| 1 | Thu Mar 27 | vs Athletics | W4-2 | 1-0 | 1.000 | T-Mobile Park · Seattle, WA |
| 2 | Fri Mar 28 | vs Athletics | L0-7 | 1-1 | .500 | T-Mobile Park · Seattle, WA |
| 3 | Sat Mar 29 | vs Athletics | L2-4 | 1-2 | .333 | T-Mobile Park · Seattle, WA |
| 4 | Sun Mar 30 | vs Athletics | W2-1 | 2-2 | .500 | T-Mobile Park · Seattle, WA |
| 5 | Mon Mar 31 | vs Tigers | L6-9 | 2-3 | .400 | T-Mobile Park · Seattle, WA |
| 6 | Tue Apr 1 | vs Tigers | L1-4 | 2-4 | .333 | T-Mobile Park · Seattle, WA |
| 7 | Wed Apr 2 | vs Tigers | W3-2 | 3-4 | .429 | T-Mobile Park · Seattle, WA |
| 8 | Fri Apr 4 | at Giants | L9-10 (11) | 3-5 | .375 | Oracle Park · San Francisco, CA |
| 9 | Sat Apr 5 | at Giants | L1-4 | 3-6 | .333 | Oracle Park · San Francisco, CA |
| 10 | Sun Apr 6 | at Giants | L4-5 | 3-7 | .300 | Oracle Park · San Francisco, CA |
| 11 | Mon Apr 7 | vs Astros | W4-3 | 4-7 | .364 | T-Mobile Park · Seattle, WA |
| 12 | Tue Apr 8 | vs Astros | L1-2 (12) | 4-8 | .333 | T-Mobile Park · Seattle, WA |
| 13 | Wed Apr 9 | vs Astros | W7-6 | 5-8 | .385 | T-Mobile Park · Seattle, WA |
| 14 | Fri Apr 11 | vs Rangers | W5-3 | 6-8 | .429 | T-Mobile Park · Seattle, WA |
| 15 | Sat Apr 12 | vs Rangers | W9-2 | 7-8 | .467 | T-Mobile Park · Seattle, WA |
| 16 | Sun Apr 13 | vs Rangers | W3-1 | 8-8 | .500 | T-Mobile Park · Seattle, WA |
| 17 | Tue Apr 15 | at Reds | L4-8 | 8-9 | .471 | Great American Ball Park · Cincinnati, OH |
| 18 | Wed Apr 16 | at Reds | W5-3 | 9-9 | .500 | Great American Ball Park · Cincinnati, OH |
| 19 | Thu Apr 17 | at Reds | W11-7 (10) | 10-9 | .526 | Great American Ball Park · Cincinnati, OH |
| 20 | Fri Apr 18 | at Blue Jays | L1-3 | 10-10 | .500 | Rogers Centre · Toronto, ON |
| 21 | Sat Apr 19 | at Blue Jays | W8-4 (12) | 11-10 | .524 | Rogers Centre · Toronto, ON |
| 22 | Sun Apr 20 | at Blue Jays | W8-3 | 12-10 | .545 | Rogers Centre · Toronto, ON |
| 23 | Tue Apr 22 | at Red Sox | L3-8 | 12-11 | .522 | Fenway Park · Boston, MA |
| 24 | Wed Apr 23 | at Red Sox | W8-5 | 13-11 | .542 | Fenway Park · Boston, MA |
| 25 | Thu Apr 24 | at Red Sox | W4-3 | 14-11 | .560 | Fenway Park · Boston, MA |
| 26 | Fri Apr 25 | vs Marlins | L4-8 | 14-12 | .538 | T-Mobile Park · Seattle, WA |
| 27 | Sat Apr 26 | vs Marlins | W14-0 | 15-12 | .556 | T-Mobile Park · Seattle, WA |
| 28 | Sun Apr 27 | vs Marlins | W7-6 | 16-12 | .571 | T-Mobile Park · Seattle, WA |
| 29 | Tue Apr 29 | vs Angels | W5-3 | 17-12 | .586 | T-Mobile Park · Seattle, WA |
| 30 | Wed Apr 30 | vs Angels | W9-3 | 18-12 | .600 | T-Mobile Park · Seattle, WA |
