| 1 | Tue Oct 8 | at Panthers | L4-6 | 0-1-0 | 0 PTS | Amerant Bank Arena · Sunrise, FL |
| 2 | Thu Oct 10 | vs Canadiens | W6-4 | 1-1-0 | 2 PTS | TD Garden · Boston, MA |
| 3 | Sat Oct 12 | vs Kings | W2-1 (OT) | 2-1-0 | 4 PTS | TD Garden · Boston, MA |
| 4 | Mon Oct 14 | vsPanthers | L3-4 | 2-2-0 | 4 PTS | TD Garden · Boston, MA |
| 5 | Wed Oct 16 | at Avalanche | W5-3 | 3-2-0 | 6 PTS | Ball Arena · Denver, CO |
| 6 | Sat Oct 19 | at Utah HC | L1-2 (OT) | 3-2-1 | 7 PTS | Delta Center · Salt Lake City, UT |
| 7 | Tue Oct 22 | at Predators | L0-4 | 3-3-1 | 7 PTS | Bridgestone Arena · Nashville, TN |
| 8 | Thu Oct 24 | vs Stars | L2-5 | 3-4-1 | 7 PTS | TD Garden · Boston, MA |
| 9 | Sat Oct 26 | vs Maple Leafs | W4-3 (OT) | 4-4-1 | 9 PTS | TD Garden · Boston, MA |
| 10 | Tue Oct 29 | vs Flyers | L0-2 | 4-5-1 | 9 PTS | TD Garden · Boston, MA |
| 11 | Thu Oct 31 | at Hurricanes | L2-8 | 4-6-1 | 9 PTS | PNC Arena · Raleigh, NC |
| 12 | Sat Nov 2 | atFlyers | W3-0 | 5-6-1 | 11 PTS | Wells Fargo Center · Philadelphia, PA |
| 13 | Sun Nov 3 | vs Kraken | W2-0 | 6-6-1 | 13 PTS | TD Garden · Boston, MA |
| 14 | Tue Nov 5 | atMaple Leafs | L0-4 | 6-7-1 | 13 PTS | Scotiabank Arena · Toronto, ON |
| 15 | Thu Nov 7 | vs Flames | W4-3 (OT) | 7-7-1 | 15 PTS | TD Garden · Boston, MA |
| 16 | Sat Nov 9 | vs Senators | L2-3 (OT) | 7-7-2 | 16 PTS | TD Garden · Boston, MA |
| 17 | Tue Nov 12 | at Blues | W3-2 | 8-7-2 | 18 PTS | Enterprise Center · St. Louis, MO |
| 18 | Thu Nov 14 | atStars | L2-7 | 8-8-2 | 18 PTS | American Airlines Center · Dallas, TX |
| 19 | Sat Nov 16 | vsBlues | L2-3 (OT) | 8-8-3 | 19 PTS | TD Garden · Boston, MA |
| 20 | Mon Nov 18 | vs Jackets | L1-5 | 8-9-3 | 19 PTS | TD Garden · Boston, MA |
| 21 | Thu Nov 21 | vsUtah HC | W1-0 | 9-9-3 | 21 PTS | TD Garden · Boston, MA |
| 22 | Sat Nov 23 | at Red Wings | W2-1 | 10-9-3 | 23 PTS | Little Caesars Arena · Detroit, MI |
| 23 | Tue Nov 26 | vs Canucks | L0-2 | 10-10-3 | 23 PTS | TD Garden · Boston, MA |
| 24 | Wed Nov 27 | at Islanders | W6-3 | 11-10-3 | 25 PTS | UBS Arena · Elmont, NY |
| 25 | Fri Nov 29 | vs Penguins | L1-2 | 11-11-3 | 25 PTS | TD Garden · Boston, MA |
| 26 | Sun Dec 1 | vsCanadiens | W6-3 | 12-11-3 | 27 PTS | TD Garden · Boston, MA |
| 27 | Tue Dec 3 | vsRed Wings | W3-2 (OT) | 13-11-3 | 29 PTS | TD Garden · Boston, MA |
| 28 | Wed Dec 4 | at Blackhawks | W4-2 | 14-11-3 | 31 PTS | United Center · Chicago, IL |
| 29 | Sat Dec 7 | vsFlyers | W4-3 (OT) | 15-11-3 | 33 PTS | TD Garden · Boston, MA |
