| 1 | Thu Mar 28 | at Yankees | L2-7 | 0-1 | .000 | Yankee Stadium · The Bronx, NY |
| 2 | Sat Mar 30 | at Yankees | W5-3 | 1-1 | .500 | Yankee Stadium · The Bronx, NY |
| 3 | Sun Mar 31 | at Yankees | W7-5 | 2-1 | .667 | Yankee Stadium · The Bronx, NY |
| 4 | Mon Apr 1 | at Blue Jays | W6-5 | 3-1 | .750 | Rogers Centre · Toronto, ON |
| 5 | Tue Apr 2 | at Blue Jays | W2-1 | 4-1 | .800 | Rogers Centre · Toronto, ON |
| 6 | Wed Apr 3 | at Blue Jays | L3-5 | 4-2 | .667 | Rogers Centre · Toronto, ON |
| 7 | Thu Apr 4 | vs Yankees | L4-8 | 4-3 | .571 | Camden Yards · Baltimore, MD |
| 8 | Sat Apr 6 | vs Yankees | L4-6 | 4-4 | .500 | Camden Yards · Baltimore, MD |
| 9 | Sun Apr 7 | vs Yankees | L3-15 | 4-5 | .444 | Camden Yards · Baltimore, MD |
| 10 | Mon Apr 8 | vs Athletics | W12-4 | 5-5 | .500 | Camden Yards · Baltimore, MD |
| 11 | Tue Apr 9 | vs Athletics | L2-13 | 5-6 | .455 | Camden Yards · Baltimore, MD |
| 12 | Wed Apr 10 | vs Athletics | L3-10 | 5-7 | .417 | Camden Yards · Baltimore, MD |
| 13 | Thu Apr 11 | vs Athletics | L5-8 | 5-8 | .385 | Camden Yards · Baltimore, MD |
| 14 | Fri Apr 12 | at Red Sox | L4-6 | 5-9 | .357 | Fenway Park · Boston, MA |
| 15 | Sat Apr 13 | at Red Sox | W9-5 | 6-9 | .400 | Fenway Park · Boston, MA |
| 16 | Sun Apr 14 | at Red Sox | L0-4 | 6-10 | .375 | Fenway Park · Boston, MA |
| 17 | Mon Apr 15 | at Red Sox | W8-1 | 7-10 | .412 | Fenway Park · Boston, MA |
| 18 | Tue Apr 16 | at Rays | L2-4 | 7-11 | .389 | Tropicana Field · St. Petersburg, FL |
| 19 | Wed Apr 17 | at Rays | L1-8 | 7-12 | .368 | Tropicana Field · St. Petersburg, FL |
| 20 | Thu Apr 18 | at Rays | W6-5 (11) | 8-12 | .400 | Tropicana Field · St. Petersburg, FL |
| 21 | Sat Apr 20 | vs Twins | L5-6 | 8-13 | .381 | Camden Yards · Baltimore, MD |
| 22 | Sat Apr 20 | vs Twins | L7-16 | 8-14 | .364 | Camden Yards · Baltimore, MD |
| 23 | Sun Apr 21 | vs Twins | L3-4 | 8-15 | .348 | Camden Yards · Baltimore, MD |
| 24 | Mon Apr 22 | vs White Sox | L2-12 | 8-16 | .333 | Camden Yards · Baltimore, MD |
| 25 | Tue Apr 23 | vs White Sox | W9-1 | 9-16 | .360 | Camden Yards · Baltimore, MD |
| 26 | Wed Apr 24 | vs White Sox | W4-3 | 10-16 | .385 | Camden Yards · Baltimore, MD |
| 27 | Fri Apr 26 | at Twins | L1-6 | 10-17 | .370 | Target Field · Minneapolis, MN |
| 28 | Sat Apr 27 | at Twins | L2-9 | 10-18 | .357 | Target Field · Minneapolis, MN |
| 29 | Sun Apr 28 | at Twins | L1-4 | 10-19 | .345 | Target Field · Minneapolis, MN |
| 30 | Mon Apr 29 | at White Sox | L3-5 | 10-20 | .333 | Guaranteed Rate Field · Chicago, IL |
| 31 | Wed May 1 | at White Sox | W5-4 | 11-20 | .355 | Guaranteed Rate Field · Chicago, IL |
| 32 | Wed May 1 | at White Sox | L6-7 | 11-21 | .344 | Guaranteed Rate Field · Chicago, IL |
| 33 | Fri May 3 | vs Rays | L0-7 | 11-22 | .333 | Camden Yards · Baltimore, MD |
