| 1 | Wed Oct 12 | at Capitals | W5-2 | 1-0-0 | 2 PTS | Capital One Arena · Washington, D.C. |
| 2 | Sat Oct 15 | vsCoyotes | W6-3 | 2-0-0 | 4 PTS | TD Garden · Boston, MA |
| 3 | Mon Oct 17 | vsPanthers | W5-3 | 3-0-0 | 6 PTS | TD Garden · Boston, MA |
| 4 | Tue Oct 18 | atSenators | L5-7 | 3-1-0 | 6 PTS | Canadian Tire Centre · Ottawa, ON |
| 5 | Thu Oct 20 | vsDucks | W2-1 (SO) | 4-1-0 | 8 PTS | TD Garden · Boston, MA |
| 6 | Sat Oct 22 | vsWild | W4-3 (OT) | 5-1-0 | 10 PTS | TD Garden · Boston, MA |
| 7 | Tue Oct 25 | vsStars | W3-1 | 6-1-0 | 12 PTS | TD Garden · Boston, MA |
| 8 | Thu Oct 27 | vsRed Wings | W5-1 | 7-1-0 | 14 PTS | TD Garden · Boston, MA |
| 9 | Fri Oct 28 | atJackets | W4-0 | 8-1-0 | 16 PTS | Nationwide Arena · Columbus, OH |
| 10 | Tue Nov 1 | atPenguins | W6-5 (OT) | 9-1-0 | 18 PTS | PPG Paints Arena · Pittsburgh, PA |
| 11 | Thu Nov 3 | atRangers | W5-2 | 10-1-0 | 20 PTS | Madison Square Garden · Manhattan, NY |
| 12 | Sat Nov 5 | atMaple Leafs | L1-2 | 10-2-0 | 20 PTS | Scotiabank Arena · Toronto, ON |
| 13 | Mon Nov 7 | vsBlues | W3-1 | 11-2-0 | 22 PTS | TD Garden · Boston, MA |
| 14 | Thu Nov 10 | vsFlames | W3-1 | 12-2-0 | 24 PTS | TD Garden · Boston, MA |
| 15 | Sat Nov 12 | atSabres | W3-1 | 13-2-0 | 26 PTS | KeyBank Center · Buffalo, NY |
| 16 | Sun Nov 13 | vsCanucks | W5-2 | 14-2-0 | 28 PTS | TD Garden · Boston, MA |
| 17 | Thu Nov 17 | vsFlyers | W4-1 | 15-2-0 | 30 PTS | TD Garden · Boston, MA |
| 18 | Sat Nov 19 | vsBlackhawks | W6-1 | 16-2-0 | 32 PTS | TD Garden · Boston, MA |
| 19 | Mon Nov 21 | atLightning | W5-3 | 17-2-0 | 34 PTS | AMALIE Arena · Tampa, FL |
| 20 | Wed Nov 23 | atPanthers | L2-5 | 17-3-0 | 34 PTS | Amerant Bank Arena · Sunrise, FL |
| 21 | Fri Nov 25 | vsHurricanes | W3-2 (OT) | 18-3-0 | 36 PTS | TD Garden · Boston, MA |
| 22 | Tue Nov 29 | vsLightning | W3-1 | 19-3-0 | 38 PTS | TD Garden · Boston, MA |
| 23 | Sat Dec 3 | vsAvalanche | W5-1 | 20-3-0 | 40 PTS | TD Garden · Boston, MA |
| 24 | Mon Dec 5 | vsKnights | L3-4 (SO) | 20-3-1 | 41 PTS | TD Garden · Boston, MA |
| 25 | Wed Dec 7 | atAvalanche | W4-0 | 21-3-1 | 43 PTS | Ball Arena · Denver, CO |
| 26 | Fri Dec 9 | atCoyotes | L3-4 | 21-4-1 | 43 PTS | Mullett Arena · Tempe, AZ |
| 27 | Sun Dec 11 | atKnights | W3-1 | 22-4-1 | 45 PTS | T-Mobile Arena · Las Vegas, NV |
| 28 | Tue Dec 13 | vsIslanders | W4-3 (SO) | 23-4-1 | 47 PTS | TD Garden · Boston, MA |
| 29 | Thu Dec 15 | vsKings | L2-3 (SO) | 23-4-2 | 48 PTS | TD Garden · Boston, MA |
| 30 | Sat Dec 17 | vsJackets | W4-2 | 24-4-2 | 50 PTS | TD Garden · Boston, MA |
