| 1 | Sat Oct 16 | vs Stars | W3-1 | 1-0-0 | 2 PTS | TD Garden · Boston, MA |
| 2 | Wed Oct 20 | atFlyers | L3-6 | 1-1-0 | 2 PTS | Wells Fargo Center · Philadelphia, PA |
| 3 | Fri Oct 22 | atSabres | W4-1 | 2-1-0 | 4 PTS | KeyBank Center · Buffalo, NY |
| 4 | Sun Oct 24 | vsSharks | W4-3 | 3-1-0 | 6 PTS | TD Garden · Boston, MA |
| 5 | Wed Oct 27 | atPanthers | L1-4 | 3-2-0 | 6 PTS | Amerant Bank Arena · Sunrise, FL |
| 6 | Thu Oct 28 | atHurricanes | L0-3 | 3-3-0 | 6 PTS | PNC Arena · Raleigh, NC |
| 7 | Sat Oct 30 | vsPanthers | W3-2 (SO) | 4-3-0 | 8 PTS | TD Garden · Boston, MA |
| 8 | Thu Nov 4 | vsRed Wings | W5-1 | 5-3-0 | 10 PTS | TD Garden · Boston, MA |
| 9 | Sat Nov 6 | atMaple Leafs | L2-5 | 5-4-0 | 10 PTS | Scotiabank Arena · Toronto, ON |
| 10 | Tue Nov 9 | vsSenators | W3-2 | 6-4-0 | 12 PTS | TD Garden · Boston, MA |
| 11 | Thu Nov 11 | vsOilers | L3-5 | 6-5-0 | 12 PTS | TD Garden · Boston, MA |
| 12 | Sat Nov 13 | atDevils | W5-2 | 7-5-0 | 14 PTS | Prudential Center · Newark, NJ |
| 13 | Sun Nov 14 | vsCanadiens | W5-2 | 8-5-0 | 16 PTS | TD Garden · Boston, MA |
| 14 | Sat Nov 20 | atFlyers | W5-2 | 9-5-0 | 18 PTS | Wells Fargo Center · Philadelphia, PA |
| 15 | Sun Nov 21 | vsFlames | L0-4 | 9-6-0 | 18 PTS | TD Garden · Boston, MA |
| 16 | Wed Nov 24 | atSabres | W5-1 | 10-6-0 | 20 PTS | KeyBank Center · Buffalo, NY |
| 17 | Fri Nov 26 | vsRangers | L2-5 | 10-7-0 | 20 PTS | TD Garden · Boston, MA |
| 18 | Sun Nov 28 | vsCanucks | W3-2 | 11-7-0 | 22 PTS | TD Garden · Boston, MA |
| 19 | Tue Nov 30 | vsRed Wings | L1-2 | 11-8-0 | 22 PTS | TD Garden · Boston, MA |
| 20 | Thu Dec 2 | atPredators | W2-0 | 12-8-0 | 24 PTS | Bridgestone Arena · Nashville, TN |
| 21 | Sat Dec 4 | vsLightning | L2-3 (OT) | 12-8-1 | 25 PTS | TD Garden · Boston, MA |
| 22 | Wed Dec 8 | atCanucks | L1-2 (SO) | 12-8-2 | 26 PTS | Rogers Arena · Vancouver, British Columbia |
| 23 | Thu Dec 9 | atOilers | W3-2 | 13-8-2 | 28 PTS | Rogers Place · Edmonton, AB |
| 24 | Sat Dec 11 | atFlames | W4-2 | 14-8-2 | 30 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 25 | Tue Dec 14 | vsKnights | L1-4 | 14-9-2 | 30 PTS | TD Garden · Boston, MA |
| 26 | Thu Dec 16 | atIslanders | L1-3 | 14-10-2 | 30 PTS | UBS Arena · Elmont, NY |
| 27 | Sat Jan 1 | vsSabres | W4-3 (OT) | 15-10-2 | 32 PTS | TD Garden · Boston, MA |
| 28 | Sun Jan 2 | atRed Wings | W5-1 | 16-10-2 | 34 PTS | Little Caesars Arena · Detroit, MI |
| 29 | Tue Jan 4 | vsDevils | W5-3 | 17-10-2 | 36 PTS | TD Garden · Boston, MA |
| 30 | Thu Jan 6 | vsWild | L2-3 | 17-11-2 | 36 PTS | TD Garden · Boston, MA |
