| 1 | Thu Mar 27 | at Astros | L1-3 | 0-1 | .000 | Minute Maid Park · Houston, TX |
| 2 | Fri Mar 28 | at Astros | W3-1 | 1-1 | .500 | Minute Maid Park · Houston, TX |
| 3 | Sat Mar 29 | at Astros | L1-2 | 1-2 | .333 | Minute Maid Park · Houston, TX |
| 4 | Mon Mar 31 | at Marlins | W10-4 | 2-2 | .500 | LoanDepot Park · Miami, FL |
| 5 | Tue Apr 1 | at Marlins | L2-4 | 2-3 | .400 | LoanDepot Park · Miami, FL |
| 6 | Wed Apr 2 | at Marlins | W6-5 (11) | 3-3 | .500 | LoanDepot Park · Miami, FL |
| 7 | Fri Apr 4 | vs Blue Jays | W5-0 | 4-3 | .571 | Citi Field · Queens, NY |
| 8 | Sat Apr 5 | vs Blue Jays | W3-2 | 5-3 | .625 | Citi Field · Queens, NY |
| 9 | Sun Apr 6 | vs Blue Jays | W2-1 | 6-3 | .667 | Citi Field · Queens, NY |
| 10 | Mon Apr 7 | vs Marlins | W2-0 | 7-3 | .700 | Citi Field · Queens, NY |
| 11 | Tue Apr 8 | vs Marlins | W10-5 | 8-3 | .727 | Citi Field · Queens, NY |
| 12 | Wed Apr 9 | vs Marlins | L0-5 | 8-4 | .667 | Citi Field · Queens, NY |
| 13 | Fri Apr 11 | at Athletics | W7-6 | 9-4 | .692 | Sutter Health Park · West Sacramento, CA |
| 14 | Sat Apr 12 | at Athletics | L1-3 | 9-5 | .643 | Sutter Health Park · West Sacramento, CA |
| 15 | Sun Apr 13 | at Athletics | W8-0 | 10-5 | .667 | Sutter Health Park · West Sacramento, CA |
| 16 | Mon Apr 14 | at Twins | W5-1 | 11-5 | .688 | Target Field · Minneapolis, MN |
| 17 | Tue Apr 15 | at Twins | L3-6 | 11-6 | .647 | Target Field · Minneapolis, MN |
| 18 | Wed Apr 16 | at Twins | L3-4 (10) | 11-7 | .611 | Target Field · Minneapolis, MN |
| 19 | Thu Apr 17 | vs Cardinals | W4-1 | 12-7 | .632 | Citi Field · Queens, NY |
| 20 | Fri Apr 18 | vs Cardinals | W5-4 | 13-7 | .650 | Citi Field · Queens, NY |
| 21 | Sat Apr 19 | vs Cardinals | W3-0 | 14-7 | .667 | Citi Field · Queens, NY |
| 22 | Sun Apr 20 | vs Cardinals | W7-4 | 15-7 | .682 | Citi Field · Queens, NY |
| 23 | Mon Apr 21 | vs Phillies | W5-4 | 16-7 | .696 | Citi Field · Queens, NY |
| 24 | Tue Apr 22 | vs Phillies | W5-1 | 17-7 | .708 | Citi Field · Queens, NY |
| 25 | Wed Apr 23 | vs Phillies | W4-3 (10) | 18-7 | .720 | Citi Field · Queens, NY |
| 26 | Fri Apr 25 | at Nationals | L4-5 | 18-8 | .692 | Nationals Park · Washington, D.C. |
| 27 | Sat Apr 26 | at Nationals | W2-0 | 19-8 | .704 | Nationals Park · Washington, D.C. |
| 28 | Sun Apr 27 | at Nationals | L7-8 | 19-9 | .679 | Nationals Park · Washington, D.C. |
| 29 | Mon Apr 28 | at Nationals | W19-5 | 20-9 | .690 | Nationals Park · Washington, D.C. |
| 30 | Tue Apr 29 | vs D-backs | W8-3 | 21-9 | .700 | Citi Field · Queens, NY |
| 31 | Wed Apr 30 | vs D-backs | L3-4 | 21-10 | .677 | Citi Field · Queens, NY |
| 32 | Thu May 1 | vs D-backs | L2-4 | 21-11 | .656 | Citi Field · Queens, NY |
