| 1 | Mon Nov 4 | at Appalachian St | W77-63 | 1-0 | 1.000 | - | ESPN+ | Holmes Convocation Center · Boone, NC |
| 2 | Sat Nov 9 | vs Wright St | L68-81 | 1-1 | .500 | - | ESPN+ | Millett Hall · Oxford, OH |
| 3 | Tue Nov 12 | vs MD-Eastern | W88-70 | 2-1 | .667 | - | ESPN+ | Millett Hall · Oxford, OH |
| 4 | Mon Nov 18 | at Michigan | L67-94 | 2-2 | .500 | - | BTN | Crisler Center · Ann Arbor, MI |
| 5 | Mon Nov 25 | vs Siena | W70-58 | 3-2 | .600 | - | | Millett Hall · Oxford, OH |
| 6 | Tue Nov 26 | at Mercer | W75-72 | 4-2 | .667 | - | | Hawkins Arena · Macon, GA |
| 7 | Mon Dec 2 | vs Air Force | W73-60 | 5-2 | .714 | - | ESPN+ | Millett Hall · Oxford, OH |
| 8 | Fri Dec 6 | at Indiana | L57-76 | 5-3 | .625 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 9 | Sun Dec 15 | vs TBD | W112-70 | 6-3 | .667 | - | ESPN+ | Millett Hall · Oxford, OH |
| 10 | Wed Dec 18 | at Vermont | L67-75 | 6-4 | .600 | - | ESPN+ | Patrick Gymnasium · Burlington, VT |
| 11 | Sun Dec 22 | vs Sacred Heart | W94-76 | 7-4 | .636 | - | ESPN+ | Millett Hall · Oxford, OH |
| 12 | Mon Dec 30 | vsTBD | W141-58 | 8-4 | .667 | - | ESPN+ | Millett Hall · Oxford, OH |
| 13 | Sat Jan 4 | vs Buffalo | W93-79 | 9-4 | .692 | - | ESPN+ | Millett Hall · Oxford, OH |
| 14 | Tue Jan 7 | at Ball State | W80-72 | 10-4 | .714 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 15 | Sat Jan 11 | vs W Michigan | W91-71 | 11-4 | .733 | - | ESPN+ | Millett Hall · Oxford, OH |
| 16 | Tue Jan 14 | at N Illinois | W84-69 | 12-4 | .750 | - | ESPN+ | NIU Convocation Center · Dekalb, IL |
| 17 | Sat Jan 18 | at Kent State | W70-61 | 13-4 | .765 | - | ESPN+ | M.A.C. Center · Kent, OH |
| 18 | Tue Jan 21 | vs Bowling Green | W84-76 | 14-4 | .778 | - | ESPN+ | Millett Hall · Oxford, OH |
| 19 | Sat Jan 25 | at Akron | L75-102 | 14-5 | .737 | - | ESPN+ | James A. Rhodes Arena · Akron, OH |
| 20 | Tue Jan 28 | vs E Michigan | W89-80 | 15-5 | .750 | - | ESPN+ | Millett Hall · Oxford, OH |
| 21 | Sat Feb 1 | vs Ohio | W73-69 | 16-5 | .762 | - | ESPN+ | Millett Hall · Oxford, OH |
| 22 | Tue Feb 4 | at C Michigan | W76-70 | 17-5 | .773 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 23 | Sat Feb 8 | vs Troy | W69-62 | 18-5 | .783 | - | ESPN+ | Millett Hall · Oxford, OH |
| 24 | Tue Feb 11 | vs Toledo | W92-80 | 19-5 | .792 | - | ESPN+ | Millett Hall · Oxford, OH |
| 25 | Sat Feb 15 | atW Michigan | L70-78 | 19-6 | .760 | - | ESPN+ | University Arena (MI) · Kalamazoo, MI |
| 26 | Tue Feb 18 | atE Michigan | L66-76 | 19-7 | .731 | - | ESPN+ | Convocation Center (MI) · Ypsilanti, MI |
| 27 | Fri Feb 21 | vsKent State | W96-92 (OT) | 20-7 | .741 | - | CBS | Millett Hall · Oxford, OH |
