| 1 | Mon Apr 6 | at Nationals | W3-1 | 1-0 | 1.000 | Nationals Park · Washington, D.C. |
| 2 | Wed Apr 8 | at Nationals | L1-2 | 1-1 | .500 | Nationals Park · Washington, D.C. |
| 3 | Thu Apr 9 | at Nationals | W6-3 | 2-1 | .667 | Nationals Park · Washington, D.C. |
| 4 | Fri Apr 10 | at Braves | L3-5 | 2-2 | .500 | Truist Park · Cumberland, GA |
| 5 | Sat Apr 11 | at Braves | L3-5 | 2-3 | .400 | Truist Park · Cumberland, GA |
| 6 | Sun Apr 12 | at Braves | W4-3 | 3-3 | .500 | Truist Park · Cumberland, GA |
| 7 | Mon Apr 13 | vs Phillies | W2-0 | 4-3 | .571 | Citi Field · Queens, NY |
| 8 | Tue Apr 14 | vs Phillies | W6-5 | 5-3 | .625 | Citi Field · Queens, NY |
| 9 | Wed Apr 15 | vs Phillies | W6-1 | 6-3 | .667 | Citi Field · Queens, NY |
| 10 | Thu Apr 16 | vs Marlins | W7-5 | 7-3 | .700 | Citi Field · Queens, NY |
| 11 | Fri Apr 17 | vs Marlins | W4-1 | 8-3 | .727 | Citi Field · Queens, NY |
| 12 | Sat Apr 18 | vs Marlins | W5-4 | 9-3 | .750 | Citi Field · Queens, NY |
| 13 | Sun Apr 19 | vs Marlins | W7-6 | 10-3 | .769 | Citi Field · Queens, NY |
| 14 | Tue Apr 21 | vs Braves | W7-1 | 11-3 | .786 | Citi Field · Queens, NY |
| 15 | Wed Apr 22 | vs Braves | W3-2 | 12-3 | .800 | Citi Field · Queens, NY |
| 16 | Thu Apr 23 | vs Braves | W6-3 | 13-3 | .813 | Citi Field · Queens, NY |
| 17 | Fri Apr 24 | at Yankees | L1-6 | 13-4 | .765 | Yankee Stadium · The Bronx, NY |
| 18 | Sat Apr 25 | at Yankees | W8-2 | 14-4 | .778 | Yankee Stadium · The Bronx, NY |
| 19 | Sun Apr 26 | at Yankees | L4-6 | 14-5 | .737 | Yankee Stadium · The Bronx, NY |
| 20 | Mon Apr 27 | at Marlins | W3-1 | 15-5 | .750 | LoanDepot Park · Miami, FL |
| 21 | Tue Apr 28 | at Marlins | L3-4 | 15-6 | .714 | LoanDepot Park · Miami, FL |
| 22 | Wed Apr 29 | at Marlins | L3-7 | 15-7 | .682 | LoanDepot Park · Miami, FL |
| 23 | Thu Apr 30 | vs Nationals | L2-8 | 15-8 | .652 | Citi Field · Queens, NY |
| 24 | Fri May 1 | vs Nationals | W4-0 | 16-8 | .667 | Citi Field · Queens, NY |
| 25 | Sat May 2 | vs Nationals | L0-1 | 16-9 | .640 | Citi Field · Queens, NY |
| 26 | Sun May 3 | vs Nationals | L0-1 | 16-10 | .615 | Citi Field · Queens, NY |
| 27 | Tue May 5 | vs Orioles | W3-2 | 17-10 | .630 | Citi Field · Queens, NY |
| 28 | Wed May 6 | vs Orioles | W5-1 | 18-10 | .643 | Citi Field · Queens, NY |
| 29 | Fri May 8 | at Phillies | L1-3 | 18-11 | .621 | Citizens Bank Park · Philadelphi, PA |
| 30 | Sat May 9 | at Phillies | W3-2 | 19-11 | .633 | Citizens Bank Park · Philadelphi, PA |