| 33 | Fri May 2 | at Cardinals | W9-3 | 22-11 | .667 | Busch Stadium · St. Louis, MO |
| 34 | Sun May 4 | at Cardinals | L5-6 | 22-12 | .647 | Busch Stadium · St. Louis, MO |
| 35 | Sun May 4 | at Cardinals | L4-5 | 22-13 | .629 | Busch Stadium · St. Louis, MO |
| 36 | Mon May 5 | at D-backs | W5-4 | 23-13 | .639 | Chase Field · Phoenix, AZ |
| 37 | Tue May 6 | at D-backs | L1-5 | 23-14 | .622 | Chase Field · Phoenix, AZ |
| 38 | Wed May 7 | at D-backs | W7-1 | 24-14 | .632 | Chase Field · Phoenix, AZ |
| 39 | Fri May 9 | vs Cubs | W7-2 | 25-14 | .641 | Citi Field · Queens, NY |
| 40 | Sat May 10 | vs Cubs | L5-6 | 25-15 | .625 | Citi Field · Queens, NY |
| 41 | Sun May 11 | vs Cubs | W6-2 | 26-15 | .634 | Citi Field · Queens, NY |
| 42 | Mon May 12 | vs Pirates | W4-3 | 27-15 | .643 | Citi Field · Queens, NY |
| 43 | Tue May 13 | vs Pirates | W2-1 | 28-15 | .651 | Citi Field · Queens, NY |
| 44 | Wed May 14 | vs Pirates | L0-4 | 28-16 | .636 | Citi Field · Queens, NY |
| 45 | Fri May 16 | at Yankees | L2-6 | 28-17 | .622 | Yankee Stadium · The Bronx, NY |
| 46 | Sat May 17 | at Yankees | W3-2 | 29-17 | .630 | Yankee Stadium · The Bronx, NY |
| 47 | Sun May 18 | at Yankees | L2-8 | 29-18 | .617 | Yankee Stadium · The Bronx, NY |
| 48 | Mon May 19 | at Red Sox | L1-3 | 29-19 | .604 | Fenway Park · Boston, MA |
| 49 | Tue May 20 | at Red Sox | L0-2 | 29-20 | .592 | Fenway Park · Boston, MA |
| 50 | Wed May 21 | at Red Sox | W5-1 | 30-20 | .600 | Fenway Park · Boston, MA |
| 51 | Fri May 23 | vs Dodgers | L5-7 (13) | 30-21 | .588 | Citi Field · Queens, NY |
| 52 | Sat May 24 | vs Dodgers | W5-2 | 31-21 | .596 | Citi Field · Queens, NY |
| 53 | Sun May 25 | vs Dodgers | W3-1 | 32-21 | .604 | Citi Field · Queens, NY |
| 54 | Mon May 26 | vs White Sox | W2-1 | 33-21 | .611 | Citi Field · Queens, NY |
| 55 | Tue May 27 | vs White Sox | W6-4 | 34-21 | .618 | Citi Field · Queens, NY |
| 56 | Wed May 28 | vs White Sox | L4-9 | 34-22 | .607 | Citi Field · Queens, NY |
| 57 | Fri May 30 | vs Rockies | W4-2 | 35-22 | .614 | Citi Field · Queens, NY |
| 58 | Sat May 31 | vs Rockies | W8-2 | 36-22 | .621 | Citi Field · Queens, NY |
| 59 | Sun Jun 1 | vs Rockies | W5-3 | 37-22 | .627 | Citi Field · Queens, NY |
| 60 | Mon Jun 2 | at Dodgers | W4-3 (10) | 38-22 | .633 | Dodger Stadium · Los Angeles, CA |
| 61 | Tue Jun 3 | at Dodgers | L5-6 (10) | 38-23 | .623 | Dodger Stadium · Los Angeles, CA |
| 62 | Wed Jun 4 | at Dodgers | W6-1 | 39-23 | .629 | Dodger Stadium · Los Angeles, CA |
| 63 | Thu Jun 5 | at Dodgers | L5-6 | 39-24 | .619 | Dodger Stadium · Los Angeles, CA |
| 64 | Fri Jun 6 | at Rockies | W4-2 | 40-24 | .625 | Coors Field · Denver, CO |
| 65 | Sat Jun 7 | at Rockies | W8-1 | 41-24 | .631 | Coors Field · Denver, CO |