| 31 | Fri May 2 | at Rangers | W13-1 | 19-12 | .613 | Globe Life Field · Arlington, TX |
| 32 | Sat May 3 | at Rangers | W2-1 | 20-12 | .625 | Globe Life Field · Arlington, TX |
| 33 | Sun May 4 | at Rangers | L1-8 | 20-13 | .606 | Globe Life Field · Arlington, TX |
| 34 | Mon May 5 | at Athletics | L6-7 (11) | 20-14 | .588 | Sutter Health Park · West Sacramento, CA |
| 35 | Tue May 6 | at Athletics | W5-3 | 21-14 | .600 | Sutter Health Park · West Sacramento, CA |
| 36 | Wed May 7 | at Athletics | W6-5 | 22-14 | .611 | Sutter Health Park · West Sacramento, CA |
| 37 | Fri May 9 | vs Blue Jays | L3-6 | 22-15 | .595 | T-Mobile Park · Seattle, WA |
| 38 | Sat May 10 | vs Blue Jays | L3-6 | 22-16 | .579 | T-Mobile Park · Seattle, WA |
| 39 | Sun May 11 | vs Blue Jays | L1-9 | 22-17 | .564 | T-Mobile Park · Seattle, WA |
| 40 | Mon May 12 | vs Yankees | L5-11 | 22-18 | .550 | T-Mobile Park · Seattle, WA |
| 41 | Tue May 13 | vs Yankees | W2-1 (11) | 23-18 | .561 | T-Mobile Park · Seattle, WA |
| 42 | Wed May 14 | vs Yankees | L2-3 | 23-19 | .548 | T-Mobile Park · Seattle, WA |
| 43 | Fri May 16 | at Padres | W5-1 | 24-19 | .558 | Petco Park · San Diego, CA |
| 44 | Sat May 17 | at Padres | W4-1 | 25-19 | .568 | Petco Park · San Diego, CA |
| 45 | Sun May 18 | at Padres | W6-1 | 26-19 | .578 | Petco Park · San Diego, CA |
| 46 | Mon May 19 | at White Sox | W5-1 | 27-19 | .587 | Guaranteed Rate Field · Chicago, IL |
| 47 | Tue May 20 | at White Sox | L0-1 | 27-20 | .574 | Guaranteed Rate Field · Chicago, IL |
| 48 | Wed May 21 | at White Sox | W6-5 | 28-20 | .583 | Guaranteed Rate Field · Chicago, IL |
| 49 | Thu May 22 | at Astros | L2-9 | 28-21 | .571 | Minute Maid Park · Houston, TX |
| 50 | Fri May 23 | at Astros | W5-3 | 29-21 | .580 | Minute Maid Park · Houston, TX |
| 51 | Sat May 24 | at Astros | L1-2 | 29-22 | .569 | Minute Maid Park · Houston, TX |
| 52 | Sun May 25 | at Astros | L3-5 | 29-23 | .558 | Minute Maid Park · Houston, TX |
| 53 | Tue May 27 | vs Nationals | W9-1 | 30-23 | .566 | T-Mobile Park · Seattle, WA |
| 54 | Wed May 28 | vs Nationals | L0-9 | 30-24 | .556 | T-Mobile Park · Seattle, WA |
| 55 | Thu May 29 | vs Nationals | L3-9 (10) | 30-25 | .545 | T-Mobile Park · Seattle, WA |
| 56 | Fri May 30 | vs Twins | L6-12 (10) | 30-26 | .536 | T-Mobile Park · Seattle, WA |
| 57 | Sat May 31 | vs Twins | W5-4 (11) | 31-26 | .544 | T-Mobile Park · Seattle, WA |
| 58 | Sun Jun 1 | vs Twins | W2-1 | 32-26 | .552 | T-Mobile Park · Seattle, WA |
