| 1 | Thu Mar 31 | at Nationals | W2-0 | 1-0 | 1.000 | Nationals Park · Washington, D.C. |
| 2 | Sat Apr 2 | at Nationals | L3-6 | 1-1 | .500 | Nationals Park · Washington, D.C. |
| 3 | Sun Apr 3 | at Nationals | W11-2 | 2-1 | .667 | Nationals Park · Washington, D.C. |
| 4 | Mon Apr 4 | at Brewers | W2-1 | 3-1 | .750 | American Family Field · Milwaukee, WI |
| 5 | Tue Apr 5 | at Brewers | L0-1 | 3-2 | .600 | American Family Field · Milwaukee, WI |
| 6 | Wed Apr 6 | at Brewers | L4-5 | 3-3 | .500 | American Family Field · Milwaukee, WI |
| 7 | Thu Apr 7 | at Brewers | L2-4 | 3-4 | .429 | American Family Field · Milwaukee, WI |
| 8 | Fri Apr 8 | vs Phillies | W6-3 | 4-4 | .500 | Truist Park · Cumberland, GA |
| 9 | Sat Apr 9 | vs Phillies | L2-10 | 4-5 | .444 | Truist Park · Cumberland, GA |
| 10 | Sun Apr 10 | vs Phillies | L0-3 | 4-6 | .400 | Truist Park · Cumberland, GA |
| 11 | Tue Apr 12 | vs Marlins | W5-0 | 5-6 | .455 | Truist Park · Cumberland, GA |
| 12 | Wed Apr 13 | vs Marlins | L1-5 | 5-7 | .417 | Truist Park · Cumberland, GA |
| 13 | Thu Apr 14 | vs Marlins | L5-6 | 5-8 | .385 | Truist Park · Cumberland, GA |
| 14 | Sat Apr 16 | vs Mets | W4-2 | 6-8 | .429 | Truist Park · Cumberland, GA |
| 15 | Sat Apr 16 | vs Mets | W4-0 | 7-8 | .467 | Truist Park · Cumberland, GA |
| 16 | Sun Apr 17 | vs Mets | L2-3 | 7-9 | .438 | Truist Park · Cumberland, GA |
| 17 | Mon Apr 18 | at Dodgers | L2-4 | 7-10 | .412 | Dodger Stadium · Los Angeles, CA |
| 18 | Tue Apr 19 | at Dodgers | W10-1 | 8-10 | .444 | Dodger Stadium · Los Angeles, CA |
| 19 | Wed Apr 20 | at Dodgers | L1-6 | 8-11 | .421 | Dodger Stadium · Los Angeles, CA |
| 20 | Thu Apr 21 | at Dodgers | L3-5 (12) | 8-12 | .400 | Dodger Stadium · Los Angeles, CA |
| 21 | Fri Apr 22 | at Giants | W4-1 | 9-12 | .429 | Oracle Park · San Francisco, CA |
| 22 | Sat Apr 23 | at Giants | W5-2 | 10-12 | .455 | Oracle Park · San Francisco, CA |
| 23 | Sun Apr 24 | at Giants | W9-6 (10) | 11-12 | .478 | Oracle Park · San Francisco, CA |
| 24 | Mon Apr 25 | at Padres | L3-5 (13) | 11-13 | .458 | Petco Park · San Diego, CA |
| 25 | Tue Apr 26 | at Padres | W8-2 | 12-13 | .480 | Petco Park · San Diego, CA |
| 26 | Wed Apr 27 | at Padres | W7-0 | 13-13 | .500 | Petco Park · San Diego, CA |
| 27 | Fri Apr 29 | vs Cardinals | L3-5 (11) | 13-14 | .481 | Truist Park · Cumberland, GA |
| 28 | Sat Apr 30 | vs Cardinals | L2-3 | 13-15 | .464 | Truist Park · Cumberland, GA |
| 29 | Sun May 1 | vs Cardinals | W6-5 | 14-15 | .483 | Truist Park · Cumberland, GA |
| 30 | Mon May 2 | vs Brewers | W6-2 | 15-15 | .500 | Truist Park · Cumberland, GA |
| 31 | Wed May 4 | vs Brewers | W8-3 | 16-15 | .516 | Truist Park · Cumberland, GA |
| 32 | Wed May 4 | vs Brewers | W8-0 | 17-15 | .531 | Truist Park · Cumberland, GA |
