| 1 | Mon Apr 3 | at Astros | L0-3 | 0-1 | .000 | Minute Maid Park · Houston, TX |
| 2 | Tue Apr 4 | at Astros | L1-2 | 0-2 | .000 | Minute Maid Park · Houston, TX |
| 3 | Wed Apr 5 | at Astros | L3-5 (13) | 0-3 | .000 | Minute Maid Park · Houston, TX |
| 4 | Thu Apr 6 | at Astros | W4-2 | 1-3 | .250 | Minute Maid Park · Houston, TX |
| 5 | Fri Apr 7 | at Angels | L1-5 | 1-4 | .200 | Angel Stadium · Anaheim, CA |
| 6 | Sat Apr 8 | at Angels | L4-5 | 1-5 | .167 | Angel Stadium · Anaheim, CA |
| 7 | Sun Apr 9 | at Angels | L9-10 | 1-6 | .143 | Angel Stadium · Anaheim, CA |
| 8 | Mon Apr 10 | vs Astros | W6-0 | 2-6 | .250 | T-Mobile Park · Seattle, WA |
| 9 | Tue Apr 11 | vs Astros | L5-7 | 2-7 | .222 | T-Mobile Park · Seattle, WA |
| 10 | Wed Apr 12 | vs Astros | L5-10 | 2-8 | .200 | T-Mobile Park · Seattle, WA |
| 11 | Fri Apr 14 | vs Rangers | W2-1 | 3-8 | .273 | T-Mobile Park · Seattle, WA |
| 12 | Sat Apr 15 | vs Rangers | W5-0 | 4-8 | .333 | T-Mobile Park · Seattle, WA |
| 13 | Sun Apr 16 | vs Rangers | W8-7 | 5-8 | .385 | T-Mobile Park · Seattle, WA |
| 14 | Mon Apr 17 | vs Marlins | W6-1 | 6-8 | .429 | T-Mobile Park · Seattle, WA |
| 15 | Tue Apr 18 | vs Marlins | L0-5 | 6-9 | .400 | T-Mobile Park · Seattle, WA |
| 16 | Wed Apr 19 | vs Marlins | W10-5 | 7-9 | .438 | T-Mobile Park · Seattle, WA |
| 17 | Thu Apr 20 | at Athletics | L6-9 | 7-10 | .412 | RingCentral Coliseum · Oakland, CA |
| 18 | Fri Apr 21 | at Athletics | L1-3 | 7-11 | .389 | RingCentral Coliseum · Oakland, CA |
| 19 | Sat Apr 22 | at Athletics | L3-4 | 7-12 | .368 | RingCentral Coliseum · Oakland, CA |
| 20 | Sun Apr 23 | at Athletics | W11-1 | 8-12 | .400 | RingCentral Coliseum · Oakland, CA |
| 21 | Tue Apr 25 | at Tigers | L9-19 | 8-13 | .381 | Comerica Park · Detroit, MI |
| 22 | Wed Apr 26 | at Tigers | W8-0 | 9-13 | .409 | Comerica Park · Detroit, MI |
| 23 | Thu Apr 27 | at Tigers | W2-1 | 10-13 | .435 | Comerica Park · Detroit, MI |
| 24 | Fri Apr 28 | at Guardians | W3-1 | 11-13 | .458 | Progressive Field · Cleveland, OH |
| 25 | Sat Apr 29 | at Guardians | L3-4 | 11-14 | .440 | Progressive Field · Cleveland, OH |
| 26 | Sun Apr 30 | at Guardians | L4-12 | 11-15 | .423 | Progressive Field · Cleveland, OH |
| 27 | Tue May 2 | vs Angels | L4-6 (11) | 11-16 | .407 | T-Mobile Park · Seattle, WA |
| 28 | Wed May 3 | vs Angels | W8-7 | 12-16 | .429 | T-Mobile Park · Seattle, WA |
| 29 | Thu May 4 | vs Angels | W11-3 | 13-16 | .448 | T-Mobile Park · Seattle, WA |
| 30 | Fri May 5 | vs Rangers | L1-3 (13) | 13-17 | .433 | T-Mobile Park · Seattle, WA |
| 31 | Sat May 6 | vs Rangers | W8-2 | 14-17 | .452 | T-Mobile Park · Seattle, WA |
| 32 | Sun May 7 | vs Rangers | W4-3 | 15-17 | .469 | T-Mobile Park · Seattle, WA |
| 33 | Tue May 9 | at Phillies | W10-9 | 16-17 | .485 | Citizens Bank Park · Philadelphi, PA |