| 34 | Sat May 4 | vs Rays | W3-0 | 12-22 | .353 | Camden Yards · Baltimore, MD |
| 35 | Mon May 6 | vs Red Sox | W4-1 | 13-22 | .371 | Camden Yards · Baltimore, MD |
| 36 | Tue May 7 | vs Red Sox | L5-8 | 13-23 | .361 | Camden Yards · Baltimore, MD |
| 37 | Wed May 8 | vs Red Sox | L1-2 (12) | 13-24 | .351 | Camden Yards · Baltimore, MD |
| 38 | Fri May 10 | vs Angels | L3-8 | 13-25 | .342 | Camden Yards · Baltimore, MD |
| 39 | Sat May 11 | vs Angels | L2-7 | 13-26 | .333 | Camden Yards · Baltimore, MD |
| 40 | Sun May 12 | vs Angels | W5-1 | 14-26 | .350 | Camden Yards · Baltimore, MD |
| 41 | Wed May 15 | at Yankees | L3-5 | 14-27 | .341 | Yankee Stadium · The Bronx, NY |
| 42 | Wed May 15 | at Yankees | L1-3 | 14-28 | .333 | Yankee Stadium · The Bronx, NY |
| 43 | Thu May 16 | at Guardians | L7-14 | 14-29 | .326 | Progressive Field · Cleveland, OH |
| 44 | Fri May 17 | at Guardians | W5-1 | 15-29 | .341 | Progressive Field · Cleveland, OH |
| 45 | Sat May 18 | at Guardians | L1-4 | 15-30 | .333 | Progressive Field · Cleveland, OH |
| 46 | Sun May 19 | at Guardians | L0-10 | 15-31 | .326 | Progressive Field · Cleveland, OH |
| 47 | Mon May 20 | vs Yankees | L7-10 | 15-32 | .319 | Camden Yards · Baltimore, MD |
| 48 | Tue May 21 | vs Yankees | L4-11 | 15-33 | .313 | Camden Yards · Baltimore, MD |
| 49 | Wed May 22 | vs Yankees | L5-7 | 15-34 | .306 | Camden Yards · Baltimore, MD |
| 50 | Thu May 23 | vs Yankees | L5-6 | 15-35 | .300 | Camden Yards · Baltimore, MD |
| 51 | Fri May 24 | at Rockies | L6-8 | 15-36 | .294 | Coors Field · Denver, CO |
| 52 | Sat May 25 | at Rockies | W9-6 | 16-36 | .308 | Coors Field · Denver, CO |
| 53 | Sun May 26 | at Rockies | L7-8 | 16-37 | .302 | Coors Field · Denver, CO |
| 54 | Mon May 27 | vs Tigers | W5-3 | 17-37 | .315 | Camden Yards · Baltimore, MD |
| 55 | Tue May 28 | vs Tigers | L0-3 | 17-38 | .309 | Camden Yards · Baltimore, MD |
| 56 | Wed May 29 | vs Tigers | L2-4 | 17-39 | .304 | Camden Yards · Baltimore, MD |
| 57 | Fri May 31 | vs Giants | W9-6 | 18-39 | .316 | Camden Yards · Baltimore, MD |
| 58 | Sat Jun 1 | vs Giants | L2-8 | 18-40 | .310 | Camden Yards · Baltimore, MD |
| 59 | Sun Jun 2 | vs Giants | L1-8 | 18-41 | .305 | Camden Yards · Baltimore, MD |
| 60 | Tue Jun 4 | at Rangers | W12-11 | 19-41 | .317 | Globe Life Field · Arlington, TX |
| 61 | Wed Jun 5 | at Rangers | L1-2 (12) | 19-42 | .311 | Globe Life Field · Arlington, TX |
| 62 | Thu Jun 6 | at Rangers | L3-4 | 19-43 | .306 | Globe Life Field · Arlington, TX |
| 63 | Fri Jun 7 | at Astros | L3-4 (11) | 19-44 | .302 | Minute Maid Park · Houston, TX |
| 64 | Sat Jun 8 | at Astros | W4-1 | 20-44 | .313 | Minute Maid Park · Houston, TX |
| 65 | Sun Jun 9 | at Astros | L0-4 | 20-45 | .308 | Minute Maid Park · Houston, TX |