| 66 | Sun Jun 8 | at Rockies | W13-5 | 42-24 | .636 | Coors Field · Denver, CO |
| 67 | Tue Jun 10 | vs Nationals | W5-4 (10) | 43-24 | .642 | Citi Field · Queens, NY |
| 68 | Wed Jun 11 | vs Nationals | W5-0 | 44-24 | .647 | Citi Field · Queens, NY |
| 69 | Thu Jun 12 | vs Nationals | W4-3 | 45-24 | .652 | Citi Field · Queens, NY |
| 70 | Fri Jun 13 | vs Rays | L5-7 | 45-25 | .643 | Citi Field · Queens, NY |
| 71 | Sat Jun 14 | vs Rays | L4-8 | 45-26 | .634 | Citi Field · Queens, NY |
| 72 | Sun Jun 15 | vs Rays | L0-9 | 45-27 | .625 | Citi Field · Queens, NY |
| 73 | Tue Jun 17 | at Braves | L4-5 (10) | 45-28 | .616 | Truist Park · Cumberland, GA |
| 74 | Wed Jun 18 | at Braves | L0-5 | 45-29 | .608 | Truist Park · Cumberland, GA |
| 75 | Thu Jun 19 | at Braves | L1-7 | 45-30 | .600 | Truist Park · Cumberland, GA |
| 76 | Fri Jun 20 | at Phillies | L2-10 | 45-31 | .592 | Citizens Bank Park · Philadelphi, PA |
| 77 | Sat Jun 21 | at Phillies | W11-4 | 46-31 | .597 | Citizens Bank Park · Philadelphi, PA |
| 78 | Sun Jun 22 | at Phillies | L1-7 | 46-32 | .590 | Citizens Bank Park · Philadelphi, PA |
| 79 | Mon Jun 23 | vs Braves | L2-3 | 46-33 | .582 | Citi Field · Queens, NY |
| 80 | Tue Jun 24 | vs Braves | L4-7 | 46-34 | .575 | Citi Field · Queens, NY |
| 81 | Wed Jun 25 | vs Braves | W7-3 | 47-34 | .580 | Citi Field · Queens, NY |
| 82 | Thu Jun 26 | vs Braves | W4-0 | 48-34 | .585 | Citi Field · Queens, NY |
| 83 | Fri Jun 27 | at Pirates | L1-9 | 48-35 | .578 | PNC Park · Pittsburgh, PA |
| 84 | Sat Jun 28 | at Pirates | L2-9 | 48-36 | .571 | PNC Park · Pittsburgh, PA |
| 85 | Sun Jun 29 | at Pirates | L1-12 | 48-37 | .565 | PNC Park · Pittsburgh, PA |
| 86 | Wed Jul 2 | vs Brewers | L2-7 | 48-38 | .558 | Citi Field · Queens, NY |
| 87 | Wed Jul 2 | vs Brewers | W7-3 | 49-38 | .563 | Citi Field · Queens, NY |
| 88 | Thu Jul 3 | vs Brewers | W3-2 | 50-38 | .568 | Citi Field · Queens, NY |
| 89 | Fri Jul 4 | vs Yankees | W6-5 | 51-38 | .573 | Citi Field · Queens, NY |
| 90 | Sat Jul 5 | vs Yankees | W12-6 | 52-38 | .578 | Citi Field · Queens, NY |
| 91 | Sun Jul 6 | vs Yankees | L4-6 | 52-39 | .571 | Citi Field · Queens, NY |
| 92 | Tue Jul 8 | at Orioles | W7-6 (10) | 53-39 | .576 | Camden Yards · Baltimore, MD |
| 93 | Thu Jul 10 | at Orioles | L1-3 | 53-40 | .570 | Camden Yards · Baltimore, MD |
| 94 | Thu Jul 10 | at Orioles | L3-7 | 53-41 | .564 | Camden Yards · Baltimore, MD |
| 95 | Fri Jul 11 | at Royals | W8-3 | 54-41 | .568 | Kauffman Stadium · Kansas City, MO |
| 96 | Sat Jul 12 | at Royals | W3-1 | 55-41 | .573 | Kauffman Stadium · Kansas City, MO |
| 97 | Sun Jul 13 | at Royals | L2-3 | 55-42 | .567 | Kauffman Stadium · Kansas City, MO |
| 98 | Fri Jul 18 | vs Reds | L4-8 | 55-43 | .561 | Citi Field · Queens, NY |