| 34 | Wed May 10 | at Phillies | W11-6 | 17-17 | .500 | Citizens Bank Park · Philadelphi, PA |
| 35 | Thu May 11 | at Blue Jays | L2-7 | 17-18 | .486 | Rogers Centre · Toronto, ON |
| 36 | Fri May 12 | at Blue Jays | L0-4 | 17-19 | .472 | Rogers Centre · Toronto, ON |
| 37 | Sat May 13 | at Blue Jays | L2-7 | 17-20 | .459 | Rogers Centre · Toronto, ON |
| 38 | Sun May 14 | at Blue Jays | L2-3 | 17-21 | .447 | Rogers Centre · Toronto, ON |
| 39 | Mon May 15 | vs Athletics | W6-5 | 18-21 | .462 | T-Mobile Park · Seattle, WA |
| 40 | Tue May 16 | vs Athletics | L6-9 | 18-22 | .450 | T-Mobile Park · Seattle, WA |
| 41 | Wed May 17 | vs Athletics | W4-0 | 19-22 | .463 | T-Mobile Park · Seattle, WA |
| 42 | Thu May 18 | vs White Sox | W5-4 | 20-22 | .476 | T-Mobile Park · Seattle, WA |
| 43 | Fri May 19 | vs White Sox | L1-2 (10) | 20-23 | .465 | T-Mobile Park · Seattle, WA |
| 44 | Sat May 20 | vs White Sox | L1-16 | 20-24 | .455 | T-Mobile Park · Seattle, WA |
| 45 | Sun May 21 | vs White Sox | L1-8 | 20-25 | .444 | T-Mobile Park · Seattle, WA |
| 46 | Tue May 23 | at Nationals | L1-10 | 20-26 | .435 | Nationals Park · Washington, D.C. |
| 47 | Wed May 24 | at Nationals | L1-5 | 20-27 | .426 | Nationals Park · Washington, D.C. |
| 48 | Thu May 25 | at Nationals | W4-2 | 21-27 | .438 | Nationals Park · Washington, D.C. |
| 49 | Fri May 26 | at Red Sox | L0-3 | 21-28 | .429 | Fenway Park · Boston, MA |
| 50 | Sat May 27 | at Red Sox | L0-6 | 21-29 | .420 | Fenway Park · Boston, MA |
| 51 | Sun May 28 | at Red Sox | W5-0 | 22-29 | .431 | Fenway Park · Boston, MA |
| 52 | Mon May 29 | at Rockies | W6-5 | 23-29 | .442 | Coors Field · Denver, CO |
| 53 | Tue May 30 | at Rockies | W10-4 | 24-29 | .453 | Coors Field · Denver, CO |
| 54 | Wed May 31 | vs Rockies | W5-0 | 25-29 | .463 | T-Mobile Park · Seattle, WA |
| 55 | Thu Jun 1 | vs Rockies | L3-6 | 25-30 | .455 | T-Mobile Park · Seattle, WA |
| 56 | Fri Jun 2 | vs Rays | W12-4 | 26-30 | .464 | T-Mobile Park · Seattle, WA |
| 57 | Sat Jun 3 | vs Rays | W9-2 | 27-30 | .474 | T-Mobile Park · Seattle, WA |
| 58 | Sun Jun 4 | vs Rays | W7-1 | 28-30 | .483 | T-Mobile Park · Seattle, WA |
| 59 | Tue Jun 6 | vs Twins | W12-3 | 29-30 | .492 | T-Mobile Park · Seattle, WA |
| 60 | Wed Jun 7 | vs Twins | W6-5 | 30-30 | .500 | T-Mobile Park · Seattle, WA |
| 61 | Thu Jun 8 | vs Twins | L1-2 | 30-31 | .492 | T-Mobile Park · Seattle, WA |
| 62 | Fri Jun 9 | vs Blue Jays | W4-2 | 31-31 | .500 | T-Mobile Park · Seattle, WA |
| 63 | Sat Jun 10 | vs Blue Jays | L2-4 | 31-32 | .492 | T-Mobile Park · Seattle, WA |
| 64 | Sun Jun 11 | vs Blue Jays | L0-4 | 31-33 | .484 | T-Mobile Park · Seattle, WA |
| 65 | Mon Jun 12 | at Twins | W14-3 | 32-33 | .492 | Target Field · Minneapolis, MN |
| 66 | Tue Jun 13 | at Twins | L7-20 | 32-34 | .485 | Target Field · Minneapolis, MN |
