| 1 | Wed Mar 20 | at Athletics | W9-7 | 1-0 | 1.000 | Sutter Health Park · West Sacramento, CA |
| 2 | Thu Mar 21 | at Athletics | W5-4 (12) | 2-0 | 1.000 | Sutter Health Park · West Sacramento, CA |
| 3 | Thu Mar 28 | vs Red Sox | W12-4 | 3-0 | 1.000 | T-Mobile Park · Seattle, WA |
| 4 | Fri Mar 29 | vs Red Sox | L6-7 | 3-1 | .750 | T-Mobile Park · Seattle, WA |
| 5 | Sat Mar 30 | vs Red Sox | W6-5 | 4-1 | .800 | T-Mobile Park · Seattle, WA |
| 6 | Sun Mar 31 | vs Red Sox | W10-8 | 5-1 | .833 | T-Mobile Park · Seattle, WA |
| 7 | Mon Apr 1 | vs Angels | W6-3 | 6-1 | .857 | T-Mobile Park · Seattle, WA |
| 8 | Tue Apr 2 | vs Angels | W2-1 | 7-1 | .875 | T-Mobile Park · Seattle, WA |
| 9 | Fri Apr 5 | at White Sox | L8-10 | 7-2 | .778 | Guaranteed Rate Field · Chicago, IL |
| 10 | Sat Apr 6 | at White Sox | W9-2 | 8-2 | .800 | Guaranteed Rate Field · Chicago, IL |
| 11 | Sun Apr 7 | at White Sox | W12-5 | 9-2 | .818 | Guaranteed Rate Field · Chicago, IL |
| 12 | Mon Apr 8 | at Royals | W13-5 | 10-2 | .833 | Kauffman Stadium · Kansas City, MO |
| 13 | Tue Apr 9 | at Royals | W6-3 | 11-2 | .846 | Kauffman Stadium · Kansas City, MO |
| 14 | Wed Apr 10 | at Royals | W6-5 | 12-2 | .857 | Kauffman Stadium · Kansas City, MO |
| 15 | Thu Apr 11 | at Royals | W7-6 (10) | 13-2 | .867 | Kauffman Stadium · Kansas City, MO |
| 16 | Fri Apr 12 | vs Astros | L6-10 | 13-3 | .813 | T-Mobile Park · Seattle, WA |
| 17 | Sat Apr 13 | vs Astros | L1-3 | 13-4 | .765 | T-Mobile Park · Seattle, WA |
| 18 | Sun Apr 14 | vs Astros | L2-3 | 13-5 | .722 | T-Mobile Park · Seattle, WA |
| 19 | Mon Apr 15 | vs Guardians | L4-6 | 13-6 | .684 | T-Mobile Park · Seattle, WA |
| 20 | Tue Apr 16 | vs Guardians | L2-4 | 13-7 | .650 | T-Mobile Park · Seattle, WA |
| 21 | Wed Apr 17 | vs Guardians | L0-1 | 13-8 | .619 | T-Mobile Park · Seattle, WA |
| 22 | Thu Apr 18 | at Angels | W11-10 | 14-8 | .636 | Angel Stadium · Anaheim, CA |
| 23 | Fri Apr 19 | at Angels | W5-3 | 15-8 | .652 | Angel Stadium · Anaheim, CA |
| 24 | Sat Apr 20 | at Angels | W6-5 | 16-8 | .667 | Angel Stadium · Anaheim, CA |
| 25 | Sun Apr 21 | at Angels | L6-8 | 16-9 | .640 | Angel Stadium · Anaheim, CA |
| 26 | Tue Apr 23 | at Padres | L3-6 | 16-10 | .615 | Petco Park · San Diego, CA |
| 27 | Wed Apr 24 | at Padres | L0-1 | 16-11 | .593 | Petco Park · San Diego, CA |
| 28 | Thu Apr 25 | vs Rangers | W14-2 | 17-11 | .607 | T-Mobile Park · Seattle, WA |
| 29 | Fri Apr 26 | vs Rangers | W5-4 (11) | 18-11 | .621 | T-Mobile Park · Seattle, WA |
| 30 | Sat Apr 27 | vs Rangers | L1-15 | 18-12 | .600 | T-Mobile Park · Seattle, WA |
| 31 | Sun Apr 28 | vs Rangers | L1-14 | 18-13 | .581 | T-Mobile Park · Seattle, WA |
| 32 | Tue Apr 30 | vs Cubs | L5-6 | 18-14 | .563 | T-Mobile Park · Seattle, WA |
| 33 | Wed May 1 | vs Cubs | L0-11 | 18-15 | .545 | T-Mobile Park · Seattle, WA |
