| 1 | Fri Apr 1 | vs D-backs | L6-7 (11) | 0-1 | .000 | Coors Field · Denver, CO |
| 2 | Sat Apr 2 | vs D-backs | W3-1 | 1-1 | .500 | Coors Field · Denver, CO |
| 3 | Tue Apr 5 | vs Dodgers | W3-0 | 2-1 | .667 | Coors Field · Denver, CO |
| 4 | Wed Apr 6 | vs Dodgers | W7-5 | 3-1 | .750 | Coors Field · Denver, CO |
| 5 | Thu Apr 7 | at Pirates | W7-1 | 4-1 | .800 | PNC Park · Pittsburgh, PA |
| 6 | Fri Apr 8 | at Pirates | L3-4 (14) | 4-2 | .667 | PNC Park · Pittsburgh, PA |
| 7 | Sat Apr 9 | at Pirates | W6-4 | 5-2 | .714 | PNC Park · Pittsburgh, PA |
| 8 | Sun Apr 10 | at Pirates | W6-5 | 6-2 | .750 | PNC Park · Pittsburgh, PA |
| 9 | Mon Apr 11 | at Mets | W7-6 | 7-2 | .778 | Citi Field · Queens, NY |
| 10 | Wed Apr 13 | at Mets | W5-4 | 8-2 | .800 | Citi Field · Queens, NY |
| 11 | Thu Apr 14 | at Mets | W6-5 | 9-2 | .818 | Citi Field · Queens, NY |
| 12 | Thu Apr 14 | at Mets | W9-4 | 10-2 | .833 | Citi Field · Queens, NY |
| 13 | Fri Apr 15 | vs Cubs | W5-0 | 11-2 | .846 | Coors Field · Denver, CO |
| 14 | Sat Apr 16 | vs Cubs | L3-8 | 11-3 | .786 | Coors Field · Denver, CO |
| 15 | Sun Apr 17 | vs Cubs | W9-5 | 12-3 | .800 | Coors Field · Denver, CO |
| 16 | Mon Apr 18 | vs Giants | L1-8 | 12-4 | .750 | Coors Field · Denver, CO |
| 17 | Tue Apr 19 | vs Giants | L3-6 | 12-5 | .706 | Coors Field · Denver, CO |
| 18 | Wed Apr 20 | vs Giants | W10-2 | 13-5 | .722 | Coors Field · Denver, CO |
| 19 | Fri Apr 22 | at Marlins | L1-4 | 13-6 | .684 | MVP Arena · Albany, NY |
| 20 | Sat Apr 23 | at Marlins | W3-1 | 14-6 | .700 | MVP Arena · Albany, NY |
| 21 | Sun Apr 24 | at Marlins | L3-6 | 14-7 | .667 | MVP Arena · Albany, NY |
| 22 | Mon Apr 25 | at Cubs | W5-3 | 15-7 | .682 | Wrigley Field · Chicago, IL |
| 23 | Tue Apr 26 | at Cubs | W4-3 | 16-7 | .696 | Wrigley Field · Chicago, IL |
| 24 | Fri Apr 29 | vs Pirates | L0-3 | 16-8 | .667 | Coors Field · Denver, CO |
| 25 | Sat Apr 30 | vs Pirates | W4-1 | 17-8 | .680 | Coors Field · Denver, CO |
| 26 | Sun May 1 | vs Pirates | L4-8 | 17-9 | .654 | Coors Field · Denver, CO |
| 27 | Tue May 3 | at D-backs | L3-4 | 17-10 | .630 | Chase Field · Phoenix, AZ |
| 28 | Wed May 4 | at D-backs | W6-4 | 18-10 | .643 | Chase Field · Phoenix, AZ |
| 29 | Thu May 5 | at D-backs | L2-3 (11) | 18-11 | .621 | Chase Field · Phoenix, AZ |
| 30 | Fri May 6 | at Giants | L3-4 | 18-12 | .600 | Oracle Park · San Francisco, CA |
| 31 | Sat May 7 | at Giants | L2-3 | 18-13 | .581 | Oracle Park · San Francisco, CA |
| 32 | Sun May 8 | at Giants | L0-3 | 18-14 | .563 | Oracle Park · San Francisco, CA |
| 33 | Mon May 9 | vs Mets | W2-1 | 19-14 | .576 | Coors Field · Denver, CO |
| 34 | Tue May 10 | vs Mets | L3-4 | 19-15 | .559 | Coors Field · Denver, CO |
