| 1 | Sun Apr 3 | at Royals | L3-4 | 0-1 | .000 | Kauffman Stadium · Kansas City, MO |
| 2 | Tue Apr 5 | at Royals | W2-0 | 1-1 | .500 | Kauffman Stadium · Kansas City, MO |
| 3 | Fri Apr 8 | vs Phillies | W7-2 | 2-1 | .667 | Citi Field · Queens, NY |
| 4 | Sat Apr 9 | vs Phillies | L0-1 | 2-2 | .500 | Citi Field · Queens, NY |
| 5 | Sun Apr 10 | vs Phillies | L2-5 | 2-3 | .400 | Citi Field · Queens, NY |
| 6 | Mon Apr 11 | vs Marlins | L3-10 | 2-4 | .333 | Citi Field · Queens, NY |
| 7 | Tue Apr 12 | vs Marlins | L1-2 | 2-5 | .286 | Citi Field · Queens, NY |
| 8 | Wed Apr 13 | vs Marlins | W2-1 | 3-5 | .375 | Citi Field · Queens, NY |
| 9 | Fri Apr 15 | at Guardians | W6-5 | 4-5 | .444 | Progressive Field · Cleveland, OH |
| 10 | Sat Apr 16 | at Guardians | L5-7 | 4-6 | .400 | Progressive Field · Cleveland, OH |
| 11 | Sun Apr 17 | at Guardians | W6-0 | 5-6 | .455 | Progressive Field · Cleveland, OH |
| 12 | Mon Apr 18 | at Phillies | W5-2 | 6-6 | .500 | Citizens Bank Park · Philadelphi, PA |
| 13 | Tue Apr 19 | at Phillies | W11-1 | 7-6 | .538 | Citizens Bank Park · Philadelphi, PA |
| 14 | Wed Apr 20 | at Phillies | L4-5 (11) | 7-7 | .500 | Citizens Bank Park · Philadelphi, PA |
| 15 | Fri Apr 22 | at Braves | W6-3 | 8-7 | .533 | Truist Park · Cumberland, GA |
| 16 | Sat Apr 23 | at Braves | W8-2 | 9-7 | .563 | Truist Park · Cumberland, GA |
| 17 | Sun Apr 24 | at Braves | W3-2 | 10-7 | .588 | Truist Park · Cumberland, GA |
| 18 | Mon Apr 25 | vs Reds | W5-3 | 11-7 | .611 | Citi Field · Queens, NY |
| 19 | Tue Apr 26 | vs Reds | W4-3 | 12-7 | .632 | Citi Field · Queens, NY |
| 20 | Wed Apr 27 | vs Reds | W5-2 | 13-7 | .650 | Citi Field · Queens, NY |
| 21 | Fri Apr 29 | vs Giants | W13-1 | 14-7 | .667 | Citi Field · Queens, NY |
| 22 | Sat Apr 30 | vs Giants | W6-5 | 15-7 | .682 | Citi Field · Queens, NY |
| 23 | Sun May 1 | vs Giants | L1-6 | 15-8 | .652 | Citi Field · Queens, NY |
| 24 | Mon May 2 | vs Braves | W4-1 | 16-8 | .667 | Citi Field · Queens, NY |
| 25 | Tue May 3 | vs Braves | L0-3 | 16-9 | .640 | Citi Field · Queens, NY |
| 26 | Wed May 4 | vs Braves | W8-0 | 17-9 | .654 | Citi Field · Queens, NY |
| 27 | Thu May 5 | at Padres | L3-5 | 17-10 | .630 | Petco Park · San Diego, CA |
| 28 | Fri May 6 | at Padres | L0-2 | 17-11 | .607 | Petco Park · San Diego, CA |
| 29 | Sat May 7 | at Padres | W6-3 | 18-11 | .621 | Petco Park · San Diego, CA |
| 30 | Sun May 8 | at Padres | W4-3 | 19-11 | .633 | Petco Park · San Diego, CA |
| 31 | Mon May 9 | at Dodgers | W4-2 | 20-11 | .645 | Dodger Stadium · Los Angeles, CA |
| 32 | Tue May 10 | at Dodgers | L2-3 | 20-12 | .625 | Dodger Stadium · Los Angeles, CA |
| 33 | Wed May 11 | at Dodgers | W4-3 | 21-12 | .636 | Dodger Stadium · Los Angeles, CA |