| 34 | Fri May 3 | at Guardians | L1-2 | 18-16 | .529 | Progressive Field · Cleveland, OH |
| 35 | Sat May 4 | at Guardians | L4-5 | 18-17 | .514 | Progressive Field · Cleveland, OH |
| 36 | Sun May 5 | at Guardians | W10-0 | 19-17 | .528 | Progressive Field · Cleveland, OH |
| 37 | Mon May 6 | at Yankees | L3-7 | 19-18 | .514 | Yankee Stadium · The Bronx, NY |
| 38 | Tue May 7 | at Yankees | L4-5 | 19-19 | .500 | Yankee Stadium · The Bronx, NY |
| 39 | Wed May 8 | at Yankees | W10-1 | 20-19 | .513 | Yankee Stadium · The Bronx, NY |
| 40 | Thu May 9 | at Yankees | L1-3 | 20-20 | .500 | Yankee Stadium · The Bronx, NY |
| 41 | Fri May 10 | at Red Sox | L1-14 | 20-21 | .488 | Fenway Park · Boston, MA |
| 42 | Sat May 11 | at Red Sox | L5-9 | 20-22 | .476 | Fenway Park · Boston, MA |
| 43 | Sun May 12 | at Red Sox | L2-11 | 20-23 | .465 | Fenway Park · Boston, MA |
| 44 | Mon May 13 | vs Athletics | W6-5 (10) | 21-23 | .477 | T-Mobile Park · Seattle, WA |
| 45 | Tue May 14 | vs Athletics | W4-3 | 22-23 | .489 | T-Mobile Park · Seattle, WA |
| 46 | Thu May 16 | vs Twins | L6-11 | 22-24 | .478 | T-Mobile Park · Seattle, WA |
| 47 | Fri May 17 | vs Twins | L1-7 | 22-25 | .468 | T-Mobile Park · Seattle, WA |
| 48 | Sat May 18 | vs Twins | L4-18 | 22-26 | .458 | T-Mobile Park · Seattle, WA |
| 49 | Sun May 19 | vs Twins | W7-4 | 23-26 | .469 | T-Mobile Park · Seattle, WA |
| 50 | Mon May 20 | at Rangers | L9-10 | 23-27 | .460 | Globe Life Field · Arlington, TX |
| 51 | Tue May 21 | at Rangers | L3-5 | 23-28 | .451 | Globe Life Field · Arlington, TX |
| 52 | Wed May 22 | at Rangers | L1-2 | 23-29 | .442 | Globe Life Field · Arlington, TX |
| 53 | Fri May 24 | at Athletics | L2-6 | 23-30 | .434 | RingCentral Coliseum · Oakland, CA |
| 54 | Sat May 25 | at Athletics | L5-6 | 23-31 | .426 | RingCentral Coliseum · Oakland, CA |
| 55 | Sun May 26 | at Athletics | L1-7 | 23-32 | .418 | RingCentral Coliseum · Oakland, CA |
| 56 | Mon May 27 | vs Rangers | W6-2 | 24-32 | .429 | T-Mobile Park · Seattle, WA |
| 57 | Tue May 28 | vs Rangers | L4-11 | 24-33 | .421 | T-Mobile Park · Seattle, WA |
| 58 | Wed May 29 | vs Rangers | L7-8 | 24-34 | .414 | T-Mobile Park · Seattle, WA |
| 59 | Thu May 30 | vs Angels | L3-9 | 24-35 | .407 | T-Mobile Park · Seattle, WA |
| 60 | Fri May 31 | vs Angels | W4-3 | 25-35 | .417 | T-Mobile Park · Seattle, WA |
| 61 | Sat Jun 1 | vs Angels | L3-6 | 25-36 | .410 | T-Mobile Park · Seattle, WA |
| 62 | Sun Jun 2 | vs Angels | L3-13 | 25-37 | .403 | T-Mobile Park · Seattle, WA |
| 63 | Mon Jun 3 | vs Astros | L2-4 | 25-38 | .397 | T-Mobile Park · Seattle, WA |
| 64 | Tue Jun 4 | vs Astros | L5-11 | 25-39 | .391 | T-Mobile Park · Seattle, WA |
| 65 | Wed Jun 5 | vs Astros | W14-1 | 26-39 | .400 | T-Mobile Park · Seattle, WA |
