| 1 | Sat Sep 3 | vs Memphis | W49-23 | 1-0 | 1.000 | Davis Wade Stadium · Starkville, MS |
| 2 | Sat Sep 10 | atArizona | W39-17 | 2-0 | 1.000 | Arizona Stadium · Tucson, AZ |
| 3 | Sat Sep 17 | atLSU | L16-31 | 2-1 | .667 | Tiger Stadium · Baton Rouge, LA |
| 4 | Sat Sep 24 | vsBowling Green | W45-14 | 3-1 | .750 | Davis Wade Stadium · Starkville, MS |
| 5 | Sat Oct 1 | vs#17Texas A&M | W42-24 | 4-1 | .800 | Davis Wade Stadium · Starkville, MS |
| 6 | Sat Oct 8 | vsArkansas | W40-17 | 5-1 | .833 | Davis Wade Stadium · Starkville, MS |
| 7 | Sat Oct 15 | atKentucky | L17-27 | 5-2 | .714 | Kroger Field · Lexington, KY |
| 8 | Sat Oct 22 | at#6Alabama | L6-30 | 5-3 | .625 | Bryant-Denny Stadium · Tuscaloosa, AL |
| 9 | Sat Nov 5 | vsAuburn | W39-33 (OT) | 6-3 | .667 | Davis Wade Stadium · Starkville, MS |
| 10 | Sat Nov 12 | vs#1Georgia | L19-45 | 6-4 | .600 | Davis Wade Stadium · Starkville, MS |
| 11 | Sat Nov 19 | vsETSU | W56-7 | 7-4 | .636 | Davis Wade Stadium · Starkville, MS |
| 12 | Thu Nov 24 | at#20Ole Miss | W24-22 | 8-4 | .667 | Vaught-Hemingway Stadium · Oxford, MS |
| BOWLS | Mon Jan 2 | atIllinois | W19-10 | 9-4 | .692 | Alumni Memorial Field at Foster Stadium · Lexington, VA |