| 33 | Thu May 5 | vs Brewers | W2-1 | 18-15 | .545 | Truist Park · Cumberland, GA |
| 34 | Fri May 6 | at Phillies | W5-0 | 19-15 | .559 | Citizens Bank Park · Philadelphi, PA |
| 35 | Sat May 7 | at Phillies | L0-3 | 19-16 | .543 | Citizens Bank Park · Philadelphi, PA |
| 36 | Sun May 8 | at Phillies | W5-2 | 20-16 | .556 | Citizens Bank Park · Philadelphi, PA |
| 37 | Tue May 10 | vs Nationals | L6-7 | 20-17 | .541 | Truist Park · Cumberland, GA |
| 38 | Wed May 11 | vs Nationals | L3-7 (11) | 20-18 | .526 | Truist Park · Cumberland, GA |
| 39 | Thu May 12 | vs Nationals | W6-5 (10) | 21-18 | .538 | Truist Park · Cumberland, GA |
| 40 | Fri May 13 | vs Phillies | L4-5 | 21-19 | .525 | Truist Park · Cumberland, GA |
| 41 | Sat May 14 | vs Phillies | W5-3 | 22-19 | .537 | Truist Park · Cumberland, GA |
| 42 | Sun May 15 | vs Phillies | W3-2 | 23-19 | .548 | Truist Park · Cumberland, GA |
| 43 | Mon May 16 | vs Astros | W3-2 | 24-19 | .558 | Truist Park · Cumberland, GA |
| 44 | Tue May 17 | vs Astros | W3-1 (11) | 25-19 | .568 | Truist Park · Cumberland, GA |
| 45 | Wed May 18 | at D-backs | L4-5 (11) | 25-20 | .556 | Chase Field · Phoenix, AZ |
| 46 | Thu May 19 | at D-backs | L1-2 | 25-21 | .543 | Chase Field · Phoenix, AZ |
| 47 | Fri May 20 | at Angels | L0-9 | 25-22 | .532 | Angel Stadium · Anaheim, CA |
| 48 | Sat May 21 | at Angels | W5-4 (12) | 26-22 | .542 | Angel Stadium · Anaheim, CA |
| 49 | Sun May 22 | at Angels | L1-4 | 26-23 | .531 | Angel Stadium · Anaheim, CA |
| 50 | Tue May 24 | at Pirates | W2-0 | 27-23 | .540 | PNC Park · Pittsburgh, PA |
| 51 | Wed May 25 | at Pirates | W4-2 (11) | 28-23 | .549 | PNC Park · Pittsburgh, PA |
| 52 | Fri May 27 | vs Reds | L1-5 | 28-24 | .538 | Truist Park · Cumberland, GA |
| 53 | Sat May 28 | vs Reds | W7-6 (12) | 29-24 | .547 | Truist Park · Cumberland, GA |
| 54 | Sun May 29 | vs Reds | W2-1 | 30-24 | .556 | Truist Park · Cumberland, GA |
| 55 | Mon May 30 | vs Padres | L2-3 (10) | 30-25 | .545 | Truist Park · Cumberland, GA |
| 56 | Tue May 31 | vs Padres | L4-5 | 30-26 | .536 | Truist Park · Cumberland, GA |
| 57 | Wed Jun 1 | vs Padres | W4-3 | 31-26 | .544 | Truist Park · Cumberland, GA |
| 58 | Fri Jun 3 | at Mets | W6-3 | 32-26 | .552 | Citi Field · Queens, NY |
| 59 | Sat Jun 4 | at Mets | L0-5 | 32-27 | .542 | Citi Field · Queens, NY |
| 60 | Sun Jun 5 | at Mets | L4-6 | 32-28 | .533 | Citi Field · Queens, NY |
| 61 | Tue Jun 7 | at Marlins | W1-0 | 33-28 | .541 | MVP Arena · Albany, NY |
| 62 | Wed Jun 8 | at Marlins | W3-2 (10) | 34-28 | .548 | MVP Arena · Albany, NY |
| 63 | Thu Jun 9 | at Marlins | W3-2 | 35-28 | .556 | MVP Arena · Albany, NY |
| 64 | Fri Jun 10 | at Astros | W11-4 | 36-28 | .563 | Minute Maid Park · Houston, TX |
| 65 | Sat Jun 11 | at Astros | W6-3 (10) | 37-28 | .569 | Minute Maid Park · Houston, TX |