| 66 | Thu Jun 6 | vs Astros | L7-8 (14) | 26-40 | .394 | T-Mobile Park · Seattle, WA |
| 67 | Fri Jun 7 | at Angels | W6-2 | 27-40 | .403 | Angel Stadium · Anaheim, CA |
| 68 | Sat Jun 8 | at Angels | L3-12 | 27-41 | .397 | Angel Stadium · Anaheim, CA |
| 69 | Sun Jun 9 | at Angels | W9-3 | 28-41 | .406 | Angel Stadium · Anaheim, CA |
| 70 | Tue Jun 11 | at Twins | L5-6 | 28-42 | .400 | Target Field · Minneapolis, MN |
| 71 | Wed Jun 12 | at Twins | W9-6 (10) | 29-42 | .408 | Target Field · Minneapolis, MN |
| 72 | Thu Jun 13 | at Twins | L5-10 | 29-43 | .403 | Target Field · Minneapolis, MN |
| 73 | Fri Jun 14 | at Athletics | W9-2 | 30-43 | .411 | RingCentral Coliseum · Oakland, CA |
| 74 | Sat Jun 15 | at Athletics | L2-11 | 30-44 | .405 | RingCentral Coliseum · Oakland, CA |
| 75 | Sun Jun 16 | at Athletics | W6-3 | 31-44 | .413 | RingCentral Coliseum · Oakland, CA |
| 76 | Mon Jun 17 | vs Royals | L4-6 | 31-45 | .408 | T-Mobile Park · Seattle, WA |
| 77 | Tue Jun 18 | vs Royals | L0-9 | 31-46 | .403 | T-Mobile Park · Seattle, WA |
| 78 | Wed Jun 19 | vs Royals | W8-2 | 32-46 | .410 | T-Mobile Park · Seattle, WA |
| 79 | Thu Jun 20 | vs Orioles | W5-2 | 33-46 | .418 | T-Mobile Park · Seattle, WA |
| 80 | Fri Jun 21 | vs Orioles | W10-9 | 34-46 | .425 | T-Mobile Park · Seattle, WA |
| 81 | Sat Jun 22 | vs Orioles | L4-8 | 34-47 | .420 | T-Mobile Park · Seattle, WA |
| 82 | Sun Jun 23 | vs Orioles | W13-3 | 35-47 | .427 | T-Mobile Park · Seattle, WA |
| 83 | Tue Jun 25 | at Brewers | W8-3 | 36-47 | .434 | American Family Field · Milwaukee, WI |
| 84 | Wed Jun 26 | at Brewers | W4-2 | 37-47 | .440 | American Family Field · Milwaukee, WI |
| 85 | Thu Jun 27 | at Brewers | L2-4 | 37-48 | .435 | American Family Field · Milwaukee, WI |
| 86 | Fri Jun 28 | at Astros | L1-2 (10) | 37-49 | .430 | Minute Maid Park · Houston, TX |
| 87 | Sat Jun 29 | at Astros | L5-6 (10) | 37-50 | .425 | Minute Maid Park · Houston, TX |
| 88 | Sun Jun 30 | at Astros | L1-6 | 37-51 | .420 | Minute Maid Park · Houston, TX |
| 89 | Tue Jul 2 | vs Cardinals | W5-4 | 38-51 | .427 | T-Mobile Park · Seattle, WA |
| 90 | Wed Jul 3 | vs Cardinals | L2-5 | 38-52 | .422 | T-Mobile Park · Seattle, WA |
| 91 | Thu Jul 4 | vs Cardinals | L4-5 | 38-53 | .418 | T-Mobile Park · Seattle, WA |
| 92 | Fri Jul 5 | vs Athletics | L2-5 | 38-54 | .413 | T-Mobile Park · Seattle, WA |
| 93 | Sat Jul 6 | vs Athletics | W6-3 | 39-54 | .419 | T-Mobile Park · Seattle, WA |
| 94 | Sun Jul 7 | vs Athletics | L4-7 | 39-55 | .415 | T-Mobile Park · Seattle, WA |
| 95 | Fri Jul 12 | at Angels | L0-13 | 39-56 | .411 | Angel Stadium · Anaheim, CA |
| 96 | Sat Jul 13 | at Angels | L2-9 | 39-57 | .406 | Angel Stadium · Anaheim, CA |
| 97 | Sun Jul 14 | at Angels | L3-6 | 39-58 | .402 | Angel Stadium · Anaheim, CA |