| 31 | Sun May 10 | at Phillies | W7-4 | 20-11 | .645 | Citizens Bank Park · Philadelphi, PA |
| 32 | Mon May 11 | at Cubs | L3-4 | 20-12 | .625 | Wrigley Field · Chicago, IL |
| 33 | Tue May 12 | at Cubs | L1-6 | 20-13 | .606 | Wrigley Field · Chicago, IL |
| 34 | Wed May 13 | at Cubs | L1-2 | 20-14 | .588 | Wrigley Field · Chicago, IL |
| 35 | Thu May 14 | at Cubs | L5-6 | 20-15 | .571 | Wrigley Field · Chicago, IL |
| 36 | Fri May 15 | vs Brewers | L0-7 | 20-16 | .556 | Citi Field · Queens, NY |
| 37 | Sat May 16 | vs Brewers | W14-1 | 21-16 | .568 | Citi Field · Queens, NY |
| 38 | Sun May 17 | vs Brewers | W5-1 | 22-16 | .579 | Citi Field · Queens, NY |
| 39 | Mon May 18 | vs Cardinals | W2-1 (14) | 23-16 | .590 | Citi Field · Queens, NY |
| 40 | Tue May 19 | vs Cardinals | L2-10 | 23-17 | .575 | Citi Field · Queens, NY |
| 41 | Wed May 20 | vs Cardinals | L0-9 | 23-18 | .561 | Citi Field · Queens, NY |
| 42 | Thu May 21 | vs Cardinals | W5-0 | 24-18 | .571 | Citi Field · Queens, NY |
| 43 | Fri May 22 | at Pirates | L1-4 | 24-19 | .558 | PNC Park · Pittsburgh, PA |
| 44 | Sat May 23 | at Pirates | L2-8 | 24-20 | .545 | PNC Park · Pittsburgh, PA |
| 45 | Sun May 24 | at Pirates | L1-9 | 24-21 | .533 | PNC Park · Pittsburgh, PA |
| 46 | Mon May 25 | vs Phillies | W6-3 | 25-21 | .543 | Citi Field · Queens, NY |
| 47 | Tue May 26 | vs Phillies | W5-4 (10) | 26-21 | .553 | Citi Field · Queens, NY |
| 48 | Wed May 27 | vs Phillies | W7-0 | 27-21 | .563 | Citi Field · Queens, NY |
| 49 | Fri May 29 | vs Marlins | L3-4 | 27-22 | .551 | Citi Field · Queens, NY |
| 50 | Sat May 30 | vs Marlins | L5-9 | 27-23 | .540 | Citi Field · Queens, NY |
| 51 | Sun May 31 | vs Marlins | W4-3 | 28-23 | .549 | Citi Field · Queens, NY |
| 52 | Mon Jun 1 | at Padres | W7-0 | 29-23 | .558 | Petco Park · San Diego, CA |
| 53 | Tue Jun 2 | at Padres | L2-7 | 29-24 | .547 | Petco Park · San Diego, CA |
| 54 | Wed Jun 3 | at Padres | L3-7 | 29-25 | .537 | Petco Park · San Diego, CA |
| 55 | Thu Jun 4 | at D-backs | W6-2 | 30-25 | .545 | Chase Field · Phoenix, AZ |
| 56 | Fri Jun 5 | at D-backs | L2-7 | 30-26 | .536 | Chase Field · Phoenix, AZ |
| 57 | Sat Jun 6 | at D-backs | L1-2 | 30-27 | .526 | Chase Field · Phoenix, AZ |
| 58 | Sun Jun 7 | at D-backs | W6-3 | 31-27 | .534 | Chase Field · Phoenix, AZ |
| 59 | Tue Jun 9 | vs Giants | L0-5 | 31-28 | .525 | Citi Field · Queens, NY |
| 60 | Wed Jun 10 | vs Giants | L5-8 | 31-29 | .517 | Citi Field · Queens, NY |
