| 1 | Mon Mar 31 | at Marlins | L1-10 | 0-1 | .000 | LoanDepot Park · Miami, FL |
| 2 | Tue Apr 1 | at Marlins | L3-4 | 0-2 | .000 | LoanDepot Park · Miami, FL |
| 3 | Wed Apr 2 | at Marlins | W6-5 | 1-2 | .333 | LoanDepot Park · Miami, FL |
| 4 | Thu Apr 3 | at Marlins | L5-8 | 1-3 | .250 | LoanDepot Park · Miami, FL |
| 5 | Fri Apr 4 | vs D-backs | W12-2 | 2-3 | .400 | Coors Field · Denver, CO |
| 6 | Sat Apr 5 | vs D-backs | W9-4 | 3-3 | .500 | Coors Field · Denver, CO |
| 7 | Sun Apr 6 | vs D-backs | L3-5 | 3-4 | .429 | Coors Field · Denver, CO |
| 8 | Mon Apr 7 | vs White Sox | W8-1 | 4-4 | .500 | Coors Field · Denver, CO |
| 9 | Tue Apr 8 | vs White Sox | L3-15 | 4-5 | .444 | Coors Field · Denver, CO |
| 10 | Wed Apr 9 | vs White Sox | W10-4 | 5-5 | .500 | Coors Field · Denver, CO |
| 11 | Fri Apr 11 | at Giants | L5-6 | 5-6 | .455 | Oracle Park · San Francisco, CA |
| 12 | Sat Apr 12 | at Giants | W1-0 | 6-6 | .500 | Oracle Park · San Francisco, CA |
| 13 | Sun Apr 13 | at Giants | L4-5 (10) | 6-7 | .462 | Oracle Park · San Francisco, CA |
| 14 | Mon Apr 14 | at Padres | L4-5 | 6-8 | .429 | Petco Park · San Diego, CA |
| 15 | Tue Apr 15 | at Padres | W3-2 | 7-8 | .467 | Petco Park · San Diego, CA |
| 16 | Wed Apr 16 | at Padres | L2-4 | 7-9 | .438 | Petco Park · San Diego, CA |
| 17 | Thu Apr 17 | at Padres | W3-1 | 8-9 | .471 | Petco Park · San Diego, CA |
| 18 | Fri Apr 18 | vs Phillies | W12-1 | 9-9 | .500 | Coors Field · Denver, CO |
| 19 | Sat Apr 19 | vs Phillies | W3-1 | 10-9 | .526 | Coors Field · Denver, CO |
| 20 | Sun Apr 20 | vs Phillies | L9-10 | 10-10 | .500 | Coors Field · Denver, CO |
| 21 | Mon Apr 21 | vs Giants | W8-2 | 11-10 | .524 | Coors Field · Denver, CO |
| 22 | Tue Apr 22 | vs Giants | W2-1 | 12-10 | .545 | Coors Field · Denver, CO |
| 23 | Wed Apr 23 | vs Giants | L10-12 (11) | 12-11 | .522 | Coors Field · Denver, CO |
| 24 | Fri Apr 25 | at Dodgers | W5-4 (11) | 13-11 | .542 | Dodger Stadium · Los Angeles, CA |
| 25 | Sat Apr 26 | at Dodgers | L3-6 | 13-12 | .520 | Dodger Stadium · Los Angeles, CA |
| 26 | Sun Apr 27 | at Dodgers | W6-1 | 14-12 | .538 | Dodger Stadium · Los Angeles, CA |
| 27 | Mon Apr 28 | at D-backs | W8-5 | 15-12 | .556 | Chase Field · Phoenix, AZ |
| 28 | Tue Apr 29 | at D-backs | W5-4 | 16-12 | .571 | Chase Field · Phoenix, AZ |
| 29 | Wed Apr 30 | at D-backs | L4-5 (10) | 16-13 | .552 | Chase Field · Phoenix, AZ |
| 30 | Thu May 1 | vs Mets | W7-4 | 17-13 | .567 | Coors Field · Denver, CO |
| 31 | Fri May 2 | vs Mets | W10-3 | 18-13 | .581 | Coors Field · Denver, CO |
| 32 | Sat May 3 | vs Mets | W11-10 | 19-13 | .594 | Coors Field · Denver, CO |
| 33 | Sun May 4 | vs Mets | L1-5 | 19-14 | .576 | Coors Field · Denver, CO |