| 59 | Tue Jun 3 | vs Orioles | L1-5 | 32-27 | .542 | T-Mobile Park · Seattle, WA |
| 60 | Wed Jun 4 | vs Orioles | L2-3 | 32-28 | .533 | T-Mobile Park · Seattle, WA |
| 61 | Thu Jun 5 | vs Orioles | L3-4 | 32-29 | .525 | T-Mobile Park · Seattle, WA |
| 62 | Fri Jun 6 | at Angels | L4-5 | 32-30 | .516 | Angel Stadium · Anaheim, CA |
| 63 | Sat Jun 7 | at Angels | L6-8 | 32-31 | .508 | Angel Stadium · Anaheim, CA |
| 64 | Sun Jun 8 | at Angels | W3-2 | 33-31 | .516 | Angel Stadium · Anaheim, CA |
| 65 | Mon Jun 9 | at D-backs | L4-8 (11) | 33-32 | .508 | Chase Field · Phoenix, AZ |
| 66 | Tue Jun 10 | at D-backs | L3-10 | 33-33 | .500 | Chase Field · Phoenix, AZ |
| 67 | Wed Jun 11 | at D-backs | L2-5 | 33-34 | .493 | Chase Field · Phoenix, AZ |
| 68 | Fri Jun 13 | vs Guardians | W7-2 | 34-34 | .500 | T-Mobile Park · Seattle, WA |
| 69 | Sat Jun 14 | vs Guardians | W4-3 | 35-34 | .507 | T-Mobile Park · Seattle, WA |
| 70 | Sun Jun 15 | vs Guardians | W6-0 | 36-34 | .514 | T-Mobile Park · Seattle, WA |
| 71 | Mon Jun 16 | vs Red Sox | L0-2 | 36-35 | .507 | T-Mobile Park · Seattle, WA |
| 72 | Tue Jun 17 | vs Red Sox | W8-0 | 37-35 | .514 | T-Mobile Park · Seattle, WA |
| 73 | Wed Jun 18 | vs Red Sox | L1-3 | 37-36 | .507 | T-Mobile Park · Seattle, WA |
| 74 | Fri Jun 20 | at Cubs | W9-4 | 38-36 | .514 | Wrigley Field · Chicago, IL |
| 75 | Sat Jun 21 | at Cubs | L7-10 | 38-37 | .507 | Wrigley Field · Chicago, IL |
| 76 | Sun Jun 22 | at Cubs | W14-6 | 39-37 | .513 | Wrigley Field · Chicago, IL |
| 77 | Mon Jun 23 | at Twins | W11-2 | 40-37 | .519 | Target Field · Minneapolis, MN |
| 78 | Tue Jun 24 | at Twins | W6-5 | 41-37 | .526 | Target Field · Minneapolis, MN |
| 79 | Wed Jun 25 | at Twins | L0-2 | 41-38 | .519 | Target Field · Minneapolis, MN |
| 80 | Thu Jun 26 | at Twins | L1-10 | 41-39 | .512 | Target Field · Minneapolis, MN |
| 81 | Fri Jun 27 | at Rangers | W7-6 (12) | 42-39 | .519 | Globe Life Field · Arlington, TX |
| 82 | Sat Jun 28 | at Rangers | L2-3 (10) | 42-40 | .512 | Globe Life Field · Arlington, TX |
| 83 | Sun Jun 29 | at Rangers | W6-4 (12) | 43-40 | .518 | Globe Life Field · Arlington, TX |
| 84 | Mon Jun 30 | vs Royals | W6-2 | 44-40 | .524 | T-Mobile Park · Seattle, WA |
| 85 | Tue Jul 1 | vs Royals | L3-6 | 44-41 | .518 | T-Mobile Park · Seattle, WA |
| 86 | Wed Jul 2 | vs Royals | W3-2 | 45-41 | .523 | T-Mobile Park · Seattle, WA |
| 87 | Thu Jul 3 | vs Royals | L2-3 | 45-42 | .517 | T-Mobile Park · Seattle, WA |
