| 1 | Thu Jan 14 | at Devils | W3-2 (SO) | 1-0-0 | 2 PTS | Prudential Center · Newark, NJ |
| 2 | Sat Jan 16 | atDevils | L1-2 (OT) | 1-0-1 | 3 PTS | Prudential Center · Newark, NJ |
| 3 | Mon Jan 18 | atIslanders | L0-1 | 1-1-1 | 3 PTS | UBS Arena · Elmont, NY |
| 4 | Thu Jan 21 | vsFlyers | W5-4 (SO) | 2-1-1 | 5 PTS | TD Garden · Boston, MA |
| 5 | Sat Jan 23 | vsFlyers | W6-1 | 3-1-1 | 7 PTS | TD Garden · Boston, MA |
| 6 | Tue Jan 26 | vsPenguins | W3-2 (OT) | 4-1-1 | 9 PTS | TD Garden · Boston, MA |
| 7 | Thu Jan 28 | vsPenguins | W4-1 | 5-1-1 | 11 PTS | TD Garden · Boston, MA |
| 8 | Sat Jan 30 | atCapitals | L3-4 (OT) | 5-1-2 | 12 PTS | Capital One Arena · Washington, D.C. |
| 9 | Mon Feb 1 | atCapitals | W5-3 | 6-1-2 | 14 PTS | Capital One Arena · Washington, D.C. |
| 10 | Wed Feb 3 | atFlyers | W4-3 (OT) | 7-1-2 | 16 PTS | Wells Fargo Center · Philadelphia, PA |
| 11 | Fri Feb 5 | atFlyers | W2-1 | 8-1-2 | 18 PTS | Wells Fargo Center · Philadelphia, PA |
| 12 | Wed Feb 10 | atRangers | W3-2 (OT) | 9-1-2 | 20 PTS | Madison Square Garden · Manhattan, NY |
| 13 | Fri Feb 12 | atRangers | W1-0 | 10-1-2 | 22 PTS | Madison Square Garden · Manhattan, NY |
| 14 | Sat Feb 13 | atIslanders | L2-4 | 10-2-2 | 22 PTS | UBS Arena · Elmont, NY |
| 15 | Thu Feb 18 | vsDevils | L2-3 | 10-3-2 | 22 PTS | TD Garden · Boston, MA |
| 16 | Sun Feb 21 | vsFlyers | W7-3 | 11-3-2 | 24 PTS | TD Garden · Boston, MA |
| 17 | Thu Feb 25 | atIslanders | L2-7 | 11-4-2 | 24 PTS | UBS Arena · Elmont, NY |
| 18 | Fri Feb 26 | atRangers | L2-6 | 11-5-2 | 24 PTS | Madison Square Garden · Manhattan, NY |
| 19 | Sun Feb 28 | atRangers | W4-1 | 12-5-2 | 26 PTS | Madison Square Garden · Manhattan, NY |
| 20 | Wed Mar 3 | vsCapitals | L1-2 (SO) | 12-5-3 | 27 PTS | TD Garden · Boston, MA |
| 21 | Fri Mar 5 | vsCapitals | W5-1 | 13-5-3 | 29 PTS | TD Garden · Boston, MA |
| 22 | Sun Mar 7 | vsDevils | L0-1 | 13-6-3 | 29 PTS | TD Garden · Boston, MA |
| 23 | Tue Mar 9 | atIslanders | L1-2 (SO) | 13-6-4 | 30 PTS | UBS Arena · Elmont, NY |
| 24 | Thu Mar 11 | vsRangers | W4-0 | 14-6-4 | 32 PTS | TD Garden · Boston, MA |
| 25 | Sat Mar 13 | vsRangers | L0-4 | 14-7-4 | 32 PTS | TD Garden · Boston, MA |
| 26 | Mon Mar 15 | atPenguins | L1-4 | 14-8-4 | 32 PTS | PPG Paints Arena · Pittsburgh, PA |
| 27 | Tue Mar 16 | atPenguins | W2-1 | 15-8-4 | 34 PTS | PPG Paints Arena · Pittsburgh, PA |
| 28 | Thu Mar 18 | atSabres | W4-1 | 16-8-4 | 36 PTS | KeyBank Center · Buffalo, NY |
| 29 | Thu Mar 25 | vsIslanders | L3-4 (OT) | 16-8-5 | 37 PTS | TD Garden · Boston, MA |
| 30 | Sat Mar 27 | vsSabres | W3-2 | 17-8-5 | 39 PTS | TD Garden · Boston, MA |
| 31 | Sun Mar 28 | vsDevils | L0-1 | 17-9-5 | 39 PTS | TD Garden · Boston, MA |
| 32 | Tue Mar 30 | vsDevils | W5-4 (SO) | 18-9-5 | 41 PTS | TD Garden · Boston, MA |
| 33 | Thu Apr 1 | vsPenguins | L1-4 | 18-10-5 | 41 PTS | TD Garden · Boston, MA |
