| 1 | Thu Apr 5 | vs Braves | W1-0 | 1-0 | 1.000 | Citi Field · Queens, NY |
| 2 | Sat Apr 7 | vs Braves | W4-2 | 2-0 | 1.000 | Citi Field · Queens, NY |
| 3 | Sun Apr 8 | vs Braves | W7-5 | 3-0 | 1.000 | Citi Field · Queens, NY |
| 4 | Mon Apr 9 | vs Nationals | W4-3 | 4-0 | 1.000 | Citi Field · Queens, NY |
| 5 | Tue Apr 10 | vs Nationals | L2-6 | 4-1 | .800 | Citi Field · Queens, NY |
| 6 | Wed Apr 11 | vs Nationals | L0-4 | 4-2 | .667 | Citi Field · Queens, NY |
| 7 | Fri Apr 13 | at Phillies | W5-2 | 5-2 | .714 | Citizens Bank Park · Philadelphi, PA |
| 8 | Sat Apr 14 | at Phillies | W5-0 | 6-2 | .750 | Citizens Bank Park · Philadelphi, PA |
| 9 | Sun Apr 15 | at Phillies | L2-8 | 6-3 | .667 | Citizens Bank Park · Philadelphi, PA |
| 10 | Mon Apr 16 | at Braves | W6-1 | 7-3 | .700 | Truist Park · Cumberland, GA |
| 11 | Tue Apr 17 | at Braves | L3-9 | 7-4 | .636 | Truist Park · Cumberland, GA |
| 12 | Wed Apr 18 | at Braves | L6-14 | 7-5 | .583 | Truist Park · Cumberland, GA |
| 13 | Fri Apr 20 | vs Giants | L3-4 (10) | 7-6 | .538 | Citi Field · Queens, NY |
| 14 | Sat Apr 21 | vs Giants | W5-4 | 8-6 | .571 | Citi Field · Queens, NY |
| 15 | Mon Apr 23 | vs Giants | L1-6 | 8-7 | .533 | Citi Field · Queens, NY |
| 16 | Mon Apr 23 | vs Giants | L2-7 | 8-8 | .500 | Citi Field · Queens, NY |
| 17 | Tue Apr 24 | vs Marlins | W2-1 | 9-8 | .529 | Citi Field · Queens, NY |
| 18 | Wed Apr 25 | vs Marlins | W5-1 | 10-8 | .556 | Citi Field · Queens, NY |
| 19 | Thu Apr 26 | vs Marlins | W3-2 | 11-8 | .579 | Citi Field · Queens, NY |
| 20 | Fri Apr 27 | at Rockies | L9-18 | 11-9 | .550 | Coors Field · Denver, CO |
| 21 | Sat Apr 28 | at Rockies | W7-5 | 12-9 | .571 | Coors Field · Denver, CO |
| 22 | Sun Apr 29 | at Rockies | W6-5 (11) | 13-9 | .591 | Coors Field · Denver, CO |
| 23 | Mon Apr 30 | at Astros | L3-4 | 13-10 | .565 | Minute Maid Park · Houston, TX |
| 24 | Tue May 1 | at Astros | L3-6 | 13-11 | .542 | Minute Maid Park · Houston, TX |
| 25 | Wed May 2 | at Astros | L1-8 | 13-12 | .520 | Minute Maid Park · Houston, TX |
| 26 | Fri May 4 | vs D-backs | L4-5 | 13-13 | .500 | Citi Field · Queens, NY |
| 27 | Sat May 5 | vs D-backs | W4-3 | 14-13 | .519 | Citi Field · Queens, NY |
| 28 | Sun May 6 | vs D-backs | W3-1 | 15-13 | .536 | Citi Field · Queens, NY |
| 29 | Mon May 7 | at Phillies | W5-2 | 16-13 | .552 | Citizens Bank Park · Philadelphi, PA |
| 30 | Tue May 8 | at Phillies | W7-4 | 17-13 | .567 | Citizens Bank Park · Philadelphi, PA |
| 31 | Wed May 9 | at Phillies | W10-6 | 18-13 | .581 | Citizens Bank Park · Philadelphi, PA |
| 32 | Fri May 11 | at Marlins | L5-6 | 18-14 | .563 | LoanDepot Park · Miami, FL |
| 33 | Sat May 12 | at Marlins | W9-3 | 19-14 | .576 | LoanDepot Park · Miami, FL |