| 66 | Sun Jun 12 | at Astros | W4-1 | 38-28 | .576 | Minute Maid Park · Houston, TX |
| 67 | Mon Jun 13 | at Astros | L3-8 | 38-29 | .567 | Minute Maid Park · Houston, TX |
| 68 | Tue Jun 14 | vs Mets | L3-4 | 38-30 | .559 | Truist Park · Cumberland, GA |
| 69 | Wed Jun 15 | vs Mets | L0-4 | 38-31 | .551 | Truist Park · Cumberland, GA |
| 70 | Thu Jun 16 | vs Mets | W9-8 (10) | 39-31 | .557 | Truist Park · Cumberland, GA |
| 71 | Fri Jun 17 | vs Rangers | L2-6 | 39-32 | .549 | Truist Park · Cumberland, GA |
| 72 | Sat Jun 18 | vs Rangers | L4-5 (10) | 39-33 | .542 | Truist Park · Cumberland, GA |
| 73 | Sun Jun 19 | vs Rangers | W4-2 | 40-33 | .548 | Truist Park · Cumberland, GA |
| 74 | Mon Jun 20 | vs Blue Jays | W2-0 | 41-33 | .554 | Truist Park · Cumberland, GA |
| 75 | Tue Jun 21 | vs Blue Jays | W5-1 | 42-33 | .560 | Truist Park · Cumberland, GA |
| 76 | Wed Jun 22 | vs Blue Jays | W5-1 | 43-33 | .566 | Truist Park · Cumberland, GA |
| 77 | Fri Jun 24 | at Padres | L2-11 | 43-34 | .558 | Petco Park · San Diego, CA |
| 78 | Sat Jun 25 | at Padres | W10-1 | 44-34 | .564 | Petco Park · San Diego, CA |
| 79 | Sun Jun 26 | at Padres | L1-4 | 44-35 | .557 | Petco Park · San Diego, CA |
| 80 | Mon Jun 27 | at Mariners | W3-1 | 45-35 | .563 | T-Mobile Park · Seattle, WA |
| 81 | Tue Jun 28 | at Mariners | W5-4 | 46-35 | .568 | T-Mobile Park · Seattle, WA |
| 82 | Wed Jun 29 | at Mariners | W5-3 | 47-35 | .573 | T-Mobile Park · Seattle, WA |
| 83 | Fri Jul 1 | vs Orioles | W4-0 | 48-35 | .578 | Truist Park · Cumberland, GA |
| 84 | Sat Jul 2 | vs Orioles | W5-4 | 49-35 | .583 | Truist Park · Cumberland, GA |
| 85 | Sun Jul 3 | vs Orioles | L4-5 | 49-36 | .576 | Truist Park · Cumberland, GA |
| 86 | Mon Jul 4 | vs Rockies | W4-1 | 50-36 | .581 | Truist Park · Cumberland, GA |
| 87 | Tue Jul 5 | vs Rockies | W5-3 | 51-36 | .586 | Truist Park · Cumberland, GA |
| 88 | Wed Jul 6 | vs Rockies | W9-1 | 52-36 | .591 | Truist Park · Cumberland, GA |
| 89 | Thu Jul 7 | vs Rockies | W6-3 | 53-36 | .596 | Truist Park · Cumberland, GA |
| 90 | Fri Jul 8 | at Phillies | L2-3 (10) | 53-37 | .589 | Citizens Bank Park · Philadelphi, PA |
| 91 | Sat Jul 9 | at Phillies | W4-1 (11) | 54-37 | .593 | Citizens Bank Park · Philadelphi, PA |
| 92 | Sun Jul 10 | at Phillies | L1-14 | 54-38 | .587 | Citizens Bank Park · Philadelphi, PA |
| 93 | Fri Jul 15 | vs Nationals | W11-1 | 55-38 | .591 | Truist Park · Cumberland, GA |
| 94 | Sat Jul 16 | vs Nationals | L2-5 | 55-39 | .585 | Truist Park · Cumberland, GA |
| 95 | Sun Jul 17 | vs Nationals | W9-8 | 56-39 | .589 | Truist Park · Cumberland, GA |
| 96 | Mon Jul 18 | at Rockies | W7-4 | 57-39 | .594 | Coors Field · Denver, CO |
| 97 | Tue Jul 19 | at Rockies | L3-12 | 57-40 | .588 | Coors Field · Denver, CO |