| 61 | Thu Jun 11 | vs Giants | W5-4 | 32-29 | .525 | Citi Field · Queens, NY |
| 62 | Fri Jun 12 | vs Braves | W5-3 | 33-29 | .532 | Citi Field · Queens, NY |
| 63 | Sat Jun 13 | vs Braves | L3-5 (11) | 33-30 | .524 | Citi Field · Queens, NY |
| 64 | Sun Jun 14 | vs Braves | W10-8 | 34-30 | .531 | Citi Field · Queens, NY |
| 65 | Mon Jun 15 | vs Blue Jays | W4-3 (11) | 35-30 | .538 | Citi Field · Queens, NY |
| 66 | Tue Jun 16 | vs Blue Jays | W3-2 | 36-30 | .545 | Citi Field · Queens, NY |
| 67 | Wed Jun 17 | at Blue Jays | L0-8 | 36-31 | .537 | Rogers Centre · Toronto, ON |
| 68 | Thu Jun 18 | at Blue Jays | L1-7 | 36-32 | .529 | Rogers Centre · Toronto, ON |
| 69 | Fri Jun 19 | at Braves | L1-2 | 36-33 | .522 | Truist Park · Cumberland, GA |
| 70 | Sat Jun 20 | at Braves | L4-6 | 36-34 | .514 | Truist Park · Cumberland, GA |
| 71 | Sun Jun 21 | at Braves | L0-1 | 36-35 | .507 | Truist Park · Cumberland, GA |
| 72 | Tue Jun 23 | at Brewers | L2-3 | 36-36 | .500 | American Family Field · Milwaukee, WI |
| 73 | Wed Jun 24 | at Brewers | L1-4 | 36-37 | .493 | American Family Field · Milwaukee, WI |
| 74 | Thu Jun 25 | at Brewers | W2-0 | 37-37 | .500 | American Family Field · Milwaukee, WI |
| 75 | Fri Jun 26 | vs Reds | W2-1 | 38-37 | .507 | Citi Field · Queens, NY |
| 76 | Sun Jun 28 | vs Reds | W2-1 (13) | 39-37 | .513 | Citi Field · Queens, NY |
| 77 | Sun Jun 28 | vs Reds | W7-2 | 40-37 | .519 | Citi Field · Queens, NY |
| 78 | Tue Jun 30 | vs Cubs | L0-1 | 40-38 | .513 | Citi Field · Queens, NY |
| 79 | Wed Jul 1 | vs Cubs | L0-2 (11) | 40-39 | .506 | Citi Field · Queens, NY |
| 80 | Thu Jul 2 | vs Cubs | L1-6 | 40-40 | .500 | Citi Field · Queens, NY |
| 81 | Fri Jul 3 | at Dodgers | W2-1 | 41-40 | .506 | Dodger Stadium · Los Angeles, CA |
| 82 | Sat Jul 4 | at Dodgers | L3-4 | 41-41 | .500 | Dodger Stadium · Los Angeles, CA |
| 83 | Sun Jul 5 | at Dodgers | W8-0 | 42-41 | .506 | Dodger Stadium · Los Angeles, CA |
| 84 | Mon Jul 6 | at Giants | W3-0 | 43-41 | .512 | Oracle Park · San Francisco, CA |
| 85 | Tue Jul 7 | at Giants | L0-3 | 43-42 | .506 | Oracle Park · San Francisco, CA |
| 86 | Wed Jul 8 | at Giants | W4-1 | 44-42 | .512 | Oracle Park · San Francisco, CA |
| 87 | Fri Jul 10 | vs D-backs | W4-2 | 45-42 | .517 | Citi Field · Queens, NY |
| 88 | Sat Jul 11 | vs D-backs | W4-2 | 46-42 | .523 | Citi Field · Queens, NY |
| 89 | Sun Jul 12 | vs D-backs | W5-3 | 47-42 | .528 | Citi Field · Queens, NY |
| 90 | Fri Jul 17 | at Cardinals | L2-3 | 47-43 | .522 | Busch Stadium · St. Louis, MO |