| 88 | Fri Jul 4 | vs Pirates | W6-0 | 46-42 | .523 | T-Mobile Park · Seattle, WA |
| 89 | Sat Jul 5 | vs Pirates | W1-0 | 47-42 | .528 | T-Mobile Park · Seattle, WA |
| 90 | Sun Jul 6 | vs Pirates | W1-0 | 48-42 | .533 | T-Mobile Park · Seattle, WA |
| 91 | Tue Jul 8 | at Yankees | L3-10 | 48-43 | .527 | Yankee Stadium · The Bronx, NY |
| 92 | Wed Jul 9 | at Yankees | L6-9 | 48-44 | .522 | Yankee Stadium · The Bronx, NY |
| 93 | Thu Jul 10 | at Yankees | L5-6 (10) | 48-45 | .516 | Yankee Stadium · The Bronx, NY |
| 94 | Fri Jul 11 | at Tigers | W12-3 | 49-45 | .521 | Comerica Park · Detroit, MI |
| 95 | Sat Jul 12 | at Tigers | W15-7 | 50-45 | .526 | Comerica Park · Detroit, MI |
| 96 | Sun Jul 13 | at Tigers | W8-4 | 51-45 | .531 | Comerica Park · Detroit, MI |
| 97 | Fri Jul 18 | vs Astros | W6-1 | 52-45 | .536 | T-Mobile Park · Seattle, WA |
| 98 | Sat Jul 19 | vs Astros | W7-6 (11) | 53-45 | .541 | T-Mobile Park · Seattle, WA |
| 99 | Sun Jul 20 | vs Astros | L3-11 | 53-46 | .535 | T-Mobile Park · Seattle, WA |
| 100 | Mon Jul 21 | vs Brewers | L0-6 | 53-47 | .530 | T-Mobile Park · Seattle, WA |
| 101 | Tue Jul 22 | vs Brewers | W1-0 | 54-47 | .535 | T-Mobile Park · Seattle, WA |
| 102 | Wed Jul 23 | vs Brewers | L2-10 | 54-48 | .529 | T-Mobile Park · Seattle, WA |
| 103 | Thu Jul 24 | at Angels | W4-2 | 55-48 | .534 | Angel Stadium · Anaheim, CA |
| 104 | Fri Jul 25 | at Angels | L2-3 (10) | 55-49 | .529 | Angel Stadium · Anaheim, CA |
| 105 | Sat Jul 26 | at Angels | W7-2 | 56-49 | .533 | Angel Stadium · Anaheim, CA |
| 106 | Sun Jul 27 | at Angels | L1-4 | 56-50 | .528 | Angel Stadium · Anaheim, CA |
| 107 | Mon Jul 28 | at Athletics | W3-1 | 57-50 | .533 | Sutter Health Park · West Sacramento, CA |
| 108 | Tue Jul 29 | at Athletics | L1-6 | 57-51 | .528 | Sutter Health Park · West Sacramento, CA |
| 109 | Wed Jul 30 | at Athletics | L4-5 | 57-52 | .523 | Sutter Health Park · West Sacramento, CA |
| 110 | Thu Jul 31 | vs Rangers | W6-0 | 58-52 | .527 | T-Mobile Park · Seattle, WA |
| 111 | Fri Aug 1 | vs Rangers | W4-3 | 59-52 | .532 | T-Mobile Park · Seattle, WA |
| 112 | Sat Aug 2 | vs Rangers | L4-6 (11) | 59-53 | .527 | T-Mobile Park · Seattle, WA |
| 113 | Sun Aug 3 | vs Rangers | W5-4 | 60-53 | .531 | T-Mobile Park · Seattle, WA |
| 114 | Tue Aug 5 | vs White Sox | W8-3 | 61-53 | .535 | T-Mobile Park · Seattle, WA |
| 115 | Wed Aug 6 | vs White Sox | W8-6 | 62-53 | .539 | T-Mobile Park · Seattle, WA |
| 116 | Thu Aug 7 | vs White Sox | W4-3 (11) | 63-53 | .543 | T-Mobile Park · Seattle, WA |
