| 1 | Thu Apr 5 | vs Phillies | L0-1 | 0-1 | .000 | PNC Park · Pittsburgh, PA |
| 2 | Sat Apr 7 | vs Phillies | W2-1 (10) | 1-1 | .500 | PNC Park · Pittsburgh, PA |
| 3 | Sun Apr 8 | vs Phillies | W5-4 | 2-1 | .667 | PNC Park · Pittsburgh, PA |
| 4 | Tue Apr 10 | at Dodgers | L1-2 | 2-2 | .500 | Dodger Stadium · Los Angeles, CA |
| 5 | Wed Apr 11 | at Dodgers | L1-4 | 2-3 | .400 | Dodger Stadium · Los Angeles, CA |
| 6 | Thu Apr 12 | at Dodgers | L2-3 | 2-4 | .333 | Dodger Stadium · Los Angeles, CA |
| 7 | Fri Apr 13 | at Giants | L0-5 | 2-5 | .286 | Oracle Park · San Francisco, CA |
| 8 | Sat Apr 14 | at Giants | L3-4 | 2-6 | .250 | Oracle Park · San Francisco, CA |
| 9 | Sun Apr 15 | at Giants | W4-1 | 3-6 | .333 | Oracle Park · San Francisco, CA |
| 10 | Mon Apr 16 | at D-backs | L1-5 | 3-7 | .300 | Chase Field · Phoenix, AZ |
| 11 | Tue Apr 17 | at D-backs | W5-4 | 4-7 | .364 | Chase Field · Phoenix, AZ |
| 12 | Wed Apr 18 | at D-backs | W2-1 | 5-7 | .417 | Chase Field · Phoenix, AZ |
| 13 | Fri Apr 20 | vs Cardinals | L1-4 | 5-8 | .385 | PNC Park · Pittsburgh, PA |
| 14 | Sat Apr 21 | vs Cardinals | W2-0 | 6-8 | .429 | PNC Park · Pittsburgh, PA |
| 15 | Sun Apr 22 | vs Cardinals | L1-5 | 6-9 | .400 | PNC Park · Pittsburgh, PA |
| 16 | Tue Apr 24 | vs Rockies | W5-4 | 7-9 | .438 | PNC Park · Pittsburgh, PA |
| 17 | Wed Apr 25 | vs Rockies | L1-2 | 7-10 | .412 | PNC Park · Pittsburgh, PA |
| 18 | Wed Apr 25 | vs Rockies | W5-1 | 8-10 | .444 | PNC Park · Pittsburgh, PA |
| 19 | Fri Apr 27 | at Braves | L1-6 | 8-11 | .421 | Truist Park · Cumberland, GA |
| 20 | Sat Apr 28 | at Braves | W4-2 | 9-11 | .450 | Truist Park · Cumberland, GA |
| 21 | Sun Apr 29 | at Braves | L3-4 | 9-12 | .429 | Truist Park · Cumberland, GA |
| 22 | Mon Apr 30 | at Braves | W9-3 | 10-12 | .455 | Truist Park · Cumberland, GA |
| 23 | Tue May 1 | at Cardinals | L7-10 | 10-13 | .435 | Busch Stadium · St. Louis, MO |
| 24 | Wed May 2 | at Cardinals | L3-12 | 10-14 | .417 | Busch Stadium · St. Louis, MO |
| 25 | Thu May 3 | at Cardinals | W6-3 | 11-14 | .440 | Busch Stadium · St. Louis, MO |
| 26 | Fri May 4 | vs Reds | L1-6 | 11-15 | .423 | PNC Park · Pittsburgh, PA |
| 27 | Sat May 5 | vs Reds | W3-2 | 12-15 | .444 | PNC Park · Pittsburgh, PA |
| 28 | Sun May 6 | vs Reds | L0-5 | 12-16 | .429 | PNC Park · Pittsburgh, PA |
| 29 | Tue May 8 | vs Nationals | W5-4 | 13-16 | .448 | PNC Park · Pittsburgh, PA |
| 30 | Wed May 9 | vs Nationals | W4-2 | 14-16 | .467 | PNC Park · Pittsburgh, PA |
| 31 | Thu May 10 | vs Nationals | L2-4 | 14-17 | .452 | PNC Park · Pittsburgh, PA |
| 32 | Fri May 11 | vs Astros | L0-1 | 14-18 | .438 | PNC Park · Pittsburgh, PA |
| 33 | Sat May 12 | vs Astros | W5-2 | 15-18 | .455 | PNC Park · Pittsburgh, PA |
