| 1 | Fri Mar 27 | at Marlins | L1-2 | 0-1 | .000 | LoanDepot Park · Miami, FL |
| 2 | Sat Mar 28 | at Marlins | L3-4 | 0-2 | .000 | LoanDepot Park · Miami, FL |
| 3 | Sun Mar 29 | at Marlins | L3-4 | 0-3 | .000 | LoanDepot Park · Miami, FL |
| 4 | Mon Mar 30 | at Blue Jays | W14-5 | 1-3 | .250 | Rogers Centre · Toronto, ON |
| 5 | Tue Mar 31 | at Blue Jays | L1-5 | 1-4 | .200 | Rogers Centre · Toronto, ON |
| 6 | Wed Apr 1 | at Blue Jays | W2-1 (10) | 2-4 | .333 | Rogers Centre · Toronto, ON |
| 7 | Fri Apr 3 | vs Phillies | L1-10 | 2-5 | .286 | Coors Field · Denver, CO |
| 8 | Sat Apr 4 | vs Phillies | L1-2 | 2-6 | .250 | Coors Field · Denver, CO |
| 9 | Sun Apr 5 | vs Phillies | W4-1 | 3-6 | .333 | Coors Field · Denver, CO |
| 10 | Mon Apr 6 | vs Astros | W9-7 | 4-6 | .400 | Coors Field · Denver, CO |
| 11 | Tue Apr 7 | vs Astros | W5-1 | 5-6 | .455 | Coors Field · Denver, CO |
| 12 | Wed Apr 8 | vs Astros | W9-1 | 6-6 | .500 | Coors Field · Denver, CO |
| 13 | Thu Apr 9 | at Padres | L3-7 (12) | 6-7 | .462 | Petco Park · San Diego, CA |
| 14 | Fri Apr 10 | at Padres | L2-5 | 6-8 | .429 | Petco Park · San Diego, CA |
| 15 | Sat Apr 11 | at Padres | L5-9 | 6-9 | .400 | Petco Park · San Diego, CA |
| 16 | Sun Apr 12 | at Padres | L2-7 | 6-10 | .375 | Petco Park · San Diego, CA |
| 17 | Tue Apr 14 | at Astros | L6-7 | 6-11 | .353 | Minute Maid Park · Houston, TX |
| 18 | Wed Apr 15 | at Astros | L1-3 | 6-12 | .333 | Minute Maid Park · Houston, TX |
| 19 | Thu Apr 16 | at Astros | W3-2 | 7-12 | .368 | Minute Maid Park · Houston, TX |
| 20 | Fri Apr 17 | vs Dodgers | L1-7 | 7-13 | .350 | Coors Field · Denver, CO |
| 21 | Sat Apr 18 | vs Dodgers | W4-3 | 8-13 | .381 | Coors Field · Denver, CO |
| 22 | Sun Apr 19 | vs Dodgers | W9-6 | 9-13 | .409 | Coors Field · Denver, CO |
| 23 | Mon Apr 20 | vs Dodgers | L3-12 | 9-14 | .391 | Coors Field · Denver, CO |
| 24 | Tue Apr 21 | vs Padres | L0-1 | 9-15 | .375 | Coors Field · Denver, CO |
| 25 | Wed Apr 22 | vs Padres | W8-3 | 10-15 | .400 | Coors Field · Denver, CO |
| 26 | Thu Apr 23 | vs Padres | L8-10 | 10-16 | .385 | Coors Field · Denver, CO |
| 27 | Fri Apr 24 | at Mets | W4-3 | 11-16 | .407 | Citi Field · Queens, NY |
| 28 | Sun Apr 26 | at Mets | W3-1 | 12-16 | .429 | Citi Field · Queens, NY |
| 29 | Sun Apr 26 | at Mets | W3-0 | 13-16 | .448 | Citi Field · Queens, NY |
| 30 | Tue Apr 28 | at Reds | L2-7 | 13-17 | .433 | Great American Ball Park · Cincinnati, OH |
| 31 | Wed Apr 29 | at Reds | W13-2 | 14-17 | .452 | Great American Ball Park · Cincinnati, OH |
| 32 | Thu Apr 30 | at Reds | L4-6 | 14-18 | .438 | Great American Ball Park · Cincinnati, OH |
| 33 | Fri May 1 | vs Braves | L6-8 | 14-19 | .424 | Coors Field · Denver, CO |
| 34 | Sat May 2 | vs Braves | L1-9 | 14-20 | .412 | Coors Field · Denver, CO |
| 35 | Sun May 3 | vs Braves | L6-11 | 14-21 | .400 | Coors Field · Denver, CO |