| 99 | Sat Jul 19 | vs Reds | L2-5 | 55-44 | .556 | Citi Field · Queens, NY |
| 100 | Sun Jul 20 | vs Reds | W3-2 | 56-44 | .560 | Citi Field · Queens, NY |
| 101 | Mon Jul 21 | vs Angels | W7-5 | 57-44 | .564 | Citi Field · Queens, NY |
| 102 | Tue Jul 22 | vs Angels | W3-2 | 58-44 | .569 | Citi Field · Queens, NY |
| 103 | Wed Jul 23 | vs Angels | W6-3 | 59-44 | .573 | Citi Field · Queens, NY |
| 104 | Fri Jul 25 | at Giants | W8-1 | 60-44 | .577 | Oracle Park · San Francisco, CA |
| 105 | Sat Jul 26 | at Giants | W2-1 | 61-44 | .581 | Oracle Park · San Francisco, CA |
| 106 | Sun Jul 27 | at Giants | W5-3 | 62-44 | .585 | Oracle Park · San Francisco, CA |
| 107 | Mon Jul 28 | at Padres | L6-7 | 62-45 | .579 | Petco Park · San Diego, CA |
| 108 | Tue Jul 29 | at Padres | L1-7 | 62-46 | .574 | Petco Park · San Diego, CA |
| 109 | Wed Jul 30 | at Padres | L0-5 | 62-47 | .569 | Petco Park · San Diego, CA |
| 110 | Fri Aug 1 | vs Giants | L3-4 (10) | 62-48 | .564 | Citi Field · Queens, NY |
| 111 | Sat Aug 2 | vs Giants | W12-6 | 63-48 | .568 | Citi Field · Queens, NY |
| 112 | Sun Aug 3 | vs Giants | L4-12 | 63-49 | .563 | Citi Field · Queens, NY |
| 113 | Mon Aug 4 | vs Guardians | L6-7 (10) | 63-50 | .558 | Citi Field · Queens, NY |
| 114 | Tue Aug 5 | vs Guardians | L2-3 | 63-51 | .553 | Citi Field · Queens, NY |
| 115 | Wed Aug 6 | vs Guardians | L1-4 | 63-52 | .548 | Citi Field · Queens, NY |
| 116 | Fri Aug 8 | at Brewers | L2-3 | 63-53 | .543 | American Family Field · Milwaukee, WI |
| 117 | Sat Aug 9 | at Brewers | L4-7 | 63-54 | .538 | American Family Field · Milwaukee, WI |
| 118 | Sun Aug 10 | at Brewers | L6-7 | 63-55 | .534 | American Family Field · Milwaukee, WI |
| 119 | Tue Aug 12 | vs Braves | W13-5 | 64-55 | .538 | Citi Field · Queens, NY |
| 120 | Wed Aug 13 | vs Braves | L6-11 | 64-56 | .533 | Citi Field · Queens, NY |
| 121 | Thu Aug 14 | vs Braves | L3-4 | 64-57 | .529 | Citi Field · Queens, NY |
| 122 | Fri Aug 15 | vs Mariners | L9-11 | 64-58 | .525 | Citi Field · Queens, NY |
| 123 | Sat Aug 16 | vs Mariners | W3-1 | 65-58 | .528 | Citi Field · Queens, NY |
| 124 | Sun Aug 17 | vs Mariners | W7-3 | 66-58 | .532 | Citi Field · Queens, NY |
| 125 | Tue Aug 19 | at Nationals | W8-1 | 67-58 | .536 | Nationals Park · Washington, D.C. |
| 126 | Wed Aug 20 | at Nationals | L4-5 | 67-59 | .532 | Nationals Park · Washington, D.C. |
| 127 | Thu Aug 21 | at Nationals | L3-9 | 67-60 | .528 | Nationals Park · Washington, D.C. |
| 128 | Fri Aug 22 | at Braves | W12-7 | 68-60 | .531 | Truist Park · Cumberland, GA |
| 129 | Sat Aug 23 | at Braves | W9-2 | 69-60 | .535 | Truist Park · Cumberland, GA |
| 130 | Sun Aug 24 | at Braves | L3-4 | 69-61 | .531 | Truist Park · Cumberland, GA |
