| 1 | Wed Oct 11 | vs Blackhawks | W3-1 | 1-0-0 | 2 PTS | TD Garden · Boston, MA |
| 2 | Sat Oct 14 | vsPredators | W3-2 | 2-0-0 | 4 PTS | TD Garden · Boston, MA |
| 3 | Thu Oct 19 | atSharks | W3-1 | 3-0-0 | 6 PTS | SAP Center · San Jose, CA |
| 4 | Sat Oct 21 | atKings | W4-2 | 4-0-0 | 8 PTS | Crypto.com Arena · Los Angeles, CA |
| 5 | Sun Oct 22 | atDucks | W3-1 | 5-0-0 | 10 PTS | Honda Center · Anaheim, CA |
| 6 | Tue Oct 24 | atBlackhawks | W3-0 | 6-0-0 | 12 PTS | United Center · Chicago, IL |
| 7 | Thu Oct 26 | vsDucks | L3-4 (OT) | 6-0-1 | 13 PTS | TD Garden · Boston, MA |
| 8 | Sat Oct 28 | vsRed Wings | W4-1 | 7-0-1 | 15 PTS | TD Garden · Boston, MA |
| 9 | Mon Oct 30 | vsPanthers | W3-2 (OT) | 8-0-1 | 17 PTS | TD Garden · Boston, MA |
| 10 | Thu Nov 2 | vsMaple Leafs | W3-2 (SO) | 9-0-1 | 19 PTS | TD Garden · Boston, MA |
| 11 | Sat Nov 4 | atRed Wings | L4-5 | 9-1-1 | 19 PTS | Little Caesars Arena · Detroit, MI |
| 12 | Mon Nov 6 | atStars | W3-2 | 10-1-1 | 21 PTS | American Airlines Center · Dallas, TX |
| 13 | Thu Nov 9 | vsIslanders | W5-2 | 11-1-1 | 23 PTS | TD Garden · Boston, MA |
| 14 | Sat Nov 11 | atCanadiens | L2-3 (OT) | 11-1-2 | 24 PTS | Bell Centre · Montreal, QC |
| 15 | Tue Nov 14 | atSabres | W5-2 | 12-1-2 | 26 PTS | KeyBank Center · Buffalo, NY |
| 16 | Sat Nov 18 | vsCanadiens | W5-2 | 13-1-2 | 28 PTS | TD Garden · Boston, MA |
| 17 | Mon Nov 20 | atLightning | L4-5 (OT) | 13-1-3 | 29 PTS | AMALIE Arena · Tampa, FL |
| 18 | Wed Nov 22 | atPanthers | W3-1 | 14-1-3 | 31 PTS | Amerant Bank Arena · Sunrise, FL |
| 19 | Fri Nov 24 | vsRed Wings | L2-5 | 14-2-3 | 31 PTS | TD Garden · Boston, MA |
| 20 | Sat Nov 25 | atRangers | L4-7 | 14-3-3 | 31 PTS | Madison Square Garden · Manhattan, NY |
| 21 | Mon Nov 27 | atJackets | L2-5 | 14-4-3 | 31 PTS | Nationwide Arena · Columbus, OH |
| 22 | Thu Nov 30 | vsSharks | W3-0 | 15-4-3 | 33 PTS | TD Garden · Boston, MA |
| 23 | Sat Dec 2 | atMaple Leafs | W4-3 (OT) | 16-4-3 | 35 PTS | Scotiabank Arena · Toronto, ON |
| 24 | Sun Dec 3 | vsJackets | W3-1 | 17-4-3 | 37 PTS | TD Garden · Boston, MA |
| 25 | Thu Dec 7 | vsSabres | L1-3 | 17-5-3 | 37 PTS | TD Garden · Boston, MA |
| 26 | Sat Dec 9 | vsCoyotes | W5-3 | 18-5-3 | 39 PTS | TD Garden · Boston, MA |
| 27 | Wed Dec 13 | atDevils | L1-2 (OT) | 18-5-4 | 40 PTS | Prudential Center · Newark, NJ |
| 28 | Fri Dec 15 | atIslanders | W5-4 (SO) | 19-5-4 | 42 PTS | UBS Arena · Elmont, NY |
| 29 | Sat Dec 16 | vsRangers | L1-2 (OT) | 19-5-5 | 43 PTS | TD Garden · Boston, MA |
| 30 | Tue Dec 19 | vsWild | L3-4 (OT) | 19-5-6 | 44 PTS | TD Garden · Boston, MA |
| 31 | Fri Dec 22 | atJets | L1-5 | 19-6-6 | 44 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 32 | Sat Dec 23 | atWild | L2-3 | 19-7-6 | 44 PTS | Xcel Energy Center · St. Paul, MN |