| 30 | Tue Dec 10 | at Jets | L1-8 | 15-12-3 | 33 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 31 | Thu Dec 12 | atKraken | L1-5 | 15-13-3 | 33 PTS | Climate Pledge Arena · Seattle, WA |
| 32 | Sat Dec 14 | atCanucks | W5-1 | 16-13-3 | 35 PTS | Rogers Arena · Vancouver, British Columbia |
| 33 | Tue Dec 17 | atFlames | W4-3 (OT) | 17-13-3 | 37 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 34 | Thu Dec 19 | at Oilers | L2-3 (OT) | 17-13-4 | 38 PTS | Rogers Place · Edmonton, AB |
| 35 | Sat Dec 21 | vs Sabres | W3-1 | 18-13-4 | 40 PTS | TD Garden · Boston, MA |
| 36 | Mon Dec 23 | vs Capitals | W4-1 | 19-13-4 | 42 PTS | TD Garden · Boston, MA |
| 37 | Fri Dec 27 | atJackets | L2-6 | 19-14-4 | 42 PTS | Nationwide Arena · Columbus, OH |
| 38 | Sat Dec 28 | vsJackets | W4-0 | 20-14-4 | 44 PTS | TD Garden · Boston, MA |
| 39 | Tue Dec 31 | atCapitals | L1-3 | 20-15-4 | 44 PTS | Capital One Arena · Washington, D.C. |
| 40 | Thu Jan 2 | at Rangers | L1-2 | 20-16-4 | 44 PTS | Madison Square Garden · Manhattan, NY |
| 41 | Sat Jan 4 | atMaple Leafs | L4-6 | 20-17-4 | 44 PTS | Scotiabank Arena · Toronto, ON |
| 42 | Sun Jan 5 | vsIslanders | L4-5 (OT) | 20-17-5 | 45 PTS | TD Garden · Boston, MA |
| 43 | Tue Jan 7 | vsOilers | L0-4 | 20-18-5 | 45 PTS | TD Garden · Boston, MA |
| 44 | Thu Jan 9 | at Lightning | L1-4 | 20-19-5 | 45 PTS | AMALIE Arena · Tampa, FL |
| 45 | Sat Jan 11 | atPanthers | W4-3 (OT) | 21-19-5 | 47 PTS | Amerant Bank Arena · Sunrise, FL |
| 46 | Tue Jan 14 | vsLightning | W6-2 | 22-19-5 | 49 PTS | TD Garden · Boston, MA |
| 47 | Sat Jan 18 | atSenators | L5-6 (SO) | 22-19-6 | 50 PTS | Canadian Tire Centre · Ottawa, ON |
| 48 | Mon Jan 20 | vs Sharks | W6-3 | 23-19-6 | 52 PTS | TD Garden · Boston, MA |
| 49 | Wed Jan 22 | at Devils | L1-5 | 23-20-6 | 52 PTS | Prudential Center · Newark, NJ |
| 50 | Thu Jan 23 | vsSenators | W2-0 | 24-20-6 | 54 PTS | TD Garden · Boston, MA |
| 51 | Sat Jan 25 | vsAvalanche | W3-1 | 25-20-6 | 56 PTS | TD Garden · Boston, MA |
| 52 | Tue Jan 28 | atSabres | L2-7 | 25-21-6 | 56 PTS | KeyBank Center · Buffalo, NY |
| 53 | Thu Jan 30 | vsJets | L2-6 | 25-22-6 | 56 PTS | TD Garden · Boston, MA |
| 54 | Sat Feb 1 | vsRangers | W6-3 | 26-22-6 | 58 PTS | TD Garden · Boston, MA |
| 55 | Tue Feb 4 | vs Wild | W3-0 | 27-22-6 | 60 PTS | TD Garden · Boston, MA |
| 56 | Wed Feb 5 | atRangers | L2-3 | 27-23-6 | 60 PTS | Madison Square Garden · Manhattan, NY |
| 57 | Sat Feb 8 | vs Knights | L3-4 | 27-24-6 | 60 PTS | TD Garden · Boston, MA |
Ducks