| 67 | Wed Jun 14 | at Twins | W6-4 | 33-34 | .493 | Target Field · Minneapolis, MN |
| 68 | Thu Jun 15 | at Twins | L2-6 | 33-35 | .485 | Target Field · Minneapolis, MN |
| 69 | Fri Jun 16 | at Rangers | L4-10 | 33-36 | .478 | Globe Life Field · Arlington, TX |
| 70 | Sat Jun 17 | at Rangers | L4-10 | 33-37 | .471 | Globe Life Field · Arlington, TX |
| 71 | Sun Jun 18 | at Rangers | W7-3 | 34-37 | .479 | Globe Life Field · Arlington, TX |
| 72 | Mon Jun 19 | vs Tigers | W6-2 | 35-37 | .486 | T-Mobile Park · Seattle, WA |
| 73 | Tue Jun 20 | vs Tigers | W5-4 (10) | 36-37 | .493 | T-Mobile Park · Seattle, WA |
| 74 | Wed Jun 21 | vs Tigers | W7-5 | 37-37 | .500 | T-Mobile Park · Seattle, WA |
| 75 | Thu Jun 22 | vs Tigers | W9-6 | 38-37 | .507 | T-Mobile Park · Seattle, WA |
| 76 | Fri Jun 23 | vs Astros | W13-3 | 39-37 | .513 | T-Mobile Park · Seattle, WA |
| 77 | Sat Jun 24 | vs Astros | L2-5 | 39-38 | .506 | T-Mobile Park · Seattle, WA |
| 78 | Sun Jun 25 | vs Astros | L2-8 | 39-39 | .500 | T-Mobile Park · Seattle, WA |
| 79 | Tue Jun 27 | vs Phillies | L2-8 | 39-40 | .494 | T-Mobile Park · Seattle, WA |
| 80 | Wed Jun 28 | vs Phillies | L4-5 | 39-41 | .487 | T-Mobile Park · Seattle, WA |
| 81 | Fri Jun 30 | at Angels | W10-0 | 40-41 | .494 | Angel Stadium · Anaheim, CA |
| 82 | Sat Jul 1 | at Angels | L0-4 | 40-42 | .488 | Angel Stadium · Anaheim, CA |
| 83 | Sun Jul 2 | at Angels | W5-3 | 41-42 | .494 | Angel Stadium · Anaheim, CA |
| 84 | Mon Jul 3 | vs Royals | L1-3 | 41-43 | .488 | T-Mobile Park · Seattle, WA |
| 85 | Tue Jul 4 | vs Royals | L3-7 | 41-44 | .482 | T-Mobile Park · Seattle, WA |
| 86 | Wed Jul 5 | vs Royals | L6-9 (10) | 41-45 | .477 | T-Mobile Park · Seattle, WA |
| 87 | Thu Jul 6 | vs Athletics | L4-7 | 41-46 | .471 | T-Mobile Park · Seattle, WA |
| 88 | Fri Jul 7 | vs Athletics | W7-2 | 42-46 | .477 | T-Mobile Park · Seattle, WA |
| 89 | Sat Jul 8 | vs Athletics | L3-4 | 42-47 | .472 | T-Mobile Park · Seattle, WA |
| 90 | Sun Jul 9 | vs Athletics | W4-0 | 43-47 | .478 | T-Mobile Park · Seattle, WA |
| 91 | Fri Jul 14 | at White Sox | W4-2 | 44-47 | .484 | Guaranteed Rate Field · Chicago, IL |
| 92 | Sat Jul 15 | at White Sox | W4-3 | 45-47 | .489 | Guaranteed Rate Field · Chicago, IL |
| 93 | Sun Jul 16 | at White Sox | W7-6 (10) | 46-47 | .495 | Guaranteed Rate Field · Chicago, IL |
| 94 | Mon Jul 17 | at Astros | W9-7 (10) | 47-47 | .500 | Minute Maid Park · Houston, TX |
| 95 | Tue Jul 18 | at Astros | L2-6 | 47-48 | .495 | Minute Maid Park · Houston, TX |
| 96 | Wed Jul 19 | at Astros | W4-1 | 48-48 | .500 | Minute Maid Park · Houston, TX |
| 97 | Thu Jul 20 | vs Yankees | L1-4 | 48-49 | .495 | T-Mobile Park · Seattle, WA |
| 98 | Fri Jul 21 | vs Yankees | L1-5 | 48-50 | .490 | T-Mobile Park · Seattle, WA |