| 34 | Mon May 5 | vs Rangers | W8-2 | 20-14 | .588 | Coors Field · Denver, CO |
| 35 | Tue May 6 | vs Rangers | W12-1 | 21-14 | .600 | Coors Field · Denver, CO |
| 36 | Wed May 7 | at Rangers | W9-2 | 22-14 | .611 | Globe Life Field · Arlington, TX |
| 37 | Thu May 8 | at Rangers | L0-5 | 22-15 | .595 | Globe Life Field · Arlington, TX |
| 38 | Fri May 9 | at Reds | L3-4 | 22-16 | .579 | Great American Ball Park · Cincinnati, OH |
| 39 | Sat May 10 | at Reds | W11-2 | 23-16 | .590 | Great American Ball Park · Cincinnati, OH |
| 40 | Sun May 11 | at Reds | L1-4 | 23-17 | .575 | Great American Ball Park · Cincinnati, OH |
| 41 | Tue May 13 | at Royals | L1-5 | 23-18 | .561 | Kauffman Stadium · Kansas City, MO |
| 42 | Wed May 14 | at Royals | L2-3 | 23-19 | .548 | Kauffman Stadium · Kansas City, MO |
| 43 | Fri May 16 | vs Padres | W3-1 | 24-19 | .558 | Coors Field · Denver, CO |
| 44 | Sat May 17 | vs Padres | L5-8 | 24-20 | .545 | Coors Field · Denver, CO |
| 45 | Sun May 18 | vs Padres | W8-6 (10) | 25-20 | .556 | Coors Field · Denver, CO |
| 46 | Tue May 20 | vs Giants | W5-4 | 26-20 | .565 | Coors Field · Denver, CO |
| 47 | Wed May 21 | vs Giants | L1-5 | 26-21 | .553 | Coors Field · Denver, CO |
| 48 | Fri May 23 | at Braves | L2-3 | 26-23 | .531 | Truist Park · Cumberland, GA |
| 49 | Sat May 24 | at Braves | W3-1 | 27-23 | .540 | Truist Park · Cumberland, GA |
| 50 | Sun May 25 | at Braves | L0-7 | 27-24 | .529 | Truist Park · Cumberland, GA |
| 51 | Mon May 26 | at Phillies | L0-9 | 27-25 | .519 | Citizens Bank Park · Philadelphi, PA |
| 52 | Tue May 27 | at Phillies | W6-2 | 28-25 | .528 | Citizens Bank Park · Philadelphi, PA |
| 53 | Wed May 28 | at Phillies | L3-6 | 28-26 | .519 | Citizens Bank Park · Philadelphi, PA |
| 54 | Fri May 30 | at Guardians | L2-5 | 28-27 | .509 | Progressive Field · Cleveland, OH |
| 55 | Sat May 31 | at Guardians | L6-7 | 28-28 | .500 | Progressive Field · Cleveland, OH |
| 56 | Sun Jun 1 | at Guardians | L4-6 | 28-29 | .491 | Progressive Field · Cleveland, OH |
| 57 | Tue Jun 3 | vs D-backs | L2-4 | 28-30 | .483 | Coors Field · Denver, CO |
| 58 | Wed Jun 4 | vs D-backs | L8-16 | 28-31 | .475 | Coors Field · Denver, CO |
| 59 | Thu Jun 5 | vs D-backs | L7-12 | 28-32 | .467 | Coors Field · Denver, CO |
| 60 | Fri Jun 6 | vs Dodgers | L2-7 | 28-33 | .459 | Coors Field · Denver, CO |
| 61 | Sat Jun 7 | vs Dodgers | W5-4 (10) | 29-33 | .468 | Coors Field · Denver, CO |
| 62 | Sun Jun 8 | vs Dodgers | L1-6 | 29-34 | .460 | Coors Field · Denver, CO |
| 63 | Mon Jun 9 | vs Braves | L1-3 | 29-35 | .453 | Coors Field · Denver, CO |
| 64 | Tue Jun 10 | vs Braves | L10-13 | 29-36 | .446 | Coors Field · Denver, CO |
| 65 | Wed Jun 11 | vs Braves | W8-2 | 30-36 | .455 | Coors Field · Denver, CO |