| 35 | Thu May 12 | vs Mets | L5-9 | 19-16 | .543 | Coors Field · Denver, CO |
| 36 | Fri May 13 | vs Padres | W12-7 | 20-16 | .556 | Coors Field · Denver, CO |
| 37 | Sat May 14 | vs Padres | L7-9 | 20-17 | .541 | Coors Field · Denver, CO |
| 38 | Sun May 15 | vs Padres | L2-8 | 20-18 | .526 | Coors Field · Denver, CO |
| 39 | Mon May 16 | vs Giants | W7-4 | 21-18 | .538 | Coors Field · Denver, CO |
| 40 | Tue May 17 | vs Giants | W5-3 | 22-18 | .550 | Coors Field · Denver, CO |
| 41 | Wed May 18 | at Phillies | L1-2 | 22-19 | .537 | Citizens Bank Park · Philadelphi, PA |
| 42 | Thu May 19 | at Phillies | W7-1 | 23-19 | .548 | Citizens Bank Park · Philadelphi, PA |
| 43 | Fri May 20 | at Brewers | L6-7 (14) | 23-20 | .535 | American Family Field · Milwaukee, WI |
| 44 | Sat May 21 | at Brewers | L2-3 | 23-21 | .523 | American Family Field · Milwaukee, WI |
| 45 | Sun May 22 | at Brewers | L1-3 | 23-22 | .511 | American Family Field · Milwaukee, WI |
| 46 | Tue May 24 | vs D-backs | W12-4 | 24-22 | .522 | Coors Field · Denver, CO |
| 47 | Tue May 24 | vs D-backs | L2-5 | 24-23 | .511 | Coors Field · Denver, CO |
| 48 | Wed May 25 | vs D-backs | L1-2 | 24-24 | .500 | Coors Field · Denver, CO |
| 49 | Thu May 26 | vs D-backs | L3-6 | 24-25 | .490 | Coors Field · Denver, CO |
| 50 | Fri May 27 | vs Cardinals | L3-10 | 24-26 | .480 | Coors Field · Denver, CO |
| 51 | Sat May 28 | vs Cardinals | W15-4 | 25-26 | .490 | Coors Field · Denver, CO |
| 52 | Sun May 29 | vs Cardinals | L3-4 | 25-27 | .481 | Coors Field · Denver, CO |
| 53 | Mon May 30 | at Dodgers | L1-7 | 25-28 | .472 | Dodger Stadium · Los Angeles, CA |
| 54 | Tue May 31 | at Dodgers | L2-8 | 25-29 | .463 | Dodger Stadium · Los Angeles, CA |
| 55 | Wed Jun 1 | at Dodgers | W3-0 | 26-29 | .473 | Dodger Stadium · Los Angeles, CA |
| 56 | Fri Jun 3 | at Giants | L1-3 | 26-30 | .464 | Oracle Park · San Francisco, CA |
| 57 | Sat Jun 4 | at Giants | W2-1 | 27-30 | .474 | Oracle Park · San Francisco, CA |
| 58 | Sun Jun 5 | at Giants | L1-2 | 27-31 | .466 | Oracle Park · San Francisco, CA |
| 59 | Mon Jun 6 | at Padres | W3-0 | 28-31 | .475 | Petco Park · San Diego, CA |
| 60 | Tue Jun 7 | at Padres | L0-2 | 28-32 | .467 | Petco Park · San Diego, CA |
| 61 | Wed Jun 8 | at Padres | W5-3 | 29-32 | .475 | Petco Park · San Diego, CA |
| 62 | Thu Jun 9 | vs Dodgers | W9-7 | 30-32 | .484 | Coors Field · Denver, CO |
| 63 | Fri Jun 10 | vs Dodgers | W6-5 | 31-32 | .492 | Coors Field · Denver, CO |
| 64 | Sat Jun 11 | vs Dodgers | L7-11 | 31-33 | .484 | Coors Field · Denver, CO |
| 65 | Sun Jun 12 | vs Dodgers | L8-10 | 31-34 | .477 | Coors Field · Denver, CO |
| 66 | Mon Jun 13 | vs Padres | L1-3 | 31-35 | .470 | Coors Field · Denver, CO |