| 34 | Sun May 13 | at Marlins | L4-8 | 19-15 | .559 | LoanDepot Park · Miami, FL |
| 35 | Mon May 14 | vs Brewers | W3-1 | 20-15 | .571 | Citi Field · Queens, NY |
| 36 | Tue May 15 | vs Brewers | L0-8 | 20-16 | .556 | Citi Field · Queens, NY |
| 37 | Wed May 16 | vs Reds | L3-6 | 20-17 | .541 | Citi Field · Queens, NY |
| 38 | Thu May 17 | vs Reds | W9-4 | 21-17 | .553 | Citi Field · Queens, NY |
| 39 | Fri May 18 | at Blue Jays | L5-14 | 21-18 | .538 | Rogers Centre · Toronto, ON |
| 40 | Sat May 19 | at Blue Jays | L0-2 | 21-19 | .525 | Rogers Centre · Toronto, ON |
| 41 | Sun May 20 | at Blue Jays | W6-5 | 22-19 | .537 | Rogers Centre · Toronto, ON |
| 42 | Mon May 21 | at Pirates | L4-5 | 22-20 | .524 | PNC Park · Pittsburgh, PA |
| 43 | Tue May 22 | at Pirates | W3-2 | 23-20 | .535 | PNC Park · Pittsburgh, PA |
| 44 | Wed May 23 | at Pirates | W3-1 | 24-20 | .545 | PNC Park · Pittsburgh, PA |
| 45 | Thu May 24 | vs Padres | L5-11 | 24-21 | .533 | Citi Field · Queens, NY |
| 46 | Fri May 25 | vs Padres | W6-1 | 25-21 | .543 | Citi Field · Queens, NY |
| 47 | Sat May 26 | vs Padres | W9-0 | 26-21 | .553 | Citi Field · Queens, NY |
| 48 | Sun May 27 | vs Padres | W2-0 | 27-21 | .563 | Citi Field · Queens, NY |
| 49 | Mon May 28 | vs Phillies | L4-8 | 27-22 | .551 | Citi Field · Queens, NY |
| 50 | Tue May 29 | vs Phillies | W6-3 | 28-22 | .560 | Citi Field · Queens, NY |
| 51 | Wed May 30 | vs Phillies | L6-10 | 28-23 | .549 | Citi Field · Queens, NY |
| 52 | Fri Jun 1 | vs Cardinals | W8-0 | 29-23 | .558 | Citi Field · Queens, NY |
| 53 | Sat Jun 2 | vs Cardinals | W5-0 | 30-23 | .566 | Citi Field · Queens, NY |
| 54 | Sun Jun 3 | vs Cardinals | W6-1 | 31-23 | .574 | Citi Field · Queens, NY |
| 55 | Mon Jun 4 | vs Cardinals | L4-5 | 31-24 | .564 | Citi Field · Queens, NY |
| 56 | Tue Jun 5 | at Nationals | L6-7 (12) | 31-25 | .554 | Nationals Park · Washington, D.C. |
| 57 | Wed Jun 6 | at Nationals | L3-5 | 31-26 | .544 | Nationals Park · Washington, D.C. |
| 58 | Thu Jun 7 | at Nationals | W3-1 | 32-26 | .552 | Nationals Park · Washington, D.C. |
| 59 | Fri Jun 8 | at Yankees | L1-9 | 32-27 | .542 | Yankee Stadium · The Bronx, NY |
| 60 | Sat Jun 9 | at Yankees | L2-4 | 32-28 | .533 | Yankee Stadium · The Bronx, NY |
| 61 | Sun Jun 10 | at Yankees | L4-5 | 32-29 | .525 | Yankee Stadium · The Bronx, NY |
| 62 | Tue Jun 12 | at Rays | W11-2 | 33-29 | .532 | Tropicana Field · St. Petersburg, FL |
| 63 | Wed Jun 13 | at Rays | W9-1 | 34-29 | .540 | Tropicana Field · St. Petersburg, FL |
| 64 | Thu Jun 14 | at Rays | W9-6 | 35-29 | .547 | Tropicana Field · St. Petersburg, FL |
| 65 | Fri Jun 15 | vs Reds | L3-7 | 35-30 | .538 | Citi Field · Queens, NY |