| 31 | Mon Dec 19 | vsPanthers | W7-3 | 25-4-2 | 52 PTS | TD Garden · Boston, MA |
| 32 | Thu Dec 22 | vsJets | W3-2 | 26-4-2 | 54 PTS | TD Garden · Boston, MA |
| 33 | Fri Dec 23 | atDevils | W4-3 | 27-4-2 | 56 PTS | Prudential Center · Newark, NJ |
| 34 | Tue Dec 27 | atSenators | L2-3 (SO) | 27-4-3 | 57 PTS | Canadian Tire Centre · Ottawa, ON |
| 35 | Wed Dec 28 | atDevils | W3-1 | 28-4-3 | 59 PTS | Prudential Center · Newark, NJ |
| 36 | Sat Dec 31 | vsSabres | L3-4 (OT) | 28-4-4 | 60 PTS | TD Garden · Boston, MA |
| 37 | Mon Jan 2 | vsPenguins | W2-1 | 29-4-4 | 62 PTS | TD Garden · Boston, MA |
| 38 | Thu Jan 5 | atKings | W5-2 | 30-4-4 | 64 PTS | Crypto.com Arena · Los Angeles, CA |
| 39 | Sat Jan 7 | atSharks | W4-2 | 31-4-4 | 66 PTS | SAP Center · San Jose, CA |
| 40 | Sun Jan 8 | atDucks | W7-1 | 32-4-4 | 68 PTS | Honda Center · Anaheim, CA |
| 41 | Thu Jan 12 | vsKraken | L0-3 | 32-5-4 | 68 PTS | TD Garden · Boston, MA |
| 42 | Sat Jan 14 | vsMaple Leafs | W4-3 | 33-5-4 | 70 PTS | TD Garden · Boston, MA |
| 43 | Mon Jan 16 | vsFlyers | W6-0 | 34-5-4 | 72 PTS | TD Garden · Boston, MA |
| 44 | Wed Jan 18 | atIslanders | W4-1 | 35-5-4 | 74 PTS | UBS Arena · Elmont, NY |
| 45 | Thu Jan 19 | atRangers | W3-1 | 36-5-4 | 76 PTS | Madison Square Garden · Manhattan, NY |
| 46 | Sun Jan 22 | vsSharks | W4-0 | 37-5-4 | 78 PTS | TD Garden · Boston, MA |
| 47 | Tue Jan 24 | atCanadiens | W4-2 | 38-5-4 | 80 PTS | Bell Centre · Montreal, QC |
| 48 | Thu Jan 26 | atLightning | L2-3 | 38-6-4 | 80 PTS | AMALIE Arena · Tampa, FL |
| 49 | Sat Jan 28 | atPanthers | L3-4 (OT) | 38-6-5 | 81 PTS | Amerant Bank Arena · Sunrise, FL |
| 50 | Sun Jan 29 | atHurricanes | L1-4 | 38-7-5 | 81 PTS | PNC Arena · Raleigh, NC |
| 51 | Wed Feb 1 | atMaple Leafs | W5-2 | 39-7-5 | 83 PTS | Scotiabank Arena · Toronto, ON |
| 52 | Sat Feb 11 | vsCapitals | L1-2 | 39-8-5 | 83 PTS | TD Garden · Boston, MA |
| 53 | Tue Feb 14 | atStars | W3-2 (OT) | 40-8-5 | 85 PTS | American Airlines Center · Dallas, TX |
| 54 | Thu Feb 16 | atPredators | W5-0 | 41-8-5 | 87 PTS | Bridgestone Arena · Nashville, TN |
| 55 | Sat Feb 18 | vsIslanders | W6-2 | 42-8-5 | 89 PTS | TD Garden · Boston, MA |
| 56 | Mon Feb 20 | vsSenators | W3-1 | 43-8-5 | 91 PTS | TD Garden · Boston, MA |
| 57 | Thu Feb 23 | atKraken | W6-5 | 44-8-5 | 93 PTS | Climate Pledge Arena · Seattle, WA |
| 58 | Sat Feb 25 | atCanucks | W3-1 | 45-8-5 | 95 PTS | Rogers Arena · Vancouver, British Columbia |
| 59 | Mon Feb 27 | atOilers | W3-2 | 46-8-5 | 97 PTS | Rogers Place · Edmonton, AB |