| 99 | Sat Jul 22 | vs Yankees | W6-5 (10) | 49-50 | .495 | T-Mobile Park · Seattle, WA |
| 100 | Sun Jul 23 | vs Yankees | L4-6 | 49-51 | .490 | T-Mobile Park · Seattle, WA |
| 101 | Mon Jul 24 | vs Red Sox | W4-0 | 50-51 | .495 | T-Mobile Park · Seattle, WA |
| 102 | Tue Jul 25 | vs Red Sox | W6-5 (13) | 51-51 | .500 | T-Mobile Park · Seattle, WA |
| 103 | Wed Jul 26 | vs Red Sox | L0-4 | 51-52 | .495 | T-Mobile Park · Seattle, WA |
| 104 | Fri Jul 28 | vs Mets | L5-7 | 51-53 | .490 | T-Mobile Park · Seattle, WA |
| 105 | Sat Jul 29 | vs Mets | W3-2 | 52-53 | .495 | T-Mobile Park · Seattle, WA |
| 106 | Sun Jul 30 | vs Mets | W9-1 | 53-53 | .500 | T-Mobile Park · Seattle, WA |
| 107 | Mon Jul 31 | at Rangers | W6-4 | 54-53 | .505 | Globe Life Field · Arlington, TX |
| 108 | Tue Aug 1 | at Rangers | W8-7 | 55-53 | .509 | Globe Life Field · Arlington, TX |
| 109 | Wed Aug 2 | at Rangers | L1-5 | 55-54 | .505 | Globe Life Field · Arlington, TX |
| 110 | Thu Aug 3 | at Royals | L4-6 | 55-55 | .500 | Kauffman Stadium · Kansas City, MO |
| 111 | Fri Aug 4 | at Royals | W5-2 | 56-55 | .505 | Kauffman Stadium · Kansas City, MO |
| 112 | Sun Aug 6 | at Royals | W8-7 | 57-55 | .509 | Kauffman Stadium · Kansas City, MO |
| 113 | Sun Aug 6 | at Royals | L1-9 | 57-56 | .504 | Kauffman Stadium · Kansas City, MO |
| 114 | Tue Aug 8 | at Athletics | W7-6 (10) | 58-56 | .509 | RingCentral Coliseum · Oakland, CA |
| 115 | Wed Aug 9 | at Athletics | W6-3 | 59-56 | .513 | RingCentral Coliseum · Oakland, CA |
| 116 | Thu Aug 10 | vs Angels | L3-6 | 59-57 | .509 | T-Mobile Park · Seattle, WA |
| 117 | Fri Aug 11 | vs Angels | L5-6 | 59-58 | .504 | T-Mobile Park · Seattle, WA |
| 118 | Sat Aug 12 | vs Angels | L3-6 | 59-59 | .500 | T-Mobile Park · Seattle, WA |
| 119 | Sun Aug 13 | vs Angels | L2-4 | 59-60 | .496 | T-Mobile Park · Seattle, WA |
| 120 | Mon Aug 14 | vs Orioles | L3-11 | 59-61 | .492 | T-Mobile Park · Seattle, WA |
| 121 | Tue Aug 15 | vs Orioles | W3-1 | 60-61 | .496 | T-Mobile Park · Seattle, WA |
| 122 | Wed Aug 16 | vs Orioles | W7-6 | 61-61 | .500 | T-Mobile Park · Seattle, WA |
| 123 | Fri Aug 18 | at Rays | W7-1 | 62-61 | .504 | Tropicana Field · St. Petersburg, FL |
| 124 | Sat Aug 19 | at Rays | W7-6 | 63-61 | .508 | Tropicana Field · St. Petersburg, FL |
| 125 | Sun Aug 20 | at Rays | L0-3 | 63-62 | .504 | Tropicana Field · St. Petersburg, FL |
| 126 | Mon Aug 21 | at Braves | W6-5 | 64-62 | .508 | Truist Park · Cumberland, GA |
| 127 | Tue Aug 22 | at Braves | L0-4 | 64-63 | .504 | Truist Park · Cumberland, GA |
| 128 | Wed Aug 23 | at Braves | W9-6 | 65-63 | .508 | Truist Park · Cumberland, GA |
| 129 | Fri Aug 25 | at Yankees | W2-1 (11) | 66-63 | .512 | Yankee Stadium · The Bronx, NY |
| 130 | Sat Aug 26 | at Yankees | L3-6 | 66-64 | .508 | Yankee Stadium · The Bronx, NY |