| 91 | Sat Jul 18 | at Cardinals | L2-12 | 47-44 | .516 | Busch Stadium · St. Louis, MO |
| 92 | Sun Jul 19 | at Cardinals | W3-1 (18) | 48-44 | .522 | Busch Stadium · St. Louis, MO |
| 93 | Mon Jul 20 | at Nationals | L2-7 | 48-45 | .516 | Nationals Park · Washington, D.C. |
| 94 | Tue Jul 21 | at Nationals | W7-2 | 49-45 | .521 | Nationals Park · Washington, D.C. |
| 95 | Wed Jul 22 | at Nationals | L3-4 | 49-46 | .516 | Nationals Park · Washington, D.C. |
| 96 | Thu Jul 23 | vs Dodgers | L0-3 | 49-47 | .510 | Citi Field · Queens, NY |
| 97 | Fri Jul 24 | vs Dodgers | L2-7 | 49-48 | .505 | Citi Field · Queens, NY |
| 98 | Sat Jul 25 | vs Dodgers | W15-2 | 50-48 | .510 | Citi Field · Queens, NY |
| 99 | Sun Jul 26 | vs Dodgers | W3-2 (10) | 51-48 | .515 | Citi Field · Queens, NY |
| 100 | Tue Jul 28 | vs Padres | W4-0 | 52-48 | .520 | Citi Field · Queens, NY |
| 101 | Wed Jul 29 | vs Padres | L3-7 | 52-49 | .515 | Citi Field · Queens, NY |
| 102 | Thu Jul 30 | vs Padres | L7-8 | 52-50 | .510 | Citi Field · Queens, NY |
| 103 | Fri Jul 31 | vs Nationals | W2-1 (12) | 53-50 | .515 | Citi Field · Queens, NY |
| 104 | Sat Aug 1 | vs Nationals | W3-2 | 54-50 | .519 | Citi Field · Queens, NY |
| 105 | Sun Aug 2 | vs Nationals | W5-2 | 55-50 | .524 | Citi Field · Queens, NY |
| 106 | Mon Aug 3 | at Marlins | W12-1 | 56-50 | .528 | LoanDepot Park · Miami, FL |
| 107 | Tue Aug 4 | at Marlins | W5-1 | 57-50 | .533 | LoanDepot Park · Miami, FL |
| 108 | Wed Aug 5 | at Marlins | W8-6 | 58-50 | .537 | LoanDepot Park · Miami, FL |
| 109 | Fri Aug 7 | at Rays | W4-3 | 59-50 | .541 | Tropicana Field · St. Petersburg, FL |
| 110 | Sat Aug 8 | at Rays | L4-5 | 59-51 | .536 | Tropicana Field · St. Petersburg, FL |
| 111 | Sun Aug 9 | at Rays | L3-4 | 59-52 | .532 | Tropicana Field · St. Petersburg, FL |
| 112 | Mon Aug 10 | vs Rockies | W4-2 | 60-52 | .536 | Citi Field · Queens, NY |
| 113 | Tue Aug 11 | vs Rockies | W4-0 | 61-52 | .540 | Citi Field · Queens, NY |
| 114 | Wed Aug 12 | vs Rockies | W3-0 | 62-52 | .544 | Citi Field · Queens, NY |
| 115 | Thu Aug 13 | vs Rockies | W12-3 | 63-52 | .548 | Citi Field · Queens, NY |
| 116 | Fri Aug 14 | vs Pirates | L2-3 (10) | 63-53 | .543 | Citi Field · Queens, NY |
| 117 | Sat Aug 15 | vs Pirates | L3-5 (14) | 63-54 | .538 | Citi Field · Queens, NY |
| 118 | Sun Aug 16 | vs Pirates | L1-8 | 63-55 | .534 | Citi Field · Queens, NY |
| 119 | Tue Aug 18 | at Orioles | W5-3 | 64-55 | .538 | Camden Yards · Baltimore, MD |