| 67 | Tue Jun 14 | vs Padres | W6-3 | 32-35 | .478 | Coors Field · Denver, CO |
| 68 | Wed Jun 15 | vs Padres | W6-3 | 33-35 | .485 | Coors Field · Denver, CO |
| 69 | Fri Jun 17 | vs Tigers | W13-6 | 34-35 | .493 | Coors Field · Denver, CO |
| 70 | Sat Jun 18 | vs Tigers | W5-4 | 35-35 | .500 | Coors Field · Denver, CO |
| 71 | Sun Jun 19 | vs Tigers | L1-9 | 35-36 | .493 | Coors Field · Denver, CO |
| 72 | Mon Jun 20 | at Guardians | W8-7 | 36-36 | .500 | Progressive Field · Cleveland, OH |
| 73 | Tue Jun 21 | at Guardians | W4-3 | 37-36 | .507 | Progressive Field · Cleveland, OH |
| 74 | Wed Jun 22 | at Guardians | L3-4 | 37-37 | .500 | Progressive Field · Cleveland, OH |
| 75 | Fri Jun 24 | at Yankees | W4-2 | 38-37 | .507 | Yankee Stadium · The Bronx, NY |
| 76 | Sat Jun 25 | at Yankees | L3-8 | 38-38 | .500 | Yankee Stadium · The Bronx, NY |
| 77 | Sun Jun 26 | at Yankees | L4-6 | 38-39 | .494 | Yankee Stadium · The Bronx, NY |
| 78 | Mon Jun 27 | at Cubs | L3-7 | 38-40 | .487 | Wrigley Field · Chicago, IL |
| 79 | Tue Jun 28 | vs White Sox | W3-2 (13) | 39-40 | .494 | Coors Field · Denver, CO |
| 80 | Wed Jun 29 | vs White Sox | L2-3 | 39-41 | .487 | Coors Field · Denver, CO |
| 81 | Thu Jun 30 | vs White Sox | L4-6 (10) | 39-42 | .481 | Coors Field · Denver, CO |
| 82 | Fri Jul 1 | vs Royals | W9-0 | 40-42 | .488 | Coors Field · Denver, CO |
| 83 | Sat Jul 2 | vs Royals | W9-6 | 41-42 | .494 | Coors Field · Denver, CO |
| 84 | Sun Jul 3 | vs Royals | L8-16 | 41-43 | .488 | Coors Field · Denver, CO |
| 85 | Mon Jul 4 | at Braves | L1-4 | 41-44 | .482 | Truist Park · Cumberland, GA |
| 86 | Tue Jul 5 | at Braves | L3-5 | 41-45 | .477 | Truist Park · Cumberland, GA |
| 87 | Wed Jul 6 | at Braves | L1-9 | 41-46 | .471 | Truist Park · Cumberland, GA |
| 88 | Thu Jul 7 | at Braves | L3-6 | 41-47 | .466 | Truist Park · Cumberland, GA |
| 89 | Fri Jul 8 | at Nationals | W3-2 | 42-47 | .472 | Nationals Park · Washington, D.C. |
| 90 | Sat Jul 9 | at Nationals | W2-1 | 43-47 | .478 | Nationals Park · Washington, D.C. |
| 91 | Sun Jul 10 | at Nationals | L0-2 | 43-48 | .473 | Nationals Park · Washington, D.C. |
| 92 | Thu Jul 14 | vs Brewers | W12-3 | 44-48 | .478 | Coors Field · Denver, CO |
| 93 | Fri Jul 15 | vs Brewers | W4-0 | 45-48 | .484 | Coors Field · Denver, CO |
| 94 | Sat Jul 16 | vs Brewers | L7-8 | 45-49 | .479 | Coors Field · Denver, CO |
| 95 | Sun Jul 17 | vs Brewers | L3-4 | 45-50 | .474 | Coors Field · Denver, CO |
| 96 | Mon Jul 18 | vs Braves | L4-7 | 45-51 | .469 | Coors Field · Denver, CO |
| 97 | Tue Jul 19 | vs Braves | W12-3 | 46-51 | .474 | Coors Field · Denver, CO |
| 98 | Wed Jul 20 | vs Braves | W3-2 | 47-51 | .480 | Coors Field · Denver, CO |
| 99 | Thu Jul 21 | vs Braves | L6-9 | 47-52 | .475 | Coors Field · Denver, CO |
