| 1 | Thu Apr 7 | at Nationals | W5-1 | 1-0 | 1.000 | Nationals Park · Washington, D.C. |
| 2 | Fri Apr 8 | at Nationals | W7-3 | 2-0 | 1.000 | Nationals Park · Washington, D.C. |
| 3 | Sat Apr 9 | at Nationals | W5-0 | 3-0 | 1.000 | Nationals Park · Washington, D.C. |
| 4 | Sun Apr 10 | at Nationals | L2-4 | 3-1 | .750 | Nationals Park · Washington, D.C. |
| 5 | Mon Apr 11 | at Phillies | L4-5 | 3-2 | .600 | Citizens Bank Park · Philadelphi, PA |
| 6 | Tue Apr 12 | at Phillies | W2-0 | 4-2 | .667 | Citizens Bank Park · Philadelphi, PA |
| 7 | Wed Apr 13 | at Phillies | W9-6 | 5-2 | .714 | Citizens Bank Park · Philadelphi, PA |
| 8 | Fri Apr 15 | vs D-backs | W10-3 | 6-2 | .750 | Citi Field · Queens, NY |
| 9 | Sat Apr 16 | vs D-backs | L2-3 | 6-3 | .667 | Citi Field · Queens, NY |
| 10 | Sun Apr 17 | vs D-backs | W5-0 | 7-3 | .700 | Citi Field · Queens, NY |
| 11 | Tue Apr 19 | vs Giants | W5-4 (10) | 8-3 | .727 | Citi Field · Queens, NY |
| 12 | Tue Apr 19 | vs Giants | W3-1 | 9-3 | .750 | Citi Field · Queens, NY |
| 13 | Wed Apr 20 | vs Giants | L2-5 | 9-4 | .692 | Citi Field · Queens, NY |
| 14 | Thu Apr 21 | vs Giants | W6-2 | 10-4 | .714 | Citi Field · Queens, NY |
| 15 | Fri Apr 22 | at D-backs | W6-5 (10) | 11-4 | .733 | Chase Field · Phoenix, AZ |
| 16 | Sat Apr 23 | at D-backs | L2-5 | 11-5 | .688 | Chase Field · Phoenix, AZ |
| 17 | Sun Apr 24 | at D-backs | W6-2 | 12-5 | .706 | Chase Field · Phoenix, AZ |
| 18 | Mon Apr 25 | at Cardinals | W5-2 | 13-5 | .722 | Busch Stadium · St. Louis, MO |
| 19 | Tue Apr 26 | at Cardinals | W3-0 | 14-5 | .737 | Busch Stadium · St. Louis, MO |
| 20 | Wed Apr 27 | at Cardinals | L5-10 | 14-6 | .700 | Busch Stadium · St. Louis, MO |
| 21 | Fri Apr 29 | vs Phillies | W3-0 | 15-6 | .714 | Citi Field · Queens, NY |
| 22 | Sat Apr 30 | vs Phillies | L1-4 | 15-7 | .682 | Citi Field · Queens, NY |
| 23 | Sun May 1 | vs Phillies | W10-6 | 16-7 | .696 | Citi Field · Queens, NY |
| 24 | Mon May 2 | vs Braves | L2-5 | 16-8 | .667 | Citi Field · Queens, NY |
| 25 | Tue May 3 | vs Braves | W5-4 | 17-8 | .680 | Citi Field · Queens, NY |
| 26 | Tue May 3 | vs Braves | W3-0 | 18-8 | .692 | Citi Field · Queens, NY |
| 27 | Wed May 4 | vs Braves | L2-9 | 18-9 | .667 | Citi Field · Queens, NY |
| 28 | Thu May 5 | at Phillies | W8-7 | 19-9 | .679 | Citizens Bank Park · Philadelphi, PA |
| 29 | Sun May 8 | at Phillies | L2-3 | 19-10 | .655 | Citizens Bank Park · Philadelphi, PA |
| 30 | Sun May 8 | at Phillies | W6-1 | 20-10 | .667 | Citizens Bank Park · Philadelphi, PA |
| 31 | Tue May 10 | at Nationals | W4-2 | 21-10 | .677 | Nationals Park · Washington, D.C. |
| 32 | Wed May 11 | at Nationals | L3-8 | 21-11 | .656 | Nationals Park · Washington, D.C. |
| 33 | Thu May 12 | at Nationals | W4-1 | 22-11 | .667 | Nationals Park · Washington, D.C. |
