| 1 | Sat Aug 30 | at Southern Miss | W34-17 | 1-0 | 1.000 | M. M. Roberts Stadium · Hattiesburg, MS |
| 2 | Sat Sep 6 | vs#12Arizona St | W24-20 | 2-0 | 1.000 | Davis Wade Stadium · Starkville, MS |
| 3 | Sat Sep 13 | vsAlcorn St | W63-0 | 3-0 | 1.000 | Davis Wade Stadium · Starkville, MS |
| 4 | Sat Sep 20 | vsN Illinois | W38-10 | 4-0 | 1.000 | Davis Wade Stadium · Starkville, MS |
| 5 | Sat Sep 27 | vs#15Tennessee | L34-41 (OT) | 4-1 | .800 | Davis Wade Stadium · Starkville, MS |
| 6 | Sat Oct 4 | at#6Texas A&M | L9-31 | 4-2 | .667 | Kyle Field · College Station, TX |
| 7 | Sat Oct 18 | atFlorida | L21-23 | 4-3 | .571 | Ben Hill Griffin Stadium · Gainesville, FL |
| 8 | Sat Oct 25 | vs#22Texas | L38-45 (OT) | 4-4 | .500 | Davis Wade Stadium · Starkville, MS |
| 9 | Sat Nov 1 | atArkansas | W38-35 | 5-4 | .556 | Razorback Stadium · Fayetteville, AR |
| 10 | Sat Nov 8 | vs#5Georgia | L21-41 | 5-5 | .500 | Davis Wade Stadium · Starkville, MS |