| 98 | Tue Jul 16 | at Athletics | L2-9 | 39-59 | .398 | RingCentral Coliseum · Oakland, CA |
| 99 | Wed Jul 17 | at Athletics | L2-10 | 39-60 | .394 | RingCentral Coliseum · Oakland, CA |
| 100 | Fri Jul 19 | vs Angels | W10-0 | 40-60 | .400 | T-Mobile Park · Seattle, WA |
| 101 | Sat Jul 20 | vs Angels | L2-6 | 40-61 | .396 | T-Mobile Park · Seattle, WA |
| 102 | Sun Jul 21 | vs Angels | L3-9 | 40-62 | .392 | T-Mobile Park · Seattle, WA |
| 103 | Mon Jul 22 | vs Rangers | W7-3 | 41-62 | .398 | T-Mobile Park · Seattle, WA |
| 104 | Tue Jul 23 | vs Rangers | L2-7 | 41-63 | .394 | T-Mobile Park · Seattle, WA |
| 105 | Wed Jul 24 | vs Rangers | W5-3 | 42-63 | .400 | T-Mobile Park · Seattle, WA |
| 106 | Thu Jul 25 | vs Tigers | W10-2 | 43-63 | .406 | T-Mobile Park · Seattle, WA |
| 107 | Fri Jul 26 | vs Tigers | W3-2 | 44-63 | .411 | T-Mobile Park · Seattle, WA |
| 108 | Sat Jul 27 | vs Tigers | W8-1 | 45-63 | .417 | T-Mobile Park · Seattle, WA |
| 109 | Sun Jul 28 | vs Tigers | W3-2 (10) | 46-63 | .422 | T-Mobile Park · Seattle, WA |
| 110 | Tue Jul 30 | at Rangers | W8-5 | 47-63 | .427 | Globe Life Field · Arlington, TX |
| 111 | Wed Jul 31 | at Rangers | L7-9 | 47-64 | .423 | Globe Life Field · Arlington, TX |
| 112 | Fri Aug 2 | at Astros | L2-10 | 47-65 | .420 | Minute Maid Park · Houston, TX |
| 113 | Sat Aug 3 | at Astros | L0-9 | 47-66 | .416 | Minute Maid Park · Houston, TX |
| 114 | Sun Aug 4 | at Astros | L1-3 | 47-67 | .412 | Minute Maid Park · Houston, TX |
| 115 | Tue Aug 6 | vs Padres | L4-9 | 47-68 | .409 | T-Mobile Park · Seattle, WA |
| 116 | Wed Aug 7 | vs Padres | W3-2 | 48-68 | .414 | T-Mobile Park · Seattle, WA |
| 117 | Fri Aug 9 | vs Rays | L3-5 | 48-69 | .410 | T-Mobile Park · Seattle, WA |
| 118 | Sat Aug 10 | vs Rays | L4-5 | 48-70 | .407 | T-Mobile Park · Seattle, WA |
| 119 | Sun Aug 11 | vs Rays | L0-1 | 48-71 | .403 | T-Mobile Park · Seattle, WA |
| 120 | Tue Aug 13 | at Tigers | W11-6 | 49-71 | .408 | Comerica Park · Detroit, MI |
| 121 | Wed Aug 14 | at Tigers | L2-3 | 49-72 | .405 | Comerica Park · Detroit, MI |
| 122 | Thu Aug 15 | at Tigers | W7-2 | 50-72 | .410 | Comerica Park · Detroit, MI |
| 123 | Fri Aug 16 | at Blue Jays | L3-7 | 50-73 | .407 | Rogers Centre · Toronto, ON |
| 124 | Sat Aug 17 | at Blue Jays | W4-3 | 51-73 | .411 | Rogers Centre · Toronto, ON |
| 125 | Sun Aug 18 | at Blue Jays | W7-0 | 52-73 | .416 | Rogers Centre · Toronto, ON |
| 126 | Mon Aug 19 | at Rays | W9-3 | 53-73 | .421 | Tropicana Field · St. Petersburg, FL |
| 127 | Tue Aug 20 | at Rays | W7-4 | 54-73 | .425 | Tropicana Field · St. Petersburg, FL |
| 128 | Wed Aug 21 | at Rays | L6-7 | 54-74 | .422 | Tropicana Field · St. Petersburg, FL |
| 129 | Fri Aug 23 | vs Blue Jays | W7-4 | 55-74 | .426 | T-Mobile Park · Seattle, WA |
| 130 | Sat Aug 24 | vs Blue Jays | L5-7 | 55-75 | .423 | T-Mobile Park · Seattle, WA |