| 33 | Wed Dec 27 | atSabres | W4-1 | 20-7-6 | 46 PTS | KeyBank Center · Buffalo, NY |
| 34 | Sat Dec 30 | vsDevils | W5-2 | 21-7-6 | 48 PTS | TD Garden · Boston, MA |
| 35 | Sun Dec 31 | atRed Wings | W5-3 | 22-7-6 | 50 PTS | Little Caesars Arena · Detroit, MI |
| 36 | Tue Jan 2 | atJackets | W4-1 | 23-7-6 | 52 PTS | Nationwide Arena · Columbus, OH |
| 37 | Thu Jan 4 | vsPenguins | L5-6 | 23-8-6 | 52 PTS | TD Garden · Boston, MA |
| 38 | Sat Jan 6 | vsLightning | W7-3 | 24-8-6 | 54 PTS | TD Garden · Boston, MA |
| 39 | Mon Jan 8 | atAvalanche | L3-4 (SO) | 24-8-7 | 55 PTS | Ball Arena · Denver, CO |
| 40 | Tue Jan 9 | atCoyotes | L3-4 (OT) | 24-8-8 | 56 PTS | Mullett Arena · Tempe, AZ |
| 41 | Thu Jan 11 | atKnights | L1-2 (OT) | 24-8-9 | 57 PTS | T-Mobile Arena · Las Vegas, NV |
| 42 | Sat Jan 13 | atBlues | W4-3 (OT) | 25-8-9 | 59 PTS | Enterprise Center · St. Louis, MO |
| 43 | Mon Jan 15 | vsDevils | W3-0 | 26-8-9 | 61 PTS | TD Garden · Boston, MA |
| 44 | Thu Jan 18 | vsAvalanche | W5-2 | 27-8-9 | 63 PTS | TD Garden · Boston, MA |
| 45 | Sat Jan 20 | vsCanadiens | W9-4 | 28-8-9 | 65 PTS | TD Garden · Boston, MA |
| 46 | Mon Jan 22 | vsJets | W4-1 | 29-8-9 | 67 PTS | TD Garden · Boston, MA |
| 47 | Wed Jan 24 | vsHurricanes | L2-3 | 29-9-9 | 67 PTS | TD Garden · Boston, MA |
| 48 | Thu Jan 25 | atSenators | W3-2 (OT) | 30-9-9 | 69 PTS | Canadian Tire Centre · Ottawa, ON |
| 49 | Sat Jan 27 | atFlyers | W6-2 | 31-9-9 | 71 PTS | Wells Fargo Center · Philadelphia, PA |
| 50 | Tue Feb 6 | vsFlames | L1-4 | 31-10-9 | 71 PTS | TD Garden · Boston, MA |
| 51 | Thu Feb 8 | vsCanucks | W4-0 | 32-10-9 | 73 PTS | TD Garden · Boston, MA |
| 52 | Sat Feb 10 | vsCapitals | L0-3 | 32-11-9 | 73 PTS | TD Garden · Boston, MA |
| 53 | Tue Feb 13 | vsLightning | L2-3 (SO) | 32-11-10 | 74 PTS | TD Garden · Boston, MA |
| 54 | Thu Feb 15 | vsKraken | L1-4 | 32-12-10 | 74 PTS | TD Garden · Boston, MA |
| 55 | Sat Feb 17 | vsKings | L4-5 (OT) | 32-12-11 | 75 PTS | TD Garden · Boston, MA |
| 56 | Mon Feb 19 | vsStars | W4-3 (SO) | 33-12-11 | 77 PTS | TD Garden · Boston, MA |
| 57 | Wed Feb 21 | atOilers | W6-5 (OT) | 34-12-11 | 79 PTS | Rogers Place · Edmonton, AB |
| 58 | Thu Feb 22 | atFlames | L2-3 (OT) | 34-12-12 | 80 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 59 | Sat Feb 24 | atCanucks | L2-3 (OT) | 34-12-13 | 81 PTS | Rogers Arena · Vancouver, British Columbia |
| 60 | Mon Feb 26 | atKraken | L3-4 (SO) | 34-12-14 | 82 PTS | Climate Pledge Arena · Seattle, WA |
| 61 | Thu Feb 29 | vsKnights | W5-4 | 35-12-14 | 84 PTS | TD Garden · Boston, MA |
| 62 | Sat Mar 2 | atIslanders | L1-5 | 35-13-14 | 84 PTS | UBS Arena · Elmont, NY |
| 63 | Mon Mar 4 | atMaple Leafs | W4-1 | 36-13-14 | 86 PTS | Scotiabank Arena · Toronto, ON |