| 34 | Thu May 12 | at Dodgers | L0-5 | 21-13 | .618 | Dodger Stadium · Los Angeles, CA |
| 35 | Fri May 13 | at Rockies | L2-5 | 21-14 | .600 | Coors Field · Denver, CO |
| 36 | Sat May 14 | at Rockies | L4-7 | 21-15 | .583 | Coors Field · Denver, CO |
| 37 | Sun May 15 | at Rockies | L3-4 | 21-16 | .568 | Coors Field · Denver, CO |
| 38 | Tue May 17 | vs Nationals | W2-0 | 22-16 | .579 | Citi Field · Queens, NY |
| 39 | Wed May 18 | vs Nationals | L1-7 | 22-17 | .564 | Citi Field · Queens, NY |
| 40 | Thu May 19 | vs Nationals | L1-9 | 22-18 | .550 | Citi Field · Queens, NY |
| 41 | Fri May 20 | vs Brewers | W3-2 | 23-18 | .561 | Citi Field · Queens, NY |
| 42 | Sat May 21 | vs Brewers | W5-4 | 24-18 | .571 | Citi Field · Queens, NY |
| 43 | Sun May 22 | vs Brewers | W3-1 | 25-18 | .581 | Citi Field · Queens, NY |
| 44 | Mon May 23 | at Nationals | W7-1 | 26-18 | .591 | Nationals Park · Washington, D.C. |
| 45 | Tue May 24 | at Nationals | L4-7 | 26-19 | .578 | Nationals Park · Washington, D.C. |
| 46 | Wed May 25 | at Nationals | W2-0 | 27-19 | .587 | Nationals Park · Washington, D.C. |
| 47 | Fri May 27 | vs Dodgers | W6-5 | 28-19 | .596 | Citi Field · Queens, NY |
| 48 | Sat May 28 | vs Dodgers | L1-9 | 28-20 | .583 | Citi Field · Queens, NY |
| 49 | Sun May 29 | vs Dodgers | L2-4 | 28-21 | .571 | Citi Field · Queens, NY |
| 50 | Mon May 30 | vs White Sox | W1-0 | 29-21 | .580 | Citi Field · Queens, NY |
| 51 | Tue May 31 | vs White Sox | L4-6 | 29-22 | .569 | Citi Field · Queens, NY |
| 52 | Wed Jun 1 | vs White Sox | L1-2 (13) | 29-23 | .558 | Citi Field · Queens, NY |
| 53 | Fri Jun 3 | at Marlins | W6-2 | 30-23 | .566 | LoanDepot Park · Miami, FL |
| 54 | Sat Jun 4 | at Marlins | W6-4 | 31-23 | .574 | LoanDepot Park · Miami, FL |
| 55 | Sun Jun 5 | at Marlins | L0-1 | 31-24 | .564 | LoanDepot Park · Miami, FL |
| 56 | Tue Jun 7 | at Pirates | L1-3 | 31-25 | .554 | PNC Park · Pittsburgh, PA |
| 57 | Tue Jun 7 | at Pirates | L1-3 | 31-26 | .544 | PNC Park · Pittsburgh, PA |
| 58 | Wed Jun 8 | at Pirates | W6-5 (10) | 32-26 | .552 | PNC Park · Pittsburgh, PA |
| 59 | Thu Jun 9 | at Brewers | W5-2 | 33-26 | .559 | American Family Field · Milwaukee, WI |
| 60 | Fri Jun 10 | at Brewers | W2-1 (11) | 34-26 | .567 | American Family Field · Milwaukee, WI |
| 61 | Sat Jun 11 | at Brewers | L4-7 | 34-27 | .557 | American Family Field · Milwaukee, WI |
| 62 | Sun Jun 12 | at Brewers | L3-5 | 34-28 | .548 | American Family Field · Milwaukee, WI |
| 63 | Tue Jun 14 | vs Pirates | L0-4 | 34-29 | .540 | Citi Field · Queens, NY |
| 64 | Wed Jun 15 | vs Pirates | W11-2 | 35-29 | .547 | Citi Field · Queens, NY |
| 65 | Thu Jun 16 | vs Pirates | W6-4 | 36-29 | .554 | Citi Field · Queens, NY |
| 66 | Fri Jun 17 | vs Braves | L1-5 | 36-30 | .545 | Citi Field · Queens, NY |
