at Guardians | W8-5 | 44-31 | .587 | Progressive Field · Cleveland, OH |
| 76 | Wed Jun 19 | at Guardians | L0-8 | 44-32 | .579 | Progressive Field · Cleveland, OH |
| 77 | Thu Jun 20 | at Guardians | L3-6 | 44-33 | .571 | Progressive Field · Cleveland, OH |
| 78 | Fri Jun 21 | at Marlins | L2-3 (10) | 44-34 | .564 | LoanDepot Park · Miami, FL |
| 79 | Sat Jun 22 | at Marlins | W9-0 | 45-34 | .570 | LoanDepot Park · Miami, FL |
| 80 | Sun Jun 23 | at Marlins | L4-6 | 45-35 | .563 | LoanDepot Park · Miami, FL |
| 81 | Mon Jun 24 | at Rays | L3-4 | 45-36 | .556 | Tropicana Field · St. Petersburg, FL |
| 82 | Tue Jun 25 | at Rays | L3-11 | 45-37 | .549 | Tropicana Field · St. Petersburg, FL |
| 83 | Wed Jun 26 | at Rays | W5-2 | 46-37 | .554 | Tropicana Field · St. Petersburg, FL |
| 84 | Fri Jun 28 | vs Twins | W3-2 (10) | 47-37 | .560 | T-Mobile Park · Seattle, WA |
| 85 | Sat Jun 29 | vs Twins | L1-5 | 47-38 | .553 | T-Mobile Park · Seattle, WA |
| 86 | Sun Jun 30 | vs Twins | L3-5 | 47-39 | .547 | T-Mobile Park · Seattle, WA |
| 87 | Tue Jul 2 | vs Orioles | L0-2 | 47-40 | .540 | T-Mobile Park · Seattle, WA |
| 88 | Wed Jul 3 | vs Orioles | L1-4 | 47-41 | .534 | T-Mobile Park · Seattle, WA |
| 89 | Thu Jul 4 | vs Orioles | W7-3 | 48-41 | .539 | T-Mobile Park · Seattle, WA |
| 90 | Fri Jul 5 | vs Blue Jays | W2-1 | 49-41 | .544 | T-Mobile Park · Seattle, WA |
| 91 | Sat Jul 6 | vs Blue Jays | L4-5 | 49-42 | .538 | T-Mobile Park · Seattle, WA |
| 92 | Sun Jul 7 | vs Blue Jays | L4-5 (10) | 49-43 | .533 | T-Mobile Park · Seattle, WA |
| 93 | Tue Jul 9 | at Padres | W8-3 | 50-43 | .538 | Petco Park · San Diego, CA |
| 94 | Wed Jul 10 | at Padres | W2-0 | 51-43 | .543 | Petco Park · San Diego, CA |
| 95 | Thu Jul 11 | at Angels | W11-0 | 52-43 | .547 | Angel Stadium · Anaheim, CA |
| 96 | Fri Jul 12 | at Angels | L5-6 (10) | 52-44 | .542 | Angel Stadium · Anaheim, CA |
| 97 | Sat Jul 13 | at Angels | L1-2 | 52-45 | .536 | Angel Stadium · Anaheim, CA |
| 98 | Sun Jul 14 | at Angels | L2-3 | 52-46 | .531 | Angel Stadium · Anaheim, CA |
| 99 | Fri Jul 19 | vs Astros | L0-3 | 52-47 | .525 | T-Mobile Park · Seattle, WA |
| 100 | Sat Jul 20 | vs Astros | L2-4 | 52-48 | .520 | T-Mobile Park · Seattle, WA |
| 101 | Sun Jul 21 | vs Astros | W6-4 | 53-48 | .525 | T-Mobile Park · Seattle, WA |
| 102 | Mon Jul 22 | vs Angels | L1-3 | 53-49 | .520 | T-Mobile Park · Seattle, WA |
| 103 | Tue Jul 23 | vs Angels | L1-5 | 53-50 | .515 | T-Mobile Park · Seattle, WA |
| 104 | Wed Jul 24 | vs Angels | L1-2 | 53-51 | .510 | T-Mobile Park · Seattle, WA |