| 117 | Fri Aug 8 | vs Rays | W3-2 | 64-53 | .547 | T-Mobile Park · Seattle, WA |
| 118 | Sat Aug 9 | vs Rays | W7-4 | 65-53 | .551 | T-Mobile Park · Seattle, WA |
| 119 | Sun Aug 10 | vs Rays | W6-3 | 66-53 | .555 | T-Mobile Park · Seattle, WA |
| 120 | Tue Aug 12 | at Orioles | W1-0 | 67-53 | .558 | Camden Yards · Baltimore, MD |
| 121 | Wed Aug 13 | at Orioles | L3-4 | 67-54 | .554 | Camden Yards · Baltimore, MD |
| 122 | Thu Aug 14 | at Orioles | L3-5 | 67-55 | .549 | Camden Yards · Baltimore, MD |
| 123 | Fri Aug 15 | at Mets | W11-9 | 68-55 | .553 | Citi Field · Queens, NY |
| 124 | Sat Aug 16 | at Mets | L1-3 | 68-56 | .548 | Citi Field · Queens, NY |
| 125 | Sun Aug 17 | at Mets | L3-7 | 68-57 | .544 | Citi Field · Queens, NY |
| 126 | Mon Aug 18 | at Phillies | L7-12 | 68-58 | .540 | Citizens Bank Park · Philadelphi, PA |
| 127 | Tue Aug 19 | at Phillies | L4-6 | 68-59 | .535 | Citizens Bank Park · Philadelphi, PA |
| 128 | Wed Aug 20 | at Phillies | L2-11 | 68-60 | .531 | Citizens Bank Park · Philadelphi, PA |
| 129 | Fri Aug 22 | vs Athletics | W3-2 | 69-60 | .535 | T-Mobile Park · Seattle, WA |
| 130 | Sat Aug 23 | vs Athletics | L1-2 (10) | 69-61 | .531 | T-Mobile Park · Seattle, WA |
| 131 | Sun Aug 24 | vs Athletics | W11-4 | 70-61 | .534 | T-Mobile Park · Seattle, WA |
| 132 | Mon Aug 25 | vs Padres | W9-6 | 71-61 | .538 | T-Mobile Park · Seattle, WA |
| 133 | Tue Aug 26 | vs Padres | L6-7 | 71-62 | .534 | T-Mobile Park · Seattle, WA |
| 134 | Wed Aug 27 | vs Padres | W4-3 | 72-62 | .537 | T-Mobile Park · Seattle, WA |
| 135 | Fri Aug 29 | at Guardians | L4-5 | 72-63 | .533 | Progressive Field · Cleveland, OH |
| 136 | Sat Aug 30 | at Guardians | L3-4 | 72-64 | .529 | Progressive Field · Cleveland, OH |
| 137 | Sun Aug 31 | at Guardians | W4-2 | 73-64 | .533 | Progressive Field · Cleveland, OH |
| 138 | Mon Sep 1 | at Rays | L2-10 | 73-65 | .529 | Tropicana Field · St. Petersburg, FL |
| 139 | Tue Sep 2 | at Rays | L5-6 | 73-66 | .525 | Tropicana Field · St. Petersburg, FL |
| 140 | Wed Sep 3 | at Rays | L4-9 | 73-67 | .521 | Tropicana Field · St. Petersburg, FL |
| 141 | Fri Sep 5 | at Braves | L1-4 | 73-68 | .518 | Truist Park · Cumberland, GA |
| 142 | Sat Sep 6 | at Braves | W10-2 | 74-68 | .521 | Truist Park · Cumberland, GA |
| 143 | Sun Sep 7 | at Braves | W18-2 | 75-68 | .524 | Truist Park · Cumberland, GA |
| 144 | Mon Sep 8 | vs Cardinals | W4-2 | 76-68 | .528 | T-Mobile Park · Seattle, WA |
| 145 | Tue Sep 9 | vs Cardinals | W5-3 | 77-68 | .531 | T-Mobile Park · Seattle, WA |