| 67 | Sat Jun 18 | vs Braves | L3-4 | 36-31 | .537 | Citi Field · Queens, NY |
| 68 | Sun Jun 19 | vs Braves | L0-6 | 36-32 | .529 | Citi Field · Queens, NY |
| 69 | Tue Jun 21 | vs Royals | W2-1 | 37-32 | .536 | Citi Field · Queens, NY |
| 70 | Wed Jun 22 | vs Royals | W4-3 | 38-32 | .543 | Citi Field · Queens, NY |
| 71 | Thu Jun 23 | at Braves | L3-4 | 38-33 | .535 | Truist Park · Cumberland, GA |
| 72 | Fri Jun 24 | at Braves | W8-6 | 39-33 | .542 | Truist Park · Cumberland, GA |
| 73 | Sat Jun 25 | at Braves | W1-0 (11) | 40-33 | .548 | Truist Park · Cumberland, GA |
| 74 | Sun Jun 26 | at Braves | L2-5 | 40-34 | .541 | Truist Park · Cumberland, GA |
| 75 | Mon Jun 27 | at Nationals | L4-11 | 40-35 | .533 | Nationals Park · Washington, D.C. |
| 76 | Tue Jun 28 | at Nationals | L0-5 | 40-36 | .526 | Nationals Park · Washington, D.C. |
| 77 | Wed Jun 29 | at Nationals | L2-4 | 40-37 | .519 | Nationals Park · Washington, D.C. |
| 78 | Thu Jun 30 | vs Cubs | W4-3 | 41-37 | .526 | Citi Field · Queens, NY |
| 79 | Fri Jul 1 | vs Cubs | W10-2 | 42-37 | .532 | Citi Field · Queens, NY |
| 80 | Sat Jul 2 | vs Cubs | W4-3 | 43-37 | .537 | Citi Field · Queens, NY |
| 81 | Sun Jul 3 | vs Cubs | W14-3 | 44-37 | .543 | Citi Field · Queens, NY |
| 82 | Mon Jul 4 | vs Marlins | W8-6 | 45-37 | .549 | Citi Field · Queens, NY |
| 83 | Tue Jul 5 | vs Marlins | L2-5 | 45-38 | .542 | Citi Field · Queens, NY |
| 84 | Wed Jul 6 | vs Marlins | W4-2 | 46-38 | .548 | Citi Field · Queens, NY |
| 85 | Thu Jul 7 | vs Nationals | W9-7 | 47-38 | .553 | Citi Field · Queens, NY |
| 86 | Fri Jul 8 | vs Nationals | L1-3 | 47-39 | .547 | Citi Field · Queens, NY |
| 87 | Sat Jul 9 | vs Nationals | L1-6 | 47-40 | .540 | Citi Field · Queens, NY |
| 88 | Sun Jul 10 | vs Nationals | L2-3 | 47-41 | .534 | Citi Field · Queens, NY |
| 89 | Fri Jul 15 | at Phillies | W5-3 | 48-41 | .539 | Citizens Bank Park · Philadelphi, PA |
| 90 | Sat Jul 16 | at Phillies | L2-4 | 48-42 | .533 | Citizens Bank Park · Philadelphi, PA |
| 91 | Sun Jul 17 | at Phillies | W5-0 | 49-42 | .538 | Citizens Bank Park · Philadelphi, PA |
| 92 | Mon Jul 18 | at Cubs | L1-5 | 49-43 | .533 | Wrigley Field · Chicago, IL |
| 93 | Tue Jul 19 | at Cubs | W2-1 | 50-43 | .538 | Wrigley Field · Chicago, IL |
| 94 | Wed Jul 20 | at Cubs | L2-6 | 50-44 | .532 | Wrigley Field · Chicago, IL |
| 95 | Fri Jul 22 | at Marlins | W5-3 | 51-44 | .537 | LoanDepot Park · Miami, FL |
| 96 | Sat Jul 23 | at Marlins | L2-7 | 51-45 | .531 | LoanDepot Park · Miami, FL |
| 97 | Sun Jul 24 | at Marlins | W3-0 | 52-45 | .536 | LoanDepot Park · Miami, FL |
| 98 | Tue Jul 26 | vs Cardinals | L2-3 | 52-46 | .531 | Citi Field · Queens, NY |
| 99 | Tue Jul 26 | vs Cardinals | W3-1 | 53-46 | .535 | Citi Field · Queens, NY |