| 105 | Fri Jul 26 | at White Sox | W10-0 | 54-51 | .514 | Guaranteed Rate Field · Chicago, IL |
| 106 | Sat Jul 27 | at White Sox | W6-3 | 55-51 | .519 | Guaranteed Rate Field · Chicago, IL |
| 107 | Sun Jul 28 | at White Sox | W6-3 | 56-51 | .523 | Guaranteed Rate Field · Chicago, IL |
| 108 | Mon Jul 29 | at Red Sox | L7-14 | 56-52 | .519 | Fenway Park · Boston, MA |
| 109 | Tue Jul 30 | at Red Sox | W10-6 | 57-52 | .523 | Fenway Park · Boston, MA |
| 110 | Wed Jul 31 | at Red Sox | L2-3 (10) | 57-53 | .518 | Fenway Park · Boston, MA |
| 111 | Fri Aug 2 | vs Phillies | W10-2 | 58-53 | .523 | T-Mobile Park · Seattle, WA |
| 112 | Sat Aug 3 | vs Phillies | W6-5 (10) | 59-53 | .527 | T-Mobile Park · Seattle, WA |
| 113 | Sun Aug 4 | vs Phillies | L0-6 | 59-54 | .522 | T-Mobile Park · Seattle, WA |
| 114 | Tue Aug 6 | vs Tigers | L2-4 | 59-55 | .518 | T-Mobile Park · Seattle, WA |
| 115 | Wed Aug 7 | vs Tigers | L2-6 | 59-56 | .513 | T-Mobile Park · Seattle, WA |
| 116 | Thu Aug 8 | vs Tigers | W4-3 | 60-56 | .517 | T-Mobile Park · Seattle, WA |
| 117 | Fri Aug 9 | vs Mets | W6-0 | 61-56 | .521 | T-Mobile Park · Seattle, WA |
| 118 | Sat Aug 10 | vs Mets | W4-0 | 62-56 | .525 | T-Mobile Park · Seattle, WA |
| 119 | Sun Aug 11 | vs Mets | W12-1 | 63-56 | .529 | T-Mobile Park · Seattle, WA |
| 120 | Tue Aug 13 | at Tigers | L1-15 | 63-57 | .525 | Comerica Park · Detroit, MI |
| 121 | Wed Aug 14 | at Tigers | L2-3 (10) | 63-58 | .521 | Comerica Park · Detroit, MI |
| 122 | Thu Aug 15 | at Tigers | L1-2 | 63-59 | .516 | Comerica Park · Detroit, MI |
| 123 | Fri Aug 16 | at Pirates | L3-5 | 63-60 | .512 | PNC Park · Pittsburgh, PA |
| 124 | Sat Aug 17 | at Pirates | L2-7 | 63-61 | .508 | PNC Park · Pittsburgh, PA |
| 125 | Sun Aug 18 | at Pirates | W10-3 | 64-61 | .512 | PNC Park · Pittsburgh, PA |
| 126 | Mon Aug 19 | at Dodgers | L0-3 | 64-62 | .508 | Dodger Stadium · Los Angeles, CA |
| 127 | Tue Aug 20 | at Dodgers | L3-6 | 64-63 | .504 | Dodger Stadium · Los Angeles, CA |
| 128 | Wed Aug 21 | at Dodgers | L4-8 | 64-64 | .500 | Dodger Stadium · Los Angeles, CA |
| 129 | Fri Aug 23 | vs Giants | W6-5 (10) | 65-64 | .504 | T-Mobile Park · Seattle, WA |
| 130 | Sat Aug 24 | vs Giants | L3-4 | 65-65 | .500 | T-Mobile Park · Seattle, WA |
| 131 | Sun Aug 25 | vs Giants | W4-3 | 66-65 | .504 | T-Mobile Park · Seattle, WA |
| 132 | Mon Aug 26 | vs Rays | W5-1 | 67-65 | .508 | T-Mobile Park · Seattle, WA |
| 133 | Tue Aug 27 | vs Rays | L2-3 | 67-66 | .504 | T-Mobile Park · Seattle, WA |