| 66 | Tue Jun 11 | vs Blue Jays | W4-2 | 21-45 | .318 | Camden Yards · Baltimore, MD |
| 67 | Wed Jun 12 | vs Blue Jays | L6-8 | 21-46 | .313 | Camden Yards · Baltimore, MD |
| 68 | Thu Jun 13 | vs Blue Jays | L3-12 | 21-47 | .309 | Camden Yards · Baltimore, MD |
| 69 | Fri Jun 14 | vs Red Sox | L2-13 | 21-48 | .304 | Camden Yards · Baltimore, MD |
| 70 | Sat Jun 15 | vs Red Sox | L2-7 | 21-49 | .300 | Camden Yards · Baltimore, MD |
| 71 | Sun Jun 16 | vs Red Sox | L6-8 (10) | 21-50 | .296 | Camden Yards · Baltimore, MD |
| 72 | Mon Jun 17 | at Athletics | L2-3 | 21-51 | .292 | RingCentral Coliseum · Oakland, CA |
| 73 | Tue Jun 18 | at Athletics | L2-16 | 21-52 | .288 | RingCentral Coliseum · Oakland, CA |
| 74 | Wed Jun 19 | at Athletics | L3-8 | 21-53 | .284 | RingCentral Coliseum · Oakland, CA |
| 75 | Thu Jun 20 | at Mariners | L2-5 | 21-54 | .280 | T-Mobile Park · Seattle, WA |
| 76 | Fri Jun 21 | at Mariners | L9-10 | 21-55 | .276 | T-Mobile Park · Seattle, WA |
| 77 | Sat Jun 22 | at Mariners | W8-4 | 22-55 | .286 | T-Mobile Park · Seattle, WA |
| 78 | Sun Jun 23 | at Mariners | L3-13 | 22-56 | .282 | T-Mobile Park · Seattle, WA |
| 79 | Tue Jun 25 | vs Padres | L3-8 | 22-57 | .278 | Camden Yards · Baltimore, MD |
| 80 | Wed Jun 26 | vs Padres | L5-10 | 22-58 | .275 | Camden Yards · Baltimore, MD |
| 81 | Fri Jun 28 | vs Guardians | W13-0 | 23-58 | .284 | Camden Yards · Baltimore, MD |
| 82 | Sat Jun 29 | vs Guardians | W13-0 | 24-58 | .293 | Camden Yards · Baltimore, MD |
| 83 | Sun Jun 30 | vs Guardians | L0-2 | 24-59 | .289 | Camden Yards · Baltimore, MD |
| 84 | Mon Jul 1 | at Rays | L3-6 | 24-60 | .286 | Tropicana Field · St. Petersburg, FL |
| 85 | Tue Jul 2 | at Rays | L3-6 | 24-61 | .282 | Tropicana Field · St. Petersburg, FL |
| 86 | Wed Jul 3 | at Rays | W9-6 | 25-61 | .291 | Tropicana Field · St. Petersburg, FL |
| 87 | Fri Jul 5 | at Blue Jays | W4-1 | 26-61 | .299 | Rogers Centre · Toronto, ON |
| 88 | Sat Jul 6 | at Blue Jays | W8-1 | 27-61 | .307 | Rogers Centre · Toronto, ON |
| 89 | Sun Jul 7 | at Blue Jays | L1-6 | 27-62 | .303 | Rogers Centre · Toronto, ON |
| 90 | Fri Jul 12 | vs Rays | L4-16 | 27-63 | .300 | Camden Yards · Baltimore, MD |
| 91 | Sat Jul 13 | vs Rays | W2-1 | 28-63 | .308 | Camden Yards · Baltimore, MD |
| 92 | Sat Jul 13 | vs Rays | L4-12 | 28-64 | .304 | Camden Yards · Baltimore, MD |
| 93 | Sun Jul 14 | vs Rays | L1-4 | 28-65 | .301 | Camden Yards · Baltimore, MD |
| 94 | Tue Jul 16 | vs Nationals | L1-8 | 28-66 | .298 | Camden Yards · Baltimore, MD |
| 95 | Wed Jul 17 | vs Nationals | W9-2 | 29-66 | .305 | Camden Yards · Baltimore, MD |
| 96 | Fri Jul 19 | vs Red Sox | W11-2 | 30-66 | .313 | Camden Yards · Baltimore, MD |
| 97 | Sat Jul 20 | vs Red Sox | L6-17 | 30-67 | .309 | Camden Yards · Baltimore, MD |
| 98 | Sun Jul 21 | vs Red Sox | W5-0 | 31-67 | .316 | Camden Yards · Baltimore, MD |