| 100 | Wed Jul 27 | vs Cardinals | L4-5 | 53-47 | .530 | Citi Field · Queens, NY |
| 101 | Thu Jul 28 | vs Rockies | L1-2 | 53-48 | .525 | Citi Field · Queens, NY |
| 102 | Fri Jul 29 | vs Rockies | L1-6 | 53-49 | .520 | Citi Field · Queens, NY |
| 103 | Sat Jul 30 | vs Rockies | L2-7 | 53-50 | .515 | Citi Field · Queens, NY |
| 104 | Sun Jul 31 | vs Rockies | W6-4 | 54-50 | .519 | Citi Field · Queens, NY |
| 105 | Mon Aug 1 | vs Yankees | L5-6 (10) | 54-51 | .514 | Citi Field · Queens, NY |
| 106 | Tue Aug 2 | vs Yankees | W7-1 | 55-51 | .519 | Citi Field · Queens, NY |
| 107 | Wed Aug 3 | at Yankees | L5-9 | 55-52 | .514 | Yankee Stadium · The Bronx, NY |
| 108 | Thu Aug 4 | at Yankees | W4-1 | 56-52 | .519 | Yankee Stadium · The Bronx, NY |
| 109 | Fri Aug 5 | at Tigers | L3-4 | 56-53 | .514 | Comerica Park · Detroit, MI |
| 110 | Sat Aug 6 | at Tigers | L5-6 | 56-54 | .509 | Comerica Park · Detroit, MI |
| 111 | Sun Aug 7 | at Tigers | W3-1 | 57-54 | .514 | Comerica Park · Detroit, MI |
| 112 | Tue Aug 9 | vs D-backs | L3-5 | 57-55 | .509 | Citi Field · Queens, NY |
| 113 | Wed Aug 10 | vs D-backs | L2-3 (12) | 57-56 | .504 | Citi Field · Queens, NY |
| 114 | Thu Aug 11 | vs D-backs | L0-9 | 57-57 | .500 | Citi Field · Queens, NY |
| 115 | Fri Aug 12 | vs Padres | L6-8 | 57-58 | .496 | Citi Field · Queens, NY |
| 116 | Sat Aug 13 | vs Padres | W3-2 (11) | 58-58 | .500 | Citi Field · Queens, NY |
| 117 | Sun Aug 14 | vs Padres | W5-1 | 59-58 | .504 | Citi Field · Queens, NY |
| 118 | Mon Aug 15 | at D-backs | L6-10 | 59-59 | .500 | Chase Field · Phoenix, AZ |
| 119 | Tue Aug 16 | at D-backs | W7-5 | 60-59 | .504 | Chase Field · Phoenix, AZ |
| 120 | Wed Aug 17 | at D-backs | L5-13 | 60-60 | .500 | Chase Field · Phoenix, AZ |
| 121 | Thu Aug 18 | at Giants | L7-10 | 60-61 | .496 | Oracle Park · San Francisco, CA |
| 122 | Fri Aug 19 | at Giants | L1-8 | 60-62 | .492 | Oracle Park · San Francisco, CA |
| 123 | Sat Aug 20 | at Giants | W9-5 | 61-62 | .496 | Oracle Park · San Francisco, CA |
| 124 | Sun Aug 21 | at Giants | W2-0 | 62-62 | .500 | Oracle Park · San Francisco, CA |
| 125 | Tue Aug 23 | at Cardinals | W7-4 | 63-62 | .504 | Busch Stadium · St. Louis, MO |
| 126 | Wed Aug 24 | at Cardinals | L1-8 | 63-63 | .500 | Busch Stadium · St. Louis, MO |
| 127 | Thu Aug 25 | at Cardinals | W10-6 | 64-63 | .504 | Busch Stadium · St. Louis, MO |
| 128 | Fri Aug 26 | vs Phillies | W9-4 | 65-63 | .508 | Citi Field · Queens, NY |
| 129 | Sat Aug 27 | vs Phillies | W12-1 | 66-63 | .512 | Citi Field · Queens, NY |
| 130 | Sun Aug 28 | vs Phillies | L1-5 | 66-64 | .508 | Citi Field · Queens, NY |
| 131 | Mon Aug 29 | vs Marlins | W2-1 (10) | 67-64 | .511 | Citi Field · Queens, NY |