| 120 | Wed Aug 19 | at Orioles | L4-5 | 64-56 | .533 | Camden Yards · Baltimore, MD |
| 121 | Fri Aug 21 | at Rockies | W14-9 | 65-56 | .537 | Coors Field · Denver, CO |
| 122 | Sat Aug 22 | at Rockies | W14-9 | 66-56 | .541 | Coors Field · Denver, CO |
| 123 | Sun Aug 23 | at Rockies | W5-1 | 67-56 | .545 | Coors Field · Denver, CO |
| 124 | Mon Aug 24 | at Phillies | W16-7 | 68-56 | .548 | Citizens Bank Park · Philadelphi, PA |
| 125 | Tue Aug 25 | at Phillies | W6-5 | 69-56 | .552 | Citizens Bank Park · Philadelphi, PA |
| 126 | Wed Aug 26 | at Phillies | W9-4 | 70-56 | .556 | Citizens Bank Park · Philadelphi, PA |
| 127 | Thu Aug 27 | at Phillies | W9-5 (13) | 71-56 | .559 | Citizens Bank Park · Philadelphi, PA |
| 128 | Fri Aug 28 | vs Red Sox | L4-6 (10) | 71-57 | .555 | Citi Field · Queens, NY |
| 129 | Sat Aug 29 | vs Red Sox | L1-3 | 71-58 | .550 | Citi Field · Queens, NY |
| 130 | Sun Aug 30 | vs Red Sox | W5-4 | 72-58 | .554 | Citi Field · Queens, NY |
| 131 | Mon Aug 31 | vs Phillies | W3-1 | 73-58 | .557 | Citi Field · Queens, NY |
| 132 | Tue Sep 1 | vs Phillies | L8-14 | 73-59 | .553 | Citi Field · Queens, NY |
| 133 | Wed Sep 2 | vs Phillies | W9-4 | 74-59 | .556 | Citi Field · Queens, NY |
| 134 | Fri Sep 4 | at Marlins | L5-6 (11) | 74-60 | .552 | LoanDepot Park · Miami, FL |
| 135 | Sat Sep 5 | at Marlins | W7-0 | 75-60 | .556 | LoanDepot Park · Miami, FL |
| 136 | Sun Sep 6 | at Marlins | L3-4 | 75-61 | .551 | LoanDepot Park · Miami, FL |
| 137 | Mon Sep 7 | at Nationals | W8-5 | 76-61 | .555 | Nationals Park · Washington, D.C. |
| 138 | Tue Sep 8 | at Nationals | W8-7 | 77-61 | .558 | Nationals Park · Washington, D.C. |
| 139 | Wed Sep 9 | at Nationals | W5-3 | 78-61 | .561 | Nationals Park · Washington, D.C. |
| 140 | Thu Sep 10 | at Braves | W7-2 | 79-61 | .564 | Truist Park · Cumberland, GA |
| 141 | Fri Sep 11 | at Braves | W5-1 | 80-61 | .567 | Truist Park · Cumberland, GA |
| 142 | Sat Sep 12 | at Braves | W6-4 | 81-61 | .570 | Truist Park · Cumberland, GA |
| 143 | Sun Sep 13 | at Braves | W10-7 (10) | 82-61 | .573 | Truist Park · Cumberland, GA |
| 144 | Mon Sep 14 | vs Marlins | W4-3 | 83-61 | .576 | Citi Field · Queens, NY |
| 145 | Tue Sep 15 | vs Marlins | L3-9 | 83-62 | .572 | Citi Field · Queens, NY |
| 146 | Wed Sep 16 | vs Marlins | L0-6 | 83-63 | .568 | Citi Field · Queens, NY |
| 147 | Fri Sep 18 | vs Yankees | W5-1 | 84-63 | .571 | Citi Field · Queens, NY |
