| 1 | Sat Sep 4 | vs Louisiana Tech | W35-34 | 1-0 | 1.000 | Davis Wade Stadium · Starkville, MS |
| 2 | Sat Sep 11 | vsNC State | W24-10 | 2-0 | 1.000 | Davis Wade Stadium · Starkville, MS |
| 3 | Sat Sep 18 | atMemphis | L29-31 | 2-1 | .667 | Simmons Bank Liberty Stadium · Memphis, TN |
| 4 | Sat Sep 25 | vsLSU | L25-28 | 2-2 | .500 | Davis Wade Stadium · Starkville, MS |
| 5 | Sat Oct 2 | at#15Texas A&M | W26-22 | 3-2 | .600 | Kyle Field · College Station, TX |
| 6 | Sat Oct 16 | vs#5Alabama | L9-49 | 3-3 | .500 | Davis Wade Stadium · Starkville, MS |
| 7 | Sat Oct 23 | atVanderbilt | W45-6 | 4-3 | .571 | FirstBank Stadium · Nashville, TN |
| 8 | Sat Oct 30 | vs#12Kentucky | W31-17 | 5-3 | .625 | Davis Wade Stadium · Starkville, MS |
| 9 | Sat Nov 6 | atArkansas | L28-31 | 5-4 | .556 | Razorback Stadium · Fayetteville, AR |
| 10 | Sat Nov 13 | at#17Auburn | W43-34 | 6-4 | .600 | Jordan-Hare Stadium · Auburn, AL |
| 11 | Sat Nov 20 | vsTennessee St | W55-10 | 7-4 | .636 | Davis Wade Stadium · Starkville, MS |
| 12 | Thu Nov 25 | vs#9Ole Miss | L21-31 | 7-5 | .583 | Davis Wade Stadium · Starkville, MS |
| BOWLS | Tue Dec 28 | atTexas Tech | L7-34 | 7-6 | .538 | Jones AT&T Stadium · Lubbock, TX |