| 31 | Sat Jan 8 | atLightning | W5-2 | 18-11-2 | 38 PTS | AMALIE Arena · Tampa, FL |
| 32 | Mon Jan 10 | atCapitals | W7-3 | 19-11-2 | 40 PTS | Capital One Arena · Washington, D.C. |
| 33 | Wed Jan 12 | vsCanadiens | W5-1 | 20-11-2 | 42 PTS | TD Garden · Boston, MA |
| 34 | Thu Jan 13 | vsFlyers | W3-2 | 21-11-2 | 44 PTS | TD Garden · Boston, MA |
| 35 | Sat Jan 15 | vsPredators | W4-3 (OT) | 22-11-2 | 46 PTS | TD Garden · Boston, MA |
| 36 | Tue Jan 18 | vsHurricanes | L1-7 | 22-12-2 | 46 PTS | TD Garden · Boston, MA |
| 37 | Thu Jan 20 | vsCapitals | W4-3 | 23-12-2 | 48 PTS | TD Garden · Boston, MA |
| 38 | Sat Jan 22 | vsJets | W3-2 | 24-12-2 | 50 PTS | TD Garden · Boston, MA |
| 39 | Mon Jan 24 | vsDucks | L3-5 | 24-13-2 | 50 PTS | TD Garden · Boston, MA |
| 40 | Wed Jan 26 | atAvalanche | L3-4 (OT) | 24-13-3 | 51 PTS | Ball Arena · Denver, CO |
| 41 | Fri Jan 28 | atCoyotes | W2-1 | 25-13-3 | 53 PTS | Mullett Arena · Tempe, AZ |
| 42 | Sun Jan 30 | atStars | L1-6 | 25-14-3 | 53 PTS | American Airlines Center · Dallas, TX |
| 43 | Tue Feb 1 | vsKraken | W3-2 | 26-14-3 | 55 PTS | TD Garden · Boston, MA |
| 44 | Tue Feb 8 | vsPenguins | L2-4 | 26-15-3 | 55 PTS | TD Garden · Boston, MA |
| 45 | Thu Feb 10 | vsHurricanes | L0-6 | 26-16-3 | 55 PTS | TD Garden · Boston, MA |
| 46 | Sat Feb 12 | atSenators | W2-0 | 27-16-3 | 57 PTS | Canadian Tire Centre · Ottawa, ON |
| 47 | Tue Feb 15 | atRangers | L1-2 (SO) | 27-16-4 | 58 PTS | Madison Square Garden · Manhattan, NY |
| 48 | Thu Feb 17 | atIslanders | L1-4 | 27-17-4 | 58 PTS | UBS Arena · Elmont, NY |
| 49 | Sat Feb 19 | atSenators | W3-2 (OT) | 28-17-4 | 60 PTS | Canadian Tire Centre · Ottawa, ON |
| 50 | Mon Feb 21 | vsAvalanche | W5-1 | 29-17-4 | 62 PTS | TD Garden · Boston, MA |
| 51 | Thu Feb 24 | atKraken | W3-2 (OT) | 30-17-4 | 64 PTS | Climate Pledge Arena · Seattle, WA |
| 52 | Sat Feb 26 | atSharks | W3-1 | 31-17-4 | 66 PTS | SAP Center · San Jose, CA |
| 53 | Mon Feb 28 | atKings | W7-0 | 32-17-4 | 68 PTS | Crypto.com Arena · Los Angeles, CA |
| 54 | Tue Mar 1 | atDucks | L3-4 | 32-18-4 | 68 PTS | Honda Center · Anaheim, CA |
| 55 | Thu Mar 3 | atKnights | W5-2 | 33-18-4 | 70 PTS | T-Mobile Arena · Las Vegas, NV |
| 56 | Sat Mar 5 | atJackets | W5-4 (SO) | 34-18-4 | 72 PTS | Nationwide Arena · Columbus, OH |
| 57 | Mon Mar 7 | vsKings | L2-3 (OT) | 34-18-5 | 73 PTS | TD Garden · Boston, MA |
| 58 | Thu Mar 10 | vsBlackhawks | W4-3 | 35-18-5 | 75 PTS | TD Garden · Boston, MA |
| 59 | Sat Mar 12 | vsCoyotes | W3-2 | 36-18-5 | 77 PTS | TD Garden · Boston, MA |