| 98 | Wed Jul 20 | at Rockies | L2-3 | 57-41 | .582 | Coors Field · Denver, CO |
| 99 | Thu Jul 21 | at Rockies | W9-6 | 58-41 | .586 | Coors Field · Denver, CO |
| 100 | Fri Jul 22 | at Reds | W6-4 | 59-41 | .590 | Great American Ball Park · Cincinnati, OH |
| 101 | Sat Jul 23 | at Reds | L2-11 | 59-42 | .584 | Great American Ball Park · Cincinnati, OH |
| 102 | Sun Jul 24 | at Reds | L3-4 | 59-43 | .578 | Great American Ball Park · Cincinnati, OH |
| 103 | Mon Jul 25 | vs Pirates | L1-3 | 59-44 | .573 | Truist Park · Cumberland, GA |
| 104 | Tue Jul 26 | vs Pirates | W4-3 (19) | 60-44 | .577 | Truist Park · Cumberland, GA |
| 105 | Wed Jul 27 | vs Pirates | W2-1 (10) | 61-44 | .581 | Truist Park · Cumberland, GA |
| 106 | Thu Jul 28 | vs Pirates | L2-5 | 61-45 | .575 | Truist Park · Cumberland, GA |
| 107 | Fri Jul 29 | vs Marlins | W5-0 | 62-45 | .579 | Truist Park · Cumberland, GA |
| 108 | Sat Jul 30 | vs Marlins | W5-1 | 63-45 | .583 | Truist Park · Cumberland, GA |
| 109 | Sun Jul 31 | vs Marlins | L1-3 | 63-46 | .578 | Truist Park · Cumberland, GA |
| 110 | Mon Aug 1 | at Nationals | L3-5 | 63-47 | .573 | Nationals Park · Washington, D.C. |
| 111 | Tue Aug 2 | at Nationals | L3-9 | 63-48 | .568 | Nationals Park · Washington, D.C. |
| 112 | Wed Aug 3 | at Nationals | W6-4 | 64-48 | .571 | Nationals Park · Washington, D.C. |
| 113 | Fri Aug 5 | at Mets | W4-1 | 65-48 | .575 | Citi Field · Queens, NY |
| 114 | Sat Aug 6 | at Mets | L7-11 | 65-49 | .570 | Citi Field · Queens, NY |
| 115 | Sun Aug 7 | at Mets | W6-5 | 66-49 | .574 | Citi Field · Queens, NY |
| 116 | Mon Aug 8 | at Marlins | W8-5 | 67-49 | .578 | MVP Arena · Albany, NY |
| 117 | Tue Aug 9 | at Marlins | W4-3 (11) | 68-49 | .581 | MVP Arena · Albany, NY |
| 118 | Wed Aug 10 | at Marlins | W6-2 | 69-49 | .585 | MVP Arena · Albany, NY |
| 119 | Fri Aug 12 | vs Cubs | W10-4 | 70-49 | .588 | Truist Park · Cumberland, GA |
| 120 | Sat Aug 13 | vs Cubs | L4-8 | 70-50 | .583 | Truist Park · Cumberland, GA |
| 121 | Sun Aug 14 | vs Cubs | L5-6 | 70-51 | .579 | Truist Park · Cumberland, GA |
| 122 | Mon Aug 15 | vs Giants | W5-4 | 71-51 | .582 | Truist Park · Cumberland, GA |
| 123 | Tue Aug 16 | vs Giants | W2-1 (11) | 72-51 | .585 | Truist Park · Cumberland, GA |
| 124 | Wed Aug 17 | vs Giants | L5-7 | 72-52 | .581 | Truist Park · Cumberland, GA |
| 125 | Thu Aug 18 | vs Giants | W1-0 | 73-52 | .584 | Truist Park · Cumberland, GA |
| 126 | Fri Aug 19 | vs D-backs | W4-2 | 74-52 | .587 | Truist Park · Cumberland, GA |
| 127 | Sat Aug 20 | vs D-backs | W8-1 | 75-52 | .591 | Truist Park · Cumberland, GA |
| 128 | Sun Aug 21 | vs D-backs | W1-0 | 76-52 | .594 | Truist Park · Cumberland, GA |
| 129 | Mon Aug 22 | at Cubs | W3-0 | 77-52 | .597 | Wrigley Field · Chicago, IL |
| 130 | Tue Aug 23 | at Cubs | W5-4 | 78-52 | .600 | Wrigley Field · Chicago, IL |