| 34 | Fri May 13 | vs Mariners | L1-2 | 22-12 | .647 | Citi Field · Queens, NY |
| 35 | Sat May 14 | vs Mariners | W5-4 | 23-12 | .657 | Citi Field · Queens, NY |
| 36 | Sun May 15 | vs Mariners | L7-8 | 23-13 | .639 | Citi Field · Queens, NY |
| 37 | Tue May 17 | vs Cardinals | W3-1 | 24-13 | .649 | Citi Field · Queens, NY |
| 38 | Tue May 17 | vs Cardinals | L3-4 | 24-14 | .632 | Citi Field · Queens, NY |
| 39 | Wed May 18 | vs Cardinals | W11-4 | 25-14 | .641 | Citi Field · Queens, NY |
| 40 | Thu May 19 | vs Cardinals | W7-6 (10) | 26-14 | .650 | Citi Field · Queens, NY |
| 41 | Sat May 21 | at Rockies | W5-1 | 27-14 | .659 | Coors Field · Denver, CO |
| 42 | Sat May 21 | at Rockies | L3-11 | 27-15 | .643 | Coors Field · Denver, CO |
| 43 | Sun May 22 | at Rockies | W2-0 | 28-15 | .651 | Coors Field · Denver, CO |
| 44 | Mon May 23 | at Giants | W13-3 | 29-15 | .659 | Oracle Park · San Francisco, CA |
| 45 | Tue May 24 | at Giants | L12-13 | 29-16 | .644 | Oracle Park · San Francisco, CA |
| 46 | Wed May 25 | at Giants | L3-9 | 29-17 | .630 | Oracle Park · San Francisco, CA |
| 47 | Fri May 27 | vs Phillies | W8-6 | 30-17 | .638 | Citi Field · Queens, NY |
| 48 | Sat May 28 | vs Phillies | W8-2 | 31-17 | .646 | Citi Field · Queens, NY |
| 49 | Sun May 29 | vs Phillies | W5-4 (10) | 32-17 | .653 | Citi Field · Queens, NY |
| 50 | Mon May 30 | vs Nationals | W13-5 | 33-17 | .660 | Citi Field · Queens, NY |
| 51 | Tue May 31 | vs Nationals | W10-0 | 34-17 | .667 | Citi Field · Queens, NY |
| 52 | Wed Jun 1 | vs Nationals | W5-0 | 35-17 | .673 | Citi Field · Queens, NY |
| 53 | Thu Jun 2 | at Dodgers | L0-2 | 35-18 | .660 | Dodger Stadium · Los Angeles, CA |
| 54 | Fri Jun 3 | at Dodgers | L1-6 | 35-19 | .648 | Dodger Stadium · Los Angeles, CA |
| 55 | Sat Jun 4 | at Dodgers | W9-4 | 36-19 | .655 | Dodger Stadium · Los Angeles, CA |
| 56 | Sun Jun 5 | at Dodgers | W5-4 (10) | 37-19 | .661 | Dodger Stadium · Los Angeles, CA |
| 57 | Mon Jun 6 | at Padres | W11-5 | 38-19 | .667 | Petco Park · San Diego, CA |
| 58 | Tue Jun 7 | at Padres | L0-7 | 38-20 | .655 | Petco Park · San Diego, CA |
| 59 | Wed Jun 8 | at Padres | L2-13 | 38-21 | .644 | Petco Park · San Diego, CA |
| 60 | Fri Jun 10 | at Angels | W7-3 | 39-21 | .650 | Angel Stadium · Anaheim, CA |
| 61 | Sat Jun 11 | at Angels | L6-11 | 39-22 | .639 | Angel Stadium · Anaheim, CA |
| 62 | Sun Jun 12 | at Angels | W4-1 | 40-22 | .645 | Angel Stadium · Anaheim, CA |
| 63 | Tue Jun 14 | vs Brewers | W4-0 | 41-22 | .651 | Citi Field · Queens, NY |
| 64 | Wed Jun 15 | vs Brewers | L2-10 | 41-23 | .641 | Citi Field · Queens, NY |
| 65 | Thu Jun 16 | vs Brewers | W5-4 | 42-23 | .646 | Citi Field · Queens, NY |
| 66 | Fri Jun 17 | vs Marlins | W10-4 | 43-23 | .652 | Citi Field · Queens, NY |