| 36 | Mon May 4 | vs Mets | L2-4 | 14-22 | .389 | Coors Field · Denver, CO |
| 37 | Wed May 6 | vs Mets | L5-10 | 14-23 | .378 | Coors Field · Denver, CO |
| 38 | Thu May 7 | vs Mets | W6-2 | 15-23 | .395 | Coors Field · Denver, CO |
| 39 | Fri May 8 | at Phillies | W9-7 (11) | 16-23 | .410 | Citizens Bank Park · Philadelphi, PA |
| 40 | Sat May 9 | at Phillies | L3-9 | 16-24 | .400 | Citizens Bank Park · Philadelphi, PA |
| 41 | Sun May 10 | at Phillies | L0-6 | 16-25 | .390 | Citizens Bank Park · Philadelphi, PA |
| 42 | Tue May 12 | at Pirates | L1-3 | 16-26 | .381 | PNC Park · Pittsburgh, PA |
| 43 | Wed May 13 | at Pirates | W10-4 | 17-26 | .395 | PNC Park · Pittsburgh, PA |
| 44 | Thu May 14 | at Pirates | L2-7 | 17-27 | .386 | PNC Park · Pittsburgh, PA |
| 45 | Fri May 15 | vs D-backs | L1-9 | 17-28 | .378 | Coors Field · Denver, CO |
| 46 | Sat May 16 | vs D-backs | W4-2 | 18-28 | .391 | Coors Field · Denver, CO |
| 47 | Sun May 17 | vs D-backs | L6-8 | 18-29 | .383 | Coors Field · Denver, CO |
| 48 | Mon May 18 | vs Rangers | W7-6 | 19-29 | .396 | Coors Field · Denver, CO |
| 49 | Tue May 19 | vs Rangers | L0-10 | 19-30 | .388 | Coors Field · Denver, CO |
| 50 | Wed May 20 | vs Rangers | L4-5 | 19-31 | .380 | Coors Field · Denver, CO |
| 51 | Thu May 21 | at D-backs | L1-2 | 19-32 | .373 | Chase Field · Phoenix, AZ |
| 52 | Fri May 22 | at D-backs | W3-2 | 20-32 | .385 | Chase Field · Phoenix, AZ |
| 53 | Sat May 23 | at D-backs | L4-5 | 20-33 | .377 | Chase Field · Phoenix, AZ |
| 54 | Sun May 24 | at D-backs | L1-9 | 20-34 | .370 | Chase Field · Phoenix, AZ |
| 55 | Mon May 25 | at Dodgers | L3-5 | 20-35 | .364 | Dodger Stadium · Los Angeles, CA |
| 56 | Tue May 26 | at Dodgers | L6-15 | 20-36 | .357 | Dodger Stadium · Los Angeles, CA |
| 57 | Wed May 27 | at Dodgers | L1-4 | 20-37 | .351 | Dodger Stadium · Los Angeles, CA |
| 58 | Fri May 29 | vs Giants | W8-6 | 21-37 | .362 | Coors Field · Denver, CO |
| 59 | Sat May 30 | vs Giants | W8-3 | 22-37 | .373 | Coors Field · Denver, CO |
| 60 | Sun May 31 | vs Giants | L6-19 | 22-38 | .367 | Coors Field · Denver, CO |
| 61 | Mon Jun 1 | at Angels | W9-8 | 23-38 | .377 | Angel Stadium · Anaheim, CA |
| 62 | Tue Jun 2 | at Angels | W8-2 | 24-38 | .387 | Angel Stadium · Anaheim, CA |
| 63 | Wed Jun 3 | at Angels | L4-11 | 24-39 | .381 | Angel Stadium · Anaheim, CA |
| 64 | Fri Jun 5 | vs Brewers | L7-9 (10) | 24-40 | .375 | Coors Field · Denver, CO |
| 65 | Sat Jun 6 | vs Brewers | L1-7 | 24-41 | .369 | Coors Field · Denver, CO |
| 66 | Sun Jun 7 | vs Brewers | L4-12 | 24-42 | .364 | Coors Field · Denver, CO |
| 67 | Tue Jun 9 | vs Cubs | W7-3 | 25-42 | .373 | Coors Field · Denver, CO |
| 68 | Wed Jun 10 | vs Cubs | W3-2 | 26-42 | .382 | Coors Field · Denver, CO |
| 69 | Thu Jun 11 | vs Cubs | L3-9 | 26-43 | .377 | Coors Field · Denver, CO |
| 70 | Fri Jun 12 | at Athletics | L4-6 | 26-44 | .371 | Sutter Health Park · West Sacramento, CA |