| 66 | Thu Jun 12 | vs Braves | W10-3 | 31-36 | .463 | Coors Field · Denver, CO |
| 67 | Fri Jun 13 | at Giants | W7-4 | 32-36 | .471 | Oracle Park · San Francisco, CA |
| 68 | Sat Jun 14 | at Giants | W5-4 | 33-36 | .478 | Oracle Park · San Francisco, CA |
| 69 | Sun Jun 15 | at Giants | W8-7 | 34-36 | .486 | Oracle Park · San Francisco, CA |
| 70 | Mon Jun 16 | at Dodgers | L1-6 | 34-37 | .479 | Dodger Stadium · Los Angeles, CA |
| 71 | Tue Jun 17 | at Dodgers | L2-4 | 34-38 | .472 | Dodger Stadium · Los Angeles, CA |
| 72 | Wed Jun 18 | at Dodgers | L0-8 | 34-39 | .466 | Dodger Stadium · Los Angeles, CA |
| 73 | Fri Jun 20 | vs Brewers | L10-13 | 34-40 | .459 | Coors Field · Denver, CO |
| 74 | Sat Jun 21 | vs Brewers | L4-9 | 34-41 | .453 | Coors Field · Denver, CO |
| 75 | Sun Jun 22 | vs Brewers | L5-6 | 34-42 | .447 | Coors Field · Denver, CO |
| 76 | Mon Jun 23 | vs Cardinals | L0-8 | 34-43 | .442 | Coors Field · Denver, CO |
| 77 | Tue Jun 24 | vs Cardinals | W10-5 | 35-43 | .449 | Coors Field · Denver, CO |
| 78 | Wed Jun 25 | vs Cardinals | L6-9 | 35-44 | .443 | Coors Field · Denver, CO |
| 79 | Thu Jun 26 | at Brewers | L4-7 | 35-45 | .438 | American Family Field · Milwaukee, WI |
| 80 | Fri Jun 27 | at Brewers | L2-3 | 35-46 | .432 | American Family Field · Milwaukee, WI |
| 81 | Sat Jun 28 | at Brewers | L4-7 | 35-47 | .427 | American Family Field · Milwaukee, WI |
| 82 | Sun Jun 29 | at Brewers | W10-4 | 36-47 | .434 | American Family Field · Milwaukee, WI |
| 83 | Mon Jun 30 | at Nationals | L3-7 | 36-48 | .429 | Nationals Park · Washington, D.C. |
| 84 | Tue Jul 1 | at Nationals | L1-7 | 36-49 | .424 | Nationals Park · Washington, D.C. |
| 85 | Wed Jul 2 | at Nationals | L3-4 | 36-50 | .419 | Nationals Park · Washington, D.C. |
| 86 | Thu Jul 3 | vs Dodgers | L2-3 | 36-51 | .414 | Coors Field · Denver, CO |
| 87 | Fri Jul 4 | vs Dodgers | L0-9 | 36-52 | .409 | Coors Field · Denver, CO |
| 88 | Sat Jul 5 | vs Dodgers | W8-7 | 37-52 | .416 | Coors Field · Denver, CO |
| 89 | Sun Jul 6 | vs Dodgers | L2-8 | 37-53 | .411 | Coors Field · Denver, CO |
| 90 | Mon Jul 7 | vs Padres | L1-6 | 37-54 | .407 | Coors Field · Denver, CO |
| 91 | Tue Jul 8 | vs Padres | W2-1 | 38-54 | .413 | Coors Field · Denver, CO |
| 92 | Wed Jul 9 | vs Padres | W6-3 | 39-54 | .419 | Coors Field · Denver, CO |
| 93 | Fri Jul 11 | vs Twins | W6-2 | 40-54 | .426 | Coors Field · Denver, CO |
| 94 | Sat Jul 12 | vs Twins | L3-9 | 40-55 | .421 | Coors Field · Denver, CO |
| 95 | Sun Jul 13 | vs Twins | L5-13 | 40-56 | .417 | Coors Field · Denver, CO |
| 96 | Fri Jul 18 | at Pirates | L2-4 | 40-57 | .412 | PNC Park · Pittsburgh, PA |
| 97 | Sat Jul 19 | at Pirates | L2-3 (11) | 40-58 | .408 | PNC Park · Pittsburgh, PA |