| 100 | Fri Jul 22 | at D-backs | W8-4 | 48-52 | .480 | Chase Field · Phoenix, AZ |
| 101 | Sat Jul 23 | at D-backs | L3-12 | 48-53 | .475 | Chase Field · Phoenix, AZ |
| 102 | Sun Jul 24 | at D-backs | L0-7 | 48-54 | .471 | Chase Field · Phoenix, AZ |
| 103 | Mon Jul 25 | at Dodgers | L5-8 | 48-55 | .466 | Dodger Stadium · Los Angeles, CA |
| 104 | Tue Jul 26 | at Dodgers | L2-3 | 48-56 | .462 | Dodger Stadium · Los Angeles, CA |
| 105 | Wed Jul 27 | at Dodgers | W3-1 | 49-56 | .467 | Dodger Stadium · Los Angeles, CA |
| 106 | Fri Jul 29 | at Padres | W3-2 | 50-56 | .472 | Petco Park · San Diego, CA |
| 107 | Sat Jul 30 | at Padres | W10-6 | 51-56 | .477 | Petco Park · San Diego, CA |
| 108 | Sun Jul 31 | at Padres | L3-8 | 51-57 | .472 | Petco Park · San Diego, CA |
| 109 | Mon Aug 1 | vs Phillies | L3-4 (10) | 51-58 | .468 | Coors Field · Denver, CO |
| 110 | Tue Aug 2 | vs Phillies | L0-5 | 51-59 | .464 | Coors Field · Denver, CO |
| 111 | Wed Aug 3 | vs Phillies | L6-8 | 51-60 | .459 | Coors Field · Denver, CO |
| 112 | Thu Aug 4 | vs Nationals | W6-3 | 52-60 | .464 | Coors Field · Denver, CO |
| 113 | Fri Aug 5 | vs Nationals | L3-5 | 52-61 | .460 | Coors Field · Denver, CO |
| 114 | Sat Aug 6 | vs Nationals | W15-7 | 53-61 | .465 | Coors Field · Denver, CO |
| 115 | Sun Aug 7 | vs Nationals | L2-3 | 53-62 | .461 | Coors Field · Denver, CO |
| 116 | Mon Aug 8 | at Reds | W10-7 | 54-62 | .466 | Great American Ball Park · Cincinnati, OH |
| 117 | Tue Aug 9 | at Reds | W3-2 | 55-62 | .470 | Great American Ball Park · Cincinnati, OH |
| 118 | Wed Aug 10 | at Reds | L2-3 | 55-63 | .466 | Great American Ball Park · Cincinnati, OH |
| 119 | Thu Aug 11 | at Reds | L1-2 | 55-64 | .462 | Great American Ball Park · Cincinnati, OH |
| 120 | Fri Aug 12 | at Cardinals | L1-6 | 55-65 | .458 | Busch Stadium · St. Louis, MO |
| 121 | Sat Aug 13 | at Cardinals | W6-1 | 56-65 | .463 | Busch Stadium · St. Louis, MO |
| 122 | Sun Aug 14 | at Cardinals | L2-6 | 56-66 | .459 | Busch Stadium · St. Louis, MO |
| 123 | Mon Aug 15 | vs Marlins | W7-4 | 57-66 | .463 | Coors Field · Denver, CO |
| 124 | Tue Aug 16 | vs Marlins | L5-6 | 57-67 | .460 | Coors Field · Denver, CO |
| 125 | Wed Aug 17 | vs Marlins | W12-5 | 58-67 | .464 | Coors Field · Denver, CO |
| 126 | Fri Aug 19 | vs Dodgers | L2-8 | 58-68 | .460 | Coors Field · Denver, CO |
| 127 | Sat Aug 20 | vs Dodgers | W7-6 (13) | 59-68 | .465 | Coors Field · Denver, CO |
| 128 | Sun Aug 21 | vs Dodgers | W5-3 | 60-68 | .469 | Coors Field · Denver, CO |
| 129 | Mon Aug 22 | vs Astros | W9-5 | 61-68 | .473 | Coors Field · Denver, CO |
| 130 | Tue Aug 23 | vs Astros | W8-6 | 62-68 | .477 | Coors Field · Denver, CO |