| 148 | Sat Sep 19 | vs Yankees | L0-5 | 84-64 | .568 | Citi Field · Queens, NY |
| 149 | Sun Sep 20 | vs Yankees | L2-11 | 84-65 | .564 | Citi Field · Queens, NY |
| 150 | Mon Sep 21 | vs Braves | W4-0 | 85-65 | .567 | Citi Field · Queens, NY |
| 151 | Tue Sep 22 | vs Braves | L2-6 | 85-66 | .563 | Citi Field · Queens, NY |
| 152 | Wed Sep 23 | vs Braves | L3-6 | 85-67 | .559 | Citi Field · Queens, NY |
| 153 | Thu Sep 24 | at Reds | W6-4 | 86-67 | .562 | Great American Ball Park · Cincinnati, OH |
| 154 | Fri Sep 25 | at Reds | W12-5 | 87-67 | .565 | Great American Ball Park · Cincinnati, OH |
| 155 | Sat Sep 26 | at Reds | W10-2 | 88-67 | .568 | Great American Ball Park · Cincinnati, OH |
| 156 | Sun Sep 27 | at Reds | W8-1 | 89-67 | .571 | Great American Ball Park · Cincinnati, OH |
| 157 | Tue Sep 29 | at Phillies | L3-4 | 89-68 | .567 | Citizens Bank Park · Philadelphi, PA |
| 158 | Wed Sep 30 | at Phillies | L5-7 | 89-69 | .563 | Citizens Bank Park · Philadelphi, PA |
| 159 | Thu Oct 1 | at Phillies | L0-3 | 89-70 | .560 | Citizens Bank Park · Philadelphi, PA |
| 160 | Sat Oct 3 | vs Nationals | L1-3 | 89-71 | .556 | Citi Field · Queens, NY |
| 161 | Sat Oct 3 | vs Nationals | L0-2 | 89-72 | .553 | Citi Field · Queens, NY |
| 162 | Sun Oct 4 | vs Nationals | W1-0 | 90-72 | .556 | Citi Field · Queens, NY |
| 163 | Fri Oct 9 | at Dodgers | W3-1 | 1-0 | 1.000 | Dodger Stadium · Los Angeles, CA |
| 164 | Sat Oct 10 | at Dodgers | L2-5 | 1-1 | .500 | Dodger Stadium · Los Angeles, CA |
| 165 | Mon Oct 12 | vs Dodgers | W13-7 | 2-1 | .667 | Citi Field · Queens, NY |
| 166 | Tue Oct 13 | vs Dodgers | L1-3 | 2-2 | .500 | Citi Field · Queens, NY |
| 167 | Thu Oct 15 | at Dodgers | W3-2 | 3-2 | .600 | Dodger Stadium · Los Angeles, CA |
| 168 | Sat Oct 17 | vs Cubs | W4-2 | 1-0 | 1.000 | Citi Field · Queens, NY |
| 169 | Sun Oct 18 | vs Cubs | W4-1 | 2-0 | 1.000 | Citi Field · Queens, NY |
| 170 | Tue Oct 20 | at Cubs | W5-2 | 3-0 | 1.000 | Wrigley Field · Chicago, IL |
| 171 | Wed Oct 21 | at Cubs | W8-3 | 4-0 | 1.000 | Wrigley Field · Chicago, IL |
| 172 | Tue Oct 27 | at Royals | L4-5 (14) | 0-1 | .000 | Kauffman Stadium · Kansas City, MO |
| 173 | Wed Oct 28 | at Royals | L1-7 | 0-2 | .000 | Kauffman Stadium · Kansas City, MO |
| 174 | Fri Oct 30 | vs Royals | W9-3 | 1-2 | .333 | Citi Field · Queens, NY |
| 175 | Sat Oct 31 | vs Royals | L3-5 | 1-3 | .250 | Citi Field · Queens, NY |
| 176 | Sun Nov 1 | vs Royals | L2-7 (12) | 1-4 | .200 | Citi Field · Queens, NY |