| 34 | Sun May 13 | vs Astros | W3-2 (12) | 16-18 | .471 | PNC Park · Pittsburgh, PA |
| 35 | Mon May 14 | at Marlins | W3-2 | 17-18 | .486 | LoanDepot Park · Miami, FL |
| 36 | Tue May 15 | at Marlins | L2-6 | 17-19 | .472 | LoanDepot Park · Miami, FL |
| 37 | Wed May 16 | at Nationals | L4-7 | 17-20 | .459 | Nationals Park · Washington, D.C. |
| 38 | Thu May 17 | at Nationals | W5-3 | 18-20 | .474 | Nationals Park · Washington, D.C. |
| 39 | Fri May 18 | at Tigers | L0-6 | 18-21 | .462 | Comerica Park · Detroit, MI |
| 40 | Sat May 19 | at Tigers | W4-3 | 19-21 | .475 | Comerica Park · Detroit, MI |
| 41 | Sun May 20 | at Tigers | L3-4 | 19-22 | .463 | Comerica Park · Detroit, MI |
| 42 | Mon May 21 | vs Mets | W5-4 | 20-22 | .476 | PNC Park · Pittsburgh, PA |
| 43 | Tue May 22 | vs Mets | L2-3 | 20-23 | .465 | PNC Park · Pittsburgh, PA |
| 44 | Wed May 23 | vs Mets | L1-3 | 20-24 | .455 | PNC Park · Pittsburgh, PA |
| 45 | Fri May 25 | vs Cubs | W1-0 | 21-24 | .467 | PNC Park · Pittsburgh, PA |
| 46 | Sat May 26 | vs Cubs | W3-2 | 22-24 | .478 | PNC Park · Pittsburgh, PA |
| 47 | Sun May 27 | vs Cubs | W10-4 | 23-24 | .489 | PNC Park · Pittsburgh, PA |
| 48 | Mon May 28 | vs Reds | W4-1 | 24-24 | .500 | PNC Park · Pittsburgh, PA |
| 49 | Tue May 29 | vs Reds | L1-8 | 24-25 | .490 | PNC Park · Pittsburgh, PA |
| 50 | Wed May 30 | vs Reds | W2-1 | 25-25 | .500 | PNC Park · Pittsburgh, PA |
| 51 | Fri Jun 1 | at Brewers | W8-2 | 26-25 | .510 | American Family Field · Milwaukee, WI |
| 52 | Sat Jun 2 | at Brewers | L1-5 | 26-26 | .500 | American Family Field · Milwaukee, WI |
| 53 | Sun Jun 3 | at Brewers | W6-5 | 27-26 | .509 | American Family Field · Milwaukee, WI |
| 54 | Tue Jun 5 | at Reds | W8-4 | 28-26 | .519 | Great American Ball Park · Cincinnati, OH |
| 55 | Wed Jun 6 | at Reds | L4-5 | 28-27 | .509 | Great American Ball Park · Cincinnati, OH |
| 56 | Thu Jun 7 | at Reds | W5-4 (10) | 29-27 | .518 | Great American Ball Park · Cincinnati, OH |
| 57 | Fri Jun 8 | vs Royals | W4-2 | 30-27 | .526 | PNC Park · Pittsburgh, PA |
| 58 | Sat Jun 9 | vs Royals | W5-3 | 31-27 | .534 | PNC Park · Pittsburgh, PA |
| 59 | Sun Jun 10 | vs Royals | W3-2 | 32-27 | .542 | PNC Park · Pittsburgh, PA |
| 60 | Tue Jun 12 | at Orioles | L6-8 | 32-28 | .533 | Camden Yards · Baltimore, MD |
| 61 | Wed Jun 13 | at Orioles | L1-7 | 32-29 | .525 | Camden Yards · Baltimore, MD |
| 62 | Thu Jun 14 | at Orioles | L6-12 | 32-30 | .516 | Camden Yards · Baltimore, MD |
| 63 | Fri Jun 15 | at Guardians | L0-2 | 32-31 | .508 | Progressive Field · Cleveland, OH |
| 64 | Sat Jun 16 | at Guardians | W9-2 | 33-31 | .516 | Progressive Field · Cleveland, OH |
| 65 | Sun Jun 17 | at Guardians | W9-5 | 34-31 | .523 | Progressive Field · Cleveland, OH |