| 98 | Sun Jul 20 | at Pirates | L3-5 | 40-59 | .404 | PNC Park · Pittsburgh, PA |
| 99 | Mon Jul 21 | vs Nationals | L2-7 | 40-60 | .400 | Coors Field · Denver, CO |
| 100 | Tue Jul 22 | vs Nationals | L4-7 | 40-61 | .396 | Coors Field · Denver, CO |
| 101 | Wed Jul 23 | vs Nationals | W6-4 | 41-61 | .402 | Coors Field · Denver, CO |
| 102 | Fri Jul 25 | vs Pirates | W8-1 | 42-61 | .408 | Coors Field · Denver, CO |
| 103 | Sat Jul 26 | vs Pirates | W8-1 | 43-61 | .413 | Coors Field · Denver, CO |
| 104 | Sun Jul 27 | vs Pirates | L5-7 | 43-62 | .410 | Coors Field · Denver, CO |
| 105 | Mon Jul 28 | at Cubs | L1-4 | 43-63 | .406 | Wrigley Field · Chicago, IL |
| 106 | Tue Jul 29 | at Cubs | L3-4 (16) | 43-64 | .402 | Wrigley Field · Chicago, IL |
| 107 | Wed Jul 30 | at Cubs | W6-4 (10) | 44-64 | .407 | Wrigley Field · Chicago, IL |
| 108 | Thu Jul 31 | at Cubs | L1-3 | 44-65 | .404 | Wrigley Field · Chicago, IL |
| 109 | Fri Aug 1 | at Tigers | L2-4 | 44-66 | .400 | Comerica Park · Detroit, MI |
| 110 | Sat Aug 2 | at Tigers | L5-11 | 44-67 | .396 | Comerica Park · Detroit, MI |
| 111 | Sun Aug 3 | at Tigers | L0-4 | 44-68 | .393 | Comerica Park · Detroit, MI |
| 112 | Tue Aug 5 | vs Cubs | L5-6 (12) | 44-69 | .389 | Coors Field · Denver, CO |
| 113 | Wed Aug 6 | vs Cubs | W13-4 | 45-69 | .395 | Coors Field · Denver, CO |
| 114 | Thu Aug 7 | vs Cubs | L2-6 | 45-70 | .391 | Coors Field · Denver, CO |
| 115 | Fri Aug 8 | at D-backs | L3-5 | 45-71 | .388 | Chase Field · Phoenix, AZ |
| 116 | Sat Aug 9 | at D-backs | L4-14 | 45-72 | .385 | Chase Field · Phoenix, AZ |
| 117 | Sun Aug 10 | at D-backs | W5-3 (10) | 46-72 | .390 | Chase Field · Phoenix, AZ |
| 118 | Mon Aug 11 | at Padres | L3-4 | 46-73 | .387 | Petco Park · San Diego, CA |
| 119 | Tue Aug 12 | at Padres | L1-4 | 46-74 | .383 | Petco Park · San Diego, CA |
| 120 | Wed Aug 13 | at Padres | L3-5 | 46-75 | .380 | Petco Park · San Diego, CA |
| 121 | Thu Aug 14 | vs Reds | W7-3 | 47-75 | .385 | Coors Field · Denver, CO |
| 122 | Fri Aug 15 | vs Reds | L2-3 | 47-76 | .382 | Coors Field · Denver, CO |
| 123 | Sun Aug 17 | vs Reds | W10-9 | 48-76 | .387 | Coors Field · Denver, CO |
| 124 | Sun Aug 17 | vs Reds | W10-5 | 49-76 | .392 | Coors Field · Denver, CO |
| 125 | Tue Aug 19 | vs Royals | L4-7 | 49-77 | .389 | Coors Field · Denver, CO |
| 126 | Wed Aug 20 | vs Royals | W5-2 | 50-77 | .394 | Coors Field · Denver, CO |
| 127 | Fri Aug 22 | vs Marlins | L5-13 | 50-78 | .391 | Coors Field · Denver, CO |
| 128 | Sat Aug 23 | vs Marlins | W5-4 (13) | 51-78 | .395 | Coors Field · Denver, CO |
| 129 | Sun Aug 24 | vs Marlins | W7-4 | 52-78 | .400 | Coors Field · Denver, CO |
| 130 | Mon Aug 25 | at Giants | W3-2 | 53-78 | .405 | Oracle Park · San Francisco, CA |