| 132 | Tue Aug 30 | vs Marlins | W7-4 | 68-64 | .515 | Citi Field · Queens, NY |
| 133 | Wed Aug 31 | vs Marlins | W5-2 | 69-64 | .519 | Citi Field · Queens, NY |
| 134 | Thu Sep 1 | vs Marlins | L4-6 | 69-65 | .515 | Citi Field · Queens, NY |
| 135 | Fri Sep 2 | vs Nationals | L1-4 | 69-66 | .511 | Citi Field · Queens, NY |
| 136 | Sat Sep 3 | vs Nationals | W3-1 | 70-66 | .515 | Citi Field · Queens, NY |
| 137 | Sun Sep 4 | vs Nationals | W5-1 | 71-66 | .518 | Citi Field · Queens, NY |
| 138 | Mon Sep 5 | at Reds | W5-0 | 72-66 | .522 | Great American Ball Park · Cincinnati, OH |
| 139 | Tue Sep 6 | at Reds | W5-3 | 73-66 | .525 | Great American Ball Park · Cincinnati, OH |
| 140 | Wed Sep 7 | at Reds | W6-3 | 74-66 | .529 | Great American Ball Park · Cincinnati, OH |
| 141 | Fri Sep 9 | at Braves | W6-4 | 75-66 | .532 | Truist Park · Cumberland, GA |
| 142 | Sat Sep 10 | at Braves | L3-4 (10) | 75-67 | .528 | Truist Park · Cumberland, GA |
| 143 | Sun Sep 11 | at Braves | W10-3 | 76-67 | .531 | Truist Park · Cumberland, GA |
| 144 | Mon Sep 12 | at Nationals | L1-8 | 76-68 | .528 | Nationals Park · Washington, D.C. |
| 145 | Tue Sep 13 | at Nationals | W4-3 (10) | 77-68 | .531 | Nationals Park · Washington, D.C. |
| 146 | Wed Sep 14 | at Nationals | L0-1 | 77-69 | .527 | Nationals Park · Washington, D.C. |
| 147 | Fri Sep 16 | vs Twins | W3-0 | 78-69 | .531 | Citi Field · Queens, NY |
| 148 | Sat Sep 17 | vs Twins | W3-2 (12) | 79-69 | .534 | Citi Field · Queens, NY |
| 149 | Sun Sep 18 | vs Twins | W3-2 | 80-69 | .537 | Citi Field · Queens, NY |
| 150 | Mon Sep 19 | vs Braves | L3-7 | 80-70 | .533 | Citi Field · Queens, NY |
| 151 | Tue Sep 20 | vs Braves | L4-5 | 80-71 | .530 | Citi Field · Queens, NY |
| 152 | Wed Sep 21 | vs Braves | L3-4 | 80-72 | .526 | Citi Field · Queens, NY |
| 153 | Thu Sep 22 | vs Phillies | W9-8 (11) | 81-72 | .529 | Citi Field · Queens, NY |
| 154 | Fri Sep 23 | vs Phillies | W10-5 | 82-72 | .532 | Citi Field · Queens, NY |
| 155 | Sat Sep 24 | vs Phillies | L8-10 | 82-73 | .529 | Citi Field · Queens, NY |
| 156 | Sun Sep 25 | vs Phillies | W17-0 | 83-73 | .532 | Citi Field · Queens, NY |
| 157 | Mon Sep 26 | at Marlins | L3-7 | 83-74 | .529 | LoanDepot Park · Miami, FL |
| 158 | Tue Sep 27 | at Marlins | W12-1 | 84-74 | .532 | LoanDepot Park · Miami, FL |
| 159 | Wed Sep 28 | at Marlins | W5-2 | 85-74 | .535 | LoanDepot Park · Miami, FL |
| 160 | Fri Sep 30 | at Phillies | W5-1 | 86-74 | .537 | Citizens Bank Park · Philadelphi, PA |
| 161 | Sat Oct 1 | at Phillies | W5-3 | 87-74 | .540 | Citizens Bank Park · Philadelphi, PA |
| 162 | Sun Oct 2 | at Phillies | L2-5 | 87-75 | .537 | Citizens Bank Park · Philadelphi, PA |
| 163 | Wed Oct 5 | vs Giants | L0-3 | 0-1 | .000 | Citi Field · Queens, NY |