| 66 | Tue Jun 19 | vs Twins | W7-2 | 35-31 | .530 | PNC Park · Pittsburgh, PA |
| 67 | Wed Jun 20 | vs Twins | L1-2 | 35-32 | .522 | PNC Park · Pittsburgh, PA |
| 68 | Thu Jun 21 | vs Twins | W9-1 | 36-32 | .529 | PNC Park · Pittsburgh, PA |
| 69 | Fri Jun 22 | vs Tigers | W4-1 | 37-32 | .536 | PNC Park · Pittsburgh, PA |
| 70 | Sat Jun 23 | vs Tigers | W4-1 | 38-32 | .543 | PNC Park · Pittsburgh, PA |
| 71 | Sun Jun 24 | vs Tigers | L2-3 | 38-33 | .535 | PNC Park · Pittsburgh, PA |
| 72 | Mon Jun 25 | at Phillies | L3-8 | 38-34 | .528 | Citizens Bank Park · Philadelphi, PA |
| 73 | Tue Jun 26 | at Phillies | L4-5 | 38-35 | .521 | Citizens Bank Park · Philadelphi, PA |
| 74 | Wed Jun 27 | at Phillies | W11-7 | 39-35 | .527 | Citizens Bank Park · Philadelphi, PA |
| 75 | Thu Jun 28 | at Phillies | W5-4 | 40-35 | .533 | Citizens Bank Park · Philadelphi, PA |
| 76 | Fri Jun 29 | at Cardinals | W14-5 | 41-35 | .539 | Busch Stadium · St. Louis, MO |
| 77 | Sat Jun 30 | at Cardinals | W7-3 | 42-35 | .545 | Busch Stadium · St. Louis, MO |
| 78 | Sun Jul 1 | at Cardinals | L4-5 | 42-36 | .538 | Busch Stadium · St. Louis, MO |
| 79 | Mon Jul 2 | vs Astros | W11-2 | 43-36 | .544 | PNC Park · Pittsburgh, PA |
| 80 | Tue Jul 3 | vs Astros | W8-7 | 44-36 | .550 | PNC Park · Pittsburgh, PA |
| 81 | Wed Jul 4 | vs Astros | W6-4 | 45-36 | .556 | PNC Park · Pittsburgh, PA |
| 82 | Thu Jul 5 | vs Astros | W2-0 | 46-36 | .561 | PNC Park · Pittsburgh, PA |
| 83 | Fri Jul 6 | vs Giants | L5-6 | 46-37 | .554 | PNC Park · Pittsburgh, PA |
| 84 | Sat Jul 7 | vs Giants | W3-1 | 47-37 | .560 | PNC Park · Pittsburgh, PA |
| 85 | Sun Jul 8 | vs Giants | W13-2 | 48-37 | .565 | PNC Park · Pittsburgh, PA |
| 86 | Fri Jul 13 | at Brewers | L7-10 | 48-38 | .558 | American Family Field · Milwaukee, WI |
| 87 | Sat Jul 14 | at Brewers | W6-4 | 49-38 | .563 | American Family Field · Milwaukee, WI |
| 88 | Sun Jul 15 | at Brewers | L1-4 | 49-39 | .557 | American Family Field · Milwaukee, WI |
| 89 | Mon Jul 16 | at Rockies | L4-5 | 49-40 | .551 | Coors Field · Denver, CO |
| 90 | Tue Jul 17 | at Rockies | W6-2 | 50-40 | .556 | Coors Field · Denver, CO |
| 91 | Wed Jul 18 | at Rockies | W9-6 | 51-40 | .560 | Coors Field · Denver, CO |
| 92 | Fri Jul 20 | vs Marlins | W4-3 | 52-40 | .565 | PNC Park · Pittsburgh, PA |
| 93 | Sat Jul 21 | vs Marlins | W5-1 | 53-40 | .570 | PNC Park · Pittsburgh, PA |
| 94 | Sun Jul 22 | vs Marlins | W3-0 | 54-40 | .574 | PNC Park · Pittsburgh, PA |
| 95 | Mon Jul 23 | vs Cubs | L0-2 | 54-41 | .568 | PNC Park · Pittsburgh, PA |
| 96 | Tue Jul 24 | vs Cubs | L1-5 | 54-42 | .563 | PNC Park · Pittsburgh, PA |
| 97 | Wed Jul 25 | vs Cubs | W3-2 | 55-42 | .567 | PNC Park · Pittsburgh, PA |
| 98 | Thu Jul 26 | at Astros | W5-3 | 56-42 | .571 | Minute Maid Park · Houston, TX |