| 131 | Wed Aug 24 | vs Astros | W7-6 (10) | 63-68 | .481 | Coors Field · Denver, CO |
| 132 | Fri Aug 26 | at Dodgers | L1-6 | 63-69 | .477 | Dodger Stadium · Los Angeles, CA |
| 133 | Sat Aug 27 | at Dodgers | L6-7 (11) | 63-70 | .474 | Dodger Stadium · Los Angeles, CA |
| 134 | Sun Aug 28 | at Dodgers | W7-6 | 64-70 | .478 | Dodger Stadium · Los Angeles, CA |
| 135 | Mon Aug 29 | at D-backs | L1-5 | 64-71 | .474 | Chase Field · Phoenix, AZ |
| 136 | Tue Aug 30 | at D-backs | L4-9 | 64-72 | .471 | Chase Field · Phoenix, AZ |
| 137 | Wed Aug 31 | at D-backs | L2-4 | 64-73 | .467 | Chase Field · Phoenix, AZ |
| 138 | Fri Sep 2 | at Padres | W3-0 | 65-73 | .471 | Petco Park · San Diego, CA |
| 139 | Sat Sep 3 | at Padres | W5-4 | 66-73 | .475 | Petco Park · San Diego, CA |
| 140 | Sun Sep 4 | at Padres | L2-7 | 66-74 | .471 | Petco Park · San Diego, CA |
| 141 | Mon Sep 5 | vs D-backs | L7-10 | 66-75 | .468 | Coors Field · Denver, CO |
| 142 | Tue Sep 6 | vs D-backs | W8-3 | 67-75 | .472 | Coors Field · Denver, CO |
| 143 | Wed Sep 7 | vs D-backs | L3-5 | 67-76 | .469 | Coors Field · Denver, CO |
| 144 | Fri Sep 9 | vs Reds | L1-4 | 67-77 | .465 | Coors Field · Denver, CO |
| 145 | Sat Sep 10 | vs Reds | W12-7 | 68-77 | .469 | Coors Field · Denver, CO |
| 146 | Sun Sep 11 | vs Reds | W4-1 | 69-77 | .473 | Coors Field · Denver, CO |
| 147 | Tue Sep 13 | at Brewers | L1-2 (11) | 69-78 | .469 | American Family Field · Milwaukee, WI |
| 148 | Wed Sep 14 | at Brewers | W6-2 | 70-78 | .473 | American Family Field · Milwaukee, WI |
| 149 | Thu Sep 15 | vs Giants | L5-8 | 70-79 | .470 | Coors Field · Denver, CO |
| 150 | Fri Sep 16 | vs Giants | L1-9 | 70-80 | .467 | Coors Field · Denver, CO |
| 151 | Sat Sep 17 | vs Giants | L5-6 | 70-81 | .464 | Coors Field · Denver, CO |
| 152 | Sun Sep 18 | vs Giants | L5-12 | 70-82 | .461 | Coors Field · Denver, CO |
| 153 | Mon Sep 19 | vs Padres | L2-8 | 70-83 | .458 | Coors Field · Denver, CO |
| 154 | Tue Sep 20 | vs Padres | L1-2 | 70-84 | .455 | Coors Field · Denver, CO |
| 155 | Wed Sep 21 | vs Padres | L0-4 | 70-85 | .452 | Coors Field · Denver, CO |
| 156 | Thu Sep 22 | at Astros | L6-9 | 70-86 | .449 | Minute Maid Park · Houston, TX |
| 157 | Fri Sep 23 | at Astros | L2-11 | 70-87 | .446 | Minute Maid Park · Houston, TX |
| 158 | Sat Sep 24 | at Astros | W4-2 (13) | 71-87 | .449 | Minute Maid Park · Houston, TX |
| 159 | Sun Sep 25 | at Astros | W19-3 | 72-87 | .453 | Minute Maid Park · Houston, TX |
| 160 | Mon Sep 26 | at Giants | L1-3 | 72-88 | .450 | Oracle Park · San Francisco, CA |
| 161 | Tue Sep 27 | at Giants | L0-7 | 72-89 | .447 | Oracle Park · San Francisco, CA |
| 162 | Wed Sep 28 | at Giants | W6-3 | 73-89 | .451 | Oracle Park · San Francisco, CA |