| 71 | Sat Jun 13 | at Athletics | L5-7 | 26-45 | .366 | Sutter Health Park · West Sacramento, CA |
| 72 | Sun Jun 14 | at Athletics | W23-9 | 27-45 | .375 | Sutter Health Park · West Sacramento, CA |
| 73 | Mon Jun 15 | at Cubs | L4-5 | 27-46 | .370 | Wrigley Field · Chicago, IL |
| 74 | Tue Jun 16 | at Cubs | W5-2 | 28-46 | .378 | Wrigley Field · Chicago, IL |
| 75 | Wed Jun 17 | at Cubs | L6-8 | 28-47 | .373 | Wrigley Field · Chicago, IL |
| 76 | Fri Jun 19 | vs Pirates | W4-3 | 29-47 | .382 | Coors Field · Denver, CO |
| 77 | Sat Jun 20 | vs Pirates | W2-1 | 30-47 | .390 | Coors Field · Denver, CO |
| 78 | Sun Jun 21 | vs Pirates | L6-8 | 30-48 | .385 | Coors Field · Denver, CO |
| 79 | Mon Jun 22 | vs Red Sox | W3-2 | 31-48 | .392 | Coors Field · Denver, CO |
| 80 | Tue Jun 23 | vs Red Sox | L2-5 | 31-49 | .388 | Coors Field · Denver, CO |
| 81 | Wed Jun 24 | vs Red Sox | W8-6 | 32-49 | .395 | Coors Field · Denver, CO |
| 82 | Fri Jun 26 | at Twins | L8-9 (10) | 32-50 | .390 | Target Field · Minneapolis, MN |
| 83 | Sat Jun 27 | at Twins | W8-5 | 33-50 | .398 | Target Field · Minneapolis, MN |
| 84 | Sun Jun 28 | at Twins | L2-3 | 33-51 | .393 | Target Field · Minneapolis, MN |
| 85 | Mon Jun 29 | vs Marlins | L7-10 | 33-52 | .388 | Coors Field · Denver, CO |
| 86 | Tue Jun 30 | vs Marlins | L3-14 | 33-53 | .384 | Coors Field · Denver, CO |
| 87 | Wed Jul 1 | vs Marlins | W6-3 | 34-53 | .391 | Coors Field · Denver, CO |
| 88 | Thu Jul 2 | vs Marlins | W14-4 | 35-53 | .398 | Coors Field · Denver, CO |
| 89 | Fri Jul 3 | vs Giants | W15-3 | 36-53 | .404 | Coors Field · Denver, CO |
| 90 | Sat Jul 4 | vs Giants | L4-6 | 36-54 | .400 | Coors Field · Denver, CO |
| 91 | Sun Jul 5 | vs Giants | W7-6 | 37-54 | .407 | Coors Field · Denver, CO |
| 92 | Mon Jul 6 | at Dodgers | L7-8 (11) | 37-55 | .402 | Dodger Stadium · Los Angeles, CA |
| 93 | Tue Jul 7 | at Dodgers | W4-3 | 38-55 | .409 | Dodger Stadium · Los Angeles, CA |
| 94 | Wed Jul 8 | at Dodgers | L3-4 | 38-56 | .404 | Dodger Stadium · Los Angeles, CA |
| 95 | Thu Jul 9 | at Giants | L2-8 | 38-57 | .400 | Oracle Park · San Francisco, CA |
| 96 | Fri Jul 10 | at Giants | W4-3 | 39-57 | .406 | Oracle Park · San Francisco, CA |
| 97 | Sat Jul 11 | at Giants | L2-4 | 39-58 | .402 | Oracle Park · San Francisco, CA |
| 98 | Sun Jul 12 | at Giants | L1-3 | 39-59 | .398 | Oracle Park · San Francisco, CA |
| 99 | Fri Jul 17 | vs Reds | L2-7 | 39-60 | .394 | Coors Field · Denver, CO |
| 100 | Sat Jul 18 | vs Reds | W10-3 | 40-60 | .400 | Coors Field · Denver, CO |
| 101 | Sun Jul 19 | vs Reds | L6-9 | 40-61 | .396 | Coors Field · Denver, CO |
| 102 | Mon Jul 20 | vs Nationals | L3-7 | 40-62 | .392 | Coors Field · Denver, CO |
| 103 | Tue Jul 21 | vs Nationals | W8-7 | 41-62 | .398 | Coors Field · Denver, CO |
| 104 | Wed Jul 22 | vs Nationals | L0-8 | 41-63 | .394 | Coors Field · Denver, CO |