| 99 | Fri Jul 27 | at Astros | W6-5 | 57-42 | .576 | Minute Maid Park · Houston, TX |
| 100 | Sat Jul 28 | at Astros | W4-3 | 58-42 | .580 | Minute Maid Park · Houston, TX |
| 101 | Sun Jul 29 | at Astros | L5-9 | 58-43 | .574 | Minute Maid Park · Houston, TX |
| 102 | Mon Jul 30 | at Cubs | L4-14 | 58-44 | .569 | Wrigley Field · Chicago, IL |
| 103 | Tue Jul 31 | at Cubs | W5-0 | 59-44 | .573 | Wrigley Field · Chicago, IL |
| 104 | Wed Aug 1 | at Cubs | W8-4 | 60-44 | .577 | Wrigley Field · Chicago, IL |
| 105 | Fri Aug 3 | at Reds | L0-3 | 60-45 | .571 | Great American Ball Park · Cincinnati, OH |
| 106 | Sat Aug 4 | at Reds | L4-5 | 60-46 | .566 | Great American Ball Park · Cincinnati, OH |
| 107 | Sun Aug 5 | at Reds | W6-2 | 61-46 | .570 | Great American Ball Park · Cincinnati, OH |
| 108 | Mon Aug 6 | vs D-backs | W4-0 | 62-46 | .574 | PNC Park · Pittsburgh, PA |
| 109 | Tue Aug 7 | vs D-backs | L4-10 | 62-47 | .569 | PNC Park · Pittsburgh, PA |
| 110 | Wed Aug 8 | vs D-backs | W7-6 | 63-47 | .573 | PNC Park · Pittsburgh, PA |
| 111 | Thu Aug 9 | vs D-backs | L3-6 | 63-48 | .568 | PNC Park · Pittsburgh, PA |
| 112 | Fri Aug 10 | vs Padres | L8-9 | 63-49 | .563 | PNC Park · Pittsburgh, PA |
| 113 | Sat Aug 11 | vs Padres | L0-5 | 63-50 | .558 | PNC Park · Pittsburgh, PA |
| 114 | Sun Aug 12 | vs Padres | W11-5 | 64-50 | .561 | PNC Park · Pittsburgh, PA |
| 115 | Mon Aug 13 | vs Dodgers | L4-5 | 64-51 | .557 | PNC Park · Pittsburgh, PA |
| 116 | Tue Aug 14 | vs Dodgers | L0-11 | 64-52 | .552 | PNC Park · Pittsburgh, PA |
| 117 | Wed Aug 15 | vs Dodgers | L3-9 | 64-53 | .547 | PNC Park · Pittsburgh, PA |
| 118 | Thu Aug 16 | vs Dodgers | W10-6 | 65-53 | .551 | PNC Park · Pittsburgh, PA |
| 119 | Fri Aug 17 | at Cardinals | W2-1 | 66-53 | .555 | Busch Stadium · St. Louis, MO |
| 120 | Sat Aug 18 | at Cardinals | L4-5 | 66-54 | .550 | Busch Stadium · St. Louis, MO |
| 121 | Sun Aug 19 | at Cardinals | W6-3 (19) | 67-54 | .554 | Busch Stadium · St. Louis, MO |
| 122 | Mon Aug 20 | at Padres | L1-3 | 67-55 | .549 | Petco Park · San Diego, CA |
| 123 | Tue Aug 21 | at Padres | L5-7 (10) | 67-56 | .545 | Petco Park · San Diego, CA |
| 124 | Wed Aug 22 | at Padres | L2-4 | 67-57 | .540 | Petco Park · San Diego, CA |
| 125 | Fri Aug 24 | vs Brewers | L5-6 | 67-58 | .536 | PNC Park · Pittsburgh, PA |
| 126 | Sat Aug 25 | vs Brewers | W4-0 | 68-58 | .540 | PNC Park · Pittsburgh, PA |
| 127 | Sun Aug 26 | vs Brewers | L0-7 | 68-59 | .535 | PNC Park · Pittsburgh, PA |
| 128 | Mon Aug 27 | vs Cardinals | L3-4 | 68-60 | .531 | PNC Park · Pittsburgh, PA |
| 129 | Tue Aug 28 | vs Cardinals | W9-0 | 69-60 | .535 | PNC Park · Pittsburgh, PA |
| 130 | Wed Aug 29 | vs Cardinals | W5-0 | 70-60 | .538 | PNC Park · Pittsburgh, PA |