| 131 | Sun Aug 27 | at Yankees | L1-10 | 66-65 | .504 | Yankee Stadium · The Bronx, NY |
| 132 | Mon Aug 28 | at Orioles | L6-7 | 66-66 | .500 | Camden Yards · Baltimore, MD |
| 133 | Tue Aug 29 | at Orioles | L0-4 | 66-67 | .496 | Camden Yards · Baltimore, MD |
| 134 | Wed Aug 30 | at Orioles | L7-8 | 66-68 | .493 | Camden Yards · Baltimore, MD |
| 135 | Fri Sep 1 | vs Athletics | W3-2 | 67-68 | .496 | T-Mobile Park · Seattle, WA |
| 136 | Sat Sep 2 | vs Athletics | W7-6 | 68-68 | .500 | T-Mobile Park · Seattle, WA |
| 137 | Sun Sep 3 | vs Athletics | W10-2 | 69-68 | .504 | T-Mobile Park · Seattle, WA |
| 138 | Mon Sep 4 | vs Astros | L2-6 | 69-69 | .500 | T-Mobile Park · Seattle, WA |
| 139 | Tue Sep 5 | vs Astros | L1-3 | 69-70 | .496 | T-Mobile Park · Seattle, WA |
| 140 | Wed Sep 6 | vs Astros | L3-5 | 69-71 | .493 | T-Mobile Park · Seattle, WA |
| 141 | Fri Sep 8 | vs Angels | W4-3 | 70-71 | .496 | T-Mobile Park · Seattle, WA |
| 142 | Sat Sep 9 | vs Angels | W8-1 | 71-71 | .500 | T-Mobile Park · Seattle, WA |
| 143 | Sun Sep 10 | vs Angels | L3-5 | 71-72 | .497 | T-Mobile Park · Seattle, WA |
| 144 | Mon Sep 11 | at Rangers | L3-5 | 71-73 | .493 | Globe Life Field · Arlington, TX |
| 145 | Tue Sep 12 | at Rangers | W10-3 | 72-73 | .497 | Globe Life Field · Arlington, TX |
| 146 | Wed Sep 13 | at Rangers | W8-1 | 73-73 | .500 | Globe Life Field · Arlington, TX |
| 147 | Thu Sep 14 | at Rangers | W10-4 | 74-73 | .503 | Globe Life Field · Arlington, TX |
| 148 | Fri Sep 15 | at Astros | L2-5 | 74-74 | .500 | Minute Maid Park · Houston, TX |
| 149 | Sat Sep 16 | at Astros | L6-8 | 74-75 | .497 | Minute Maid Park · Houston, TX |
| 150 | Sun Sep 17 | at Astros | L1-7 | 74-76 | .493 | Minute Maid Park · Houston, TX |
| 151 | Tue Sep 19 | vs Rangers | L1-3 | 74-77 | .490 | T-Mobile Park · Seattle, WA |
| 152 | Wed Sep 20 | vs Rangers | L6-8 | 74-78 | .487 | T-Mobile Park · Seattle, WA |
| 153 | Thu Sep 21 | vs Rangers | L2-4 | 74-79 | .484 | T-Mobile Park · Seattle, WA |
| 154 | Fri Sep 22 | vs Guardians | W3-1 | 75-79 | .487 | T-Mobile Park · Seattle, WA |
| 155 | Sat Sep 23 | vs Guardians | L4-11 | 75-80 | .484 | T-Mobile Park · Seattle, WA |
| 156 | Sun Sep 24 | vs Guardians | L2-4 | 75-81 | .481 | T-Mobile Park · Seattle, WA |
| 157 | Mon Sep 25 | at Athletics | W7-1 | 76-81 | .484 | RingCentral Coliseum · Oakland, CA |
| 158 | Tue Sep 26 | at Athletics | W6-3 | 77-81 | .487 | RingCentral Coliseum · Oakland, CA |
| 159 | Wed Sep 27 | at Athletics | L5-6 | 77-82 | .484 | RingCentral Coliseum · Oakland, CA |
| 160 | Fri Sep 29 | at Angels | L5-6 | 77-83 | .481 | Angel Stadium · Anaheim, CA |
| 161 | Sat Sep 30 | at Angels | W6-4 | 78-83 | .484 | Angel Stadium · Anaheim, CA |
| 162 | Sun Oct 1 | at Angels | L2-6 | 78-84 | .481 | Angel Stadium · Anaheim, CA |