| 1 | Mon Nov 3 | vs Old Dominion | W87-72 | - | 1-0 | 1.000 | - | ESPN+ | Millett Hall · Oxford, OH |
| 2 | Fri Nov 7 | vsTBD | W129-49 | - | 2-0 | 1.000 | - | ESPN+ | Millett Hall · Oxford, OH |
| 3 | Sat Nov 15 | atAir Force | W76-61 | - | 3-0 | 1.000 | - | | Clune Arena · Colorado Springs, CO |
| 4 | Thu Nov 20 | vsMercyhurst | W76-71 | - | 4-0 | 1.000 | - | ESPN+ | Millett Hall · Oxford, OH |
| 5 | Sun Nov 23 | vsAR-Pine Bluff | W111-84 | - | 5-0 | 1.000 | - | ESPN+ | Millett Hall · Oxford, OH |
| 6 | Wed Nov 26 | atUNC Greensboro | W82-71 | -10½ | 6-0 | 1.000 | - | | Greensboro Coliseum · Greensboro, NC |
| 7 | Tue Dec 2 | vsTBD | W109-65 | - | 7-0 | 1.000 | - | ESPN+ | Millett Hall · Oxford, OH |
| 8 | Sat Dec 6 | vsMaine | W93-61 | -17½ | 8-0 | 1.000 | - | ESPN+ | Millett Hall · Oxford, OH |
| 9 | Wed Dec 10 | atUNC Asheville | W90-87 (OT) | -6½ | 9-0 | 1.000 | - | ESPN+ | Kimmel Arena · Asheville, NC |
| 10 | Sat Dec 13 | atE Kentucky | W79-69 | -5½ | 10-0 | 1.000 | - | ESPN+ | McBrayer Arena · Richmond, KY |
| 11 | Tue Dec 16 | atWright St | W83-76 | -1½ | 11-0 | 1.000 | - | ESPN+ | Nutter Center · Dayton, OH |
| 12 | Sat Dec 20 | atBall State | W86-77 | -7½ | 12-0 | 1.000 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 13 | Mon Dec 22 | vsTBD | W135-81 | - | 13-0 | 1.000 | - | ESPN+ | Millett Hall · Oxford, OH |
| 14 | Tue Dec 30 | atBowling Green | W93-83 | +6½ | 14-0 | 1.000 | - | ESPN+ | Stroh Center · Bowling Green, OH |
| 15 | Sat Jan 3 | vsAkron | W76-73 | +4½ | 15-0 | 1.000 | - | ESPN+ | Millett Hall · Oxford, OH |
| 16 | Tue Jan 6 | vsW Michigan | W87-76 | -14½ | 16-0 | 1.000 | - | ESPN+ | Millett Hall · Oxford, OH |
| 17 | Fri Jan 9 | atToledo | W87-73 | +1½ | 17-0 | 1.000 | - | CBS Sports Network | Savage Arena · Toledo, OH |
| 18 | Tue Jan 13 | vsC Michigan | W100-61 | -15½ | 18-0 | 1.000 | - | ESPN+ | Millett Hall · Oxford, OH |
| 19 | Sat Jan 17 | vsBuffalo | W105-102 (OT) | -10½ | 19-0 | 1.000 | - | ESPN+ | Millett Hall · Oxford, OH |
| 20 | Tue Jan 20 | atKent State | W107-101 (OT) | +1½ | 20-0 | 1.000 | #25 | ESPN+ | M.A.C. Center · Kent, OH |
| 21 | Tue Jan 27 | vsUMass | W86-84 | -9½ | 21-0 | 1.000 | #24 | ESPNU | Millett Hall · Oxford, OH |
| 22 | Sat Jan 31 | vsN Illinois | W85-61 | -16½ | 22-0 | 1.000 | #24 | ESPN+ | Millett Hall · Oxford, OH |
| 23 | Tue Feb 3 | atBuffalo | W73-71 | -4½ | 23-0 | 1.000 | #23 | ESPN+ | Alumni Arena · Buffalo, NY |
| 24 | Sat Feb 7 | atMarshall | W90-74 | -1½ | 24-0 | 1.000 | #23 | ESPN+ | Cam Henderson Center · Huntington, WV |
| 25 | Fri Feb 13 | vsOhio | W90-74 | -7½ | 25-0 | 1.000 | #23 | ESPN | Millett Hall · Oxford, OH |
| 26 | Tue Feb 17 | atUMass | W86-77 | -3½ | 26-0 | 1.000 | #22 | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 27 | Fri Feb 20 | vsBowling Green | W91-77 | -8½ | 27-0 | 1.000 | #22 | CBS Sports Network | Millett Hall · Oxford, OH |
| 28 | Tue Feb 24 | atE Michigan | W74-64 | -8½ | 28-0 | 1.000 | #21 | ESPN+ | Convocation Center (MI) · Ypsilanti, MI |
| 29 | Fri Feb 27 | atW Michigan | W69-67 | -12½ | 29-0 | 1.000 | #21 | CBS Sports Network | University Arena (MI) · Kalamazoo, MI |
| 30 | Tue Mar 3 | vsToledo | W74-72 | -7½ | 30-0 | 1.000 | #19 | ESPN+ | Millett Hall · Oxford, OH |
| 31 | Fri Mar 6 | atOhio | W110-108 (OT) | -3½ | 31-0 | 1.000 | #19 | ESPN2 | Convocation Center (OH) · Athens, OH |
| 32 | Thu Mar 12 | vsUMass | L83-87 | -6½ | 31-1 | .969 | #20 | ESPN+ | Millett Hall · Oxford, OH |
| R0 | Wed Mar 18 | at11SMU | W89-79 | +6½ | 32-1 | .970 | #11 | truTV | UD Arena · Dayton, OH |
| R1 | Fri Mar 20 | at6Tennessee | L56-78 | +12½ | 32-2 | .941 | #11 | TBS | Xfinity Mobile Arena · Philadelphia, PA |