| 67 | Sat Jun 18 | vs Marlins | W3-2 | 44-23 | .657 | Citi Field · Queens, NY |
| 68 | Sun Jun 19 | vs Marlins | L2-6 | 44-24 | .647 | Citi Field · Queens, NY |
| 69 | Mon Jun 20 | vs Marlins | W6-0 | 45-24 | .652 | Citi Field · Queens, NY |
| 70 | Tue Jun 21 | at Astros | L2-8 | 45-25 | .643 | Minute Maid Park · Houston, TX |
| 71 | Wed Jun 22 | at Astros | L3-5 | 45-26 | .634 | Minute Maid Park · Houston, TX |
| 72 | Fri Jun 24 | at Marlins | W5-3 | 46-26 | .639 | LoanDepot Park · Miami, FL |
| 73 | Sat Jun 25 | at Marlins | W5-3 | 47-26 | .644 | LoanDepot Park · Miami, FL |
| 74 | Sun Jun 26 | at Marlins | L2-3 | 47-27 | .635 | LoanDepot Park · Miami, FL |
| 75 | Tue Jun 28 | vs Astros | L1-9 | 47-28 | .627 | Citi Field · Queens, NY |
| 76 | Wed Jun 29 | vs Astros | L0-2 | 47-29 | .618 | Citi Field · Queens, NY |
| 77 | Fri Jul 1 | vs Rangers | W4-3 | 48-29 | .623 | Citi Field · Queens, NY |
| 78 | Sat Jul 2 | vs Rangers | L3-7 | 48-30 | .615 | Citi Field · Queens, NY |
| 79 | Sun Jul 3 | vs Rangers | W4-1 | 49-30 | .620 | Citi Field · Queens, NY |
| 80 | Mon Jul 4 | at Reds | W7-4 | 50-30 | .625 | Great American Ball Park · Cincinnati, OH |
| 81 | Tue Jul 5 | at Reds | L0-1 | 50-31 | .617 | Great American Ball Park · Cincinnati, OH |
| 82 | Wed Jul 6 | at Reds | W8-3 (10) | 51-31 | .622 | Great American Ball Park · Cincinnati, OH |
| 83 | Thu Jul 7 | vs Marlins | W10-0 | 52-31 | .627 | Citi Field · Queens, NY |
| 84 | Fri Jul 8 | vs Marlins | L2-5 | 52-32 | .619 | Citi Field · Queens, NY |
| 85 | Sat Jul 9 | vs Marlins | W5-4 (10) | 53-32 | .624 | Citi Field · Queens, NY |
| 86 | Sun Jul 10 | vs Marlins | L0-2 (10) | 53-33 | .616 | Citi Field · Queens, NY |
| 87 | Mon Jul 11 | at Braves | W4-1 | 54-33 | .621 | Truist Park · Cumberland, GA |
| 88 | Tue Jul 12 | at Braves | L1-4 | 54-34 | .614 | Truist Park · Cumberland, GA |
| 89 | Wed Jul 13 | at Braves | W7-3 | 55-34 | .618 | Truist Park · Cumberland, GA |
| 90 | Thu Jul 14 | at Cubs | W8-0 | 56-34 | .622 | Wrigley Field · Chicago, IL |
| 91 | Sat Jul 16 | at Cubs | W2-1 (11) | 57-34 | .626 | Wrigley Field · Chicago, IL |
| 92 | Sat Jul 16 | at Cubs | W4-3 (10) | 58-34 | .630 | Wrigley Field · Chicago, IL |
| 93 | Sun Jul 17 | at Cubs | L2-3 | 58-35 | .624 | Wrigley Field · Chicago, IL |
| 94 | Fri Jul 22 | vs Padres | L1-4 | 58-36 | .617 | Citi Field · Queens, NY |
| 95 | Sat Jul 23 | vs Padres | L1-2 | 58-37 | .611 | Citi Field · Queens, NY |
| 96 | Sun Jul 24 | vs Padres | W8-5 | 59-37 | .615 | Citi Field · Queens, NY |
| 97 | Tue Jul 26 | vs Yankees | W6-3 | 60-37 | .619 | Citi Field · Queens, NY |
| 98 | Wed Jul 27 | vs Yankees | W3-2 | 61-37 | .622 | Citi Field · Queens, NY |
| 99 | Fri Jul 29 | at Marlins | W6-4 | 62-37 | .626 | LoanDepot Park · Miami, FL |