| 99 | Mon Jul 22 | at D-backs | L3-6 | 31-68 | .313 | Chase Field · Phoenix, AZ |
| 100 | Tue Jul 23 | at D-backs | W7-2 | 32-68 | .320 | Chase Field · Phoenix, AZ |
| 101 | Wed Jul 24 | at D-backs | L2-5 | 32-69 | .317 | Chase Field · Phoenix, AZ |
| 102 | Thu Jul 25 | at Angels | W10-8 (16) | 33-69 | .324 | Angel Stadium · Anaheim, CA |
| 103 | Fri Jul 26 | at Angels | W9-3 | 34-69 | .330 | Angel Stadium · Anaheim, CA |
| 104 | Sat Jul 27 | at Angels | W8-7 | 35-69 | .337 | Angel Stadium · Anaheim, CA |
| 105 | Sun Jul 28 | at Angels | L4-5 | 35-70 | .333 | Angel Stadium · Anaheim, CA |
| 106 | Mon Jul 29 | at Padres | L1-8 | 35-71 | .330 | Petco Park · San Diego, CA |
| 107 | Tue Jul 30 | at Padres | W8-5 | 36-71 | .336 | Petco Park · San Diego, CA |
| 108 | Thu Aug 1 | vs Blue Jays | L2-11 | 36-72 | .333 | Camden Yards · Baltimore, MD |
| 109 | Fri Aug 2 | vs Blue Jays | L2-5 | 36-73 | .330 | Camden Yards · Baltimore, MD |
| 110 | Sat Aug 3 | vs Blue Jays | W6-4 | 37-73 | .336 | Camden Yards · Baltimore, MD |
| 111 | Sun Aug 4 | vs Blue Jays | W6-5 | 38-73 | .342 | Camden Yards · Baltimore, MD |
| 112 | Mon Aug 5 | vs Yankees | L6-9 | 38-74 | .339 | Camden Yards · Baltimore, MD |
| 113 | Tue Aug 6 | vs Yankees | L4-9 | 38-75 | .336 | Camden Yards · Baltimore, MD |
| 114 | Wed Aug 7 | vs Yankees | L2-14 | 38-76 | .333 | Camden Yards · Baltimore, MD |
| 115 | Fri Aug 9 | vs Astros | L2-3 | 38-77 | .330 | Camden Yards · Baltimore, MD |
| 116 | Sat Aug 10 | vs Astros | L2-23 | 38-78 | .328 | Camden Yards · Baltimore, MD |
| 117 | Sun Aug 11 | vs Astros | W8-7 | 39-78 | .333 | Camden Yards · Baltimore, MD |
| 118 | Mon Aug 12 | at Yankees | L5-8 | 39-79 | .331 | Yankee Stadium · The Bronx, NY |
| 119 | Mon Aug 12 | at Yankees | L8-11 | 39-80 | .328 | Yankee Stadium · The Bronx, NY |
| 120 | Tue Aug 13 | at Yankees | L3-8 | 39-81 | .325 | Yankee Stadium · The Bronx, NY |
| 121 | Wed Aug 14 | at Yankees | L5-6 | 39-82 | .322 | Yankee Stadium · The Bronx, NY |
| 122 | Fri Aug 16 | at Red Sox | L1-9 | 39-83 | .320 | Fenway Park · Boston, MA |
| 123 | Sat Aug 17 | at Red Sox | L0-4 | 39-84 | .317 | Fenway Park · Boston, MA |
| 124 | Sun Aug 18 | at Red Sox | L7-13 | 39-85 | .315 | Fenway Park · Boston, MA |
| 125 | Mon Aug 19 | vs Royals | L4-5 | 39-86 | .312 | Camden Yards · Baltimore, MD |
| 126 | Tue Aug 20 | vs Royals | W4-1 | 40-86 | .317 | Camden Yards · Baltimore, MD |
| 127 | Wed Aug 21 | vs Royals | W8-1 | 41-86 | .323 | Camden Yards · Baltimore, MD |
| 128 | Thu Aug 22 | vs Rays | L2-5 | 41-87 | .320 | Camden Yards · Baltimore, MD |
| 129 | Fri Aug 23 | vs Rays | L1-7 | 41-88 | .318 | Camden Yards · Baltimore, MD |
| 130 | Sat Aug 24 | vs Rays | W7-1 | 42-88 | .323 | Camden Yards · Baltimore, MD |