| 66 | Sat Jun 16 | vs Reds | L1-4 | 35-31 | .530 | Citi Field · Queens, NY |
| 67 | Sun Jun 17 | vs Reds | L1-3 | 35-32 | .522 | Citi Field · Queens, NY |
| 68 | Mon Jun 18 | vs Orioles | W5-0 | 36-32 | .529 | Citi Field · Queens, NY |
| 69 | Tue Jun 19 | vs Orioles | W5-0 | 37-32 | .536 | Citi Field · Queens, NY |
| 70 | Wed Jun 20 | vs Orioles | W4-3 | 38-32 | .543 | Citi Field · Queens, NY |
| 71 | Fri Jun 22 | vs Yankees | W6-4 | 39-32 | .549 | Citi Field · Queens, NY |
| 72 | Sat Jun 23 | vs Yankees | L3-4 | 39-33 | .542 | Citi Field · Queens, NY |
| 73 | Sun Jun 24 | vs Yankees | L5-6 | 39-34 | .534 | Citi Field · Queens, NY |
| 74 | Mon Jun 25 | at Cubs | L1-6 | 39-35 | .527 | Wrigley Field · Chicago, IL |
| 75 | Tue Jun 26 | at Cubs | L3-5 | 39-36 | .520 | Wrigley Field · Chicago, IL |
| 76 | Wed Jun 27 | at Cubs | W17-1 | 40-36 | .526 | Wrigley Field · Chicago, IL |
| 77 | Thu Jun 28 | at Dodgers | W3-2 | 41-36 | .532 | Dodger Stadium · Los Angeles, CA |
| 78 | Fri Jun 29 | at Dodgers | W9-0 | 42-36 | .538 | Dodger Stadium · Los Angeles, CA |
| 79 | Sat Jun 30 | at Dodgers | W5-0 | 43-36 | .544 | Dodger Stadium · Los Angeles, CA |
| 80 | Sun Jul 1 | at Dodgers | L3-8 | 43-37 | .537 | Dodger Stadium · Los Angeles, CA |
| 81 | Tue Jul 3 | vs Phillies | W11-1 | 44-37 | .543 | Citi Field · Queens, NY |
| 82 | Wed Jul 4 | vs Phillies | L2-9 | 44-38 | .537 | Citi Field · Queens, NY |
| 83 | Thu Jul 5 | vs Phillies | W6-5 | 45-38 | .542 | Citi Field · Queens, NY |
| 84 | Fri Jul 6 | vs Cubs | L7-8 | 45-39 | .536 | Citi Field · Queens, NY |
| 85 | Sat Jul 7 | vs Cubs | W3-1 | 46-39 | .541 | Citi Field · Queens, NY |
| 86 | Sun Jul 8 | vs Cubs | L0-7 | 46-40 | .535 | Citi Field · Queens, NY |
| 87 | Fri Jul 13 | at Braves | L5-7 | 46-41 | .529 | Truist Park · Cumberland, GA |
| 88 | Sat Jul 14 | at Braves | L7-8 | 46-42 | .523 | Truist Park · Cumberland, GA |
| 89 | Sun Jul 15 | at Braves | L1-6 | 46-43 | .517 | Truist Park · Cumberland, GA |
| 90 | Tue Jul 17 | at Nationals | L4-5 (10) | 46-44 | .511 | Nationals Park · Washington, D.C. |
| 91 | Wed Jul 18 | at Nationals | L3-4 | 46-45 | .505 | Nationals Park · Washington, D.C. |
| 92 | Thu Jul 19 | at Nationals | W9-5 | 47-45 | .511 | Nationals Park · Washington, D.C. |
| 93 | Fri Jul 20 | vs Dodgers | L6-7 | 47-46 | .505 | Citi Field · Queens, NY |
| 94 | Sat Jul 21 | vs Dodgers | L5-8 | 47-47 | .500 | Citi Field · Queens, NY |
| 95 | Sun Jul 22 | vs Dodgers | L3-8 (12) | 47-48 | .495 | Citi Field · Queens, NY |
| 96 | Mon Jul 23 | vs Nationals | L2-8 (10) | 47-49 | .490 | Citi Field · Queens, NY |
| 97 | Tue Jul 24 | vs Nationals | L2-5 | 47-50 | .485 | Citi Field · Queens, NY |
| 98 | Wed Jul 25 | vs Nationals | L2-5 | 47-51 | .480 | Citi Field · Queens, NY |