| 60 | Tue Feb 28 | atFlames | W4-3 (OT) | 47-8-5 | 99 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 61 | Thu Mar 2 | vsSabres | W7-1 | 48-8-5 | 101 PTS | TD Garden · Boston, MA |
| 62 | Sat Mar 4 | vsRangers | W4-2 | 49-8-5 | 103 PTS | TD Garden · Boston, MA |
| 63 | Thu Mar 9 | vsOilers | L2-3 | 49-9-5 | 103 PTS | TD Garden · Boston, MA |
| 64 | Sat Mar 11 | vsRed Wings | W3-2 | 50-9-5 | 105 PTS | TD Garden · Boston, MA |
| 65 | Sun Mar 12 | atRed Wings | L3-5 | 50-10-5 | 105 PTS | Little Caesars Arena · Detroit, MI |
| 66 | Tue Mar 14 | atBlackhawks | L3-6 | 50-11-5 | 105 PTS | United Center · Chicago, IL |
| 67 | Thu Mar 16 | atJets | W3-0 | 51-11-5 | 107 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 68 | Sat Mar 18 | atWild | W5-2 | 52-11-5 | 109 PTS | Xcel Energy Center · St. Paul, MN |
| 69 | Sun Mar 19 | atSabres | W7-0 | 53-11-5 | 111 PTS | KeyBank Center · Buffalo, NY |
| 70 | Tue Mar 21 | vsSenators | W2-1 | 54-11-5 | 113 PTS | TD Garden · Boston, MA |
| 71 | Thu Mar 23 | vsCanadiens | W4-2 | 55-11-5 | 115 PTS | TD Garden · Boston, MA |
| 72 | Sat Mar 25 | vsLightning | W2-1 | 56-11-5 | 117 PTS | TD Garden · Boston, MA |
| 73 | Sun Mar 26 | atHurricanes | W4-3 (SO) | 57-11-5 | 119 PTS | PNC Arena · Raleigh, NC |
| 74 | Tue Mar 28 | vsPredators | L1-2 | 57-12-5 | 119 PTS | TD Garden · Boston, MA |
| 75 | Thu Mar 30 | vsJackets | W2-1 (OT) | 58-12-5 | 121 PTS | TD Garden · Boston, MA |
| 76 | Sat Apr 1 | atPenguins | W4-3 | 59-12-5 | 123 PTS | PPG Paints Arena · Pittsburgh, PA |
| 77 | Sun Apr 2 | atBlues | W4-3 (SO) | 60-12-5 | 125 PTS | Enterprise Center · St. Louis, MO |
| 78 | Thu Apr 6 | vsMaple Leafs | W2-1 (OT) | 61-12-5 | 127 PTS | TD Garden · Boston, MA |
| 79 | Sat Apr 8 | vsDevils | W2-1 | 62-12-5 | 129 PTS | TD Garden · Boston, MA |
| 80 | Sun Apr 9 | atFlyers | W5-3 | 63-12-5 | 131 PTS | Wells Fargo Center · Philadelphia, PA |
| 81 | Tue Apr 11 | vsCapitals | W5-2 | 64-12-5 | 133 PTS | TD Garden · Boston, MA |
| 82 | Thu Apr 13 | atCanadiens | W5-4 | 65-12-5 | 135 PTS | Bell Centre · Montreal, QC |
| 1 | Mon Apr 17 | vsPanthers | W3-1 | 1-0 | 1.000 | TD Garden · Boston, MA |
| 2 | Wed Apr 19 | vsPanthers | L3-6 | 1-1 | .500 | TD Garden · Boston, MA |
| 3 | Fri Apr 21 | atPanthers | W4-2 | 2-1 | .667 | Amerant Bank Arena · Sunrise, FL |
| 4 | Sun Apr 23 | atPanthers | W6-2 | 3-1 | .750 | Amerant Bank Arena · Sunrise, FL |
| 5 | Wed Apr 26 | vsPanthers | L3-4 (OT) | 3-2 | .600 | TD Garden · Boston, MA |
| 6 | Fri Apr 28 | atPanthers | L5-7 | 3-3 | .500 | Amerant Bank Arena · Sunrise, FL |
| 7 | Sun Apr 30 | vsPanthers | L3-4 (OT) | 3-4 | .429 | TD Garden · Boston, MA |