| 146 | Wed Sep 10 | vs Cardinals | W4-2 (13) | 78-68 | .534 | T-Mobile Park · Seattle, WA |
| 147 | Thu Sep 11 | vs Angels | W7-6 (12) | 79-68 | .537 | T-Mobile Park · Seattle, WA |
| 148 | Fri Sep 12 | vs Angels | W2-1 | 80-68 | .541 | T-Mobile Park · Seattle, WA |
| 149 | Sat Sep 13 | vs Angels | W5-3 | 81-68 | .544 | T-Mobile Park · Seattle, WA |
| 150 | Sun Sep 14 | vs Angels | W11-2 | 82-68 | .547 | T-Mobile Park · Seattle, WA |
| 151 | Tue Sep 16 | at Royals | W12-5 | 83-68 | .550 | Kauffman Stadium · Kansas City, MO |
| 152 | Wed Sep 17 | at Royals | L5-7 | 83-69 | .546 | Kauffman Stadium · Kansas City, MO |
| 153 | Thu Sep 18 | at Royals | W2-0 | 84-69 | .549 | Kauffman Stadium · Kansas City, MO |
| 154 | Fri Sep 19 | at Astros | W4-0 | 85-69 | .552 | Minute Maid Park · Houston, TX |
| 155 | Sat Sep 20 | at Astros | W6-4 | 86-69 | .555 | Minute Maid Park · Houston, TX |
| 156 | Sun Sep 21 | at Astros | W7-3 | 87-69 | .558 | Minute Maid Park · Houston, TX |
| 157 | Tue Sep 23 | vs Rockies | W4-3 | 88-69 | .561 | T-Mobile Park · Seattle, WA |
| 158 | Wed Sep 24 | vs Rockies | W9-2 | 89-69 | .563 | T-Mobile Park · Seattle, WA |
| 159 | Thu Sep 25 | vs Rockies | W6-2 | 90-69 | .566 | T-Mobile Park · Seattle, WA |
| 160 | Fri Sep 26 | vs Dodgers | L2-3 | 90-70 | .563 | T-Mobile Park · Seattle, WA |
| 161 | Sat Sep 27 | vs Dodgers | L3-5 | 90-71 | .559 | T-Mobile Park · Seattle, WA |
| 162 | Sun Sep 28 | vs Dodgers | L1-6 | 90-72 | .556 | T-Mobile Park · Seattle, WA |
| 163 | Sat Oct 4 | vs Tigers | L2-3 (11) | 0-1 | .000 | T-Mobile Park · Seattle, WA |
| 164 | Sun Oct 5 | vs Tigers | W3-2 | 1-1 | .500 | T-Mobile Park · Seattle, WA |
| 165 | Tue Oct 7 | at Tigers | W8-4 | 2-1 | .667 | Comerica Park · Detroit, MI |
| 166 | Wed Oct 8 | at Tigers | L3-9 | 2-2 | .500 | Comerica Park · Detroit, MI |
| 167 | Fri Oct 10 | vs Tigers | W3-2 (15) | 3-2 | .600 | T-Mobile Park · Seattle, WA |
| 168 | Sun Oct 12 | at Blue Jays | W3-1 | 1-0 | 1.000 | Rogers Centre · Toronto, ON |
| 169 | Mon Oct 13 | at Blue Jays | W10-3 | 2-0 | 1.000 | Rogers Centre · Toronto, ON |
| 170 | Wed Oct 15 | vs Blue Jays | L4-13 | 2-1 | .667 | T-Mobile Park · Seattle, WA |
| 171 | Thu Oct 16 | vs Blue Jays | L2-8 | 2-2 | .500 | T-Mobile Park · Seattle, WA |
| 172 | Fri Oct 17 | vs Blue Jays | W6-2 | 3-2 | .600 | T-Mobile Park · Seattle, WA |
| 173 | Sun Oct 19 | at Blue Jays | L2-6 | 3-3 | .500 | Rogers Centre · Toronto, ON |
| 174 | Mon Oct 20 | at Blue Jays | L3-4 | 3-4 | .429 | Rogers Centre · Toronto, ON |