| 131 | Mon Aug 25 | vs Phillies | W13-3 | 70-61 | .534 | Citi Field · Queens, NY |
| 132 | Tue Aug 26 | vs Phillies | W6-5 | 71-61 | .538 | Citi Field · Queens, NY |
| 133 | Wed Aug 27 | vs Phillies | W6-0 | 72-61 | .541 | Citi Field · Queens, NY |
| 134 | Thu Aug 28 | vs Marlins | L4-7 | 72-62 | .537 | Citi Field · Queens, NY |
| 135 | Fri Aug 29 | vs Marlins | W19-9 | 73-62 | .541 | Citi Field · Queens, NY |
| 136 | Sat Aug 30 | vs Marlins | L8-11 | 73-63 | .537 | Citi Field · Queens, NY |
| 137 | Sun Aug 31 | vs Marlins | L1-5 | 73-64 | .533 | Citi Field · Queens, NY |
| 138 | Mon Sep 1 | at Tigers | W10-8 | 74-64 | .536 | Comerica Park · Detroit, MI |
| 139 | Tue Sep 2 | at Tigers | W12-5 | 75-64 | .540 | Comerica Park · Detroit, MI |
| 140 | Wed Sep 3 | at Tigers | L2-6 | 75-65 | .536 | Comerica Park · Detroit, MI |
| 141 | Fri Sep 5 | at Reds | W5-4 | 76-65 | .539 | Great American Ball Park · Cincinnati, OH |
| 142 | Sat Sep 6 | at Reds | L3-6 | 76-66 | .535 | Great American Ball Park · Cincinnati, OH |
| 143 | Sun Sep 7 | at Reds | L2-3 | 76-67 | .531 | Great American Ball Park · Cincinnati, OH |
| 144 | Mon Sep 8 | at Phillies | L0-1 | 76-68 | .528 | Citizens Bank Park · Philadelphi, PA |
| 145 | Tue Sep 9 | at Phillies | L3-9 | 76-69 | .524 | Citizens Bank Park · Philadelphi, PA |
| 146 | Wed Sep 10 | at Phillies | L3-11 | 76-70 | .521 | Citizens Bank Park · Philadelphi, PA |
| 147 | Thu Sep 11 | at Phillies | L4-6 | 76-71 | .517 | Citizens Bank Park · Philadelphi, PA |
| 148 | Fri Sep 12 | vs Rangers | L3-8 | 76-72 | .514 | Citi Field · Queens, NY |
| 149 | Sat Sep 13 | vs Rangers | L2-3 | 76-73 | .510 | Citi Field · Queens, NY |
| 150 | Sun Sep 14 | vs Rangers | W5-2 (10) | 77-73 | .513 | Citi Field · Queens, NY |
| 151 | Tue Sep 16 | vs Padres | W8-3 | 78-73 | .517 | Citi Field · Queens, NY |
| 152 | Wed Sep 17 | vs Padres | L4-7 | 78-74 | .513 | Citi Field · Queens, NY |
| 153 | Thu Sep 18 | vs Padres | W6-1 | 79-74 | .516 | Citi Field · Queens, NY |
| 154 | Fri Sep 19 | vs Nationals | W12-6 | 80-74 | .519 | Citi Field · Queens, NY |
| 155 | Sat Sep 20 | vs Nationals | L3-5 (11) | 80-75 | .516 | Citi Field · Queens, NY |
| 156 | Sun Sep 21 | vs Nationals | L2-3 | 80-76 | .513 | Citi Field · Queens, NY |
| 157 | Tue Sep 23 | at Cubs | W9-7 | 81-76 | .516 | Wrigley Field · Chicago, IL |
| 158 | Wed Sep 24 | at Cubs | L3-10 | 81-77 | .513 | Wrigley Field · Chicago, IL |
| 159 | Thu Sep 25 | at Cubs | W8-5 | 82-77 | .516 | Wrigley Field · Chicago, IL |
| 160 | Fri Sep 26 | at Marlins | L2-6 | 82-78 | .512 | LoanDepot Park · Miami, FL |
| 161 | Sat Sep 27 | at Marlins | W5-0 | 83-78 | .516 | LoanDepot Park · Miami, FL |
| 162 | Sun Sep 28 | at Marlins | L0-4 | 83-79 | .512 | LoanDepot Park · Miami, FL |