| 131 | Sun Aug 25 | vs Rays | W8-3 | 43-88 | .328 | Camden Yards · Baltimore, MD |
| 132 | Tue Aug 27 | at Nationals | W2-0 | 44-88 | .333 | Nationals Park · Washington, D.C. |
| 133 | Wed Aug 28 | at Nationals | L4-8 | 44-89 | .331 | Nationals Park · Washington, D.C. |
| 134 | Fri Aug 30 | at Royals | W14-2 | 45-89 | .336 | Kauffman Stadium · Kansas City, MO |
| 135 | Sat Aug 31 | at Royals | L5-7 | 45-90 | .333 | Kauffman Stadium · Kansas City, MO |
| 136 | Sun Sep 1 | at Royals | L4-6 | 45-91 | .331 | Kauffman Stadium · Kansas City, MO |
| 137 | Mon Sep 2 | at Rays | L4-5 (10) | 45-92 | .328 | Tropicana Field · St. Petersburg, FL |
| 138 | Tue Sep 3 | at Rays | W4-2 | 46-92 | .333 | Tropicana Field · St. Petersburg, FL |
| 139 | Tue Sep 3 | at Rays | L0-2 | 46-93 | .331 | Tropicana Field · St. Petersburg, FL |
| 140 | Thu Sep 5 | vs Rangers | L1-3 | 46-94 | .329 | Camden Yards · Baltimore, MD |
| 141 | Fri Sep 6 | vs Rangers | L6-7 | 46-95 | .326 | Camden Yards · Baltimore, MD |
| 142 | Sat Sep 7 | vs Rangers | L4-9 | 46-96 | .324 | Camden Yards · Baltimore, MD |
| 143 | Sun Sep 8 | vs Rangers | L4-10 | 46-97 | .322 | Camden Yards · Baltimore, MD |
| 144 | Tue Sep 10 | vs Dodgers | L3-7 | 46-98 | .319 | Camden Yards · Baltimore, MD |
| 145 | Wed Sep 11 | vs Dodgers | W7-3 | 47-98 | .324 | Camden Yards · Baltimore, MD |
| 146 | Thu Sep 12 | vs Dodgers | L2-4 | 47-99 | .322 | Camden Yards · Baltimore, MD |
| 147 | Fri Sep 13 | at Tigers | W6-2 | 48-99 | .327 | Comerica Park · Detroit, MI |
| 148 | Sat Sep 14 | at Tigers | L4-8 (12) | 48-100 | .324 | Comerica Park · Detroit, MI |
| 149 | Sun Sep 15 | at Tigers | W8-2 | 49-100 | .329 | Comerica Park · Detroit, MI |
| 150 | Mon Sep 16 | at Tigers | L2-5 | 49-101 | .327 | Comerica Park · Detroit, MI |
| 151 | Tue Sep 17 | vs Blue Jays | L5-8 | 49-102 | .325 | Camden Yards · Baltimore, MD |
| 152 | Wed Sep 18 | vs Blue Jays | L10-11 | 49-103 | .322 | Camden Yards · Baltimore, MD |
| 153 | Thu Sep 19 | vs Blue Jays | L4-8 | 49-104 | .320 | Camden Yards · Baltimore, MD |
| 154 | Fri Sep 20 | vs Mariners | W5-3 | 50-104 | .325 | Camden Yards · Baltimore, MD |
| 155 | Sat Sep 21 | vs Mariners | L6-7 (13) | 50-105 | .323 | Camden Yards · Baltimore, MD |
| 156 | Sun Sep 22 | vs Mariners | W2-1 | 51-105 | .327 | Camden Yards · Baltimore, MD |
| 157 | Mon Sep 23 | at Blue Jays | L10-11 (15) | 51-106 | .325 | Rogers Centre · Toronto, ON |
| 158 | Tue Sep 24 | at Blue Jays | W11-4 | 52-106 | .329 | Rogers Centre · Toronto, ON |
| 159 | Wed Sep 25 | at Blue Jays | L2-3 | 52-107 | .327 | Rogers Centre · Toronto, ON |
| 160 | Fri Sep 27 | at Red Sox | W4-1 | 53-107 | .331 | Fenway Park · Boston, MA |
| 161 | Sat Sep 28 | at Red Sox | W9-4 | 54-107 | .335 | Fenway Park · Boston, MA |
| 162 | Sun Sep 29 | at Red Sox | L4-5 | 54-108 | .333 | Fenway Park · Boston, MA |