| 100 | Sat Jul 30 | at Marlins | W4-0 | 63-37 | .630 | LoanDepot Park · Miami, FL |
| 101 | Sun Jul 31 | at Marlins | W9-3 | 64-37 | .634 | LoanDepot Park · Miami, FL |
| 102 | Mon Aug 1 | at Nationals | W7-3 | 65-37 | .637 | Nationals Park · Washington, D.C. |
| 103 | Tue Aug 2 | at Nationals | L1-5 | 65-38 | .631 | Nationals Park · Washington, D.C. |
| 104 | Wed Aug 3 | at Nationals | W9-5 | 66-38 | .635 | Nationals Park · Washington, D.C. |
| 105 | Thu Aug 4 | vs Braves | W6-4 | 67-38 | .638 | Citi Field · Queens, NY |
| 106 | Fri Aug 5 | vs Braves | L6-9 | 67-39 | .632 | Citi Field · Queens, NY |
| 107 | Sat Aug 6 | vs Braves | W8-5 | 68-39 | .636 | Citi Field · Queens, NY |
| 108 | Sat Aug 6 | vs Braves | W6-2 | 69-39 | .639 | Citi Field · Queens, NY |
| 109 | Sun Aug 7 | vs Braves | W5-2 | 70-39 | .642 | Citi Field · Queens, NY |
| 110 | Mon Aug 8 | vs Reds | W5-1 | 71-39 | .645 | Citi Field · Queens, NY |
| 111 | Tue Aug 9 | vs Reds | W6-2 | 72-39 | .649 | Citi Field · Queens, NY |
| 112 | Wed Aug 10 | vs Reds | W10-2 | 73-39 | .652 | Citi Field · Queens, NY |
| 113 | Fri Aug 12 | vs Phillies | L1-2 (10) | 73-40 | .646 | Citi Field · Queens, NY |
| 114 | Sat Aug 13 | vs Phillies | W1-0 | 74-40 | .649 | Citi Field · Queens, NY |
| 115 | Sun Aug 14 | vs Phillies | W6-0 | 75-40 | .652 | Citi Field · Queens, NY |
| 116 | Mon Aug 15 | at Braves | L1-13 | 75-41 | .647 | Truist Park · Cumberland, GA |
| 117 | Tue Aug 16 | at Braves | L0-5 | 75-42 | .641 | Truist Park · Cumberland, GA |
| 118 | Wed Aug 17 | at Braves | W9-7 | 76-42 | .644 | Truist Park · Cumberland, GA |
| 119 | Thu Aug 18 | at Braves | L2-3 | 76-43 | .639 | Truist Park · Cumberland, GA |
| 120 | Fri Aug 19 | at Phillies | W7-2 | 77-43 | .642 | Citizens Bank Park · Philadelphi, PA |
| 121 | Sat Aug 20 | at Phillies | W8-2 | 78-43 | .645 | Citizens Bank Park · Philadelphi, PA |
| 122 | Sat Aug 20 | at Phillies | L1-4 | 78-44 | .639 | Citizens Bank Park · Philadelphi, PA |
| 123 | Sun Aug 21 | at Phillies | W10-9 | 79-44 | .642 | Citizens Bank Park · Philadelphi, PA |
| 124 | Mon Aug 22 | at Yankees | L2-4 | 79-45 | .637 | Yankee Stadium · The Bronx, NY |
| 125 | Tue Aug 23 | at Yankees | L2-4 | 79-46 | .632 | Yankee Stadium · The Bronx, NY |
| 126 | Thu Aug 25 | vs Rockies | W3-1 | 80-46 | .635 | Citi Field · Queens, NY |
| 127 | Fri Aug 26 | vs Rockies | W7-6 | 81-46 | .638 | Citi Field · Queens, NY |
| 128 | Sat Aug 27 | vs Rockies | W3-0 | 82-46 | .641 | Citi Field · Queens, NY |
| 129 | Sun Aug 28 | vs Rockies | L0-1 | 82-47 | .636 | Citi Field · Queens, NY |
| 130 | Tue Aug 30 | vs Dodgers | L3-4 | 82-48 | .631 | Citi Field · Queens, NY |
| 131 | Wed Aug 31 | vs Dodgers | W2-1 | 83-48 | .634 | Citi Field · Queens, NY |
| 132 | Thu Sep 1 | vs Dodgers | W5-3 | 84-48 | .636 | Citi Field · Queens, NY |