| 60 | Tue Mar 15 | atBlackhawks | W2-1 (OT) | 37-18-5 | 79 PTS | United Center · Chicago, IL |
| 61 | Wed Mar 16 | atWild | L2-4 | 37-19-5 | 79 PTS | Xcel Energy Center · St. Paul, MN |
| 62 | Fri Mar 18 | atJets | W4-2 | 38-19-5 | 81 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 63 | Mon Mar 21 | atCanadiens | W3-2 (OT) | 39-19-5 | 83 PTS | Bell Centre · Montreal, QC |
| 64 | Thu Mar 24 | vsLightning | W3-2 | 40-19-5 | 85 PTS | TD Garden · Boston, MA |
| 65 | Sat Mar 26 | vsIslanders | W6-3 | 41-19-5 | 87 PTS | TD Garden · Boston, MA |
| 66 | Tue Mar 29 | vsMaple Leafs | L4-6 | 41-20-5 | 87 PTS | TD Garden · Boston, MA |
| 67 | Thu Mar 31 | vsDevils | W8-1 | 42-20-5 | 89 PTS | TD Garden · Boston, MA |
| 68 | Sat Apr 2 | vsJackets | W5-2 | 43-20-5 | 91 PTS | TD Garden · Boston, MA |
| 69 | Mon Apr 4 | atJackets | W3-2 (OT) | 44-20-5 | 93 PTS | Nationwide Arena · Columbus, OH |
| 70 | Tue Apr 5 | atRed Wings | L3-5 | 44-21-5 | 93 PTS | Little Caesars Arena · Detroit, MI |
| 71 | Fri Apr 8 | atLightning | W2-1 (OT) | 45-21-5 | 95 PTS | AMALIE Arena · Tampa, FL |
| 72 | Sun Apr 10 | atCapitals | L2-4 | 45-22-5 | 95 PTS | Capital One Arena · Washington, D.C. |
| 73 | Tue Apr 12 | vsBlues | L2-4 | 45-23-5 | 95 PTS | TD Garden · Boston, MA |
| 74 | Thu Apr 14 | vsSenators | L2-3 | 45-24-5 | 95 PTS | TD Garden · Boston, MA |
| 75 | Sat Apr 16 | vsPenguins | W2-1 | 46-24-5 | 97 PTS | TD Garden · Boston, MA |
| 76 | Tue Apr 19 | atBlues | W3-2 (OT) | 47-24-5 | 99 PTS | Enterprise Center · St. Louis, MO |
| 77 | Thu Apr 21 | atPenguins | L0-4 | 47-25-5 | 99 PTS | PPG Paints Arena · Pittsburgh, PA |
| 78 | Sat Apr 23 | vsRangers | W3-1 | 48-25-5 | 101 PTS | TD Garden · Boston, MA |
| 79 | Sun Apr 24 | atCanadiens | W5-3 | 49-25-5 | 103 PTS | Bell Centre · Montreal, QC |
| 80 | Tue Apr 26 | vsPanthers | W4-2 | 50-25-5 | 105 PTS | TD Garden · Boston, MA |
| 81 | Thu Apr 28 | vsSabres | W5-0 | 51-25-5 | 107 PTS | TD Garden · Boston, MA |
| 82 | Fri Apr 29 | atMaple Leafs | L2-5 | 51-26-5 | 107 PTS | Scotiabank Arena · Toronto, ON |
| 1 | Mon May 2 | atHurricanes | L1-5 | 0-1 | .000 | PNC Arena · Raleigh, NC |
| 2 | Wed May 4 | atHurricanes | L2-5 | 0-2 | .000 | PNC Arena · Raleigh, NC |
| 3 | Fri May 6 | vsHurricanes | W4-2 | 1-2 | .333 | TD Garden · Boston, MA |
| 4 | Sun May 8 | vsHurricanes | W5-2 | 2-2 | .500 | TD Garden · Boston, MA |
| 5 | Tue May 10 | atHurricanes | L1-5 | 2-3 | .400 | PNC Arena · Raleigh, NC |
| 6 | Thu May 12 | vsHurricanes | W5-2 | 3-3 | .500 | TD Garden · Boston, MA |
| 7 | Sat May 14 | atHurricanes | L2-3 | 3-4 | .429 | PNC Arena · Raleigh, NC |