| 131 | Tue Aug 26 | at Giants | L0-3 | 53-79 | .402 | Oracle Park · San Francisco, CA |
| 132 | Wed Aug 27 | at Giants | L2-4 | 53-80 | .398 | Oracle Park · San Francisco, CA |
| 133 | Thu Aug 28 | at Giants | L1-4 | 53-81 | .396 | Oracle Park · San Francisco, CA |
| 134 | Fri Aug 29 | at D-backs | L2-5 | 53-82 | .393 | Chase Field · Phoenix, AZ |
| 135 | Sat Aug 30 | at D-backs | W2-0 | 54-82 | .397 | Chase Field · Phoenix, AZ |
| 136 | Sun Aug 31 | at D-backs | L2-6 | 54-83 | .394 | Chase Field · Phoenix, AZ |
| 137 | Mon Sep 1 | vs Giants | L2-4 | 26-22 | .542 | Coors Field · Denver, CO |
| 138 | Mon Sep 1 | vs Giants | W10-9 | 55-83 | .399 | Coors Field · Denver, CO |
| 139 | Tue Sep 2 | vs Giants | L7-12 | 55-84 | .396 | Coors Field · Denver, CO |
| 140 | Wed Sep 3 | vs Giants | W9-2 | 56-84 | .400 | Coors Field · Denver, CO |
| 141 | Fri Sep 5 | vs Padres | W3-0 | 57-84 | .404 | Coors Field · Denver, CO |
| 142 | Sat Sep 6 | vs Padres | W7-6 (12) | 58-84 | .408 | Coors Field · Denver, CO |
| 143 | Sun Sep 7 | vs Padres | W6-0 | 59-84 | .413 | Coors Field · Denver, CO |
| 144 | Mon Sep 8 | at Mets | L2-3 | 59-85 | .410 | Citi Field · Queens, NY |
| 145 | Tue Sep 9 | at Mets | L0-2 | 59-86 | .407 | Citi Field · Queens, NY |
| 146 | Wed Sep 10 | at Mets | L0-2 | 59-87 | .404 | Citi Field · Queens, NY |
| 147 | Fri Sep 12 | at Cardinals | L1-5 | 59-88 | .401 | Busch Stadium · St. Louis, MO |
| 148 | Sat Sep 13 | at Cardinals | L4-5 | 59-89 | .399 | Busch Stadium · St. Louis, MO |
| 149 | Sun Sep 14 | at Cardinals | L1-4 | 59-90 | .396 | Busch Stadium · St. Louis, MO |
| 150 | Mon Sep 15 | vs Dodgers | L3-11 | 59-91 | .393 | Coors Field · Denver, CO |
| 151 | Tue Sep 16 | vs Dodgers | W10-4 | 60-91 | .397 | Coors Field · Denver, CO |
| 152 | Wed Sep 17 | vs Dodgers | W16-2 | 61-91 | .401 | Coors Field · Denver, CO |
| 153 | Thu Sep 18 | vs D-backs | W7-6 | 62-91 | .405 | Coors Field · Denver, CO |
| 154 | Fri Sep 19 | vs D-backs | W15-3 | 63-91 | .409 | Coors Field · Denver, CO |
| 155 | Sat Sep 20 | vs D-backs | W5-1 | 64-91 | .413 | Coors Field · Denver, CO |
| 156 | Sun Sep 21 | vs D-backs | W8-3 | 65-91 | .417 | Coors Field · Denver, CO |
| 157 | Mon Sep 22 | at Padres | L0-1 | 65-92 | .414 | Petco Park · San Diego, CA |
| 158 | Tue Sep 23 | at Padres | W3-2 | 66-92 | .418 | Petco Park · San Diego, CA |
| 159 | Wed Sep 24 | at Padres | L3-4 | 66-93 | .415 | Petco Park · San Diego, CA |
| 160 | Fri Sep 26 | at Dodgers | L4-7 | 66-94 | .412 | Dodger Stadium · Los Angeles, CA |
| 161 | Sat Sep 27 | at Dodgers | L5-6 (12) | 66-95 | .410 | Dodger Stadium · Los Angeles, CA |
| 162 | Sun Sep 28 | at Dodgers | L5-10 | 66-96 | .407 | Dodger Stadium · Los Angeles, CA |