| 131 | Wed Aug 24 | at Cubs | L2-3 | 78-53 | .595 | Wrigley Field · Chicago, IL |
| 132 | Thu Aug 25 | at Cubs | W8-3 | 79-53 | .598 | Wrigley Field · Chicago, IL |
| 133 | Fri Aug 26 | at Mets | L0-6 | 79-54 | .594 | Citi Field · Queens, NY |
| 134 | Tue Aug 30 | vs Nationals | L2-9 | 79-55 | .590 | Truist Park · Cumberland, GA |
| 135 | Wed Aug 31 | vs Nationals | W3-1 | 80-55 | .593 | Truist Park · Cumberland, GA |
| 136 | Thu Sep 1 | vs Nationals | W5-2 | 81-55 | .596 | Truist Park · Cumberland, GA |
| 137 | Fri Sep 2 | vs Dodgers | L6-8 | 81-56 | .591 | Truist Park · Cumberland, GA |
| 138 | Sat Sep 3 | vs Dodgers | L1-2 (10) | 81-57 | .587 | Truist Park · Cumberland, GA |
| 139 | Sun Sep 4 | vs Dodgers | W4-3 | 82-57 | .590 | Truist Park · Cumberland, GA |
| 140 | Mon Sep 5 | at Phillies | L0-9 | 82-58 | .586 | Citizens Bank Park · Philadelphi, PA |
| 141 | Tue Sep 6 | at Phillies | L3-6 | 82-59 | .582 | Citizens Bank Park · Philadelphi, PA |
| 142 | Wed Sep 7 | at Phillies | L2-3 | 82-60 | .577 | Citizens Bank Park · Philadelphi, PA |
| 143 | Thu Sep 8 | at Mets | W6-5 | 83-60 | .580 | Citi Field · Queens, NY |
| 144 | Thu Sep 8 | at Mets | W5-1 | 84-60 | .583 | Citi Field · Queens, NY |
| 145 | Fri Sep 9 | at Cardinals | L3-4 (10) | 84-61 | .579 | Busch Stadium · St. Louis, MO |
| 146 | Sat Sep 10 | at Cardinals | L3-4 | 84-62 | .575 | Busch Stadium · St. Louis, MO |
| 147 | Sun Sep 11 | at Cardinals | L3-6 | 84-63 | .571 | Busch Stadium · St. Louis, MO |
| 148 | Mon Sep 12 | vs Marlins | L4-5 (12) | 84-64 | .568 | Truist Park · Cumberland, GA |
| 149 | Tue Sep 13 | vs Marlins | W7-1 | 85-64 | .570 | Truist Park · Cumberland, GA |
| 150 | Wed Sep 14 | vs Marlins | W4-1 | 86-64 | .573 | Truist Park · Cumberland, GA |
| 151 | Fri Sep 16 | vs Mets | L2-12 | 86-65 | .570 | Truist Park · Cumberland, GA |
| 152 | Sat Sep 17 | vs Mets | W1-0 | 87-65 | .572 | Truist Park · Cumberland, GA |
| 153 | Sun Sep 18 | vs Mets | L5-7 | 87-66 | .569 | Truist Park · Cumberland, GA |
| 154 | Mon Sep 19 | at Marlins | L5-6 | 87-67 | .565 | MVP Arena · Albany, NY |
| 155 | Tue Sep 20 | at Marlins | W4-0 | 88-67 | .568 | MVP Arena · Albany, NY |
| 156 | Wed Sep 21 | at Marlins | L0-4 | 88-68 | .564 | MVP Arena · Albany, NY |
| 157 | Fri Sep 23 | at Nationals | W7-4 | 89-68 | .567 | Nationals Park · Washington, D.C. |
| 158 | Sat Sep 24 | at Nationals | L1-4 | 89-69 | .563 | Nationals Park · Washington, D.C. |
| 159 | Sun Sep 25 | at Nationals | L0-3 | 89-70 | .560 | Nationals Park · Washington, D.C. |
| 160 | Mon Sep 26 | vs Phillies | L2-4 | 89-71 | .556 | Truist Park · Cumberland, GA |
| 161 | Tue Sep 27 | vs Phillies | L1-7 | 89-72 | .553 | Truist Park · Cumberland, GA |
| 162 | Wed Sep 28 | vs Phillies | L3-4 (13) | 89-73 | .549 | Truist Park · Cumberland, GA |