| 64 | Tue Mar 5 | vsOilers | L1-2 (OT) | 36-13-15 | 87 PTS | TD Garden · Boston, MA |
| 65 | Thu Mar 7 | vsMaple Leafs | W4-1 | 37-13-15 | 89 PTS | TD Garden · Boston, MA |
| 66 | Sat Mar 9 | vsPenguins | W5-1 | 38-13-15 | 91 PTS | TD Garden · Boston, MA |
| 67 | Mon Mar 11 | vsBlues | L1-5 | 38-14-15 | 91 PTS | TD Garden · Boston, MA |
| 68 | Thu Mar 14 | atCanadiens | W2-1 (OT) | 39-14-15 | 93 PTS | Bell Centre · Montreal, QC |
| 69 | Sat Mar 16 | vsFlyers | W6-5 | 40-14-15 | 95 PTS | TD Garden · Boston, MA |
| 70 | Tue Mar 19 | vsSenators | W6-2 | 41-14-15 | 97 PTS | TD Garden · Boston, MA |
| 71 | Thu Mar 21 | vsRangers | L2-5 | 41-15-15 | 97 PTS | TD Garden · Boston, MA |
| 72 | Sat Mar 23 | atFlyers | L2-3 | 41-16-15 | 97 PTS | Wells Fargo Center · Philadelphia, PA |
| 73 | Tue Mar 26 | atPanthers | W4-3 | 42-16-15 | 99 PTS | Amerant Bank Arena · Sunrise, FL |
| 74 | Wed Mar 27 | atLightning | L1-3 | 42-17-15 | 99 PTS | AMALIE Arena · Tampa, FL |
| 75 | Sat Mar 30 | atCapitals | W3-2 (SO) | 43-17-15 | 101 PTS | Capital One Arena · Washington, D.C. |
| 76 | Tue Apr 2 | atPredators | W3-0 | 44-17-15 | 103 PTS | Bridgestone Arena · Nashville, TN |
| 77 | Thu Apr 4 | atHurricanes | W4-1 | 45-17-15 | 105 PTS | PNC Arena · Raleigh, NC |
| 78 | Sat Apr 6 | vsPanthers | W3-2 (OT) | 46-17-15 | 107 PTS | TD Garden · Boston, MA |
| 79 | Tue Apr 9 | vsHurricanes | L1-4 | 46-18-15 | 107 PTS | TD Garden · Boston, MA |
| 80 | Sat Apr 13 | atPenguins | W6-4 | 47-18-15 | 109 PTS | PPG Paints Arena · Pittsburgh, PA |
| 81 | Mon Apr 15 | atCapitals | L0-2 | 47-19-15 | 109 PTS | Capital One Arena · Washington, D.C. |
| 82 | Tue Apr 16 | vsSenators | L1-3 | 47-20-15 | 109 PTS | TD Garden · Boston, MA |
| 1 | Sat Apr 20 | vsMaple Leafs | W5-1 | 1-0 | 1.000 | TD Garden · Boston, MA |
| 2 | Mon Apr 22 | vsMaple Leafs | L2-3 | 1-1 | .500 | TD Garden · Boston, MA |
| 3 | Wed Apr 24 | atMaple Leafs | W4-2 | 2-1 | .667 | Scotiabank Arena · Toronto, ON |
| 4 | Sat Apr 27 | atMaple Leafs | W3-1 | 3-1 | .750 | Scotiabank Arena · Toronto, ON |
| 5 | Tue Apr 30 | vsMaple Leafs | L1-2 (OT) | 3-2 | .600 | TD Garden · Boston, MA |
| 6 | Thu May 2 | atMaple Leafs | L1-2 | 3-3 | .500 | Scotiabank Arena · Toronto, ON |
| 7 | Sat May 4 | vsMaple Leafs | W2-1 (OT) | 4-3 | .571 | TD Garden · Boston, MA |
| 1 | Mon May 6 | atPanthers | W5-1 | 1-0 | 1.000 | Amerant Bank Arena · Sunrise, FL |
| 2 | Wed May 8 | atPanthers | L1-6 | 1-1 | .500 | Amerant Bank Arena · Sunrise, FL |
| 3 | Fri May 10 | vsPanthers | L2-6 | 1-2 | .333 | TD Garden · Boston, MA |
| 4 | Sun May 12 | vsPanthers | L2-3 | 1-3 | .250 | TD Garden · Boston, MA |
| 5 | Tue May 14 | atPanthers | W2-1 | 2-3 | .400 | Amerant Bank Arena · Sunrise, FL |
| 6 | Fri May 17 | vsPanthers | L1-2 | 2-4 | .333 | TD Garden · Boston, MA |