| 105 | Fri Jul 24 | at Brewers | W5-2 | 42-63 | .400 | American Family Field · Milwaukee, WI |
| 106 | Sat Jul 25 | at Brewers | L5-8 | 42-64 | .396 | American Family Field · Milwaukee, WI |
| 107 | Sun Jul 26 | at Brewers | L2-11 | 42-65 | .393 | American Family Field · Milwaukee, WI |
| 108 | Tue Jul 28 | at Padres | L7-8 | 42-66 | .389 | Petco Park · San Diego, CA |
| 109 | Wed Jul 29 | at Padres | L1-3 | 42-67 | .385 | Petco Park · San Diego, CA |
| 110 | Fri Jul 31 | vs Royals | W3-1 | 43-67 | .391 | Coors Field · Denver, CO |
| 111 | Sat Aug 1 | vs Royals | W12-6 | 44-67 | .396 | Coors Field · Denver, CO |
| 112 | Sun Aug 2 | vs Royals | W8-1 | 45-67 | .402 | Coors Field · Denver, CO |
| 113 | Mon Aug 3 | vs Rays | L9-13 | 45-68 | .398 | Coors Field · Denver, CO |
| 114 | Tue Aug 4 | vs Rays | L7-9 (11) | 45-69 | .395 | Coors Field · Denver, CO |
| 115 | Wed Aug 5 | vs Rays | L0-4 | 45-70 | .391 | Coors Field · Denver, CO |
| 116 | Fri Aug 7 | at Cardinals | L2-3 | 45-71 | .388 | Busch Stadium · St. Louis, MO |
| 117 | Sat Aug 8 | at Cardinals | W8-6 | 46-71 | .393 | Busch Stadium · St. Louis, MO |
| 118 | Sun Aug 9 | at Cardinals | L4-7 | 46-72 | .390 | Busch Stadium · St. Louis, MO |
| 119 | Mon Aug 10 | at D-backs | L0-9 | 46-73 | .387 | Chase Field · Phoenix, AZ |
| 120 | Tue Aug 11 | at D-backs | W3-2 | 47-73 | .392 | Chase Field · Phoenix, AZ |
| 121 | Wed Aug 12 | at D-backs | W6-4 | 48-73 | .397 | Chase Field · Phoenix, AZ |
| 122 | Fri Aug 14 | at Giants | W5-2 | 49-73 | .402 | Oracle Park · San Francisco, CA |
| 123 | Sat Aug 15 | at Giants | L1-7 | 49-74 | .398 | Oracle Park · San Francisco, CA |
| 124 | Sun Aug 16 | at Giants | W13-7 | 50-74 | .403 | Oracle Park · San Francisco, CA |
| 125 | Mon Aug 17 | vs Dodgers | L5-11 | 50-75 | .400 | Coors Field · Denver, CO |
| 126 | Tue Aug 18 | vs Dodgers | L6-7 | 50-76 | .397 | Coors Field · Denver, CO |
| 127 | Wed Aug 19 | vs Dodgers | L4-6 (10) | 50-77 | .394 | Coors Field · Denver, CO |
| 128 | Fri Aug 21 | vs Guardians | L1-9 | 50-78 | .391 | Coors Field · Denver, CO |
| 129 | Sat Aug 22 | vs Guardians | L3-4 | 50-79 | .388 | Coors Field · Denver, CO |
| 130 | Sun Aug 23 | vs Guardians | L2-7 | 50-80 | .385 | Coors Field · Denver, CO |
| 131 | Mon Aug 24 | at Nationals | L3-13 | 50-81 | .382 | Nationals Park · Washington, D.C. |
| 132 | Tue Aug 25 | at Nationals | W3-1 | 51-81 | .386 | Nationals Park · Washington, D.C. |
| 133 | Wed Aug 26 | at Nationals | W13-1 | 52-81 | .391 | Nationals Park · Washington, D.C. |
| 134 | Thu Aug 27 | at Nationals | L1-7 | 52-82 | .388 | Nationals Park · Washington, D.C. |
| 135 | Fri Aug 28 | at Braves | L4-6 | 52-83 | .385 | Truist Park · Cumberland, GA |
| 136 | Sat Aug 29 | at Braves | L1-2 | 52-84 | .382 | Truist Park · Cumberland, GA |
| 137 | Sun Aug 30 | at Braves | L2-3 (10) | 52-85 | .380 | Truist Park · Cumberland, GA |