| 133 | Fri Sep 2 | vs Nationals | W7-3 | 85-48 | .639 | Citi Field · Queens, NY |
| 134 | Sat Sep 3 | vs Nationals | L1-7 | 85-49 | .634 | Citi Field · Queens, NY |
| 135 | Sun Sep 4 | vs Nationals | L1-7 | 85-50 | .630 | Citi Field · Queens, NY |
| 136 | Tue Sep 6 | at Pirates | L2-8 | 85-51 | .625 | PNC Park · Pittsburgh, PA |
| 137 | Wed Sep 7 | at Pirates | W5-1 | 86-51 | .628 | PNC Park · Pittsburgh, PA |
| 138 | Wed Sep 7 | at Pirates | W10-0 | 87-51 | .630 | PNC Park · Pittsburgh, PA |
| 139 | Fri Sep 9 | at Marlins | L3-6 | 87-52 | .626 | LoanDepot Park · Miami, FL |
| 140 | Sat Sep 10 | at Marlins | W11-3 | 88-52 | .629 | LoanDepot Park · Miami, FL |
| 141 | Sun Sep 11 | at Marlins | W9-3 | 89-52 | .631 | LoanDepot Park · Miami, FL |
| 142 | Mon Sep 12 | vs Cubs | L2-5 | 89-53 | .627 | Citi Field · Queens, NY |
| 143 | Tue Sep 13 | vs Cubs | L1-4 | 89-54 | .622 | Citi Field · Queens, NY |
| 144 | Wed Sep 14 | vs Cubs | L3-6 | 89-55 | .618 | Citi Field · Queens, NY |
| 145 | Thu Sep 15 | vs Pirates | W7-1 | 90-55 | .621 | Citi Field · Queens, NY |
| 146 | Fri Sep 16 | vs Pirates | W4-3 | 91-55 | .623 | Citi Field · Queens, NY |
| 147 | Sat Sep 17 | vs Pirates | W5-1 | 92-55 | .626 | Citi Field · Queens, NY |
| 148 | Sun Sep 18 | vs Pirates | W7-3 | 93-55 | .628 | Citi Field · Queens, NY |
| 149 | Mon Sep 19 | at Brewers | W7-2 | 94-55 | .631 | American Family Field · Milwaukee, WI |
| 150 | Tue Sep 20 | at Brewers | W7-5 | 95-55 | .633 | American Family Field · Milwaukee, WI |
| 151 | Wed Sep 21 | at Brewers | L0-6 | 95-56 | .629 | American Family Field · Milwaukee, WI |
| 152 | Fri Sep 23 | at Athletics | W9-2 | 96-56 | .632 | RingCentral Coliseum · Oakland, CA |
| 153 | Sat Sep 24 | at Athletics | L4-10 | 96-57 | .627 | RingCentral Coliseum · Oakland, CA |
| 154 | Sun Sep 25 | at Athletics | W13-4 | 97-57 | .630 | RingCentral Coliseum · Oakland, CA |
| 155 | Tue Sep 27 | vs Marlins | L4-6 | 97-58 | .626 | Citi Field · Queens, NY |
| 156 | Wed Sep 28 | vs Marlins | W5-4 (10) | 98-58 | .628 | Citi Field · Queens, NY |
| 157 | Fri Sep 30 | at Braves | L2-5 | 98-59 | .624 | Truist Park · Cumberland, GA |
| 158 | Sat Oct 1 | at Braves | L2-4 | 98-60 | .620 | Truist Park · Cumberland, GA |
| 159 | Sun Oct 2 | at Braves | L3-5 | 98-61 | .616 | Truist Park · Cumberland, GA |
| 160 | Tue Oct 4 | vs Nationals | W4-2 | 99-61 | .619 | Citi Field · Queens, NY |
| 161 | Tue Oct 4 | vs Nationals | W8-0 | 100-61 | .621 | Citi Field · Queens, NY |
| 162 | Wed Oct 5 | vs Nationals | W9-2 | 101-61 | .623 | Citi Field · Queens, NY |
| 163 | Fri Oct 7 | vs Padres | L1-7 | 0-1 | .000 | Citi Field · Queens, NY |
| 164 | Sat Oct 8 | vs Padres | W7-3 | 1-1 | .500 | Citi Field · Queens, NY |
| 165 | Sun Oct 9 | vs Padres | L0-6 | 1-2 | .333 | Citi Field · Queens, NY |