| 1 | Mon Nov 4 | at Appalachian St | W77-63 | - | 1-0 | 1.000 | - | ESPN+ | Holmes Convocation Center · Boone, NC |
| 2 | Sat Nov 9 | vsWright St | L68-81 | - | 1-1 | .500 | - | ESPN+ | Millett Hall · Oxford, OH |
| 3 | Tue Nov 12 | vsMD-Eastern | W88-70 | - | 2-1 | .667 | - | ESPN+ | Millett Hall · Oxford, OH |
| 4 | Mon Nov 18 | atMichigan | L67-94 | - | 2-2 | .500 | - | Big Ten Network | Crisler Center · Ann Arbor, MI |
| 5 | Mon Nov 25 | vsSiena | W70-58 | - | 3-2 | .600 | - | | Millett Hall · Oxford, OH |
| 6 | Tue Nov 26 | atMercer | W75-72 | - | 4-2 | .667 | - | | Hawkins Arena · Macon, GA |
| 7 | Mon Dec 2 | vsAir Force | W73-60 | - | 5-2 | .714 | - | ESPN+ | Millett Hall · Oxford, OH |
| 8 | Fri Dec 6 | atIndiana | L57-76 | - | 5-3 | .625 | - | Big Ten Network | Simon Skjodt Assembly Hall · Bloomington, IN |
| 9 | Sun Dec 15 | vsTBD | W112-70 | - | 6-3 | .667 | - | ESPN+ | Millett Hall · Oxford, OH |
| 10 | Wed Dec 18 | atVermont | L67-75 | - | 6-4 | .600 | - | ESPN+ | Patrick Gymnasium · Burlington, VT |
| 11 | Sun Dec 22 | vsSacred Heart | W94-76 | - | 7-4 | .636 | - | ESPN+ | Millett Hall · Oxford, OH |
| 12 | Mon Dec 30 | vsTBD | W141-58 | - | 8-4 | .667 | - | ESPN+ | Millett Hall · Oxford, OH |
| 13 | Sat Jan 4 | vsBuffalo | W93-79 | - | 9-4 | .692 | - | ESPN+ | Millett Hall · Oxford, OH |
| 14 | Tue Jan 7 | atBall State | W80-72 | - | 10-4 | .714 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 15 | Sat Jan 11 | vsW Michigan | W91-71 | - | 11-4 | .733 | - | ESPN+ | Millett Hall · Oxford, OH |
| 16 | Tue Jan 14 | atN Illinois | W84-69 | - | 12-4 | .750 | - | ESPN+ | NIU Convocation Center · Dekalb, IL |
| 17 | Sat Jan 18 | atKent State | W70-61 | - | 13-4 | .765 | - | ESPN+ | M.A.C. Center · Kent, OH |
| 18 | Tue Jan 21 | vsBowling Green | W84-76 | - | 14-4 | .778 | - | ESPN+ | Millett Hall · Oxford, OH |
| 19 | Sat Jan 25 | atAkron | L75-102 | - | 14-5 | .737 | - | ESPN+ | James A. Rhodes Arena · Akron, OH |
| 20 | Tue Jan 28 | vsE Michigan | W89-80 | - | 15-5 | .750 | - | ESPN+ | Millett Hall · Oxford, OH |
| 21 | Sat Feb 1 | vsOhio | W73-69 | - | 16-5 | .762 | - | ESPN+ | Millett Hall · Oxford, OH |
| 22 | Tue Feb 4 | atC Michigan | W76-70 | - | 17-5 | .773 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 23 | Sat Feb 8 | vsTroy | W69-62 | - | 18-5 | .783 | - | ESPN+ | Millett Hall · Oxford, OH |
| 24 | Tue Feb 11 | vsToledo | W92-80 | - | 19-5 | .792 | - | ESPN+ | Millett Hall · Oxford, OH |
| 25 | Sat Feb 15 | atW Michigan | L70-78 | - | 19-6 | .760 | - | ESPN+ | University Arena (MI) · Kalamazoo, MI |
| 26 | Tue Feb 18 | atE Michigan | L66-76 | - | 19-7 | .731 | - | ESPN+ | Convocation Center (MI) · Ypsilanti, MI |
| 27 | Fri Feb 21 | vsKent State | W96-92 (OT) | - | 20-7 | .741 | - | CBS Sports Network | Millett Hall · Oxford, OH |
| 28 | Tue Feb 25 | vsN Illinois | W87-58 | - | 21-7 | .750 | - | ESPN+ | Millett Hall · Oxford, OH |
| 29 | Sat Mar 1 | atOhio | L66-75 | - | 21-8 | .724 | - | ESPN+ | Convocation Center (OH) · Athens, OH |
| 30 | Tue Mar 4 | atBuffalo | W84-69 | - | 22-8 | .733 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 31 | Fri Mar 7 | vsBall State | W79-66 | - | 23-8 | .742 | - | ESPNU | Millett Hall · Oxford, OH |
| 32 | Thu Mar 13 | vsE Michigan | W81-75 | - | 24-8 | .750 | - | ESPN+ | Millett Hall · Oxford, OH |
| 33 | Fri Mar 14 | vsKent State | W72-64 | - | 25-8 | .758 | - | CBS Sports Network | Millett Hall · Oxford, OH |
| 34 | Sat Mar 15 | atAkron | L74-76 | - | 25-9 | .735 | - | ESPN2 | James A. Rhodes Arena · Akron, OH |