| 99 | Thu Jul 26 | at D-backs | W3-1 | 48-51 | .485 | Chase Field · Phoenix, AZ |
| 100 | Fri Jul 27 | at D-backs | L5-11 | 48-52 | .480 | Chase Field · Phoenix, AZ |
| 101 | Sat Jul 28 | at D-backs | L3-6 | 48-53 | .475 | Chase Field · Phoenix, AZ |
| 102 | Sun Jul 29 | at D-backs | W5-1 | 49-53 | .480 | Chase Field · Phoenix, AZ |
| 103 | Mon Jul 30 | at Giants | W8-7 (10) | 50-53 | .485 | Oracle Park · San Francisco, CA |
| 104 | Tue Jul 31 | at Giants | L1-4 | 50-54 | .481 | Oracle Park · San Francisco, CA |
| 105 | Wed Aug 1 | at Giants | W2-1 | 51-54 | .486 | Oracle Park · San Francisco, CA |
| 106 | Thu Aug 2 | at Giants | W9-1 | 52-54 | .491 | Oracle Park · San Francisco, CA |
| 107 | Fri Aug 3 | at Padres | L1-3 | 52-55 | .486 | Petco Park · San Diego, CA |
| 108 | Sat Aug 4 | at Padres | W6-2 | 53-55 | .491 | Petco Park · San Diego, CA |
| 109 | Sun Aug 5 | at Padres | L3-7 | 53-56 | .486 | Petco Park · San Diego, CA |
| 110 | Tue Aug 7 | vs Marlins | L2-4 | 53-57 | .482 | Citi Field · Queens, NY |
| 111 | Wed Aug 8 | vs Marlins | L0-13 | 53-58 | .477 | Citi Field · Queens, NY |
| 112 | Thu Aug 9 | vs Marlins | W6-1 | 54-58 | .482 | Citi Field · Queens, NY |
| 113 | Fri Aug 10 | vs Braves | L0-4 | 54-59 | .478 | Citi Field · Queens, NY |
| 114 | Sat Aug 11 | vs Braves | L3-9 | 54-60 | .474 | Citi Field · Queens, NY |
| 115 | Sun Aug 12 | vs Braves | W6-5 | 55-60 | .478 | Citi Field · Queens, NY |
| 116 | Tue Aug 14 | at Reds | L0-3 | 55-61 | .474 | Great American Ball Park · Cincinnati, OH |
| 117 | Wed Aug 15 | at Reds | L1-6 | 55-62 | .470 | Great American Ball Park · Cincinnati, OH |
| 118 | Thu Aug 16 | at Reds | W8-4 | 56-62 | .475 | Great American Ball Park · Cincinnati, OH |
| 119 | Fri Aug 17 | at Nationals | L4-6 | 56-63 | .471 | Nationals Park · Washington, D.C. |
| 120 | Sat Aug 18 | at Nationals | W2-0 | 57-63 | .475 | Nationals Park · Washington, D.C. |
| 121 | Sun Aug 19 | at Nationals | L2-5 | 57-64 | .471 | Nationals Park · Washington, D.C. |
| 122 | Mon Aug 20 | vs Rockies | L1-3 | 57-65 | .467 | Citi Field · Queens, NY |
| 123 | Tue Aug 21 | vs Rockies | L2-6 | 57-66 | .463 | Citi Field · Queens, NY |
| 124 | Wed Aug 22 | vs Rockies | L2-5 | 57-67 | .460 | Citi Field · Queens, NY |
| 125 | Thu Aug 23 | vs Rockies | L0-1 | 57-68 | .456 | Citi Field · Queens, NY |
| 126 | Fri Aug 24 | vs Astros | L1-3 | 57-69 | .452 | Citi Field · Queens, NY |
| 127 | Sat Aug 25 | vs Astros | W3-1 | 58-69 | .457 | Citi Field · Queens, NY |
| 128 | Sun Aug 26 | vs Astros | W2-1 | 59-69 | .461 | Citi Field · Queens, NY |
| 129 | Tue Aug 28 | at Phillies | W9-5 (10) | 60-69 | .465 | Citizens Bank Park · Philadelphi, PA |
| 130 | Wed Aug 29 | at Phillies | W3-2 | 61-69 | .469 | Citizens Bank Park · Philadelphi, PA |