| 134 | Wed Aug 28 | vs Rays | W6-2 | 68-66 | .507 | T-Mobile Park · Seattle, WA |
| 135 | Fri Aug 30 | at Angels | W9-5 | 69-66 | .511 | Angel Stadium · Anaheim, CA |
| 136 | Sat Aug 31 | at Angels | L4-5 | 69-67 | .507 | Angel Stadium · Anaheim, CA |
| 137 | Sun Sep 1 | at Angels | L2-3 | 69-68 | .504 | Angel Stadium · Anaheim, CA |
| 138 | Mon Sep 2 | at Athletics | L4-5 | 69-69 | .500 | RingCentral Coliseum · Oakland, CA |
| 139 | Tue Sep 3 | at Athletics | L2-3 | 69-70 | .496 | RingCentral Coliseum · Oakland, CA |
| 140 | Wed Sep 4 | at Athletics | W16-3 | 70-70 | .500 | RingCentral Coliseum · Oakland, CA |
| 141 | Thu Sep 5 | at Athletics | W6-4 | 71-70 | .504 | RingCentral Coliseum · Oakland, CA |
| 142 | Fri Sep 6 | at Cardinals | W6-1 | 72-70 | .507 | Busch Stadium · St. Louis, MO |
| 143 | Sat Sep 7 | at Cardinals | L0-2 | 72-71 | .503 | Busch Stadium · St. Louis, MO |
| 144 | Sun Sep 8 | at Cardinals | W10-4 | 73-71 | .507 | Busch Stadium · St. Louis, MO |
| 145 | Tue Sep 10 | vs Padres | L3-7 | 73-72 | .503 | T-Mobile Park · Seattle, WA |
| 146 | Wed Sep 11 | vs Padres | W5-2 | 74-72 | .507 | T-Mobile Park · Seattle, WA |
| 147 | Thu Sep 12 | vs Rangers | L4-5 | 74-73 | .503 | T-Mobile Park · Seattle, WA |
| 148 | Fri Sep 13 | vs Rangers | W5-4 | 75-73 | .507 | T-Mobile Park · Seattle, WA |
| 149 | Sat Sep 14 | vs Rangers | W5-4 | 76-73 | .510 | T-Mobile Park · Seattle, WA |
| 150 | Sun Sep 15 | vs Rangers | W7-0 | 77-73 | .513 | T-Mobile Park · Seattle, WA |
| 151 | Tue Sep 17 | vs Yankees | L2-11 | 77-74 | .510 | T-Mobile Park · Seattle, WA |
| 152 | Wed Sep 18 | vs Yankees | L1-2 (10) | 77-75 | .507 | T-Mobile Park · Seattle, WA |
| 153 | Thu Sep 19 | vs Yankees | W3-2 | 78-75 | .510 | T-Mobile Park · Seattle, WA |
| 154 | Fri Sep 20 | at Rangers | W8-2 | 79-75 | .513 | Globe Life Field · Arlington, TX |
| 155 | Sat Sep 21 | at Rangers | W8-4 | 80-75 | .516 | Globe Life Field · Arlington, TX |
| 156 | Sun Sep 22 | at Rangers | L5-6 | 80-76 | .513 | Globe Life Field · Arlington, TX |
| 157 | Mon Sep 23 | at Astros | W6-1 | 81-76 | .516 | Minute Maid Park · Houston, TX |
| 158 | Tue Sep 24 | at Astros | L3-4 | 81-77 | .513 | Minute Maid Park · Houston, TX |
| 159 | Wed Sep 25 | at Astros | W8-1 | 82-77 | .516 | Minute Maid Park · Houston, TX |
| 160 | Fri Sep 27 | vs Athletics | W2-0 | 83-77 | .519 | T-Mobile Park · Seattle, WA |
| 161 | Sat Sep 28 | vs Athletics | W7-6 (10) | 84-77 | .522 | T-Mobile Park · Seattle, WA |
| 162 | Sun Sep 29 | vs Athletics | W6-4 | 85-77 | .525 | T-Mobile Park · Seattle, WA |