| 34 | Sat Apr 3 | vsPenguins | W7-5 | 19-10-5 | 43 PTS | TD Garden · Boston, MA |
| 35 | Mon Apr 5 | vsFlyers | L2-3 (OT) | 19-10-6 | 44 PTS | TD Garden · Boston, MA |
| 36 | Tue Apr 6 | atFlyers | W4-2 | 20-10-6 | 46 PTS | Wells Fargo Center · Philadelphia, PA |
| 37 | Thu Apr 8 | atCapitals | W4-2 | 21-10-6 | 48 PTS | Capital One Arena · Washington, D.C. |
| 38 | Sat Apr 10 | atFlyers | L2-3 | 21-11-6 | 48 PTS | Wells Fargo Center · Philadelphia, PA |
| 39 | Sun Apr 11 | vsCapitals | L1-8 | 21-12-6 | 48 PTS | TD Garden · Boston, MA |
| 40 | Tue Apr 13 | vsSabres | W3-2 (SO) | 22-12-6 | 50 PTS | TD Garden · Boston, MA |
| 41 | Thu Apr 15 | vsIslanders | W4-1 | 23-12-6 | 52 PTS | TD Garden · Boston, MA |
| 42 | Fri Apr 16 | vsIslanders | W3-0 | 24-12-6 | 54 PTS | TD Garden · Boston, MA |
| 43 | Sun Apr 18 | vsCapitals | W6-3 | 25-12-6 | 56 PTS | TD Garden · Boston, MA |
| 44 | Tue Apr 20 | atSabres | W2-0 | 26-12-6 | 58 PTS | KeyBank Center · Buffalo, NY |
| 45 | Thu Apr 22 | atSabres | W5-1 | 27-12-6 | 60 PTS | KeyBank Center · Buffalo, NY |
| 46 | Fri Apr 23 | atSabres | L4-6 | 27-13-6 | 60 PTS | KeyBank Center · Buffalo, NY |
| 47 | Sun Apr 25 | atPenguins | L0-1 | 27-14-6 | 60 PTS | PPG Paints Arena · Pittsburgh, PA |
| 48 | Tue Apr 27 | atPenguins | W3-1 | 28-14-6 | 62 PTS | PPG Paints Arena · Pittsburgh, PA |
| 49 | Thu Apr 29 | vsSabres | W5-2 | 29-14-6 | 64 PTS | TD Garden · Boston, MA |
| 50 | Sat May 1 | vsSabres | W6-2 | 30-14-6 | 66 PTS | TD Garden · Boston, MA |
| 51 | Mon May 3 | atDevils | W3-0 | 31-14-6 | 68 PTS | Prudential Center · Newark, NJ |
| 52 | Tue May 4 | atDevils | L3-4 (OT) | 31-14-7 | 69 PTS | Prudential Center · Newark, NJ |
| 53 | Thu May 6 | vsRangers | W4-0 | 32-14-7 | 71 PTS | TD Garden · Boston, MA |
| 54 | Sat May 8 | vsRangers | L4-5 | 32-15-7 | 71 PTS | TD Garden · Boston, MA |
| 55 | Mon May 10 | vsIslanders | W3-2 (OT) | 33-15-7 | 73 PTS | TD Garden · Boston, MA |
| 56 | Tue May 11 | atCapitals | L1-2 | 33-16-7 | 73 PTS | Capital One Arena · Washington, D.C. |
| 1 | Sat May 15 | atCapitals | L2-3 (OT) | 0-1 | .000 | Capital One Arena · Washington, D.C. |
| 2 | Mon May 17 | atCapitals | W4-3 (OT) | 1-1 | .500 | Capital One Arena · Washington, D.C. |
| 3 | Wed May 19 | vsCapitals | W3-2 (OT) | 2-1 | .667 | TD Garden · Boston, MA |
| 4 | Fri May 21 | vsCapitals | W4-1 | 3-1 | .750 | TD Garden · Boston, MA |
| 5 | Sun May 23 | atCapitals | W3-1 | 4-1 | .800 | Capital One Arena · Washington, D.C. |
| 1 | Sat May 29 | vsIslanders | W5-2 | 1-0 | 1.000 | TD Garden · Boston, MA |
| 2 | Mon May 31 | vsIslanders | L3-4 (OT) | 1-1 | .500 | TD Garden · Boston, MA |
| 3 | Thu Jun 3 | atIslanders | W2-1 (OT) | 2-1 | .667 | UBS Arena · Elmont, NY |
| 4 | Sat Jun 5 | atIslanders | L1-4 | 2-2 | .500 | UBS Arena · Elmont, NY |
| 5 | Mon Jun 7 | vsIslanders | L4-5 | 2-3 | .400 | TD Garden · Boston, MA |
| 6 | Wed Jun 9 | atIslanders | L2-6 | 2-4 | .333 | UBS Arena · Elmont, NY |