| 131 | Thu Aug 30 | at Phillies | L2-3 | 61-70 | .466 | Citizens Bank Park · Philadelphi, PA |
| 132 | Fri Aug 31 | at Marlins | W3-0 | 62-70 | .470 | LoanDepot Park · Miami, FL |
| 133 | Sat Sep 1 | at Marlins | W5-3 | 63-70 | .474 | LoanDepot Park · Miami, FL |
| 134 | Sun Sep 2 | at Marlins | W5-1 | 64-70 | .478 | LoanDepot Park · Miami, FL |
| 135 | Mon Sep 3 | at Cardinals | L4-5 | 64-71 | .474 | Busch Stadium · St. Louis, MO |
| 136 | Tue Sep 4 | at Cardinals | L1-5 | 64-72 | .471 | Busch Stadium · St. Louis, MO |
| 137 | Wed Sep 5 | at Cardinals | W6-2 | 65-72 | .474 | Busch Stadium · St. Louis, MO |
| 138 | Fri Sep 7 | vs Braves | L0-3 | 65-73 | .471 | Citi Field · Queens, NY |
| 139 | Sat Sep 8 | vs Braves | L3-11 | 65-74 | .468 | Citi Field · Queens, NY |
| 140 | Sun Sep 9 | vs Braves | L2-3 (10) | 65-75 | .464 | Citi Field · Queens, NY |
| 141 | Mon Sep 10 | vs Nationals | L1-5 | 65-76 | .461 | Citi Field · Queens, NY |
| 142 | Tue Sep 11 | vs Nationals | L3-5 | 65-77 | .458 | Citi Field · Queens, NY |
| 143 | Wed Sep 12 | vs Nationals | L0-2 | 65-78 | .455 | Citi Field · Queens, NY |
| 144 | Fri Sep 14 | at Brewers | W7-3 | 66-78 | .458 | American Family Field · Milwaukee, WI |
| 145 | Sat Sep 15 | at Brewers | L6-9 | 66-79 | .455 | American Family Field · Milwaukee, WI |
| 146 | Sun Sep 16 | at Brewers | L0-3 | 66-80 | .452 | American Family Field · Milwaukee, WI |
| 147 | Mon Sep 17 | vs Phillies | L1-3 | 66-81 | .449 | Citi Field · Queens, NY |
| 148 | Wed Sep 19 | vs Phillies | L2-3 | 66-82 | .446 | Citi Field · Queens, NY |
| 149 | Thu Sep 20 | vs Phillies | L1-16 | 66-83 | .443 | Citi Field · Queens, NY |
| 150 | Fri Sep 21 | vs Marlins | W7-3 | 67-83 | .447 | Citi Field · Queens, NY |
| 151 | Sat Sep 22 | vs Marlins | W4-3 | 68-83 | .450 | Citi Field · Queens, NY |
| 152 | Sun Sep 23 | vs Marlins | W3-2 | 69-83 | .454 | Citi Field · Queens, NY |
| 153 | Mon Sep 24 | vs Pirates | W6-2 | 70-83 | .458 | Citi Field · Queens, NY |
| 154 | Tue Sep 25 | vs Pirates | L6-10 | 70-84 | .455 | Citi Field · Queens, NY |
| 155 | Wed Sep 26 | vs Pirates | W6-0 | 71-84 | .458 | Citi Field · Queens, NY |
| 156 | Thu Sep 27 | vs Pirates | W6-5 | 72-84 | .462 | Citi Field · Queens, NY |
| 157 | Fri Sep 28 | at Braves | W3-1 | 73-84 | .465 | Truist Park · Cumberland, GA |
| 158 | Sat Sep 29 | at Braves | L0-2 | 73-85 | .462 | Truist Park · Cumberland, GA |
| 159 | Sun Sep 30 | at Braves | L2-6 | 73-86 | .459 | Truist Park · Cumberland, GA |
| 160 | Mon Oct 1 | at Marlins | L2-3 | 73-87 | .456 | LoanDepot Park · Miami, FL |
| 161 | Tue Oct 2 | at Marlins | L3-4 (11) | 73-88 | .453 | LoanDepot Park · Miami, FL |
| 162 | Wed Oct 3 | at Marlins | W4-2 | 74-88 | .457 | LoanDepot Park · Miami, FL |