| 131 | Fri Aug 31 | at Brewers | L3-9 | 70-61 | .534 | American Family Field · Milwaukee, WI |
| 132 | Sat Sep 1 | at Brewers | L2-3 | 70-62 | .530 | American Family Field · Milwaukee, WI |
| 133 | Sun Sep 2 | at Brewers | L8-12 | 70-63 | .526 | American Family Field · Milwaukee, WI |
| 134 | Mon Sep 3 | vs Astros | L1-5 | 70-64 | .522 | PNC Park · Pittsburgh, PA |
| 135 | Tue Sep 4 | vs Astros | W6-2 | 71-64 | .526 | PNC Park · Pittsburgh, PA |
| 136 | Wed Sep 5 | vs Astros | W6-3 | 72-64 | .529 | PNC Park · Pittsburgh, PA |
| 137 | Fri Sep 7 | vs Cubs | L2-12 | 72-65 | .526 | PNC Park · Pittsburgh, PA |
| 138 | Sat Sep 8 | vs Cubs | L3-4 | 72-66 | .522 | PNC Park · Pittsburgh, PA |
| 139 | Sun Sep 9 | vs Cubs | L2-4 | 72-67 | .518 | PNC Park · Pittsburgh, PA |
| 140 | Mon Sep 10 | at Reds | L3-4 (14) | 72-68 | .514 | Great American Ball Park · Cincinnati, OH |
| 141 | Tue Sep 11 | at Reds | L3-5 | 72-69 | .511 | Great American Ball Park · Cincinnati, OH |
| 142 | Wed Sep 12 | at Reds | L1-2 | 72-70 | .507 | Great American Ball Park · Cincinnati, OH |
| 143 | Fri Sep 14 | at Cubs | L4-7 | 72-71 | .503 | Wrigley Field · Chicago, IL |
| 144 | Sat Sep 15 | at Cubs | W7-6 | 73-71 | .507 | Wrigley Field · Chicago, IL |
| 145 | Sun Sep 16 | at Cubs | L9-13 | 73-72 | .503 | Wrigley Field · Chicago, IL |
| 146 | Mon Sep 17 | at Cubs | W3-0 | 74-72 | .507 | Wrigley Field · Chicago, IL |
| 147 | Tue Sep 18 | vs Brewers | L0-6 | 74-73 | .503 | PNC Park · Pittsburgh, PA |
| 148 | Wed Sep 19 | vs Brewers | L1-3 | 74-74 | .500 | PNC Park · Pittsburgh, PA |
| 149 | Thu Sep 20 | vs Brewers | L7-9 | 74-75 | .497 | PNC Park · Pittsburgh, PA |
| 150 | Fri Sep 21 | at Astros | L1-7 | 74-76 | .493 | Minute Maid Park · Houston, TX |
| 151 | Sat Sep 22 | at Astros | L1-4 | 74-77 | .490 | Minute Maid Park · Houston, TX |
| 152 | Sun Sep 23 | at Astros | W8-1 | 75-77 | .493 | Minute Maid Park · Houston, TX |
| 153 | Mon Sep 24 | at Mets | L2-6 | 75-78 | .490 | Citi Field · Queens, NY |
| 154 | Tue Sep 25 | at Mets | W10-6 | 76-78 | .494 | Citi Field · Queens, NY |
| 155 | Wed Sep 26 | at Mets | L0-6 | 76-79 | .490 | Citi Field · Queens, NY |
| 156 | Thu Sep 27 | at Mets | L5-6 | 76-80 | .487 | Citi Field · Queens, NY |
| 157 | Fri Sep 28 | vs Reds | L0-1 | 76-81 | .484 | PNC Park · Pittsburgh, PA |
| 158 | Sat Sep 29 | vs Reds | W2-1 | 77-81 | .487 | PNC Park · Pittsburgh, PA |
| 159 | Sun Sep 30 | vs Reds | L3-4 | 77-82 | .484 | PNC Park · Pittsburgh, PA |
| 160 | Mon Oct 1 | vs Braves | W2-1 | 78-82 | .487 | PNC Park · Pittsburgh, PA |
| 161 | Tue Oct 2 | vs Braves | W5-1 | 79-82 | .491 | PNC Park · Pittsburgh, PA |
| 162 | Wed Oct 3 | vs Braves | L0-4 | 79-83 | .488 | PNC Park · Pittsburgh, PA |