| 131 | Sun Aug 25 | vs Blue Jays | W3-1 | 56-75 | .427 | T-Mobile Park · Seattle, WA |
| 132 | Mon Aug 26 | vs Yankees | L4-5 | 56-76 | .424 | T-Mobile Park · Seattle, WA |
| 133 | Tue Aug 27 | vs Yankees | L0-7 | 56-77 | .421 | T-Mobile Park · Seattle, WA |
| 134 | Wed Aug 28 | vs Yankees | L3-7 | 56-78 | .418 | T-Mobile Park · Seattle, WA |
| 135 | Thu Aug 29 | at Rangers | W5-3 | 57-78 | .422 | Globe Life Field · Arlington, TX |
| 136 | Fri Aug 30 | at Rangers | L3-6 | 57-79 | .419 | Globe Life Field · Arlington, TX |
| 137 | Sat Aug 31 | at Rangers | L2-3 | 57-80 | .416 | Globe Life Field · Arlington, TX |
| 138 | Sun Sep 1 | at Rangers | W11-3 | 58-80 | .420 | Globe Life Field · Arlington, TX |
| 139 | Mon Sep 2 | at Cubs | L1-5 | 58-81 | .417 | Wrigley Field · Chicago, IL |
| 140 | Tue Sep 3 | at Cubs | L1-6 | 58-82 | .414 | Wrigley Field · Chicago, IL |
| 141 | Thu Sep 5 | at Astros | L9-11 (13) | 58-83 | .411 | Minute Maid Park · Houston, TX |
| 142 | Fri Sep 6 | at Astros | L4-7 | 58-84 | .408 | Minute Maid Park · Houston, TX |
| 143 | Sat Sep 7 | at Astros | L1-2 | 58-85 | .406 | Minute Maid Park · Houston, TX |
| 144 | Sun Sep 8 | at Astros | L1-21 | 58-86 | .403 | Minute Maid Park · Houston, TX |
| 145 | Tue Sep 10 | vs Reds | W4-3 | 59-86 | .407 | T-Mobile Park · Seattle, WA |
| 146 | Wed Sep 11 | vs Reds | W5-3 | 60-86 | .411 | T-Mobile Park · Seattle, WA |
| 147 | Thu Sep 12 | vs Reds | L5-11 | 60-87 | .408 | T-Mobile Park · Seattle, WA |
| 148 | Fri Sep 13 | vs White Sox | L7-9 | 60-88 | .405 | T-Mobile Park · Seattle, WA |
| 149 | Sat Sep 14 | vs White Sox | W2-1 (10) | 61-88 | .409 | T-Mobile Park · Seattle, WA |
| 150 | Sun Sep 15 | vs White Sox | W11-10 | 62-88 | .413 | T-Mobile Park · Seattle, WA |
| 151 | Tue Sep 17 | at Pirates | W6-0 | 63-88 | .417 | PNC Park · Pittsburgh, PA |
| 152 | Wed Sep 18 | at Pirates | W4-1 | 64-88 | .421 | PNC Park · Pittsburgh, PA |
| 153 | Thu Sep 19 | at Pirates | W6-5 (11) | 65-88 | .425 | PNC Park · Pittsburgh, PA |
| 154 | Fri Sep 20 | at Orioles | L3-5 | 65-89 | .422 | Camden Yards · Baltimore, MD |
| 155 | Sat Sep 21 | at Orioles | W7-6 (13) | 66-89 | .426 | Camden Yards · Baltimore, MD |
| 156 | Sun Sep 22 | at Orioles | L1-2 | 66-90 | .423 | Camden Yards · Baltimore, MD |
| 157 | Tue Sep 24 | vs Astros | L0-3 | 66-91 | .420 | T-Mobile Park · Seattle, WA |
| 158 | Wed Sep 25 | vs Astros | L0-3 | 66-92 | .418 | T-Mobile Park · Seattle, WA |
| 159 | Thu Sep 26 | vs Athletics | L1-3 | 66-93 | .415 | T-Mobile Park · Seattle, WA |
| 160 | Fri Sep 27 | vs Athletics | W4-3 | 67-93 | .419 | T-Mobile Park · Seattle, WA |
| 161 | Sat Sep 28 | vs Athletics | L0-1 | 67-94 | .416 | T-Mobile Park · Seattle, WA |
| 162 | Sun Sep 29 | vs Athletics | W3-1 | 68-94 | .420 | T-Mobile Park · Seattle, WA |